Dinçer İşoğlu, Sevil
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Dincer, Sevil
Dinçer, S
Isoglu, S. Dincer
Isoglu, Sevil Dincer
Dinçer, S
Isoglu, S. Dincer
Isoglu, Sevil Dincer
Job Title
Prof. Dr.
Email Address
sevil.dincer@agu.edu.tr
Main Affiliation
04.01. Biyomühendislik
Status
Current Staff
Website
ORCID ID
Scopus Author ID
Turkish CoHE Profile ID
Google Scholar ID
WoS Researcher ID
Sustainable Development Goals
13
CLIMATE ACTION
0
Research Products
15
LIFE ON LAND
0
Research Products
8
DECENT WORK AND ECONOMIC GROWTH
0
Research Products
10
REDUCED INEQUALITIES
0
Research Products
2
ZERO HUNGER
0
Research Products
6
CLEAN WATER AND SANITATION
0
Research Products
14
LIFE BELOW WATER
0
Research Products
11
SUSTAINABLE CITIES AND COMMUNITIES
0
Research Products
16
PEACE, JUSTICE AND STRONG INSTITUTIONS
0
Research Products
5
GENDER EQUALITY
0
Research Products
9
INDUSTRY, INNOVATION AND INFRASTRUCTURE
0
Research Products
7
AFFORDABLE AND CLEAN ENERGY
0
Research Products
4
QUALITY EDUCATION
0
Research Products
1
NO POVERTY
0
Research Products
17
PARTNERSHIPS FOR THE GOALS
0
Research Products
3
GOOD HEALTH AND WELL-BEING
8
Research Products
12
RESPONSIBLE CONSUMPTION AND PRODUCTION
0
Research Products
Documents
37
Citations
1524
h-index
-
Documents
44
Citations
1446
Scholarly Output
20
Articles
16
Views / Downloads
0/0
Supervised MSc Theses
0
Supervised PhD Theses
0
WoS Citation Count
211
Scopus Citation Count
215
WoS h-index
9
Scopus h-index
9
Patents
0
Projects
0
WoS Citations per Publication
10.55
Scopus Citations per Publication
10.75
Open Access Source
3
Supervised Theses
0
| Journal | Count |
|---|---|
| Journal of Applied Polymer Science | 2 |
| Fibers and Polymers | 2 |
| Polymer Bulletin | 2 |
| FEBS Open Bio | 2 |
| Macromolecular Bioscience | 2 |
Current Page: 1 / 3
Scopus Quartile Distribution
Competency Cloud
20 results
Scholarly Output Search Results
Now showing 1 - 10 of 20
Article Citation - WoS: 35Citation - Scopus: 39Advances in Micelle-Based Drug Delivery: Cross-Linked Systems(Bentham Science Publ Ltd, 2017) Isoglu, Ismail Alper; Ozsoy, Yildiz; Isoglu, Sevil DincerThere are several barriers that drug molecules encounter in body beginning from kidney filtration and reticulo-endothelial system (RES) clearance to cellular trafficking. Multifunctional nanocarriers have a great potential for the delivery of drugs by enhancing therapeutic activity of existing methodologies. A variety of nanocarriers are constructed by different material types, which have unique physicochemical properties for drug delivery applications. Micelles formed by amphiphilic polymers are one of the most important drug/nanocarrier formulation products, in which the core part is suitable for encapsulation of hydrophobic agent whereas the outer shell can be utilized for targeting the drug to the disease area. Micelles as self-assembled nanostructures may encounter difficulties in biodistribution of encapsulated drugs because they have a tendency to be dissociated in dilution or high ionic strength. Therefore, therapeutic efficiency is decreased and it requires high amount of drug to be administered to achieve more efficient result. To overcome this problem, covalently stabilized structures produced by cross-linking in core or shell part, which can prevent the micelle dissociation and regulate drug release, have been proposed. These systems can be designed as responsive systems in which cross-links are degradable or hydrolysable under specific conditions such as low pH or reductive environment. These are enhancing characteristics in drug delivery because their cleavage allows the release of bioactive agent encapsulated in the carrier at a certain site or time. This review describes the chemical methodologies for the preparation of cross-linked micelles, and reports an update of latest studies in literature.Article Citation - WoS: 11Citation - Scopus: 12Antibacterial Bilayered Skin Patches Made of HPMA and Quaternary Poly(4-Vinyl Pyridine)(Korean Fiber Soc, 2018) Isoglu, I. Alper; Demirkan, Cemre; Seker, Mine Gul; Tuzlakoglu, Kadriye; Isoglu, Sevil DincerThis study aimed to produce poly(4-vinyl pyridine) and hydroxypropyl methacrylamide (HPMA)-based bilayer wound dressings materials enhancing healing mechanism for the wounds which have self-healing problem and high infection risk. These materials were designed to protect wound from secondary traumas caused microorganism invasion and do not have toxic substance release problem. Synthesis of quaternary poly(4-vinyl pyridine) (poly(Q4-VP)) which is the antibacterial layer of wound dressing material was carried out in two stages. At first stage, poly(4-vinyl pyridine) polymer was synthesized from 4-vinyl pyridine monomer by free radical polymerization. Then, poly(Q4-VP) was synthesized from poly(4-VP) by alkylation reaction with 6-bromocaproic acid. Resulted polymer was structurally characterized by FT-IR. The macroporous spongy structure, as the lower layer of wound dressing material, was prepared by cryogelation of HPMA. Then, the antibacterial polymer was electrospun onto the cryogel structure and bilayered material was obtained. Cryogel structure, fiber morphology and layer integration was examined by SEM. In order to enhance wound healing process, ascorbic acid (vitamin C) was loaded to cryogel layer and release was followed by spectrophotometrically. The antimicrobial properties of the materials were examined against Escherichia coli, Staphylococcus aureus and Candida albicans, respectively. According to the results, bilayered, antibacterial and antifungal against Staphylococcus aureus and Candida albicans, temporary wound dressings which can stimulate wound healing and have high swelling capacity were obtained successfully.Conference Object Investigation of a Novel Antibacterial Wound Dressing PCL/Gelatin Membranes With Viburnum Opulus Plant Extract(Wiley, 2023) Yuruk, A.; Isoglu, S. Dincer; Isoglu, I. A.Article Citation - WoS: 14Citation - Scopus: 14Preparation of Antibacterial Electrospun Poly(D, L-Lactide-co-Glycolide)/Gelatin Blend Membranes Containing Hypericum Capitatum Var. Capitatum(Taylor & Francis As, 2021) Aksit, Nazende Nur; Gurdap, Seda; Isoglu, Sevil Dincer; Isoglu, Ismail AlperIn this study, we fabricated poly(D, L-lactide-co-glycolide)/gelatin (PLGA/gelatin) membranes containing different amounts of Hypericum capitatum var. capitatum (HCC) extract (1, 5, 7.5, 10 wt%) by electrospinning technique. We investigated chemical, morphological, physical, and mechanical properties as well as in vitro degradation behavior of the electrospun membranes. We also evaluated the antibacterial activity of the electrospun membranes against Escherichia coli and Staphylococcus aureus. Viability, adhesion, and attachment of human fibroblast cells on the electrospun membranes on pre-set days were evaluated by the colorimetric CellTiter 96(R) AQueous One Solution Cell Proliferation Assay (MTS assay), scanning electron microscopy (SEM), and 4',6-Diamidino-2-Phenylindole (DAPI) staining.Article Citation - WoS: 12Citation - Scopus: 13Sulfobetaine-Based Homo- and Copolymers by Raft: Cross-Linked Micelles and Aqueous Solution Properties(Amer Chemical Soc, 2022) Gurdap, Seda; Bayram, Nazende Nur; Isoglu, Ismail Alper; Isoglu, Sevil Dincer; Dinçer İşoǧlu, SevilIn this study, we describe the synthesis and aqueous solution behavior of temperature-sensitive N-(3-sulfopropyl)-N-methacroyloxyethyl-N,N-dimethylammonium betaine (SBMA) homopolymers and core cross-linked micelles (CCMs) with an SBMA shell. Reversible addition- fragmentation chain transfer polymerization has been utilized to synthesize sulfobetaine homopolymers, followed by CCM formation during copoly-merization in the presence of an acid-degradable cross-linker. First, SBMA homopolymers of varying chain lengths were synthesized, and it has been demonstrated that an increase in the chain length and concentration of the homopolymer resulted in an increase in the upper critical solution temperature (UCST). Besides, micelles showed concentration-dependent dual temperature-sensitive behavior with UCST and LCST transitions. Also, homopolymers and CCMs were characterized by FTIR, H-1-NMR, GPC, and TEM. Micelle formation and temperature sensitivity were also investigated by DLS. As a result, stabilized micelles were successfully prepared with the motivation of preventing premature drug release and achieving a pH-and temperature-controlled system. Due to their dual-responsive characteristics, the CCMs show promising potential to be used as smart drug carriers for controlled delivery.Article Citation - WoS: 38Citation - Scopus: 38pH- and Temperature-Responsive Amphiphilic Diblock Copolymers of 4-Vinylpyridine and Oligoethyleneglycol Methacrylate Synthesized by RAFT Polymerization(Elsevier Sci Ltd, 2014) Topuzogullari, Murat; Bulmus, Volga; Dalgakiran, Eray; Dincer, SevilDiblock copolymers of 4-vinylpyridine (4VP) and oligoethyleneglycol methyl ether methacrylate (OEGMA) were synthesized for the first time using RAFT polymerization technique as potential drug delivery systems. Effects of the number of ethylene glycol units in OEGMA, chain length of hydrophobic P4VP block, pH, concentration and temperature on the solution behavior of the copolymers were investigated comprehensively. Copolymer chains formed micelles at pH values higher than 5 whereas unimeric polymers were observed to exist below pH 5, owing to the repulsion between positively charged P4VP blocks. The size of the micelles was dependent on the relative length of blocks, P4VP and POEGMA. Thermo-responsive properties of copolymers were investigated depending on the pH and length of P4VP block. The increase in the length of P4VP block decreased the LCST substantially at pH 7. At pH 3, LCST of copolymers shifted to higher temperatures due to the increased interaction of copolymers with water through positively charged P4VP block. (C) 2013 Elsevier Ltd. All rights reserved.Article Citation - WoS: 8Citation - Scopus: 8RAFT-Mediated Synthesis of Poly( N-(2-Hydroxypropyl)Methacrylamide-b-4-vinylpyridine)by Conventional and Microwave Heating(Springer, 2013) Ozdemir, Zeynep; Topuzogullari, Murat; Isoglu, Ismail Alper; Dincer, SevilWe report the synthesis of N-(2-hydroxypropyl)methacrylamide (HPMA) macroCTA and HPMA-b-4-Vinylpyridine block copolymers via reversible addition-fragmentation chain transfer (RAFT) reaction. Polymerization was carried out in dimethylformamide (DMF) at 70 A degrees C using 4-Cyano-4(thiobenzoylthio) pentanoic acid as chain transfer agent and AIBN as an initiator. Control over molecular weight and composition was achieved by altering the CTA, monomer and initiator feed ratio. The controlled living character of the polymerization was verified with pseudo-first-order kinetic plots, a linear increase of the molecular weight with conversion, and low polydispersities (PDIs a parts per thousand currency sign 1.2). Effect of microwave heating on the homo- and copolymer formation was investigated and the rates were significantly higher than those observed under conventional heating conditions. These polymerization reactions were in controlled fashion resulting in polymers with low PDIs, too. These polymers have a great potential to be used in developing delivery vehicles and conjugates for further drug or gene delivery applications.Article Citation - WoS: 21Citation - Scopus: 21Polyethylenimine Modified and Non-Modified Polymeric Micelles Used for Nasal Administration of Carvedilol(Amer Scientific Publishers, 2015) Kahraman, Emine; Karagoz, Ayse; Dincer, Sevil; Ozsoy, YildizThis study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.Article Engineering a Bilayered Scaffold as a Potential Cardiac Patch: From Scaffold Design to in Vitro Assessment(Springer Singapore Pte Ltd, 2025) Yuruk, Adile; Duzler, Ayhan; Isoglu, Sevil Dincer; Isoglu, Ismail AlperIn this study, we developed a novel bilayered scaffold consisting of a bottom layer composed of the Decellularized Bovine Pericardium (DP) coated with Polyaniline Nanoparticles (PANINPs) and a top layer made of an electrospun Poly(lactic-co-glycolic acid)/Gelatin (PLGA/Gel) membrane incorporated with Vascular Endothelial Growth Factor (VEGF) and hawthorn extract. Functionally, the DP supplies native Extracellular Matrix (ECM) components and mechanical support, while PANINPs provide conductivity. The electrospun PLGA/Gel layer mimics fibrous ECM. It incorporates bioactives, with VEGF promoting pro-angiogenic stimulation and hawthorn extract enhancing anticoagulant activity, as well as increasing surface hydrophilicity. The tissue adhesive ensures the interfacial integrity between the two layers. Decellularization efficiency was confirmed histologically using 4 ',6-diamidino-2-phenylindole (DAPI) and Hematoxylin-Eosin (H&E) staining. The DP exhibited a DNA content of 115.9 +/- 47.8 ng/mg DNA, compared to 982.88 +/- 395.42 ng/mg in Native Pericardium (NP). The PANINPs had an average particle size of 104.94 +/- 13.7 nm. The conductivity of PANINPs-coated decellularized pericardium was measured to be 9.093 +/- 8.6 x 10- 4 S/cm using the four-point probe method. PLGA/Gel membranes containing hawthorn extract (1%, 5%, 10%, and 15% w/v) and VEGF (0.1 mu g/mL, 0.5 mu g/mL, and 1 mu g/mL) were fabricated by electrospinning, resulting in fiber diameters between 850 and 1200 nm and pore sizes between 14 and 20 mu m. The anticoagulant efficiency of the membranes containing hawthorn extract reached 430 s in the Activated Partial Thromboplastin Time Assay (aPTT). Mechanical testing revealed a tensile strength of 22.70 +/- 6.33 MPa, an elongation of 53.58 +/- 10.63%, and Young's modulus of 0.67 +/- 0.10 MPa. The scaffold also exhibited over 91% cell viability and excellent cardiomyocyte adhesion. The hemolysis ratio was determined to be 0.421 +/- 0.191%, which confirms its blood compatibility. Our results indicate that the proposed bilayered scaffold can be a promising candidate for cardiac patch applications.Conference Object Poly(OEGMA)-B Block Copolymer Nanocarriers for Anticancer Agent Release(Wiley, 2018) Aksit, N. N.; Topuzogullari, M.; Isoglu, I. A.; El Khatib, M.; Isoglu, S. Dincer
