Immunomagnetic separation of B type acute lymphoblastic leukemia cells from bone marrow with flow cytometry validation and microfluidic chip measurements

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dc.contributor.author Icoz, Kutay
dc.contributor.author Eken, Ahmet
dc.contributor.author Cinar, Suzan
dc.contributor.author Murat, Aysegul
dc.contributor.author Ozcan, Servet
dc.contributor.author Unal, Ekrem
dc.contributor.author Deniz, Gunnur
dc.contributor.authorID 0000-0002-8330-7010 en_US
dc.contributor.authorID 0000-0002-0947-6166 en_US
dc.contributor.department AGÜ, Yaşam ve Doğa Bilimleri Fakültesi, Biyomühendislik Bölümü en_US
dc.date.accessioned 2021-01-25T11:20:29Z
dc.date.available 2021-01-25T11:20:29Z
dc.date.issued 2020 en_US
dc.description This work was supported by the Turkiye Bilimsel ve Teknolojik Arastirma Kurumu [project number: 115E020]. en_US
dc.description.abstract In order to detect the blast cells from bone marrow of patients, one strategy is to first isolate the cells using immunomagnetic beads. The aim of this study was to report the experimental results of the immunomagnetic separation efficiency of the blast cells from bone marrow of pediatric leukemia patients. To test the efficiency of immunomagnetic separation, flow cytometry measurements at critical steps were performed. We here reported 94.5% capture efficiency for CD10 nano beads. Patients samples were also analyzed with a microfluidic chip to test the feasibility for further developments. en_US
dc.description.sponsorship Turkiye Bilimsel ve Teknolojik Arastirma Kurumu (TUBITAK) 115E020 en_US
dc.identifier.issn 0149-6395
dc.identifier.issn 1520-5754
dc.identifier.uri https://doi.org/10.1080/01496395.2020.1835983
dc.identifier.uri https://hdl.handle.net/20.500.12573/479
dc.language.iso eng en_US
dc.publisher TAYLOR & FRANCIS INC, 530 WALNUT STREET, STE 850, PHILADELPHIA, PA 19106 USA en_US
dc.relation.isversionof 10.1080/01496395.2020.1835983 en_US
dc.relation.journal SEPARATION SCIENCE AND TECHNOLOGY en_US
dc.relation.publicationcategory Makale - Uluslararası - Editör Denetimli Dergi en_US
dc.relation.tubitak 115E020
dc.rights info:eu-repo/semantics/openAccess en_US
dc.subject microfluidic chip en_US
dc.subject hematogone en_US
dc.subject bone marrow en_US
dc.subject flow cytometry en_US
dc.subject immunomagnetic separation en_US
dc.subject B type acute lymphoblastic leukemia en_US
dc.title Immunomagnetic separation of B type acute lymphoblastic leukemia cells from bone marrow with flow cytometry validation and microfluidic chip measurements en_US
dc.type article en_US

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