Revealing Genome-Wide mRNA and MicroRNA Expression Patterns in Leukemic Cells Highlighted HSA-MIR as a Tumor Suppressor for Regain of Chemotherapeutic Imatinib Response due to Targeting STAT5A
| dc.contributor.author | Kaymaz, Burcin Tezcanli | |
| dc.contributor.author | Gunel, Nur Selvi | |
| dc.contributor.author | Ceyhan, Metin | |
| dc.contributor.author | Cetintas, Vildan Bozok | |
| dc.contributor.author | Ozel, Buket | |
| dc.contributor.author | Yandim, Melis Kartal | |
| dc.contributor.author | Can, Buket Kosova | |
| dc.date.accessioned | 2025-09-25T10:56:31Z | |
| dc.date.available | 2025-09-25T10:56:31Z | |
| dc.date.issued | 2015 | |
| dc.description | Baran, Yusuf/0000-0002-1056-4673; Kartal Yandim, Melis/0000-0003-0573-4276; Ozel, Buket/0000-0003-2659-4129; Kipcak, Sezgi/0000-0003-0615-3844; Tezcanli Kaymaz, Burcin/0000-0003-1832-1454; Bozok, Vildan/0000-0003-3915-6363; Adan, Aysun/0000-0002-3747-8580 | en_US |
| dc.description.abstract | BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to be overcome. In this study, we aimed to determine differing genome-wide MicroRNA (miRNA) and messenger RNA (mRNA) expression profiles in imatinib resistant (K562/IMA-3 mu M) and parental cells by targeting STAT5A via small interfering RNA (siRNA) applications. After determining possible therapeutic miRNAs, we aimed to check their effects upon cell viability and proliferation, apoptosis, and find a possible miRNA | en_US |
| dc.description.sponsorship | Ege University Research Fund [APAK 2013-TIP/083] | en_US |
| dc.description.sponsorship | This study was financially supported by Ege University Research Fund [grant number APAK 2013-TIP/083] to BTK. | en_US |
| dc.identifier.doi | 10.1007/s13277-015-3509-9 | |
| dc.identifier.issn | 1010-4283 | |
| dc.identifier.issn | 1423-0380 | |
| dc.identifier.scopus | 2-s2.0-84944280437 | |
| dc.identifier.uri | https://doi.org/10.1007/s13277-015-3509-9 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12573/4571 | |
| dc.language.iso | en | en_US |
| dc.publisher | Sage Publications Ltd | en_US |
| dc.relation.ispartof | Tumor Biology | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Imatinib Resistance | en_US |
| dc.subject | STAT5A | en_US |
| dc.subject | siRNA | en_US |
| dc.subject | Transcriptome and miRNome Array | en_US |
| dc.subject | Apoptosis | en_US |
| dc.title | Revealing Genome-Wide mRNA and MicroRNA Expression Patterns in Leukemic Cells Highlighted HSA-MIR as a Tumor Suppressor for Regain of Chemotherapeutic Imatinib Response due to Targeting STAT5A | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Baran, Yusuf/0000-0002-1056-4673 | |
| gdc.author.id | Kartal Yandim, Melis/0000-0003-0573-4276 | |
| gdc.author.id | Ozel, Buket/0000-0003-2659-4129 | |
| gdc.author.id | Kipcak, Sezgi/0000-0003-0615-3844 | |
| gdc.author.id | Tezcanli Kaymaz, Burcin/0000-0003-1832-1454 | |
| gdc.author.id | Bozok, Vildan/0000-0003-3915-6363 | |
| gdc.author.id | Adan, Aysun/0000-0002-3747-8580 | |
| gdc.author.scopusid | 55253674000 | |
| gdc.author.scopusid | 59157898600 | |
| gdc.author.scopusid | 56637961000 | |
| gdc.author.scopusid | 24830456300 | |
| gdc.author.scopusid | 56638649300 | |
| gdc.author.scopusid | 37050733400 | |
| gdc.author.scopusid | 55349824100 | |
| gdc.author.wosid | Kartal Yandim, Melis/O-1535-2015 | |
| gdc.author.wosid | Kipcak, Sezgi/Abb-7883-2020 | |
| gdc.author.wosid | Baran, Yusuf/F-8535-2012 | |
| gdc.author.wosid | Bozok, Vildan/C-2946-2014 | |
| gdc.author.wosid | Tezcanli Kaymaz, Burcin/A-1225-2018 | |
| gdc.author.wosid | Aktan, Çağdaş/A-4732-2009 | |
| gdc.bip.impulseclass | C4 | |
| gdc.bip.influenceclass | C4 | |
| gdc.bip.popularityclass | C4 | |
| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
| gdc.collaboration.industrial | false | |
| gdc.description.department | Abdullah Gül University | en_US |
| gdc.description.departmenttemp | [Kaymaz, Burcin Tezcanli; Gunel, Nur Selvi; Cetintas, Vildan Bozok; Ozel, Buket; Kipcak, Sezgi; Aktan, Cagdas; Can, Buket Kosova] Ege Univ, Sch Med, Dept Med Biol, Izmir, Turkey; [Ceyhan, Metin] 9 Eylul Univ, Sch Med, Dept Oncol, Izmir, Turkey; [Yandim, Melis Kartal; Gokbulut, Aysun Adan] Izmir Inst Technol, Dept Mol Biol & Genet, Izmir, Turkey; [Baran, Yusuf] Abdullah Gul Univ, Fac Life & Nat Sci, Kayseri, Turkey | en_US |
| gdc.description.endpage | 7927 | en_US |
| gdc.description.issue | 10 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q3 | |
| gdc.description.startpage | 7915 | en_US |
| gdc.description.volume | 36 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | N/A | |
| gdc.identifier.openalex | W271935301 | |
| gdc.identifier.pmid | 25953263 | |
| gdc.identifier.wos | WOS:000362969900065 | |
| gdc.index.type | WoS | |
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| gdc.index.type | PubMed | |
| gdc.oaire.accesstype | GOLD | |
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| gdc.oaire.influence | 3.3882617E-9 | |
| gdc.oaire.isgreen | true | |
| gdc.oaire.keywords | Blotting, Western | |
| gdc.oaire.keywords | Apoptosis | |
| gdc.oaire.keywords | Real-Time Polymerase Chain Reaction | |
| gdc.oaire.keywords | Leukemia, Myelogenous, Chronic, BCR-ABL Positive | |
| gdc.oaire.keywords | Biomarkers, Tumor | |
| gdc.oaire.keywords | STAT5 Transcription Factor | |
| gdc.oaire.keywords | Tumor Cells, Cultured | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | RNA, Messenger | |
| gdc.oaire.keywords | Imatinib resistance | |
| gdc.oaire.keywords | RNA, Small Interfering | |
| gdc.oaire.keywords | Protein Kinase Inhibitors | |
| gdc.oaire.keywords | Cell Proliferation | |
| gdc.oaire.keywords | Oligonucleotide Array Sequence Analysis | |
| gdc.oaire.keywords | Gene Expression Regulation, Leukemic | |
| gdc.oaire.keywords | Genome, Human | |
| gdc.oaire.keywords | Reverse Transcriptase Polymerase Chain Reaction | |
| gdc.oaire.keywords | Gene Expression Profiling | |
| gdc.oaire.keywords | Chronic myeloid leukemia | |
| gdc.oaire.keywords | Transcriptome and miRNome array | |
| gdc.oaire.keywords | STAT5A | |
| gdc.oaire.keywords | MicroRNAs | |
| gdc.oaire.keywords | Drug Resistance, Neoplasm | |
| gdc.oaire.keywords | siRNA | |
| gdc.oaire.keywords | Imatinib Mesylate | |
| gdc.oaire.popularity | 1.2236993E-8 | |
| gdc.oaire.publicfunded | false | |
| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.oaire.sciencefields | 0303 health sciences | |
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| gdc.openalex.toppercent | TOP 1% | |
| gdc.opencitations.count | 26 | |
| gdc.plumx.crossrefcites | 12 | |
| gdc.plumx.mendeley | 20 | |
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