Micro- and Nanodevices Integrated With Biomolecular Probes
| dc.contributor.author | Alapan, Yunus | |
| dc.contributor.author | Icoz, Kutay | |
| dc.contributor.author | Gurkan, Umut A. | |
| dc.date.accessioned | 2025-09-25T10:50:42Z | |
| dc.date.available | 2025-09-25T10:50:42Z | |
| dc.date.issued | 2015 | |
| dc.description | Alapan, Yunus/0000-0003-3064-7342; Gurkan, Umut A./0000-0002-0331-9960; Icoz, Kutay/0000-0002-0947-6166 | en_US |
| dc.description.abstract | Understanding how biomolecules, proteins and cells interact with their surroundings and other biological entities has become the fundamental design criterion for most biomedical micro- and nanodevices. Advances in biology, medicine, and nanofabrication technologies complement each other and allow us to engineer new tools based on biomolecules utilized as probes. Engineered micro/nanosystems and biomolecules in nature have remarkably robust compatibility in terms of function, size, and physical properties. This article presents the state of the art in micro- and nanoscale devices designed and fabricated with biomolecular probes as their vital constituents. General design and fabrication concepts are presented and three major platform technologies are highlighted: microcantilevers, micro/nanopillars, and microfluidics. Overview of each technology, typical fabrication details, and application areas are presented by emphasizing significant achievements, current challenges, and future opportunities. (C) 2015 Elsevier Inc. All rights reserved. | en_US |
| dc.description.sponsorship | Doris Duke Charitable Foundation [2013126]; Coulter-Case Translational Research Partnership Award; Steven Garverick Memorial Innovation Incentive Award; Clinical and Translational Science Collaborative (CTSC) of Cleveland from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health (NIH) [UL1TR000439]; NIH roadmap for Medical Research; University Center for Innovation in Teaching and Education (UCITE) | en_US |
| dc.description.sponsorship | This work was supported in part by Grant # 2013126 from the Doris Duke Charitable Foundation, Coulter-Case Translational Research Partnership Award, Steven Garverick Memorial Innovation Incentive Award, and an award from the Clinical and Translational Science Collaborative (CTSC) of Cleveland: UL1TR000439 from the National Center for Advancing Translational Sciences (NCATS) component of the National Institutes of Health (NIH) and NIH roadmap for Medical Research. Its contents are solely the responsibility of the authors and do not necessarily represent the official views of the NIH. Y. A. and U. A. G. acknowledge the Center for Integration of Medicine & Innovative Technology (CIMIT) Student Technology Prize for Primary Healthcare. U. A. G. would like to thank the University Center for Innovation in Teaching and Education (UCITE) for the Glennan Fellowship, which supports the Scientific Art Program and art student internship at Case Biomanufacturing and Microfabrication Laboratory. The authors acknowledge Bin-Da Chan and Cagri Savran from Purdue University for their help in the preparation of Fig. 3a, and Selim Ozden for his help in preparing Fig. 3b and Fig. 5c. | en_US |
| dc.identifier.doi | 10.1016/j.biotechadv.2015.09.001 | |
| dc.identifier.issn | 0734-9750 | |
| dc.identifier.issn | 1873-1899 | |
| dc.identifier.scopus | 2-s2.0-84950136858 | |
| dc.identifier.uri | https://doi.org/10.1016/j.biotechadv.2015.09.001 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12573/4192 | |
| dc.language.iso | en | en_US |
| dc.publisher | Pergamon-Elsevier Science Ltd | en_US |
| dc.relation.ispartof | Biotechnology Advances | en_US |
| dc.rights | info:eu-repo/semantics/openAccess | en_US |
| dc.subject | Biosensing | en_US |
| dc.subject | Micro/Nanofabrication | en_US |
| dc.subject | Microcantilevers | en_US |
| dc.subject | Micro/Nanopillars | en_US |
| dc.subject | Microfluidic Channels | en_US |
| dc.subject | Surface Functionalization | en_US |
| dc.subject | Cell Adhesion | en_US |
| dc.subject | Biomolecules | en_US |
| dc.subject | Cell Isolation | en_US |
| dc.subject | Point-of-Care Diagnosis | en_US |
| dc.title | Micro- and Nanodevices Integrated With Biomolecular Probes | en_US |
| dc.type | Article | en_US |
| dspace.entity.type | Publication | |
| gdc.author.id | Alapan, Yunus/0000-0003-3064-7342 | |
| gdc.author.id | Gurkan, Umut A./0000-0002-0331-9960 | |
| gdc.author.id | Icoz, Kutay/0000-0002-0947-6166 | |
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| gdc.author.wosid | Gurkan, Umut/Z-2496-2019 | |
| gdc.author.wosid | Icoz, Kutay/Abi-3903-2020 | |
| gdc.author.wosid | Alapan, Yunus/U-4880-2017 | |
| gdc.author.wosid | Icoz, Kutay/J-2063-2015 | |
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| gdc.description.department | Abdullah Gül University | en_US |
| gdc.description.departmenttemp | [Alapan, Yunus; Gurkan, Umut A.] Case Western Reserve Univ, Mech & Aerosp Engn Dept, Case Biomfg & Microfabricat Lab, Cleveland, OH 44106 USA; [Icoz, Kutay] Abdullah Gul Univ, Elect & Elect Engn Dept, Bio Micro Nano Devices & Sensors Lab, TR-38080 Kayseri, Turkey; [Gurkan, Umut A.] Case Western Reserve Univ, Dept Biomed Engn, Cleveland, OH 44106 USA; [Gurkan, Umut A.] Case Western Reserve Univ, Dept Orthopaed, Cleveland, OH 44106 USA; [Gurkan, Umut A.] Louis Stokes Cleveland Vet Affairs Med Ctr, Adv Platform Technol Ctr, Cleveland, OH 44106 USA | en_US |
| gdc.description.endpage | 1743 | en_US |
| gdc.description.issue | 8 | en_US |
| gdc.description.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
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| gdc.description.startpage | 1727 | en_US |
| gdc.description.volume | 33 | en_US |
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| gdc.oaire.keywords | Biomolecules | |
| gdc.oaire.keywords | Microfluidics | |
| gdc.oaire.keywords | Cell adhesion | |
| gdc.oaire.keywords | Proteins | |
| gdc.oaire.keywords | Biosensing Techniques | |
| gdc.oaire.keywords | Biosensing; Micro/nanofabricalion | |
| gdc.oaire.keywords | Point-of-care diagnosis | |
| gdc.oaire.keywords | Micro/nanopillars | |
| gdc.oaire.keywords | Surface functionalization | |
| gdc.oaire.keywords | Molecular Probes | |
| gdc.oaire.keywords | Cell isolation | |
| gdc.oaire.keywords | Microfluidic channels | |
| gdc.oaire.keywords | Humans | |
| gdc.oaire.keywords | Nanotechnology | |
| gdc.oaire.keywords | Microcantilevers | |
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| gdc.virtual.author | İçöz, Kutay | |
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