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The scientific memory of Abdullah Gül University. Publications, projects, and researchers—all in one place. The heart of open science beats here. 'Open Science. Visible Impact.'

Scholarly Output

2880

Organisations

Other

682

Abdullah Gül Üniversitesi Açık Erişim Yönergesi

Other

571

Machine Learning Approaches for Internet of Things Based Vehicle Type Classification and Network Anomaly Detection

Doctoral Thesis

476

Modüler Mimarlık Kavramının Konut Tasarımı Üzerindeki Etki ve Gelişimi

Aksoyak, Ömer Devrim

Master Thesis

455

Genetik ve Enfeksiyon Hastalıklarının Tespiti için Makine Öğrenmesi Yöntemleri

Aydın, Zafer

Doctoral Thesis

419

Recombinant Production of GLP-1 Analogue Using Escherichia Coli Host Organism

Fidan, Özkan

Master Thesis

312

Graph Theory Based Traffic Light Management

Master Thesis

303

A Comprehensive Perspective Into the Use of Origami in Architecture

Metin, Buket

Master Thesis

282

Scheduling the Turkish Super Football League

Sütçü, Muhammed

Master Thesis

177

Early Detection of Forest Fire From Video Utilizing Temporal Information

Aydın, Zafer

Doctoral Thesis

153

Recent Submitted Publications

Article

Minimization of Thermal Stresses in Instrumented Cutting Tools with Embedded Thin Film Thermocouples

(Korean Society of Mechanical Engineers, 2026-04) Kesriklioglu, Sinan; Sivesoglu, Abdurrahman

Conference Object

Impact of Physico-Chemical Characteristics on the Mechanical Strength and Pore Structure of Air Lime Mortars with Isparta Tuff and Banahmeta Additives

(e d P Sciences, 2024) Su-Cadirci, Tugce Busra; Ball, Richard J.; Baki, Vahiddin Alperen; Dabanli, Omer; Calabria-Holley, Juliana

The physical and chemical interactions between the lime and pozzolans in conservation mortars are fundamental to sustainable building practices. Here, we report experimental investigations on pure air lime mortar, air lime-isparta tuff mortar, and air lime-banahmeta mortar. Isparta Tuff is formed from volcanic rocks found in the Southwest between Isparta and Burdur city centres in Anatolia, belonging to the Golcuk volcanism. The microstructural and physiochemical interactions of these mixed designs were investigated. Importantly, this study quantifies critical performance parameters of air lime mortars incorporating Isparta tuff as a pozzolan. It supports using local and natural volcanic tuffs in developing sustainable mortars for the conservation of historical assets in Turkey.

Article

Unveiling the Therapeutic Role of 3D-Cultured Mesenchymal Stem Cells in Diabetic Foot Ulcers through Transcriptomic Integration and Fibroblast Modulation

(Springer, 2026-03-31) Ozturk, Esengul; Bicer, Mesude

Background Diabetic foot ulcers (DFUs) are among the most severe complications of diabetes mellitus and remain difficult to manage due to chronic inflammation, defective angiogenesis, delayed tissue repair, which increase the risk of recurrence and limb amputation. Standard treatments, such as debridement, infection management, pressure off-loading and revascularization, are commonly used, however; these interventions often inadequate to fully restore effective wound repair. Mesenchymal stem cells (MSCs) have attracted remarkable interest due to their potential regenerative ability and paracrine activity. Nevertheless, the molecular interaction between MSCs and fibroblasts under hyperglycemic conditions has not been fully elucidated. Objective This study aimed to examine differentially expressed genes (DEGs) associated with DFUs and MSC-related regenerative mechanisms using transcriptomic datasets (such as GSE143735, GSE199939, and GSE217709). Methods and results Differentially expressed genes and protein-protein interaction (PPI) network analysis were performed to determine central regulatory genes. Four key genes including CXCL1, MMP9, THBS1, and POSTN were recognized as hub genes related to inflammatory response, extracellular matrix reorganization, and angiogenesis. For experimental validation, L929 murine fibroblasts were exposed to high-glucose conditions to set-up an in vitro diabetic model and subsequently treated with MSCs with/without a 3D platform. Hyperglycemic conditions significantly reduced fibroblast proliferation and migration downregulated the expression of the identified hub genes and enhanced apoptotic activity. MSC treatment partially increased cellular function, while MSCs embedded into 3D culture enhanced a more pronounced recovery in both gene expression patterns and functional assays. Conclusions These findings suggest that high glucose impair fibroblast functions for wound repair, while 3D-cultured MSCs enhance regenerative responses and may represent a promising strategy for diabetic wound healing.

Master Thesis

Üç boyutlu kültürde mezenkimal kök hücre ile diyabetik ülser iyileşmesinin moleküler temelinin ortaya çıkarılması

(2026) Öztürk, Esengül; Çalışkan, Mesude Biçer

Diyabetik ayak ülserleri (DFU), diyabetin uzun vadede oluşturduğu bir rahatsızlık türüdür ve kalıcı inflamasyona, bozulmuş anjiyogeneze ve ekstrasellüler matriks (ECM) disfonksiyonuna neden olur, hatta ampütasyon ile sonuçlanabilir. Mezenkimal kök hücrelerin (MKH) rejeneratif ve immünomodülatör yetenekleri sayesinde diyabetik yara tedavisinde güçlü stratejilerden biri olarak önerilmektedir; ancak, bu iyileşmeyi sağlayan moleküler yollar hala belirsizdir. Bu tez, NCBI-GEO veri tabanından elde edilen (GSE143735, GSE199939 ve GSE217709) transkriptomik veri kümelerinin analizini içermektedir. Birincil amaç, DFU'lar ve MKH aktivitesiyle ilişkili, farklı şekilde ifade edilen genlerin (DEG'ler) belirlenmesidir. İleri biyoenformatik analizler, temel olarak inflamatuar düzenleme ECM yeniden şekillenmesi ve anjiyogenezde rol oynayan dört çekirdek merkez genin (CXCL1, MMP9, THBS1 ve POSTN) tanımlanmasını sağladı. Bu sonuçları doğrulamak için, L929 fare fibroblastları yüksek glikoz (YG) ortamında kültürlendi. Ardından yalnızca MKH ve MKH+üç boyutlu (3B) bir kültür platformuyla tedavi edildi. HG, fibroblast fonksiyonunu ve merkez genlerin ekspresyonu inhibe ederken, MKH'ler, özellikle 3B ortamda fibroblast canlılığını ve genlerin ekspresyonunu önemli ölçüde geri kazandırdı. Genel olarak, bu çalışma, DFU'ların bir özelliği olan bozulmuş fibroblast fonksiyonuna yeni bir bakış açısı sunmakta ve 3B-MKH tabanlı sistemlerin hücresel onarım yanıtlarını etkili bir şekilde artırabileceğini göstermektedir.

Book Part

The Role of Wind Energy in a Sustainable Energy Transition Agenda

(IGI Global, 2026-02-27) Şahin, Kübra Nur

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