On-Demand Weighing of Single Dry Biological Particles Over a 5-Order Dynamic Range
| dc.contributor.author | Chan, Bin-Da | |
| dc.contributor.author | Icoz, Kutay | |
| dc.contributor.author | Huang, Wanfeng | |
| dc.contributor.author | Chang, Chun-Li | |
| dc.contributor.author | Savran, Cagri A. | |
| dc.date.accessioned | 2025-09-25T10:53:49Z | |
| dc.date.available | 2025-09-25T10:53:49Z | |
| dc.date.issued | 2014 | |
| dc.description | Icoz, Kutay/0000-0002-0947-6166; | en_US |
| dc.description.abstract | We report a simple and highly versatile system to select and weigh individual dry biological particles. The system is composed of a microtweezer to pick and place individual particles and a cantilever-based resonator to weigh them. The system can weigh entities that vary from a red blood cell (similar to 10(-11) g) to the eye-brain complex of an insect (similar to 10(-6) g), covering a 5-order-of-magnitude mass range. Due to its versatility and ease of use, this weighing method is highly compatible with established laboratory practices. The system can provide complementary mass information for a wide variety of individual particles imaged using scanning electron microscopy and determine comparative weights of individual biological entities that are attached to microparticles as well as weigh fractions of individual biological entities that have been subjected to focused ion beam milling. | en_US |
| dc.description.sponsorship | National Science Foundation [1343069]; Directorate For Engineering; Div Of Electrical, Commun & Cyber Sys [1343069] Funding Source: National Science Foundation | en_US |
| dc.description.sponsorship | The authors thank Dr. Shadia Jalal from Indiana University School of Medicine for providing the A549 cell line, Dr. Philip Low from Purdue University Department of Chemistry for providing the KB cell line, Dr. Nancy C. Emery from Purdue University Department of Biological Sciences for providing the pollen grains, Dr. Timothy Ratliff and Hsing-Hui Wang from Purdue University Center for Cancer Research for providing the mouse prostate stem cell spheres, Dr. Vikki M. Weake and Jingqun Ma from Purdue University Department of Biochemistry for providing the eye-brain complexes of larval Drosophilae, Dr. Jenna Rickus from Purdue University Agricultural and Biological Engineering for providing the mouse pancreatic islet spheroids, Dr. Deepika Dhawan from Purdue University Department of Veterinary Clinical Sciences for providing the K9TCC-AN cells, and Laurie M. Mueller from Purdue University Life Science Microscopy Facility for coaching the cell fixation and HMDS-drying procedures as well as conducting the cell milling process. This work was supported by a National Science Foundation Award 1343069. | en_US |
| dc.identifier.doi | 10.1039/c4lc00765d | |
| dc.identifier.issn | 1473-0197 | |
| dc.identifier.issn | 1473-0189 | |
| dc.identifier.scopus | 2-s2.0-84907638104 | |
| dc.identifier.uri | https://doi.org/10.1039/c4lc00765d | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12573/4326 | |
| dc.language.iso | en | en_US |
| dc.publisher | Royal Soc Chemistry | en_US |
| dc.relation.ispartof | Lab on a Chip | en_US |
| dc.rights | info:eu-repo/semantics/closedAccess | en_US |
| dc.title | On-Demand Weighing of Single Dry Biological Particles Over a 5-Order Dynamic Range | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Icoz, Kutay/0000-0002-0947-6166 | |
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| gdc.author.scopusid | 6505826959 | |
| gdc.author.wosid | Icoz, Kutay/J-2063-2015 | |
| gdc.author.wosid | Icoz, Kutay/Abi-3903-2020 | |
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| gdc.description.department | Abdullah Gül University | en_US |
| gdc.description.departmenttemp | [Chan, Bin-Da; Huang, Wanfeng; Chang, Chun-Li; Savran, Cagri A.] Purdue Univ, Sch Mech Engn, W Lafayette, IN 47907 USA; [Icoz, Kutay] Abdullah Gul Univ, TR-38039 Kayseri, Turkey; [Chan, Bin-Da; Icoz, Kutay; Huang, Wanfeng; Chang, Chun-Li; Savran, Cagri A.] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA; [Icoz, Kutay; Savran, Cagri A.] Weldon Sch Biomed Engn, W Lafayette, IN 47907 USA | en_US |
| gdc.description.endpage | 4196 | en_US |
| gdc.description.issue | 21 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.startpage | 4188 | en_US |
| gdc.description.volume | 14 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
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| gdc.identifier.openalex | W2127221055 | |
| gdc.identifier.pmid | 25162712 | |
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| gdc.oaire.keywords | Erythrocytes | |
| gdc.oaire.keywords | Models, Biological | |
| gdc.oaire.keywords | Mice | |
| gdc.oaire.keywords | Micromanipulation | |
| gdc.oaire.keywords | Cell Line, Tumor | |
| gdc.oaire.keywords | Microscopy, Electron, Scanning | |
| gdc.oaire.keywords | Animals | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Pollen | |
| gdc.oaire.keywords | Particle Size | |
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| gdc.oaire.sciencefields | 0301 basic medicine | |
| gdc.oaire.sciencefields | 0303 health sciences | |
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| gdc.virtual.author | İçöz, Kutay | |
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