TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/396

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3D Sampling of K-Space With Non-Cartesian Trajectories in MR Imaging
(Gazi Univ, Fac Engineering Architecture, 2025) Dundar, Mehmet Sait; Gumus, Kazim Z.; Yilmaz, Bulent
This study presents an innovative approach to 3D k-space sampling in MR imaging using non-Cartesian concentric shell trajectories. The method involves 32 concentric shells of varying radii, allowing for rapid data acquisition through undersampling techniques. Simulations using IDEA software demonstrate that this approach can fill the k-space in less than one second, a significant time reduction compared to traditional FLASH sequences that can take 3-4 minutes. The concentric shell model enhances imaging efficiency by minimizing artifacts and ensuring uniform k-space filling, leading to higher resolution and faster scans. This technique shows promise for clinical applications, particularly in dynamic imaging scenarios such as acute stroke and pediatric radiology, where speed and precision are critical. As illustrated in Figure A, the concentric shell trajectories enable uniform k-space filling, significantly reducing scan times and improving image quality. These results are based on the simulations conducted with IDEA software.
Citation - WoS: 4
Citation - Scopus: 4
All-Polymer Ultrasonic Transducer Design for an Intravascular Ultrasonography Application
(Tubitak Scientific & Technological Research Council Turkey, 2019) Hah, Dooyoung
Intravascular ultrasonography (IVUS), a medical imaging modality, is used to obtain cross-sectional views of blood vessels from inside. In IVUS, transducers are brought to the proximity of the imaging targets so that high-resolution images can be obtained at high frequency without much concern of signal attenuation. To eliminate mechanical rotation rendered in conventional IVUS, it is proposed to manufacture a transducer array on a flexible substrate and wrap it around a cylindrical frame. The transducer of consideration is a capacitive micromachined ultrasonic transducer (CMUT). The whole device needs to be made out of polymers to be able to endure a high degree of bending (radius: 1 mm) Bending of the devices leads to considerable changes in the device characteristics, including resonant frequency and pull-in voltage due to geometrical dimension changes and stress induced. The main purpose of this work is to understand the effect of bending on the device characteristics by means of finite element analysis. Another objective of the work is to understand the relationships between such an effect and the device geometries. It is learned that the bending-induced stress depends strongly on anchor width, membrane thickness, and substrate thickness. It is also learned that resonant frequency and pull-in voltage become lower in most cases because of using a flexible substrate in comparison to those of the device on a rigid substrate. Bending-induced stress increases the spring constant and hence increases resonant frequency and pull-in voltage, although this effect is relatively weaker. For most of the device geometries, pull-in voltage is too high for the polymer material to endure. This is the main drawback of the all-polymer CMUT. In order to meet the design goal of 20 MHz resonant frequency, the membrane radius has to be smaller than 7.7 mu m for a thickness of 3 mu m.
Citation - WoS: 2
Citation - Scopus: 2
Analysis of Optical Gyroscopes With Vertically Stacked Ring Resonators
(Tubitak Scientific & Technological Research Council Turkey, 2021) Hah, Dooyoung
Without any moving part, optical gyroscopes exhibit superior reliability and accuracy in comparison to mechanical sensors. Microring-resonator-based optical gyroscopes emerged as alternatives for bulky conventional Sagnac interferometer sensors, especially attractive for applications with limited footprints. Previously, it has been reported that planar incorporation of multiple resonators does not bring about improvement in sensitivity for a given area because the increase in Sagnac phase accumulation does not outrun the increase of area. Therefore, it was naturally suggested to consider vertical stacking of ring resonators because then, the resonators can share the same footprint. In this work, sensitivity performances of such configurations with vertically stacked microring resonators are analyzed and compared to that of a basic (single-resonator) configuration. Through comprehensive study, it is learned that the sensitivity performance of the devices with vertically-stacked resonators (either with a single bus waveguide or with two bus waveguides) does not exceed that of the basic sensor device (single resonator with one bus waveguide), i.e. the basic structure is yet to be remained as the most efficient configuration.
Apatinib Sensitizes Human Breast Cancer Cells Against Navitoclax and Venetoclax Despite Up-Regulated Bcl-2 and Mcl-1 Gene Expressions
(Kare Publ, 2021) Kavakcioglu Yardimci, Berna; Ozgun Acar, Ozden; Semiz, Asli; Sen, Alaattin
OBJECTIVE Defects in apoptotic cell death which restrict the success of conventional cytotoxic therapies have pivotal roles in a number of pathological conditions including cancer. However, a novel drug class targeting pro-survival Bcl-2 protein family members has been developed with the understanding of the structures and interactions of Bcl-2 proteins. Within this new class, Bcl-2/Bcl-xL inhibitor Navitoclax and Bcl-2 specific inhibitor Venetoclax have been shown to demonstrate strong anticancer activities on several types of cancers. But their low affinity to other anti-apoptotic proteins limits their clinical usage. Here, we investigated the cytotoxic and apoptotic effects of Navitoclax/Venetoclax and their combinations with specific tyrosine kinase inhibitor Apatinib on estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. METHODS MTT assay was used for the evaluation of the inhibition of cancer cell proliferation. ELISA test and Quantitative real-time PCR assay was performed to determine the role of caspase-3, Bak, Bax, Bcl-2, Bcl-xL and Mcl-1 proteins in the inhibition of cell proliferation triggered by the tested agents. RESULTS We found that aggressive MDA-MB-231 cell line was more sensitive to all tested agents. Apatinib significantly enhanced Navitoclax/Venetoclax mediated inhibition of cell viability in both cancer cell lines despite up-regulation in the expression levels of Bcl-2 and Mcl-1 genes. We further demonstrated significant Bak/Bax and caspase-3 expression in less aggressive MCF-7 cells. CONCLUSION Our findings have impacts on Navitoclax/Venetoclax plus Apatinib based therapy for breast adenocarcinoma. On the other hand, further studies should be conducted to elucidate the mechanisms underlying synergistic effects of Navitoclax/Venetoclax plus Apatinib combinations.
Citation - WoS: 1
Assessment of Installed Power for Inclined Belt Conveyors Using Genetic Algorithm and Artificial Neural Networks
(Konya Teknik Univ, 2022) Koken, Ekin
In this study, the installed power (P inst , kW) of several inclined belt conveyors operating in the mining industry of Turkey was investigated through two soft computing algorithms (i.e., genetic expression programming (GEP) and artificial neural networks (ANN)). For this purpose, the most crucial belt (i.e., belt length (L), belt width (W), belt inclination (alpha)), operational (i.e., belt speed (Vb) b ) and throughput (Q)) and infrastructural (belt weight (Wb) b ) and idler weight (Wid)) id )) features of 42 belt conveyors were collected for each investigated belt conveyor. The collected data was transformed into a comprehensive dataset for soft computing analyses. Based on the GEP and ANN analyses, two robust predictive models were proposed to estimate the P inst . The performance of the proposed models was evaluated using several statistical indicators, and the statistical evaluations demonstrated that the models yielded a correlation of determination (R2) 2 ) greater than 0.95. Nevertheless, the ANN-based model has slightly overperformed in predicting the P inst values. In conclusion, the proposed models can be reliably used to estimate the P inst for the investigated conveyor belts. In addition, the mathematical expressions of the proposed models were given in the present study to let users implement them more efficiently.
Citation - WoS: 2
Citation - Scopus: 3
An Asymptotic-Numerical Hybrid Method for Singularly Perturbed System of Two-Point Reaction-Diffusion Boundary-Value Problems
(Tubitak Scientific & Technological Research Council Turkey, 2019) Cengizci, Suleyman; Natesan, Srinivasan; Atay, Mehmet Tank
This article focuses on the numerical approximate solution of singularly perturbed systems of second-order reaction-diffusion two-point boundary-value problems for ordinary differential equations. To handle these types of problems, a numerical-asymptotic hybrid method has been used. In this hybrid approach, an efficient asymptotic method, the so-called successive complementary expansion method (SCEM) is employed first, and then a numerical method based on finite differences is applied to approximate the solution of corresponding singularly perturbed reaction-diffusion systems. Two illustrative examples are provided to demonstrate the efficiency, robustness, and easy applicability of the present method with convergence properties.
Barriers in Sustainable Lean Supply Chain Management: Implementation in SMEs
(Ege Univ, Fac. Economics & Admin. Sciences, 2025) Kazancoglu, Yigit; Takcı, Ebru; Ada, Erhan
As the world undergoes significant transformations in various domains, including technology, energy supply and communication, the idea of sustainability has become a significant issue. This study investigates the barriers to Sustainable Lean Supply Chain (SLSC) management within Small and Medium-Sized Enterprises (SMEs) and explores the structural interrelationships among these barriers. A comprehensive literature review was carried out to recognize critical elements relevant to the research topic, resulting in the identification of fifteen specific elements that account for 85% of the barriers in SLSC management. The DEMATEL method was used to evaluate the significance and influence levels of these factors. Furthermore, structured in-depth interviews were conducted with ten experts representing sectors that constitute 85% of the SMEs operating in Kayseri Organized Industrial Zone (OIZ), Turkey, including metal products, furniture, plastic packaging, construction materials, textiles and food. The findings reveal that strategies represent the most significant barrier to SLSC management in SMEs. The barriers were analyzed in two dimensions: influencing and influenced factors. The primary influencing factor identified was laws, standards, regulations, and legislation while the most significant influenced factor was found supply and suppliers. The study concludes with findings and actionable recommendations for practitioners and decision-makers.
Citation - WoS: 3
Combined Effect of Midostaurin and Sphingosine Kinase-1 Inhibitor on FMS-Like Tyrosine Kinase 3 (FLT3) Wild Type Acute Myeloid Leukemia Cells
(Walter de Gruyter Gmbh, 2022) Sahin, Hande Nur; Adan, Aysun
Objectives Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cancers, but not in FLT3 wild-type AML. We aimed to develop new therapeutic strategies to combat FLT3 wild-type AML by combining midostaurin with SK-1 inhibitor (SKI II) in THP1 cells. Methods The anti-proliferative effects of midostaurin, SKI II and in combination on THP1 cells were determined by MTT assay. The combination indexes were calculated using calcusyn software. SK-1 expression and PARP cleavage were checked by western blot. Cell cycle distributions (PI staining) and apoptosis (annexin-V/PI dual staining) were assessed by flow cytometry for each agent alone and in combinations. Results Midostaurin decreased SK-1 protein level. Midostaurin, SKI II and certain combinations decreased cell viability in a dose dependent manner. The combined anti-leukemic effects of the aforementioned drug combination afforded additive effect. Co-administration induced both necrosis and apoptosis via phosphatidylserine externalization, PARP cleavage and cell cycle arrest at G0/G1 and S phases. Conclusions Targeting sphingosine kinase-1 together with FLT3 inhibition could be a novel mechanism to increase limited clinic response to midostaurin in wild-type FLT3 overexpressing AML after further pre-clinical studies.
Citation - WoS: 1
Citation - Scopus: 1
The Comparison of Fragility Curves of Moment-Resisting and Braced Frames Used in Steel Structures Under Varying Wind Load
(Turkish Chamber Civil Engineers, 2025) Ozalp, Abdulkadir; Gokdemir, Hande; Ciftci, Cihan
In this study, the performance of two different steel structure types (moment-resisting frame and braced frame) under wind loading was compared by addressing the fragility curves of these structure types. To perform this comparison, the dimensions of the members of these structural systems were first determined. Then, nonlinear static pushover analyses were conducted to assess the performance levels of each frame type. After applying these analyses, time-history analyses were performed with 100 different wind loads for each varying equivalent mean wind speed. Afterwards, the probability of exceeding the predetermined structural performance limits of the structure types was determined using Monte Carlo simulation method. Finally, the results of the simulation method were used to adapt the maximum likelihood estimation method to obtain the fragility curves of the structures. To conclude, it has been revealed that the material cost of the structure doubles when diagonal elements are used, but the wind speed required for a 100% collapse probability to occur in the braced frame is twice as high compared to the moment-resisting frame.
Citation - WoS: 1
Citation - Scopus: 2
Complementary Medicines Used in Ulcerative Colitis and Unintended Interactions With Cytochrome P450-Dependent Drug-Metabolizing Enzymes
(Tubitak Scientific & Technological Research Council Turkey, 2022) Sen, Alaattin
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people have led to the application of complementary therapies due to the common belief that they are natural and safe, as well as due to the consideration of the side effect of current drugs. Curcumin, cannabinoids, wheatgrass, Boswellia, wormwood and Aloe vera are among the most commonly used complementary medicines in UC. However, these treatments may have adverse and toxic effects due to unintended interactions with drugs or drug-metabolizing enzymes such as cytochrome P450s; thus, being ignorant of these interactions might cause deleterious effects with severe consequences. In addition, the lack of complete and controlled long-term studies with the use of these complementary medicines regarding drug metabolism pose additional risk and unsafety. Thus, this review aims to give an overview of the potential interactions of drug-metabolizing enzymes with the complementary botanical medicines used in UC, drawing attention to possible adverse effects.
Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
(Galenos Publishing House, 2025) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.
Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.
Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia
(Istanbul Univ, 2022) Cicek, Enes; Kucuktas, Fulya Mina; Yenigul, Munevver; Akcok, Emel Basak Gencer
Objectives: Acute myeloid leukemia (AML) is a highly aggressive heterogeneous hematopoietic malignancy characterized by a rapid and abnormal proliferation of immature myeloid leukemia cells in the bone marrow and peripheral blood. Aberrant alterations in signal transduction pathways are strongly associated with the progression of AML. This study aimed to investigate cell viability and the cell cycle in AML cells by targeting the Hedgehog and mTOR signaling pathways with rapamycin and GANT61. Materials and Method: The antiproliferative effect of rapamycin and GANT61 was assessed by the MTT cell viability assay in two AML cell lines: CMK and MOLM-13. The effect of the inhibitors on cell-cycle distribution was determined using propidium iodide staining and measured with flow cytometry. Results: Rapamycin, an mTOR inhibitor, and GANT61, a Gli-1 inhibitor, decreased the cell proliferation of CMK and MOLM-13 cells. The IC20 values, which is the drug concentration that inhibits cell growth by 20%, were combined and administered to the cells. The results show the drugs to have a combinatorial inhibitory effect on CMK cells but not on MOLM-13 cells. In addition, the combination of drugs arrested the cells during the G0/G1 phase. Conclusion: This study suggests a novel combination therapy approach for AML via mTOR and Hedgehog signaling pathway inhibition using rapamycin and GANT61, respectively. It also suggest further studies be performed to reveal the mechanism of action.
Dayım: Bir İnsanoğlunun Portresi
(TURKISH LIBRARIANS ASSOC, YENISEHIR, NECATIBEY CAD, ELGIN SOK, PO BOX 175, ANKARA, 06440, TURKEY, 2019) Donmez, Rasim Ozgur
This is a memoir written by his nephew about our colleague Ali Can, who passed away in last July.
Değişen Yükseköğretim Sistemini Sosyokültürel ve Mekânsal Bağlamlarda Yeniden Düşünmek
(DEOMED PUBL, ISTANBUL, GUR SOK 7-B, FIKIRTEPE 34720 KADIKOY, ISTANBUL, 00000, TURKEY, 2020) Ayten, Asim Mustafa; Gover, Ibrahim Hakan
Education and research are vital for social development and progress. The changing sociocultural structures and new needs have resulted in some important functional changes in higher education systems with a deep impact on universities serving these needs at the highest level. Besides experiencing these functional changes, the universities today have become spaces of socialization with their social, cultural and sports facilities, replacing their traditional spatial role of offering education only. The local dynamics changing with globalization have now reshaped the global and local roles of universities, highlighting the added value they provide to the society. Sociocultural changes trigger all these functional and structural changes in universities. Therefore, sociocultural factors and their importance should not be ignored in a changing higher education system. In this study, the impact of sociocultural factors with their related spatial structures on world higher education system will be analyzed within their historical contexts, and some suggestions for future universities will be offered considering the current changes. In the first part of the study, the changes in societies and universities will be presented within the historical context. In the second part, the spatial forms and structures of universities will be discussed. In the third part, the catalytic effects of the specific sociocultural factors will be highlighted and elaborated on. Finally, some suggestions will be made for the universities of the future in the light of the current situation and the data available.
Efficiency of L-DOPA+TiO2 Modified RO Membrane on Salinity Gradient Energy Generation by Pressure Retarded Osmosis
(Pamukkale Univ, 2024) Ates, Nuray; Saki, Seda; Gokcek, Murat; Uzal, Nigmet
Harvesting energy from the salinity gradient of seawater and river water using pressure retarded osmosis (PRO) has been a major research topic of recent years. However, there is a need for efficient PRO membranes that can generate high power density and are pressure resistant, as the performance of current membranes on the market is poor. In this study, specific energy potential of PRO process using LDOPA+TiO2 modified BW30-LE membrane was evaluated on synthetic and real water samples. Polyamide BW30-LE RO membrane was modified by L-DOPA, L-DOPA+0.5 wt% TiO2 and L-DOPA+1 wt% TiO2. The effect of hydraulic pressure and temperature on generation of power density were evaluated for 5, 10, and 15 bar pressures, as well as 10 degrees C, 20 degrees C, and 30 degrees C degrees. The incorporation of TiO2 nanoparticles with L-DOPA increased the water flux by increasing the surface hydrophilicity and roughness of the membrane surface. The maximum specific power was observed as 1.6 W/m(2) for L-DOPA+1 wt% TiO2 modified BW30-LE membrane at 15 bar pressure. Besides, Mediterranean and Aegean, Black Sea water samples were used as draw solution and Seyhan, Ceyhan, Buyuk Menderes, Gediz, Yesilirmak, and Kizilirmak Rivers were used as feed solution. The highest osmotic power density was obtained by using L-DOPA+1 wt% TiO2 modified BW30-LE membrane with Ceyhan River as feed and Mediterranean Sea water as draw solution, which have the highest differences in salinity. In the mixture of Mediterranean and Ceyhan River, the highest power density was obtained at 10 bar pressure at 30 +/- 5 degrees C with 0.70 W/m(2).
Elastic Modulus Prediction for Fiber-Reinforced Concretes
(Pamukkale Univ, 2020) Yagmur, Eren
In this study, the effects of different discrete fiber types on the elastic modulus of concrete are investigated. For this purpose, 260 cylindrical pressure test specimens are compiled. The fiber types considered are steel, PVA, polypropylene, polyolefin, basalt and olefin. The results of the study are showed that if the ratio of coarse aggregate to fine aggregate exceeds 1.5 for all fiber types, the compressive strength of concrete decreases. It has been observed that the elastic modulus increases in cases where the fiber aspect ratio of the steel fibers is less than and equal to 60, while the elastic modulus decreases for values greater than 60. An elastic modulus equation, which applies to all fiber types considered, is proposed. The proposed equation is compared with the experimental results and the other formulas in the literature and the validity of the equations for different cases are questioned.
Enlightening the Molecular Mechanisms of Type 2 Diabetes With a Novel Pathway Clustering and Pathway Subnetwork Approach
(Tubitak Scientific & Technological Research Council Turkey, 2022) Bakir-Gungor, Burcu; Yazici, Miray Unlu; Goy, Gokhan; Temiz, Mustafa
Type 2 diabetes mellitus (T2D) constitutes 90% of the diabetes cases, and it is a complex multifactorial disease. In the last decade, genome-wide association studies (GWASs) for T2D successfully pinpointed the genetic variants (typically single nucleotide polymorphisms, SNPs) that associate with disease risk. In order to diminish the burden of multiple testing in GWAS, researchers attempted to evaluate the collective effects of interesting variants. In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need to be developed. In this respect, here we reanalyze three metaanalysis data of GWAS in T2D, using the methodology that we have developed to identify disease-associated pathways by combining nominally significant evidence of genetic association with the known biochemical pathways, protein-protein interaction (PPI) networks, and the functional information of selected SNPs. In this research effort, to enlighten the molecular mechanisms underlying T2D development and progress, we integrated different in silico approaches that proceed in top-down manner and bottom-up manner, and presented a comprehensive analysis at protein subnetwork, pathway, and pathway subnetwork levels. Using the mutual information based on the shared genes, the identified protein subnetworks and the affected pathways of each dataset were compared. While most of the identified pathways recapitulate the pathophysiology of T2D, our results show that incorporating SNP functional properties, PPI networks into GWAS can dissect leading molecular pathways, and it could offer improvement over traditional enrichment strategies.
Estimating the Power Draw of Grizzly Feeders Used in Crushing-Screening Plants Through Soft Computing Algorithms
(Konya Teknik Univ, 2024) Koken, Ekin
In this study, the power draw (P) of several grizzly feeders used in the Turkish Mining Industry (TMI) is investigated by considering the classification and regression tree (CART), random forest (RF) and adaptive neuro-fuzzy inference system (ANFIS) algorithms. For this purpose, a comprehensive field survey is performed to collect quantitative data, including power draw (P) of some grizzly feeders and their working conditions such as feeder width (W), feeder length (L), feeder capacity (Q), and characteristic feed size (F80). 80 ). Before applying the soft computing methodologies, correlation analyses are performed between the input parameters and the output (P). According to these analyses, it is found that W and L are highly associated with P. On the other hand, Q is moderately correlated with P. Consequently, numerous soft computing models were run to estimate the P of the grizzly feeders. Soft computing analysis results demonstrate no superiority between the performances of RF and CART models. The RF analysis results indicate that the W is necessary for evaluating P for grizzly feeders. On the other hand, the ANFIS-based predictive model is found to be the best tool to estimate varying P values, and it satisfies promising results with a correlation of determination value (R2) of 0.97. It is believed that the findings obtained from the present study can guide relevant engineers in selecting the proper motors propelling grizzly feeders.
Evaluation of Sub-Network Search Programs in Epilepsy-Related GWAS Dataset
(Pamukkale Univ, 2022) Adanur Dedeturk, Beyhan; Bakir Gungor, Burcu
The active sub-network detection aims to find a group of interconnected genes of disease-related genes in a protein-protein interaction network. In recent years, several algorithms have been developed for this problem. In this study, the analysis of disease-specific sub-network identification programs is evaluated using epilepsy data set. Under the same conditions and with the same data set, 9 different programs are run and results of their Greedy algorithm, Genetic algorithm, Simulated Annealing Algorithm, MCC (Maximal Clique Centrality) algorithm, MCODE (Molecular Complex Detection) algorithm, and PEWCC (Protein Complex Detection using Weighted Clustering Coefficient) algorithm are shown. The top-scoring 5 modules of each program, are compared using fold enrichment analysis and normalized mutual information. Also, the identified subnetworks are functionally enriched using a hypergeometric test, and hence, disease-associated biological pathways are identified. In addition, running times and features of the programs are comparatively evaluated.
An Evaluation of the Rural Landscapes as Heritage From Habitus Perspective
(Geleneksel Yayincilik Ltd Stl, 2024) Elagoz Timur, Bahar; Asiliskender, Burak
Rural heritage areas consist of natural and built environments produced concerning local and traditional life practices, production -consumption habits, and intangible values of societies. This environment is created vernacularly using local materials and construction techniques due to the topographical features where it is built and is in contact with local users. For this reason, it is valuable to explain the meaning of vernacular architecture to understand its users and the habitus that emerges from it. Historical rural settlements, which have found their place in conservation theories over time, attract attention with their traditional and vernacular architecture.These areas, called "rural landscape as heritage" by definition developed by ICOMOS-IFLA, are accepted as a whole with their tangible and intangible components such as natural, archaeological, and architectural. Today, plenty of research is about integrated conservation issues of rural landscape heritages. The study, differently from theirs, plans to discuss the rural landscapes through habitus. It is possible to interpret the vernacular architecture produced in rural landscapes by understanding its user and the habitus in which it emerges. Moreover, there is a dynamic link between the traditional rural areas and the habitus of societies that produce and are produced by their daily lifestyles, traditions, collective memories, and histories. The habitus, which is always transformed, begins to adapt its environment to the change by this link. In this changing process, effects such as industrialization, technological developments, and globalization threaten rural landscapes to lose their authentic values. The first step in the conservation of rural landscapes lies in understanding these areas and their values and making change predictable. From this point of view, this study questions the role of habitus in the formation and life cycle of rural heritage. The research and the hypothesis created aim to contribute to the studies about sustainable living in rural landscapes by revealing the structuring effect of the habitus between the rural landscapes and their natural, built, and socio-cultural environments. In the study, the method developed from the literature to understand rural landscapes and their dynamics without studying the case is presented for use in rural landscape heritage conservation studies. Habitus connects the natural, tangible, and intangible components of rural landscapes by the balance it creates and contributes to the formation and maintenance of the spirit of place. In order to understand this balance and draw attention to holistic conservation approaches, the network of relations has been tried to be revealed in detail. Within the scope of the study, the definition of habitus was explained through the environment and practices, and its relationship with the rural landscape was conveyed through a single structure and settlement. The transition of living heritage is inevitable, but when it cannot be managed according to international regulations, the consequences will be the loss of rural heritage, which represents societies' traditional lifestyles. The proposed approach needs to be customized and re-established for each different rural landscape heritage site. Because each heritage site is unique and has its own conservation problems. It is critical to raise awareness about the effects of habitus change in rural landscapes and their management and to emphasize the importance of creating resilient rural heritage areas that can accompany change by preserving authentic values.

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