Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Article
    Enhanced Mg–Zn–Ca Alloys Reinforced with Rare Earth Oxides for Biomedical Applications: Experimental Insights and ANFIS-Based Modeling
    (Springer, 2026) Mozafari, Farzin; Deka, Surja; Mallick, Ashis
    To enhance the corrosion resistance, biocompatibility, tribological, and mechanical properties of magnesium (Mg) alloys intended for biomedical implants, a new approach utilizing a microwave-sintered in situ hot extrusion-based powder metallurgy process was used to develop Mg-4Zn-0.5Ca/xCeO2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_2$$\end{document} (x = 0.5, 1, and 1.5 vol%) nanocomposites. The introduction of ceria nanoparticles (CONPs) has improved the compression characteristics of the nanocomposites in comparison with the monolithic Mg, and the ternary base alloy. The corrosion test results revealed that the alloy and nanocomposites promoted the formation of the magnesium hydroxide (Mg(OH)2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_2$$\end{document}) and hydroxyapatite (HA) layers on the sample surface. Among all samples, Mg-4Zn-0.5Ca /1.0CeO2\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$_2$$\end{document} demonstrated the lowest corrosion rate. In vitro cytocompatibility assessments were conducted through an extract assay method for different time periods, employing MG-63 cells. The developed alloy and nanocomposites demonstrated no harmful effects on MG-63 cells. An investigation into the dry sliding tribological characteristics of the alloy and nanocomposites at varied loads revealed several wear mechanisms, including abrasion, adhesion, delamination, oxidation, and plastic deformation. The addition of CONPs significantly enhanced the wear resistance of the nanocomposites. Our results provide a new venue to enhance the biocompatibility and in vitro degradation behavior of well-established Mg-Zn-Ca alloys, with a particular focus on the mechanical integrity of the developed samples for their clinical usage. An Adaptive Neuro-Fuzzy Inference system (ANFIS)-based modeling approach was also developed to individually characterize nanocomposite corrosion, cell viability, and wear behavior. The predictions offer compelling evidence of the reliability and accuracy of the proposed modeling strategy.
  • Article
    Alexithymia, Rumination and Binge Drinking: The Mediating Role of Drinking Motives
    (Springer, 2026) Sokmez, Asli Bugay; Coskun, Muhammet; Alpay, Pelin; Kovács, Lilla Nóra; Kocsel, Natália; Kökönyei, Gyöngyi
    The objective of this study was to investigate whether the relationship between alexithymia and rumination, reflecting deficits in emotion processing and difficulties in emotion regulation, and binge drinking is mediated by drinking motives. A cross-sectional study was conducted with university students (N = 367, Mage = 22.38) who reported alcohol use in the past 30 days. Participants completed an online questionnaire comprising the Toronto Alexithymia Scale, the Alcohol Use Disorders Identification Test, the Drinking Motives Questionnaire, the Ruminative Response Scale, and the UPPS Impulsive Behaviour Scale. Binge drinking in the past 30 days was measured with a single item. The results of the mediation analyses indicated that the Difficulties in Identifying Feelings (DIF) component of alexithymia was directly related to risky drinking indexed by binge drinking in the past 30 days or the Alcohol Use Disorders Identification Test (AUDIT). The relationship between the DIF and the AUDIT was mediated by coping motives. Additionally, social motives mediated the relationship between reflection and binge drinking, while coping motives mediated the relationship between brooding and AUDIT, as well as between reflection and AUDIT. These findings confirm the importance of investigating emotion regulation as a proximal factor of risky drinking.
  • Article
    Unveiling the Therapeutic Role of 3D-Cultured Mesenchymal Stem Cells in Diabetic Foot Ulcers through Transcriptomic Integration and Fibroblast Modulation
    (Springer, 2026-03-31) Ozturk, Esengul; Bicer, Mesude
    Background Diabetic foot ulcers (DFUs) are among the most severe complications of diabetes mellitus and remain difficult to manage due to chronic inflammation, defective angiogenesis, delayed tissue repair, which increase the risk of recurrence and limb amputation. Standard treatments, such as debridement, infection management, pressure off-loading and revascularization, are commonly used, however; these interventions often inadequate to fully restore effective wound repair. Mesenchymal stem cells (MSCs) have attracted remarkable interest due to their potential regenerative ability and paracrine activity. Nevertheless, the molecular interaction between MSCs and fibroblasts under hyperglycemic conditions has not been fully elucidated. Objective This study aimed to examine differentially expressed genes (DEGs) associated with DFUs and MSC-related regenerative mechanisms using transcriptomic datasets (such as GSE143735, GSE199939, and GSE217709). Methods and results Differentially expressed genes and protein-protein interaction (PPI) network analysis were performed to determine central regulatory genes. Four key genes including CXCL1, MMP9, THBS1, and POSTN were recognized as hub genes related to inflammatory response, extracellular matrix reorganization, and angiogenesis. For experimental validation, L929 murine fibroblasts were exposed to high-glucose conditions to set-up an in vitro diabetic model and subsequently treated with MSCs with/without a 3D platform. Hyperglycemic conditions significantly reduced fibroblast proliferation and migration downregulated the expression of the identified hub genes and enhanced apoptotic activity. MSC treatment partially increased cellular function, while MSCs embedded into 3D culture enhanced a more pronounced recovery in both gene expression patterns and functional assays. Conclusions These findings suggest that high glucose impair fibroblast functions for wound repair, while 3D-cultured MSCs enhance regenerative responses and may represent a promising strategy for diabetic wound healing.
  • Book Part
    Citation - Scopus: 1
    Social Capital, Rurality, and Accessibility: A Comparative Study Between Turkey and Italy
    (Springer, 2020) Reggiani, Aura; Östh, John; Türk, Umut; Dolciotti, Martina; Nijkamp, Peter
  • Article
    Prosocial Behavior as Bridge and Buffer: Exploring Its Dual Role between Stress and Mental Health in Emerging Adults
    (Springer, 2026-03-16) Coskun, Muhammet; Arslan, Gokmen; Genc, Emel; Caprara, Gian Vittorio
    The present study investigated the dual role of prosocial behavior among emerging adults in a non-Western cultural con-text. Within this scope, first, adaptation and validation of the Adult Prosocialness Behavior Scale (PBS) was carried out for Turkish population. Then, it tested both mediating and moderating functions of prosocial behavior in the links from stress to subjective wellbeing (SWB) and quality of life. To this end, a sample of 419 emerging adults (41.3% males and 58.7% females) completed an online survey. Results revealed Turkish version of the APBS to be a reliable and valid mea-surement tool for assessing prosocial behavior. Regarding the main hypotheses, serial multiple mediation analysis revealed that perceived stress predicted quality of life through the sequential pathway of prosocial behavior and SWB. Additionally, the moderated-mediation analysis confirmed the moderating role of prosocial behavior in the relationship between stress. Nevertheless, moderated mediation index did not reveal a significant conditional indirect effect of prosocial behavior for the indirect path from stress on quality of life through SWB. Overall, findings suggest that prosocial behavior plays a dual role as both a 'bridge' (mediator) and a 'buffer' (moderator) in the relationship between stress and mental health.
  • Article
    Environmental Sustainability in Fragile States: The Role of Corruption Control, Political Stability, and Household Consumption in Somalia
    (Springer, 2026-03-28) Mohamed, Amir Mohamud; Warsame, Abdimalik Ali; Dirie, Khadar Ahmed
    The maintenance of environmental sustainability represents a worldwide pressing issue, especially for Somalia as an emerging nation that deals with environmental degradation because of unstable political leadership combined with corruption and financial limitations. This study analyzes the impact of corruption control, political stability, and household consumption on environmental degradation in Somalia. The study employs the kernel regularized machine learning method (KRLS) and a time-varying Granger causality approach. The KRLS addresses regression and classification tasks without depending on assumptions of linearity or additivity, whereas the time-varying Granger causality fixes instabilities caused by structural breaks, regime shifts, and provides a cause-effect relationships for specific years. The empirical results of the KRLS indicate that corruption control enhances environmental quality by reducing environmental degradation, whereas household consumption impedes it. Additionally, political stability has no discernible impact on environmental degradation. The time-varying Granger causality result revealed no significant causality from corruption control to environmental degradation in the forward and rolling windows. Two episodes of Granger causalities (2009-2011 and 2013-2016) are observed from corruption control to environmental degradation, and one episode of causality (2001-2004) from political stability to environmental degradation was detected in the recursive result. Finally, four episodes of causalities (2005-2007, 2008-2011, and 2014-2015) are observed from household consumption to environmental degradation in Somalia in the recursive result. This could be justified by the fact that climate consequences-droughts and floods-inhibit livelihood sources such as livestock and agriculture. Hence, people put pressure on forests in search of alternative income sources. Nevertheless, the study delivers practical recommendations to policymakers about using governance structures and economic decisions along with institutional mechanisms for creating sustainable environmental practices.
  • Article
    Wireless Communication System Design for Point Machine Detection and Monitoring in Railways
    (Springer, 2026-03-09) Talu, Burak; Cetin, Fatih; Kilic, Veli Tayfun; Elden, Burakhan; Sanlier, Saban Duran
    This paper reports on a wireless communication system that is used in railways to instantly detect and continuously monitor point machine positions. Also, with the system the position information is transmitted wirelessly to a train driver. The designed system is composed of TX and RX units. It has a compact structure and is fully modular. The TX unit of the system is placed near the railway point machines and the RX unit is located on a train. The designed system was constructed, and measurements were obtained on-site. Results show that the system point machine position data were accurately transmitted at 1350 m range which is much longer than the safe braking distance of a train. In addition, the measured 1 s data sampling time of the system allows the driver to continuously monitor current RPM positions as well as state changes. The maximum delay was found to be 3 s in the limit range of the communication. It is found that the system has a low power consumption and the designed system can work for long hours. The findings indicate that the designed wireless communication system has a high potential to be used in railways to prevent accidents and contribute to the overall safety and efficiency of operations.
  • Article
    Effects of Gelatinization Process on Some Physicochemical Parameters, Pasting Characteristics and Some Nutritional Properties of Pulsed Based Flour Blends
    (Springer, 2026-02-17) Kahraman, Kevser; Yuksel, Ferhat; Karaman, Safa
    In this study, a flour mixture was composed by three different flours (wheat flour (WF), cranberry bean flour (CBF) and lentil flour (LF)) depending on a constructed mixture design and some physicochemical parameters, pasting characteristics and some nutritional properties were investigated before and after gelatinization process. The highest total dietary fiber content was determined for the sole cranberry bean flour. After gelatinization of the samples, total dietary fiber levels of the samples increased significantly, and it ranged between 4.70 and 25.16% for uncooked samples and 8.46-29.09% for cooked samples. Resistant starch (RS) content of the samples was also affected by the gelatinization process. Wheat flour showed an increase in the RS content after gelatinization process and similar increment in the RS content was observed for the sole lentil flour. Peak viscosity was the highest for the wheat flour (2318 cP) and lowest for the lentil flour (716.5 cP). Glycemic index of the cooked samples changed significantly, and it ranged between 94.4 and 123.5. This study showed that making flour composite and gelatinization process had a significant effect on the pasting properties and nutritional characteristics of the pulse-based flour mixture.
  • Article
    Depositional Model, Cyclicity, and Hydrocarbon Potential of the Eocene Sakesar Carbonate Ramp, Salt Range, Pakistan
    (Springer, 2026-02-02) Shah, Syed Bilawal Ali; Shah, Syed Haider Ali
    The Sakesar Formation in the Salt Range, Pakistan, represents a well-developed Eocene carbonate ramp deposited along the southern Tethyan margin. This study integrates petrographic analysis, palynofacies evaluation, organic geochemical measurements and sequence stratigraphic interpretation to characterise the depositional environments, diagenetic evolution, and petroleum system potential of the formation. Six microfacies (MF1-MF6) were identified through thin-section petrography ranging from high-energy shoal grainstones to low-energy lagoonal marls. Quantitative palynofacies analysis shows energy dependent trends in organic matter composition, with shoal facies dominated by opaque phytoclasts and lagoonal facies enriched in amorphous organic matter (AOM). Organic geochemical measurements including Total Organic Carbon (TOC), Hydrogen Index (HI), Oxygen Index (OI), and Rock-Eval pyrolysis parameters, combined with vitrinite reflectance (Ro) data, indicate that lagoonal marl-micrite facies (MF6) contain Type II kerogen with the highest TOC values (2.80%), elevated HI (293 mg hydrocarbons per gram TOC), and peak oil-window maturity (0.72% Ro). These attributes identify MF6 as the primary oil-prone source rock. Mid-ramp wackestones and packstones (MF3-MF4) possess moderate generative potential and serve as internal seals or baffles, whereas high-energy shoal facies (MF1-MF2) show favourable reservoir characteristics but limited source potential. Sequence-stratigraphic analysis demonstrates that maximum flooding surfaces (MFS) frequently coincide with organic-rich MF6 intervals, producing predictable vertical stacking of source, seal, and reservoir units at parasequence scale. The integrated petrographic, palynofacies, and geochemical framework confirms the dual role of the Sakesar Formation as both a reservoir and a source-seal interval, with metre-scale cyclicity enhancing hydrocarbon charge and trapping efficiency. These findings refine the depositional and petroleum system model of the Sakesar carbonate ramp and provide valuable predictive analogues for Eocene carbonate exploration within the Himalayan foreland basin and related Tethyan settings.
  • Article
    Enhanced Photoluminescence and Stability of CsPbBr3 Perovskite Nanocrystals Through AuCl Doping
    (Springer, 2026-02) Khorasani, Azam; Mutlugun, Evren
    This study delves into the transformative effects of inorganic gold chloride (AuCl) doping on all-inorganic cesium lead bromide (CsPbBr3) colloidal perovskite quantum dots (PeQDs). Using a precise hot injection synthesis method, AuCl was introduced at concentrations ranging from 0 to 10%, enabling a comprehensive analysis of its impact on the structural, morphological, and optical characteristics of CsPbBr3 PeQDs. We systematically investigated how varying AuCl levels influence photoluminescence (PL), PL quantum yield (PLQY), and the stability of these quantum dots. Advanced characterization techniques, including X-ray diffraction (XRD), scanning transmission electron microscopy (STEM), energy dispersive X-ray analysis (EDX), Fourier-transform infrared spectroscopy (FTIR), UV-Vis absorption, steady-state PL, absolute PL measurement, and time-resolved PL (TRPL), provided a detailed insight into these changes. Our findings indicate that AuCl doping is successfully integrated into CsPbBr3 PeQDs, with 5% identified as the optimal concentration. At this level, the quantum dots show enhanced PLQY, superior crystallinity, and increased stability at 50 degrees C and in ethanol solvent compared to undoped samples. While higher doping levels reduce QY and PL slightly, they still outperform the undoped CsPbBr3 PeQDs. These results demonstrate that AuCl doping can fine-tune the structural and optical properties of CsPbBr3 PeQDs, marking a significant step forward in developing tailored materials for advanced optoelectronic applications.