TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/396

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Apatinib Sensitizes Human Breast Cancer Cells Against Navitoclax and Venetoclax Despite Up-Regulated Bcl-2 and Mcl-1 Gene Expressions
(Kare Publ, 2021) Kavakcioglu Yardimci, Berna; Ozgun Acar, Ozden; Semiz, Asli; Sen, Alaattin; Acar, Ozden Ozgun; Yardımcı, Berna Kavakcıoğlu
OBJECTIVE Defects in apoptotic cell death which restrict the success of conventional cytotoxic therapies have pivotal roles in a number of pathological conditions including cancer. However, a novel drug class targeting pro-survival Bcl-2 protein family members has been developed with the understanding of the structures and interactions of Bcl-2 proteins. Within this new class, Bcl-2/Bcl-xL inhibitor Navitoclax and Bcl-2 specific inhibitor Venetoclax have been shown to demonstrate strong anticancer activities on several types of cancers. But their low affinity to other anti-apoptotic proteins limits their clinical usage. Here, we investigated the cytotoxic and apoptotic effects of Navitoclax/Venetoclax and their combinations with specific tyrosine kinase inhibitor Apatinib on estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. METHODS MTT assay was used for the evaluation of the inhibition of cancer cell proliferation. ELISA test and Quantitative real-time PCR assay was performed to determine the role of caspase-3, Bak, Bax, Bcl-2, Bcl-xL and Mcl-1 proteins in the inhibition of cell proliferation triggered by the tested agents. RESULTS We found that aggressive MDA-MB-231 cell line was more sensitive to all tested agents. Apatinib significantly enhanced Navitoclax/Venetoclax mediated inhibition of cell viability in both cancer cell lines despite up-regulation in the expression levels of Bcl-2 and Mcl-1 genes. We further demonstrated significant Bak/Bax and caspase-3 expression in less aggressive MCF-7 cells. CONCLUSION Our findings have impacts on Navitoclax/Venetoclax plus Apatinib based therapy for breast adenocarcinoma. On the other hand, further studies should be conducted to elucidate the mechanisms underlying synergistic effects of Navitoclax/Venetoclax plus Apatinib combinations.
Atatürk’ün Esir Aldığı Yunan General Nikolaos Trikupis ve Talas Üsera Garnizonu
(Sabit Dokuyan, 2023) Karataş, Murat; Metin, Mehmet
After the First World War, especially with the support of England, the Greek army invaded Anatolian lands on the way to realize Megali Idea (Greater Greece). The regular army of the Turkish Grand National Assembly established on the Western Front dealt the final blow to the Greek army with The Great Offensive and the Battle of the Commander –in-Chief. In addition to the Greek soldiers captured in the wars before this victory, many Greek soldiers, as well as the commander –in-chief of the Greek army, General Trikupis, and her entourage were also captured after the said victory. As the number of prisoners increased rapidly after The Great Offensive and the Battle of the Commander –in-Chief, the captive officers were transferred to Afyon, Kırşehir and Kayseri. Other military and civilian prisoners were transferred to different parts of Anatolia. Greek prisoners of war were kept in the prisoner garrisons until the implementation of the document on the mutual release of prisoners signed between the states of Turkey and Greece at the Lausanne Peace Conference. Only Greek Officers remained in Talas Prisoner Garrison, one of these prisoner garrisons. The Talas Prisoner Garrison was inspected twice by international Committee of the Red Cross. The delegation prepared reports on the condition of the prisoners and the garrison. In this study, the captivity of General Trikupis on the battlefield, the Talas Prisoner Garrison and situation of the captive Greek officers staying here, the aid of the Red Crescent Society to the prisoners will be emphasized. The Study was planned to be prepared by making use archival resources, memoirs, newspapers and copyright-reviewed works. © 2023 Elsevier B.V., All rights reserved.
Bazı geleneksel Türk gıdalarından laktik asit bakterilerinin izolasyonu
(2021) DOĞAN Osman; CEBECİ Aysun
Amaç: Bu çalışma ülkemizde geleneksel yöntemlerle üretilen gıda ürünlerindenlaktik asit bakterilerinin izolasyonunu ve tanımlanmasını sağlamak amacıylayapılmıştır.Materyal ve Yöntem: Çalışma kapsamında Van otlu peynir ve ekşi hamur örneğikullanılmıştır. Bu örnekler içerdikleri laktik asit bakterileri için çalışılmış vetanımlanmaları için biyokimyasal ve PCR bazlı moleküler biyolojik tekniklere tabitutulmuşlardır. Biyokimyasal testler kapsamında örnekler, Gram reaksiyonları,katalaz aktivitesi, gaz üretimi, 10oC ve 45oC'de, %6 ve %16 NaCl konsantrasyonda,pH 4.4 ve pH 9.6’da gelişim göstermeleri açısından incelenmiştir. Moleküler biyolojideneyleri kapsamında ise tür ve suş düzeyinde tanımlama için PCR-RFLP, 16SrRNA gen dizileme ve RAPD-PCR teknikleri kullanılmıştır.Araştırma Bulguları: Bir dizi mikrobiyolojik deneylerin sonucunda 26 adet bakteripotansiyel laktik asit bakterisi olarak izole edilmiştir. Bunlardan 25 adedininLactobacillus, Pediococcus ve Enterococcus cinslerine ait olduğu tespit edilmiş vetür ve suş düzeyinde tanımlanmaları sağlanmıştır. Kalan bir adet izolat iseStaphylococcus hominis olarak tanımlanmıştır.Sonuç: Çalışmamız sonucunda 25 adet laktik asit bakterisi gen dizileme ve RAPDPCR teknikleri kullanılarak tür ve suş düzeyinde başarıyla tanımlanmıştır.
Citation - WoS: 3
Combined Effect of Midostaurin and Sphingosine Kinase-1 Inhibitor on FMS-Like Tyrosine Kinase 3 (FLT3) Wild Type Acute Myeloid Leukemia Cells
(Walter de Gruyter Gmbh, 2022) Sahin, Hande Nur; Adan, Aysun
Objectives Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cancers, but not in FLT3 wild-type AML. We aimed to develop new therapeutic strategies to combat FLT3 wild-type AML by combining midostaurin with SK-1 inhibitor (SKI II) in THP1 cells. Methods The anti-proliferative effects of midostaurin, SKI II and in combination on THP1 cells were determined by MTT assay. The combination indexes were calculated using calcusyn software. SK-1 expression and PARP cleavage were checked by western blot. Cell cycle distributions (PI staining) and apoptosis (annexin-V/PI dual staining) were assessed by flow cytometry for each agent alone and in combinations. Results Midostaurin decreased SK-1 protein level. Midostaurin, SKI II and certain combinations decreased cell viability in a dose dependent manner. The combined anti-leukemic effects of the aforementioned drug combination afforded additive effect. Co-administration induced both necrosis and apoptosis via phosphatidylserine externalization, PARP cleavage and cell cycle arrest at G0/G1 and S phases. Conclusions Targeting sphingosine kinase-1 together with FLT3 inhibition could be a novel mechanism to increase limited clinic response to midostaurin in wild-type FLT3 overexpressing AML after further pre-clinical studies.
A Comparative Study of Unet Variants for Low-Grade Glioma Segmentation in Magnetic Resonance Imaging
(Inonu University, 2025) Guzel, Yasin; Aydin, Zafer
Brain tumors originating from glial cells are pathological entities that significantly impact quality of life and are classified based on their malignancy into low-grade gliomas (LGGs) and high-grade gliomas (HGGs). While the more aggressive HGGs have been extensively studied, LGGs are of critical importance for early diagnosis due to their potential progression to HGGs if left untreated. This has driven researchers to develop methods for the rapid and consistent diagnosis of LGGs. In this study, three models—UNet, Transformer UNet, and Super Vision UNet—were comparatively evaluated for the automatic segmentation of LGGs using magnetic resonance imaging (MRI) data. Multimodal MRI scans from 110 patients, retrieved from The Cancer Imaging Archive (TCIA), were used to train the models. Performance was evaluated using Dice Coefficient, Tversky Index, and Intersection over Union (IoU) metrics. The Super Vision UNet achieves the highest Dice (0.9115) and Tversky (0.9154) scores, while the Transformer UNet attains the highest IoU (0.8789). Both advanced models demonstrate superior segmentation performance with lower loss values compared to the conventional UNet. Visual outputs indicate that the modern architectures delineate tumor contours with greater precision. These results highlight the effectiveness and reliability of contemporary UNet-based and Transformer-based architectures in segmenting complex tumor structures such as LGGs. Integrating these models into clinical decision support systems holds promise for enhancing the speed and accuracy of the diagnostic process. © 2025 Elsevier B.V., All rights reserved.
Citation - Scopus: 1
Comparison of Mechanical and Physical Properties of Screed With and Without Expanded Polystyrene (EPS) Particles
(Yildiz Technical University, 2022) Kiliç, Fikret Merih; Yorulmaz, Hediye; Özuzun, Sümeyye; Durak, Uğur; İLkentapar, Serhan; Karahan, Okan; Atis, C. D.
In this study, in order to observe the mechanical and physical properties of ordinary screed, sandy-lightweight screed and lightweight screed samples, expanded polystyrene (EPS) was used as fine aggregate and lightweight screed systems were produced by replacing sand at 100%, 50% and 0%. Samples of cement dosages of 250, 300, 350 kg/m3 were produced for lightweight screeds, sandy-lightweight screeds and ordinary screeds. Unit weight, water absorption capacity, flexural strength, compressive strength, fire resistance, abrasion and thermal conductivity tests were performed on the produced screed systems. As a result of the research, it was determined that as EPS ratio increases in screed system; unit weights decreased, water absorption rates increased. Besides, the flexural and compressive strengths, fire and abrasion resistance are also decreased. However, it was observed that the thermal conductivity coefficient reduced with the increment of EPS particles in the screed. In normal, sandy-lightweight and lightweight screeds, it was determined that as the cement dosage increased; the unit weights, flexural and compressive strengths, fire and abrasion resistance increased, water absorption capacity and the thermal conductivity coefficient decreased. © 2022 Elsevier B.V., All rights reserved.
Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
(Galenos Publishing House, 2025) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.; Demirci, Muserref Duygu Sacar
Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.
Citation - Scopus: 1
Correlation of PAPP-A Values With Maternal Characteristics, Biochemical and Ultrasonographic Markers of Pregnancy
(Marmara Univ, Fac Medicine, 2021) Kaymakcalan, Hande; Uzut, Ommu Gulsum; Harkonen, Juho; Bakir Gungor, Burcu; Bakir-gungor, Burcu; Söylemez, Ümmü Gülsüm
Objective: Our aim is to investigate whether there is a correlation of pregnancy-associated plasma protein A (PAPP-A) values with other variables in pregnancy and maternal characteristics. Materials and Methods: We retrospectively analyzed the relation between the PAPP-A levels, demographics, biochemical and ultrasonographic markers of the first trimester screening of 11,842 pregnant women seen at a tertiary hospital between November 2002 and November 2008. Results: A significant difference between PAPP-A values of the diabetic and non-diabetic pregnant women were observed (p=0.0005, Mann-Whitney U test). In terms of weight, crown-rump length, Beta-hCG values, significant differences were observed between low and medium level PAPP-A subgroups and between low and high level PAPP-A subgroups. PAPP-A levels were found to differ significantly between the pregnant women of Caucasian origin and other racial origins. Conclusions: Pregnant women with different ethnic and medical backgrounds have different PAPP-A values and other markers of the aneuploidy screening. 'lb make patient specific risk predictions, understanding these interactions and differences is important. Future studies are needed to understand the pathopyhsiology behind these differences.
Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia
(Istanbul Univ, 2022) Cicek, Enes; Kucuktas, Fulya Mina; Yenigul, Munevver; Akcok, Emel Basak Gencer
Objectives: Acute myeloid leukemia (AML) is a highly aggressive heterogeneous hematopoietic malignancy characterized by a rapid and abnormal proliferation of immature myeloid leukemia cells in the bone marrow and peripheral blood. Aberrant alterations in signal transduction pathways are strongly associated with the progression of AML. This study aimed to investigate cell viability and the cell cycle in AML cells by targeting the Hedgehog and mTOR signaling pathways with rapamycin and GANT61. Materials and Method: The antiproliferative effect of rapamycin and GANT61 was assessed by the MTT cell viability assay in two AML cell lines: CMK and MOLM-13. The effect of the inhibitors on cell-cycle distribution was determined using propidium iodide staining and measured with flow cytometry. Results: Rapamycin, an mTOR inhibitor, and GANT61, a Gli-1 inhibitor, decreased the cell proliferation of CMK and MOLM-13 cells. The IC20 values, which is the drug concentration that inhibits cell growth by 20%, were combined and administered to the cells. The results show the drugs to have a combinatorial inhibitory effect on CMK cells but not on MOLM-13 cells. In addition, the combination of drugs arrested the cells during the G0/G1 phase. Conclusion: This study suggests a novel combination therapy approach for AML via mTOR and Hedgehog signaling pathway inhibition using rapamycin and GANT61, respectively. It also suggest further studies be performed to reveal the mechanism of action.
Deprem Anında ve Sonrasında Dönüşebilen Tasarım Önerileri: Günlük Kullanımdan Hayat Kurtaran Birimlere
(Afet ve Acil Durum Yonetimi Baskanligi (AFAD), 2025) Özmen, Nihan Muş; Kurtuluş, Vacide Betül
Depremler, yıkılan binalar ve devrilen eşyalar nedeniyle meydana gelen yaralanmalarla insan hayatını ciddi şekilde tehdit etmektedir. Bu çalışma, mobilyalara kendini kurtarma alanları entegre ederek ezilme yaralanmalarını önlemeyi ve deprem sonrası barınma ihtiyaçlarını karşılamayı amaçlayan tasarım önerileri sunmaktır. 2022 Güz döneminde Abdullah Gül Üniversitesi Deneysel Tasarım Stüdyosu kapsamında yürütülen çalışma, tanınmış bir mobilya tasarım firmasıyla iş birliği içinde gerçekleştirilmiştir. Öğrenciler hem günlük yaşamda işlevsel hem de afet anlarında acil barınma alanı olarak kullanılabilecek çift amaçlı mobilya tasarımları geliştirmiştir. Projeler, deprem sırasında ve sonrasında kullanılmak üzere iki ana kategoriye ayrılmış; yaşam ve çalışma mekânlarında, dönüşebilir mobilya tasarımlarına odaklanmıştır. Bulgular, işlevsel ve uyarlanabilir tasarımlar yoluyla risk azaltma ve deprem sonrası uyum konularında yenilikçi yaklaşımları ortaya koymaktadır.
Citation - Scopus: 2
Determining Datum Temperature and Apparent Activation Energy: An Approach for Mineral Admixtures Incorporated Cementitious Systems
(Tulpar Academic Publishing, 2024) Atasever, Muhammet; Tokyay, Mustafa
The maturity method is used to predict the strength of concrete by monitoring its temperature history. Accuracy of maturity method relies on the dependable determination of the datum temperature and the apparent activation energy. The current study introduces a new approach, complementing those in ASTM C1074-11, for determining the datum temperature and apparent activation energy. The experimental study involved using two different mineral additives to portland cement at 6%, 20%, and 35% replacement amounts. The mortars were then cured at temperatures of 5, 20, and 40 °C, and their strengths were determined. Subsequently, the datum temperatures and apparent activation energies for these mixtures were calculated using both the proposed approach and the alternatives from ASTM C1074-11. Strength estimations were conducted in conjunction with commonly used maturity functions. The results indicate that the proposed approach determines the datum temperature and apparent activation energy reliably for mineral admixture-incorporated mortars. Furthermore, the predicted strengths, derived from the datum temperature and apparent activation energy calculated through the proposed approach, show a closer alignment with the experimental results when applying the Nurse-Saul and Hansen-Pedersen equations, as opposed to the Rastrup and Weaver-Sadgrove models. © 2024 Elsevier B.V., All rights reserved.
Developing a Label Propagation Approach for Cancer Subtype Classification Problem
(TUBITAK, 2022) Güner, P.; Bakir-Güngör, B.; Coşkun, M.; Şahan, Pınar Güner
Cancer is a disease in which abnormal cells grow uncontrollably and invade other tissues. Several types of cancer have various subtypes with different clinical and biological implications. Based on these differences, treatment methods need to be customized. The identification of distinct cancer subtypes is an important problem in bioinformatics, since it can guide future precision medicine applications. In order to design targeted treatments, bioinformatics methods attempt to discover common molecular pathology of different cancer subtypes. Along this line, several computational methods have been proposed to discover cancer subtypes or to stratify cancer into informative subtypes. However, existing works do not consider the sparseness of data (genes having low degrees) and result in an ill-conditioned solution. To address this shortcoming, in this paper, we propose an alternative unsupervised method to stratify cancer patients into subtypes using applied numerical algebra techniques. More specifically, we applied a label propagation-based approach to stratify somatic mutation profiles of colon, head and neck, uterine, bladder, and breast tumors. We evaluated the performance of our method by comparing it to the baseline methods. Extensive experiments demonstrate that our approach highly renders tumor classification tasks by largely outperforming the state-of-the-art unsupervised and supervised approaches. © 2022 Elsevier B.V., All rights reserved.
Citation - Scopus: 1
Düzce Kent Merkezi Zeminlerinin Sıvılaşma Potansiyelinin Değerlendirilmesi
(TMMOB - Jeoloji Muhendisleri Odasi jmo@jmo.org.tr, 2019) Akin, Muge K.
Soil liquefaction is one of the ground deformations occurred during an earthquake which may cause serious damages such as settlement and tilting of structures due to loss of bearing capacity of foundations. Düzce and its surrounding settle on a plain which consists of silty and sandy layers with shallow groundwater level. Besides, the North Anatolian Fault Zone is a major seismic source which is capable of producing large magnitude earthquakes. All these data point out that the ground deformations like liquefaction and lateral spreading may occur during a probable large earthquake around Düzce and its close vicinity. In this study, the geotechnical data of 40 boreholes drilled to determine the local ground conditions and the groundwater level in Düzce were considered. Based on the field studies, it was aimed to evaluate the liquefaction potential considering the fact that the groundwater level is shallow as well as the subsurface soil is composed of loose alluvium. Liquefaction Potential Index (LPI) and Liquefaction Severity Index (LSI) methods were taken into account and the liquefaction potential of Düzce province was determined and mapped with respect to various earthquake scenarios in GIS environment. These maps are compared on the basis of different scenarios. Accordingly, it is concluded that the liquefaction potential is high-very high in the south and south-eastern sections of the study area where the construction of new residential buildings progressively continues. © 2019 Elsevier B.V., All rights reserved.
Effects of Dry Particle Coating With Nano-and Microparticles on Early Compressive Strength of Portland Cement Pastes
(Tulpar Academic Publishing, 2021) Yorulmaz, Hediye; Özuzun, Sümeyye; Uzal, Burak; İLkentapar, Serhan; Durak, Uğur; Karahan, Okan; Atis, C. D.
It is known that nano-and microparticles have been very popular in recent years since their advantages. However, due to the very small size of such materials, they have very high tendency to agglomeration particularly for nanoparticles. Therefore, it is critical that they are properly distributed in the system to which they are added. This paper investigated the effects of dry particle coating with nano-and microparticles to solve the agglomeration problem. For a clear evaluation, paste samples were preferred to detemine the compressive strength. Nano-SiO2 and nano-CaCO3, microCaCO3 and micro-SiO2, also known as silica fume, were selected as particulate additives. It was studied by the addition of various percentages (0.3, 0.7, 1, 2, 3 and 5%) of nano-and microparticles in cementitious systems, replacing cement by weight with and without dry particle coating. Dry particle coating was made by using a highspeed paddle mixer. Portland cement and additive particles were mixed at 1500 rpm for 30 seconds in high-speed powder mixer designed for this purpose. The 3-day compressive strength of the cement-based samples to which particles were added at the specified rates was determined and the effect of the dry particle coating on the early strength was investigated. According to the results, it was observed that the production of paste with the dry particle coating technique gave higher compressive strength compared to the production of paste directly in early period. Especially with dry particle coating, compressive strength increased more than 100% in paste samples containing 0.3% nano-SiO2 compared to direct addition without coating. © 2024 Elsevier B.V., All rights reserved.
Citation - Scopus: 1
Electricity Load Forecasting Using Deep Learning and Novel Hybrid Models
(Sakarya University, 2022) Sutcu, Muhammed; Şahi̇n, Kübra Nur; Koloğlu, Yunus; Çelikel, Mevlüt Emirhan; Gulbahar, Ibrahim Tümay
Load forecasting is an essential task which is executed by electricity retail companies. By predicting the demand accurately, companies can prevent waste of resources and blackouts. Load forecasting directly affect the financial of the company and the stability of the Turkish Electricity Market. This study is conducted with an electricity retail company, and main focus of the study is to build accurate models for load. Datasets with novel features are preprocessed, then deep learning models are built in order to achieve high accuracy for these problems. Furthermore, a novel method for solving regression problems with classification approach (discretization) is developed for this study. In order to obtain more robust model, an ensemble model is developed and the success of individual models are evaluated in comparison to each other. © 2025 Elsevier B.V., All rights reserved.
Enlightening the Molecular Mechanisms of Type 2 Diabetes With a Novel Pathway Clustering and Pathway Subnetwork Approach
(Tubitak Scientific & Technological Research Council Turkey, 2022) Bakir-Gungor, Burcu; Yazici, Miray Unlu; Goy, Gokhan; Temiz, Mustafa; Ünlü Yazici, Miray
Type 2 diabetes mellitus (T2D) constitutes 90% of the diabetes cases, and it is a complex multifactorial disease. In the last decade, genome-wide association studies (GWASs) for T2D successfully pinpointed the genetic variants (typically single nucleotide polymorphisms, SNPs) that associate with disease risk. In order to diminish the burden of multiple testing in GWAS, researchers attempted to evaluate the collective effects of interesting variants. In this regard, pathway-based analyses of GWAS became popular to discover novel multigenic functional associations. Still, to reveal the unaccounted 85 to 90% of T2D variation, which lies hidden in GWAS datasets, new post-GWAS strategies need to be developed. In this respect, here we reanalyze three metaanalysis data of GWAS in T2D, using the methodology that we have developed to identify disease-associated pathways by combining nominally significant evidence of genetic association with the known biochemical pathways, protein-protein interaction (PPI) networks, and the functional information of selected SNPs. In this research effort, to enlighten the molecular mechanisms underlying T2D development and progress, we integrated different in silico approaches that proceed in top-down manner and bottom-up manner, and presented a comprehensive analysis at protein subnetwork, pathway, and pathway subnetwork levels. Using the mutual information based on the shared genes, the identified protein subnetworks and the affected pathways of each dataset were compared. While most of the identified pathways recapitulate the pathophysiology of T2D, our results show that incorporating SNP functional properties, PPI networks into GWAS can dissect leading molecular pathways, and it could offer improvement over traditional enrichment strategies.
Ethyl Vinyl Acetate (EVA) Composites With Nanoclays and Boric Acid: Thermal and Mechanical Properties
(Turkish Energy, Nuclear and Mining Research Agency, 2025) Erdem, İlker; Kapçı, Mehmet Fazıl; Avcı, Şeyma
Polimerler pek çok uygulamada kullanılmaktadırlar fakat yanabilir olmaları sorun teşkil etmektedir. Polimerlere yanma dayanımı seramikler gibi (oksitler, hidroksitler, killer, vb.) inorganik malzemeler kullanılarak kazandırılabilir. Bu katkıların ilavesi polimer-inorganik kompozitlerin mekanik özelliklerini de değiştirebilir ki kompozit hazırlamada bu da dikkate alınmalıdır. Bu çalışmada etil vinil asetata (EVA) iki faklı nano-kil (ağırlıkça 20/100 oranına kadar) ve borik asit eklenerek polimerin yanmasında olası gecikme araştırılmıştır. Nano-kil ve BA ilavesinin etkisini belirlemek için saf polimer ve polimer-inorganik kompozitler için mekanik özellikler de belirlenmiştir. Hazırlanan nanokompozitlerin kimyasal yapıları (FT-IR, XRD), ısıl özellikleri (TGA), mekanik özellikleri (çekme testi) ve yanma davranışları değerlendirilmiştir. En yüksek nano-kil içeriğine sahip NC 1.4 örneği en uzun sürede yanmıştır. NC 2 örneğinin diğer örneklerden daha yüksek gerilim dayanımına ve Young katsayısına sahip olduğu bulunmuştur. Nano-killerdeki organik yüzey dönüştürücüler ve BA ilavesi nano-kil/EVA kompozitlerinin ısıl ve mekanik özellikleri üzerinde etkili olmuştur.
Citation - Scopus: 2
Evaluating the Microbial Growth Kinetics and Artificial Gastric Digestion Survival of a Novel Pichia Kudriavzevii FOL-04
(Field Crops Central Research Institute, 2022) Gumustop, Ismail; Ortakci, Fatih
Present study aims to explore Pichia kudriavzevii FOL-04 (FOL-04)’s: i) survival against artificial gastric juice (AGJ) and artificial bile juice (ABJ), ii) growth kinetics in shake flask (SF) and fed-batch trials (FBT). Survival of FOL-04 as measured by relative cell density (RCD) against AGJ and ABJ was screened at four different pH-levels (control, 3, 2, 1.5) and ox-bile concentrations (control, 0.2%, 1%, 2%), respectively. Growth kinetics was calculated by periodic measurement of OD600 in SF (225 rpm, 30°C) or in FBT using exponential feeding regimen where pH, dissolved-oxygen and temperature were controlled at 5.5, 21%, and 30°C, respectively. The doubling-time, maximum specific growth rate, and final cell densities achieved for SF and FBT were 81.7min, 1.67, 11.79 and 170.4 min, 4.75, 37.95, respectively. RCDs calculated were similar for pH=3 and control vs both were significantly higher(p<0.05) than pH=1.5 and 2 with the latter two pH-levels were not significantly different(p>0.05). RCDs were similar across control, 0.2%, and 1% ox-bile levels(p>0.05). However, 2% ox-bile yielded significantly lower RCD (p<0.05) compared to all except 1%. FOL-04 is a potential probiotic candidate showing robustness against AGJ and ABJ and remarkable biomass increase was achieved when grown under FBT which could pave the way for developing a yeast-based probiotic using this strain. © 2023 Elsevier B.V., All rights reserved.
Citation - Scopus: 5
Extraction of Lanthanum and Cerıum from a Bastnasite Ore By Direct Acidic Leaching
(Chamber of Mining Engineers of Turkey, 2020) Kursunoglu, Sait; Top, S.; Hussaini, Shokrullah; Gokcen, H. S.; Altiner, Mahmut; Ozsarac, Safak; Kaya, Muammer
The extraction of lanthanum (La) and cerium (Ce) from a bastnasite ore by direct acidic leaching was investigated. The effects of acid concentration and leaching temperature on the extraction of La and Ce from the ore were tested. Using nitric (NHO3), more than 85% of the La and Ce were simultaneously extracted into leach solution whereas the La and Ce dissolutions were determined as less than 85% by using sulfuric acid (H2SO4). The La dissolution exceeded 90% by using hydrochloric acid (HCl); however, the Ce dissolution remained below 85% under the following conditions: solid-to-liquid ratio of 20% (w/v), the acid concentration of 20%, leaching temperature of 25°C and leaching time of 1 h. The result revealed that HNO3 could be used as a solvent for the maximum simultaneous extraction of the La and Ce from the bastnasite ore. The leaching temperature had no crucial effect on the dissolution of La and Ce when HNO3 or HCl solutions were preferred as a solvating agent. However, the leaching temperature had a slight positive effect on the dissolutions of La and Ce when H2SO4 was used as a solvent. © 2023 Elsevier B.V., All rights reserved.
Citation - Scopus: 2
Impact of High Speed Railway Systems on Inter-Regional Trips and Accessibility in Turkey
(Istanbul Teknik Universitesi, Faculty of Architecture itudergisi@itu.edu.tr, 2020) Baş, Ahmet; Yüzer, Mehmet Ali
High-speed trains are faster, safer, more comfortable than road transport for trips of 250–1000 kilometers. Accordingly, a significant increase has been observed in inter-city railway transport following the construction of high-speed railway (HSR) connections. The present study shows the effects of HSR on accessibility and potential savings in time when compared to other transportation modes. The time saved by HSR systems has been shown to change purpose trip. The level of accessibility provided by the HSR between Konya–Ankara–Istanbul link is compared with the accessibility of other travel modes through an investigation of the weighted average travel times and an analysis of costs. Furthermore, data gathered from a field study carried out among users of the Konya-Ankara HSR link is used to identify the distribution of travel choices among different transportation modes, based on such social and economic indicators as income, car ownership and employment status. It is found that HSR service increases accessibility between cities, and changes travel demands and purpose, in favor of railways, and that economic factors such as income and car ownership are important in the use of HSR services. Finally, this research identifies social and cultural activities as a new reason for travel, in which users diversify their travel destinations because of the time savings offered by HSR systems. © 2020 Elsevier B.V., All rights reserved.

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