Sarı Türk, Sibel

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Profile URL
https://hdl.handle.net/20.500.12573/2775
Name Variants
Sari, Sibel
Sarı, Sıbel
Sibel Sarı
Job Title
Dr. Öğr. Üyesi
Email Address
sibel.sari@agu.edu.tr
Main Affiliation
04.02. Moleküler Biyoloji ve Genetik
Status
Current Staff
Website
ORCID ID
0000-0002-2505-5804
Scopus Author ID
Turkish CoHE Profile ID
186250
Google Scholar ID
7izoBNEAAAAJ
WoS Researcher ID
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5403_Sibel Sarı Türk.jpg (14.93 KB)

Sustainable Development Goals

13

CLIMATE ACTION
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17

PARTNERSHIPS FOR THE GOALS
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8

DECENT WORK AND ECONOMIC GROWTH
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9

INDUSTRY, INNOVATION AND INFRASTRUCTURE
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12

RESPONSIBLE CONSUMPTION AND PRODUCTION
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16

PEACE, JUSTICE AND STRONG INSTITUTIONS
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11

SUSTAINABLE CITIES AND COMMUNITIES
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1

NO POVERTY
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6

CLEAN WATER AND SANITATION
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10

REDUCED INEQUALITIES
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14

LIFE BELOW WATER
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1

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15

LIFE ON LAND
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5

GENDER EQUALITY
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4

QUALITY EDUCATION
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AFFORDABLE AND CLEAN ENERGY
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3

GOOD HEALTH AND WELL-BEING
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2

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2

ZERO HUNGER
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Scholarly Output

2

Articles

1

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4/6

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1

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JournalCount
Türk Doğa ve Fen Dergisi1
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  • Thumbnail Image
    Book Part
    Sustainable Strategies for Cancer Phytomedicine: Balancing Efficacy and the Environment Responsibility
    (Springer Nature, 2025) Sari, Sibel; Saylan, Demet
    Cancer is a complex disease, with approximately six million new cases reported annually. Despite the numerous treatment strategies employed worldwide, the severity of cancer continues to increase. Conventional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are standard practices, but their clinical success is constrained by toxic side effects leading to damage to healthy tissues, unavoidable off-target effects, and significant cancer recurrence resulting from incomplete surgical removal. Therefore, interest in alternative therapies sourced primarily from natural products is increasing. The popularity of phytomedicine in cancer treatment approaches is increasing because of its efficacy, affordability, accessibility, and minimal adverse effects. Additionally, green chemistry approaches can be used to synthesize a wide array of anticancer drugs with various chemical structures, enhancing their therapeutic efficacy while minimizing or eliminating side effects and toxicity. The enhanced efficacy of cancer medicines made from plants is achieved via molecular innovations that support precise targeting. Various drug delivery systems that aim to reduce environmental pollution while reducing waste can be optimized for better results in therapy through nanotechnology. The delivery of effective cancer therapies while preserving the environment for generations to come is the objective of this approach, which includes green chemistry, sustainable production, and molecular developments. © 2025 Elsevier B.V., All rights reserved.
  • Thumbnail Image
    Article
    Aurora Kinases: Their Role in Cancer and Cellular Processes
    (2024) Sarı, Sıbel; Özsoy, Elif Rumeysa
    Aurora kinazlar, Aurora A, B ve C şeklinde tanımlanan üç üyeye sahip, hücre döngüsünün düzenlenmesinde kritik rolleri olan yüksek oranda korunmuş serin/treonin kinaz ailesine ait proteinlerdir. Aurora kinazlar, kromozom stabilitesinin korunmasında önemli rolleri olan mitotik düzenleyiciler olarak hizmet etmektedir. Mitozdaki çeşitli olaylarda kritik roller üstlenen Aurora kinazlar, kromozomal ve sitoskeletal olayların koordinasyonu, iğ ipliği oluşumu kontrolü ve sitokinez gibi olaylarda görev alarak hücre döngüsünün sorunsuz ilerlemesini sağlamaktadır. Mitotik fonksiyonlarının yanı sıra, Aurora kinazlar mayoz bölünmenin düzenlenmesi süreçlerinde de yer almaktadırlar. Aurora kinazların gen amplifikasyonu/mutasyonu ve aşırı ifadesi çeşitli solid ve hematolojik kanserlerde tespit edilmiştir. Aurora kinazlar mitotik rolleri ile ilişkilendirilen onkojenik fonksiyonları ile kanser hücrelerinin çoğalması ve hayatta kalmalarını sağlamaktadırlar. Aurora kinaz aktivitesinin bozulması, sentrozom fonksiyonunda, iğ ipliklerinin oluşumunda, kromozomal hizalanmada ve sitokinezde sorunlara neden olarak mitotik anormallikler ve genetik istikrarsızlığa yol açmaktadır. Bu bulgular, Aurora kinazların kanserdeki önemli fonksiyonlarını vurgulayarak kanser terapötikleri için değerli hedefler olarak tanınmalarını sağlamaktadır. Bu derleme, Aurora kinazların yapı ve fonksiyonlarına genel bir bakış sunarak, bu kinazların kanserdeki onkojenik rollerini aydınlatmaktadır.