Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Integrative Bioinformatics Prediction of West Nile Virus-Derived microRNAs Reveals Potential Host Regulatory Interactions(Elsevier Sci Ltd, 2026-08) Demirci, Muserref Duygu Sacar; Orhan, Mehmet Emin; Erginkoc, Altay Nida; Saçar Demirci, Müşerref DuyguWest Nile virus (WNV) is a mosquito-borne flavivirus linked to severe neuroinvasive disease. Although host and vector microRNAs (miRNAs) have been implicated in viral infection, the presence and functional relevance of WNV-encoded miRNAs remain largely unexplored. Here, we developed an integrative bioinformatics pipeline that combines multiple miRNA prediction algorithms with secondary structure screening and host transcriptomic data to identify high-confidence candidate WNV-derived mature miRNAs. Overlap-based confidence scoring and differential expression support from RNA-seq datasets prioritized a small subset of putative miRNA-mRNA interactions with potential roles in infection-associated gene regulation. A competitive endogenous RNA network constructed from predicted mRNA, lncRNA, and circRNA targets highlighted pathways involving innate immunity, GPCR and Wnt signaling, RNA degradation, and viral replication. Together, these findings provide a reproducible computational workflow and nominate testable regulatory interactions for future experimental validation.Article Citation - WoS: 1Citation - Scopus: 1Numerical Analysis and Experimental Comparison of Stress and Stiffness Parameters of Steel Reinforced Geopolymer Concrete Columns(Elsevier Sci Ltd, 2026-01) Ozbayrak, Ahmet; Kucukgoncu, Hurmet; Aslanbay, Huseyin Hilmi; Aslanbay, Yuksel Gul; Altun, FatihDespite extensive research, Geopolymer concrete (GPC) lacks reinforced concrete construction and design specifications. Developing such specifications requires comprehensive studies to promote the use of GPC, which is known for its superior performance and environmental benefits compared to ordinary Portland cement concrete (OPC). This study numerically investigated and compared the behavior and strength of fly ash-based geopolymer-reinforced concrete columns with the experimental results. Comparisons with OPC were made based on existing specifications. Herein, FEM analyses were conducted on 16 GPC and 4 OPC columns under eccentric axial compressive loads. Parameters such as eccentricity, reinforcement ratio, curing method, and activation solution ratios were varied. According to average numerical results, the GPC columns have 7% more moment capacity and 30% more curvature values than OPC. Moreover, GPC columns absorbed more energy than OPC columns. Also, GPC columns have higher axial load and bending moment carrying capacities than OPC for numerical results. Error analysis between FEM and experimental data revealed a strong correlation, with MAPE values of 8.88% (axial load) and 7.20% (moment) for GPC columns, confirming the reliability of the numerical model. ACI 318 and Eurocode 2 specifications were deemed applicable for GPC columns, provided axial loads are limited per TEC 2018.Article Citation - WoS: 12Citation - Scopus: 12The Role of Energy Efficiency, Renewable Resources, Green Innovation, and Fiscal Decentralization in Sustainable Development: Evidence From OECD Countries(Elsevier Sci Ltd, 2025-08) Binsaeed, Rima H.; Khan, Zeeshan; Dogan, Eyup; Rahim, SyedEnergy efficiency and renewable resources for sustainable development are novel discussion areas for academics and researchers. Similarly, most developed and emerging countries are experiencing fiscal decentralization to enhance regional development. However, the importance of these sectors in sustainable development is still unclear in the literature. This research investigates the influence of energy efficiency, renewable energy, green innovation, and fiscal decentralization on sustainable development. Using the data for 18 fiscally decentralized OECD countries from 1995 to 2020, the roles of linear and nonlinear green innovation and renewable energy are also considered. This study uses novel moment quantile regression and finds that revenue decentralization, expenditure decentralization, and fiscal decentralization are significant drivers of sustainable development. Additionally, energy efficiency and value-added manufacturing significantly enhance sustainability in the region. However, green innovation and renewables are resources that exhibit a U-shaped association with sustainable development. The robustness of these results is validated via a series of parametric and nonparametric approaches. From the policy perspective, this research suggests improved research and development on renewable energy, green innovation, and energy efficiency could significantly encourage the OECD's journey towards sustainable development. Additionally, subnational governments should be given more fiscal autonomy, which may encourage regional level investments and boost the confidence of clean energy producing sectors to accelerate sustainable regional development.Article Citation - WoS: 65Citation - Scopus: 71The Nexus Between Global Carbon and Renewable Energy Sources: A Step Towards Sustainability(Elsevier Sci Ltd, 2023-09) Dogan, Eyup; Luni, Tania; Majeed, Muhammad Tariq; Tzeremes, PanayiotisThe energy transition is at the core of sustainable development as it helps to combat global warming and climate change. Similarly, carbon markets also support the climate change mitigation. Therefore, by realizing the potential role of clean energy and carbon markets in ensuring environmental sustainability, this study analyzes the spillovers and connectedness between the environment (global carbon) and renewable energy sources (wind, solar, geothermal, biofuel, and fuel cell). The empirical analysis is conducted by applying the novel "TVP-VAR" connectedness framework of Balcilar et al. (2021) on the daily data over the period from August 1, 2014, to February 4, 2022. The findings show that solar and biofuel appear as the highest net shock transmitter among alternative renewable sources while global carbon is shown as the net receiver of shocks. The largest transmission of shocks to global carbon is observed from wind followed by solar. Although these findings support the connectedness between renewable energy and the environment, however this connectedness is influenced by economic crises such as the oil crisis and pandemic crisis. During COVID-19, the fuel cell was the highest transmitter of shocks. The results are important for policy formulation, investment, and portfolio management as they provide insights into the interconnectedness and help in boosting climate actions.Article Citation - WoS: 1Citation - Scopus: 1The Impact of the COVID-19 Pandemic on Satisfaction With Healthcare Services in Türkiye(Elsevier Sci Ltd, 2024-08) Ugur, Zeynep B.; Durak, AysenurObjectives: This study aims at evaluating whether the healthcare system in Turkey performed well or not from the perspective of patients during the COVID-19 pandemic. Methods: For this purpose, we compare the satisfaction with healthcare services pre-pandemic and during the pandemic. We utilize the Life Satisfaction Survey conducted by Turkish Statistical Institute (TurkStat) between 2013 and 2021 and employ probit regression method. Results: The research results do not show any change in satisfaction with healthcare services in the pandemic years of 2020 and 2021. In addition, the satisfaction with healthcare services of people with health conditions, those without health insurance, and those whose premiums are covered by the state (green card holders) did not decrease during the pandemic period. The analysis results reveal that the satisfaction of people over 65 years old and those having health conditions with healthcare services increased during the pandemic period. Conclusion: When the findings are evaluated as a whole, we can conclude that Turkey performed well from the users' perspective during the pandemic. Public interest summary: This study analyzes the impact of the pandemic on satisfaction with healthcare services in Turkey. To do this, we utilize Life Satisfaction Survey between 2013 and 2021. The regression results indicate that satisfaction with healthcare services has not changed during the pandemic. Moreover, we report an increase in satisfaction scores for elderly and those with health conditions in the pandemic years. We also find satisfaction of people without health insurance, and those whose premiums are covered by the state (green card holders) does not change. Our analysis points Turkey did well in managing pandemic period in terms of healthcare services satisfaction.Article Citation - WoS: 2Citation - Scopus: 2Route Choice to Inform Navigation System Design and Accessibility Analysis for Older Pedestrians: A Scoping Review(Elsevier Sci Ltd, 2025-10) Fulman, Nir; Huber, Johannes; Lloyd, Armagan Teke; Foshag, Kathrin; Grinblat, Yulia; Turk, Umut; Zipf, AlexanderIntroduction: Routing systems can support older adults by helping them overcome barriers to walking, promoting independence and well-being. The paths generated by these systems also inform urban accessibility metrics, such as those used in 15-min-city planning. Yet current systems rarely reflect the preferences or constraints of older pedestrians. Empirical studies of route choice can help close this gap by revealing how people trade off different route attributes in real settings. Methods: We conducted a scoping review, following PRISMA-ScR guidelines, of empirical studies analyzing pedestrian route choice among adults. The goal was to identify findings that could inform the design of more age-inclusive routing tools. Results: Eleven studies met the inclusion criteria, eight of which focused exclusively on older adults. Despite varied contexts, three consistent themes emerged: (i) sidewalk quality and manageable gradients; (ii) aesthetic and sensory comfort, including greenery, low noise, and good lighting; and (iii) access to benches, transit, and everyday amenities. However, most studies relied on qualitative methods, limiting direct integration into routing algorithms. Conclusions: Future work should prioritize hybrid qualitative-quantitative designs, large-scale sampling of routes, and fine-grained mapping of micro-barriers. Analyses should account for age, gender, and functional ability, and consider circular leisure walks as a distinct travel pattern. These directions can enhance the usability and equity of routing systems and urban planning frameworks.Article Citation - WoS: 9Citation - Scopus: 9Reaction Kinetics and Properties of Pumice-Based Geopolymer Systems Cured at Room Temperature(Elsevier Sci Ltd, 2023-12) Kucukyildirim, Enver; Yorulmaz, Hediye; Durak, Ugur; Ilkentapar, Serhan; Uzal, Burak; Karahan, Okan; Atis, Cengiz DuranThis research investigated the kinetics of pumice-based geopolymer systems and their physical and mechanical properties. The effect of the Na2SiO3/NaOH ratio of geopolymer systems on the rate of heat evolution and total heat of reaction were examined via isothermal calorimetry of geopolymer pastes prepared with Na2SiO3/NaOH ratios of 2.5, 3, and 3.5. Hardened pastes were also studied with thermo-gravimetric analysis to determine weight loss. In addition, the unit weights and compressive strengths of the pastes prepared using pumice were measured. Although the hydration process starts the earliest in pumice-based geopolymer pastes with a Na2SiO3/ NaOH ratio of 2, they have the lowest total hydration temperature. Na2SiO3/NaOH ratio of 2.5 by mass, shows higher weight loss obtained from TGA results. The compressive strength of the paste sample, prepared with a Na2SiO3/NaOH ratio of 3.5 by mass, was the highest, with 36.30 MPa at 28d. Depending on the Na2SiO3/NaOH ratio, it is thought that as the amount of Na2SiO3 increases in the samples, silica gel formation increases in later ages.Article Citation - WoS: 16Citation - Scopus: 18Piezoresistivity and Piezopermittivity of Cement-Based Sensors Under Quasi-Static Stress and Changing Moisture(Elsevier Sci Ltd, 2024-04) Zhang, Jiacheng; Heath, Andrew; Ball, Richard J.; Chen, Binling; Tan, Linzhen; Li, Guisheng; Paine, KevinIntegrated cement-based sensors offer an economic alternative to extrinsic sensors for health monitoring applications in concrete structures due to their high strength to cost ratio, geometrical versatility, low shrinkage, and natural compatibility. Nonetheless, their performance under in-service conditions were in lack of investigations. While the piezoresistivity (change in resistance with stress) has been commonly used for mechanical sensing, the piezopermittivity (change in capacitive reactance with stress) is rarely characterized. Exploiting the high relative permittivity and electrical conductivity of carbon fibre reinforced cement-based sensors, this study investigates the piezoresistivity and piezopermittivity under changing stress and moisture using electrochemical impedance spectroscopy (EIS). Two types of sensors were evaluated: one containing 0.5 vol% of carbon fibres whose electrical conductivity was ionically dominant, and another with electronically dominant (1.2 vol% of carbon fibres) conductivity. Results highlighted that the piezopermittivity is "moisture content-dominant" whilst the piezoresistivity is "fibre content-dominant". As the moisture content decreased, the sensitivity of piezopermittivity for both sensor types decreased, while the sensitivity of piezoresistivity decreased for the ionically dominant sensor but increased for the electronically dominant sensor. The piezoresistivity of the electronically dominant sensor was less sensitive than piezopermittivity at a water saturation of 80%. Conversely, the piezoresistivity of the ionically dominant sensor was more sensitive than piezopermittivity at the tested water saturations <= 80%. For the first time, this study presents the combined effects of moisture and fibre content on the pressure sensitive response of cement-based sensors through a dual-phase (i.e., piezoresistivity and piezopermittivity) EIS interpretation technique, providing valuable information to benefit further behaviour prediction and single-effect recognition in the field scenario where the sensors are subject to simultaneousArticle Citation - WoS: 46Citation - Scopus: 46Nuclear Energy Consumption, Energy Access and Energy Poverty: Policy Implications for the COP27 and Environmental Sustainability(Elsevier Sci Ltd, 2023-11) Bashir, Muhammad Farhan; Ma, Beiling; Sharif, Arshian; Ao, Tong; Koca, KemalThe ever-increasing energy resource demand and subsequent environmental challenges mean that policymakers have shifted their focus to nuclear energy to address energy and environmental issues due to its unlimited potential. The current study investigates the role of nuclear energy consumption to unveil contextual information and report novel evidence concerning the significance of energy and environmental policies. This research is a novel attempt to outline methodological and topical contributions, thematic analysis, co-citation analysis, and country-collaboration analysis. As energy and environmental solutions have been prioritized within sustainable development goals, our research approach would allow policymakers and researchers to understand the extent to which nuclear energy can provide solutions towards environmental sustainability and identify research limitations to overcome by future studies. Moreover, our extensive analysis allows us to argue that nuclear energy impacts energy demand and is the most critical factor in fulfilling environmental commitments under regional and international environmental agreements.Article Citation - WoS: 20Citation - Scopus: 22Multi-Objective Turbine Allocation on a Wind Farm Site(Elsevier Sci Ltd, 2024-02) Dincer, A. E.; Demir, A.; Yilmaz, K.The Multi-Objective Turbine Allocation (MOTA) method is introduced as a novel approach for wind farm layout optimization and site selection. By incorporating Geographic Information System (GIS) tools and the Analytical Hierarchy Process (AHP), the MOTA method offers a comprehensive solution to balance energy production, cost factors, and environmental impacts. In this study, the MOTA method is applied to Go center dot kceada, Turkiye, for wind farm development. Results show that the MOTA method effectively proposes the optimum wind farm layout by selecting the best site for each turbine. The sequential turbine allocation approach, integration of multiple objectives, and use of GIS tools and AHP are the key capabilities and novelties of the MOTA method. The method allows for flexible investment decisions, considering technical and economic aspects. The outcomes from the Go center dot kceada case study highlight the effectiveness of the MOTA method in maximizing energy production while considering cost factors and environmental impacts. The results indicate that for the selected objective functions, the optimal net profit is attained with the installation of 155 turbines on Go center dot kceada. The MOTA method presents a practical and efficient solution for wind farm development, contributing to sustainable and efficient renewable energy generation.
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