WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394

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In-silico Identification of Papillary Thyroid Carcinoma Molecular Mechanisms
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2019) Ersoz, Nur Sebnem; Guzel, Yasin; Bakir-Gungor, Burcu
Representing approximately 70% to 80% of thyroid cancers, papillary thyroid cancer (PTC) is the most common type of thyroid cancers. PTC is seen in all age groups, but it is seen more frequently in women than in men. Detection of biomarker proteins of papillary thyroid cancinoma plays an important role in the diagnosis of the disease. In this study, we aim to find target genes and pathways that are associated with papillar thyroid carcinoma, by integrating different bioinformatics methods. For this purpose, usingin-silico methodologies, candidate genes and pathways that could explain disease development mechanisms are identified. Throughout this study, firstly we identified differentially expressed genes as the amount of their protein product differ between patient and healthy groups. Secondly, by using active subnetworks search algorithms, topologic analyses and functional enrichment tests, candidate proteins,which could be thought as PTC biomarkers, and affected pathways are identified.
Ensemble Churn Prediction for Internet Service Provider with Machine Learning Techniques
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2020) Goy, Gokhan; Kolukisa, Burak; Bahcevan, Cenk; Gungor, Vehbi Cagri
With the developing technology in every fields, a competitive marketing environment has been arised In this competitive environment analyzing customer behavior has become vital In particular, the ability to easily change any service provider has become vet) , critical for the company to continue its existence At the same time, the amount of financial resources spent on retaining instituters much less than to obtain new clients. In this context, the traditional methods of examining vast amount of data obtained today for establishing decision support systems have lost their validities In this study. we used a dataset which is provided by TurkNet serving as an internet service provider in Turkey. Various preprocessing steps has performed on this dataset and then classification algorithms ran. Afterwards results have obtained and compared. The results of these experiments analyzed in terms of the area under the curve value In this context the aunt successful classifier algorithm has been determined as the Random Trees algorithm with a value of 0.936.
Computer-Aided Classification of Breast Cancer Histopathological Images
(IEEE345 E 47TH ST, NEW YORK, NY 10017 USA, 2017) Aksebzeci, Bekir Hakan; Kayaalti, Omer
Nowadays, one of the most common types of cancer is breast cancer. The early and accurate diagnosis of breast cancer has great importance in the treatment of the disease. In the diagnosis of breast cancer, histopathological analysis of cell and tissue specimens taken by biopsy is considered as the gold standard. Histopathological analysis is a tedious process that is highly dependent on the knowledge and experience of the pathologists. In this study; it is aimed to develop a computer-aided system that can reduce the workload of pathologists and help them in their diagnosis. An image set containing benign and malignant tumor images of breast cancer has been studied. To perform texture analysis on tumor images; first order statistics, Gabor and gray-level co-occurrence matrix (GLCM) feature extraction methods have been applied. Then, various classifiers were applied to the obtained feature matrices and their performances were compared. The highest classification accuracy was achieved 82.06% by Random Forests classifier with feature combination of Gabor and GLCM methods. The results presented here show that computer-assisted diagnosis of breast cancer is a promising field.
Değişen Yükseköğretim Sistemini Sosyokültürel ve Mekânsal Bağlamlarda Yeniden Düşünmek
(DEOMED PUBL, ISTANBUL, GUR SOK 7-B, FIKIRTEPE 34720 KADIKOY, ISTANBUL, 00000, TURKEY, 2020) Ayten, Asim Mustafa; Gover, Ibrahim Hakan
Education and research are vital for social development and progress. The changing sociocultural structures and new needs have resulted in some important functional changes in higher education systems with a deep impact on universities serving these needs at the highest level. Besides experiencing these functional changes, the universities today have become spaces of socialization with their social, cultural and sports facilities, replacing their traditional spatial role of offering education only. The local dynamics changing with globalization have now reshaped the global and local roles of universities, highlighting the added value they provide to the society. Sociocultural changes trigger all these functional and structural changes in universities. Therefore, sociocultural factors and their importance should not be ignored in a changing higher education system. In this study, the impact of sociocultural factors with their related spatial structures on world higher education system will be analyzed within their historical contexts, and some suggestions for future universities will be offered considering the current changes. In the first part of the study, the changes in societies and universities will be presented within the historical context. In the second part, the spatial forms and structures of universities will be discussed. In the third part, the catalytic effects of the specific sociocultural factors will be highlighted and elaborated on. Finally, some suggestions will be made for the universities of the future in the light of the current situation and the data available.
Real-Time Robotic Car Control Using Brainwaves and Head Movement
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2018) Ozturk, Nedime; Yilmaz, Bulent; Onver, Ahmet Yasin
Emotiv Epoc Headset is a portable and low-cost device. In this study, Emotiv Epoc headset was used in order to obtain real-time gyro and EEG signals. The aim of this study was to control a robotic car in real-time by using head movement and opening and closing of the eyes. The maximum and minimum amplitude of the gyro signal, and the ratios of the beta waves of O1 and O2 channel to alpha waves of the same channels were used as threshold values. These threshold values were used to determine the direction of the robotic car. Because of its low-cost and easy implementation, Arduino Uno was used to manage the robotic car. This study has shown that brain waves and head movements can control a device in real time. This system has the potential to be used in neurofeedback and brain-computer interface applications.
Detection of Variation Instances on Colonoscopy Videos using Structural Similarity Index
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2018) Kacmaz, Rukiye Nur; Yilmaz, Bulent
The aim of this study is to reduce the number of images extracted from the videos recorded by the specialists during the colonoscopy process for further examination, thereby enabling the specialist to deal with fewer images. Since the images obtained from the videos are very similar, the main assumption of this study is that the whole video can be represented by fewer images. The approach used in this study is the structural similarity index. Totally, images were obtained from 4 different videos coming from healthy, ulcerative colitis, Crohn's, and polyp patients. The noisy images in these videos were eliminated manually. When the structural similarity index between two consecutive clear images was less than 0.83, the second image was selected and shown to the specialist for his/her examination. By this way, the frames carrying significantly new information from the videos were defined as the variation instances. The tests on healthy or diseased colon videos showed that only 5-10% of the clear images provide significantly new information.
Identification of Shared Pathways Among Immune Related Diseases Utilizing Active Subnetworks
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2020) Eryilmaz, Mahmut Kaan; Kuzudisli, Cihan; Gungor, Burcu Bakir
Different, but related diseases often contain shared symptoms indicating the presence of possible overlaps in underlying pathogenic mechanisms. The identification of the shared pathways and related factors across these diseases helps to better understand the causes of these diseases, to prevent and treat these diseases. In this study, using immune-related diseases, we proposed a new method on how to compare the development mechanisms of related diseases based on biological pathways. Following the developments in genomic technologies, the genotyping gets cheaper and easier, and hence genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) could he identified. With the help of these studies, in which around a million of SNPs are scanned, the variations and genes that could have a role in specific disease development could be detected. In this study, via using available GWAS datasets and human protein-protein interaction network, and via detecting active subnetworks and affected pathways, seven immune related diseases are analyzed. Via investigating the similarities among the identified pathways for related diseases, we aim to define the underlying pathogenic mechanisms, and hence to contribute to the elucidation of disease development mechanisms and to the drug repositioning studies.
Dayım: Bir İnsanoğlunun Portresi
(TURKISH LIBRARIANS ASSOC, YENISEHIR, NECATIBEY CAD, ELGIN SOK, PO BOX 175, ANKARA, 06440, TURKEY, 2019) Donmez, Rasim Ozgur
This is a memoir written by his nephew about our colleague Ali Can, who passed away in last July.
In-Silico Methods to Identify Common MicroRNAs and Pathways of Neuromuscular Diseases
(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2019) Yazici, Miray Unlu; Menges, Evrim Aksu; Ulum, Yeliz Z. Akkaya; Hayta, Burcu Balci; Bakir-Gungor, Burcu
Neuromuscular disorders (NMD) are a heterogeneous group of diseases characterized by the loss of function of the peripheral nerves and muscles. However, there are no effective and widespread therapeutic approaches to prevent or delay the progression of these disease types. microRNAs (miRNAs) which cause significant changes in gene expression by binding to target messenger RNAs (mRNAs), are known to have an effect on disease mechanisms. In this study, by integrating different bioinformatics methods, we aim to find miRNAs, target genes and pathways related to a group of neuromuscular diseases. For this purpose, we determined 17 miRNAs that show significant expression changes between patient and healthy groups; predicted target genes of these miRNAs; and identified affected pathways using subnetwork discovery, functional enrichment based algorithms. In our study, we integrated different in-silico approaches that proceed in top-down manner or bottom-up manner. The identified candidate miRNAs, genes and pathways, which could help to explain neuromuscular disease development mechanisms, are now under investigation in wet-lab.

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