Magnetic Micro/Nanoparticle Flocculation-Based Signal Amplification for Biosensing
| dc.contributor.author | Mzava, Omary | |
| dc.contributor.author | Tas, Zehra | |
| dc.contributor.author | Icoz, Kutay | |
| dc.date.accessioned | 2025-09-25T10:50:33Z | |
| dc.date.available | 2025-09-25T10:50:33Z | |
| dc.date.issued | 2016 | |
| dc.description | Icoz, Kutay/0000-0002-0947-6166 | en_US |
| dc.description.abstract | We report a time and cost efficient signal amplification method for biosensors employing magnetic particles. In this method, magnetic particles in an applied external magnetic field form magnetic dipoles, interact with each other, and accumulate along the magnetic field lines. This magnetic interaction does not need any biomolecular coating for binding and can be controlled with the strength of the applied magnetic field. The accumulation can be used to amplify the corresponding pixel area that is obtained from an image of a single magnetic particle. An application of the method to the Escherichia coli 0157: H7 bacteria samples is demonstrated in order to show the potential of the approach. A minimum of threefold to a maximum of 60-fold amplification is reached from a single bacteria cell under a magnetic field of 20 mT. | en_US |
| dc.description.sponsorship | TUBITAK [114E886, 2215]; AGU BAP [2015-11] | en_US |
| dc.description.sponsorship | The authors acknowledge TUBITAK (Project No: 114E886) and AGU BAP (2015-11) for financial support. Omary Mzava acknowledges TUBITAK for the scholarship (2215). The authors also thank Professor Cagri Savran from Purdue University for valuable discussions, Hulya Sarayli and Nurdan Yapar from City Control Lab for the valuable information about E. coli staining and capturing procedures, and Cengiz Gazeloglu for the discussions on statistical analysis. | en_US |
| dc.identifier.doi | 10.2147/IJN.S108692 | |
| dc.identifier.issn | 1178-2013 | |
| dc.identifier.issn | 1176-9114 | |
| dc.identifier.scopus | 2-s2.0-84973473001 | |
| dc.identifier.uri | https://doi.org/10.2147/IJN.S108692 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12573/4164 | |
| dc.language.iso | en | en_US |
| dc.publisher | Dove Medical Press Ltd | en_US |
| dc.relation.ispartof | International Journal of Nanomedicine | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Magnetic Micro/Nanoparticle Accumulation | en_US |
| dc.subject | Signal Amplification | en_US |
| dc.subject | Image-Based Detection | en_US |
| dc.subject | Magnetic Dipole-Dipole Interaction | en_US |
| dc.subject | Magnetic Dipole–Dipole Interaction | |
| dc.title | Magnetic Micro/Nanoparticle Flocculation-Based Signal Amplification for Biosensing | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Icoz, Kutay/0000-0002-0947-6166 | |
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| gdc.author.wosid | Icoz, Kutay/Abi-3903-2020 | |
| gdc.author.wosid | Icoz, Kutay/J-2063-2015 | |
| gdc.bip.impulseclass | C5 | |
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| gdc.coar.access | open access | |
| gdc.coar.type | text::journal::journal article | |
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| gdc.description.department | Abdullah Gül University | en_US |
| gdc.description.departmenttemp | [Mzava, Omary; Tas, Zehra; Icoz, Kutay] Abdullah Gul Univ, Dept Elect & Elect Engn, BioMINDS Bio Micro Nano Devices & Sensors Lab, Kayseri, Turkey; [Icoz, Kutay] Abdullah Gul Univ, Bioengn Dept, Kayseri, Turkey | en_US |
| gdc.description.endpage | 2631 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
| gdc.description.scopusquality | Q1 | |
| gdc.description.startpage | 2619 | en_US |
| gdc.description.volume | 11 | en_US |
| gdc.description.woscitationindex | Science Citation Index Expanded | |
| gdc.description.wosquality | Q1 | |
| gdc.identifier.openalex | W2414200731 | |
| gdc.identifier.pmid | 27354793 | |
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| gdc.oaire.keywords | Medicine (General) | |
| gdc.oaire.keywords | Iron | |
| gdc.oaire.keywords | Biosensing Techniques | |
| gdc.oaire.keywords | Escherichia coli O157 | |
| gdc.oaire.keywords | R5-920 | |
| gdc.oaire.keywords | International Journal of Nanomedicine | |
| gdc.oaire.keywords | image based detection | |
| gdc.oaire.keywords | Particle Size | |
| gdc.oaire.keywords | magnetic micro/nanoparticle accumulation | |
| gdc.oaire.keywords | Magnetite Nanoparticles | |
| gdc.oaire.keywords | Original Research | |
| gdc.oaire.keywords | magnetic micro/nano particle accumulation | |
| gdc.oaire.keywords | Optical Imaging | |
| gdc.oaire.keywords | image-based detection | |
| gdc.oaire.keywords | Flocculation | |
| gdc.oaire.keywords | Signal Processing, Computer-Assisted | |
| gdc.oaire.keywords | Microspheres | |
| gdc.oaire.keywords | signal amplification | |
| gdc.oaire.keywords | Magnetic Fields | |
| gdc.oaire.keywords | magnetic dipole-dipole interaction | |
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| gdc.oaire.sciencefields | 0301 basic medicine | |
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| gdc.oaire.sciencefields | 01 natural sciences | |
| gdc.oaire.sciencefields | 03 medical and health sciences | |
| gdc.oaire.sciencefields | 0303 health sciences | |
| gdc.oaire.sciencefields | 0104 chemical sciences | |
| gdc.oaire.sciencefields | 0210 nano-technology | |
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| gdc.virtual.author | İçöz, Kutay | |
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