İçöz, Kutay
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Icoz, Kutay İçöz, Kutay
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01. Abdullah Gül University
Mühendislik Fakültesi
Elektrik-Elektronik Mühendisliği
Mühendislik Fakültesi
Elektrik-Elektronik Mühendisliği
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Former Staff
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No research topics data found.
Sustainable Development Goals
1NO POVERTY
0
Research Products
2ZERO HUNGER
0
Research Products
3GOOD HEALTH AND WELL-BEING
18
Research Products
4QUALITY EDUCATION
1
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5GENDER EQUALITY
0
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6CLEAN WATER AND SANITATION
0
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7AFFORDABLE AND CLEAN ENERGY
0
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8DECENT WORK AND ECONOMIC GROWTH
0
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9INDUSTRY, INNOVATION AND INFRASTRUCTURE
2
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10REDUCED INEQUALITIES
0
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11SUSTAINABLE CITIES AND COMMUNITIES
0
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12RESPONSIBLE CONSUMPTION AND PRODUCTION
0
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13CLIMATE ACTION
0
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14LIFE BELOW WATER
3
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15LIFE ON LAND
0
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16PEACE, JUSTICE AND STRONG INSTITUTIONS
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17PARTNERSHIPS FOR THE GOALS
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Scholarly Output
46
Articles
30
Views / Downloads
1130/673
Supervised MSc Theses
7
Supervised PhD Theses
2
WoS Citation Count
345
Scopus Citation Count
425
Patents
0
Projects
1
WoS Citations per Publication
7.50
Scopus Citations per Publication
9.24
Open Access Source
27
Supervised Theses
9
| Journal | Count |
|---|---|
| Biomedical Signal Processing and Control | 3 |
| Applied Sciences-Basel | 2 |
| Sensors and Actuators A-Physical | 2 |
| Journal of Polytechnic-Politeknik Dergisi | 2 |
| Advanced Materials Interfaces | 1 |
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46 results
Scholarly Output Search Results
Now showing 1 - 10 of 46
Conference Object Image-Processing Based Signal Readout Method For MRD Biochip(Institute of Electrical and Electronics Engineers Inc., 2019-04) Uslu, Fatma; İçöz, Kutay; Taşdemir, KasímThe response of the cancer patients to chemotherapy treatment varies from person to person. For some patients cancer cells are resistant to treatment and these cells can relapse again which is known as minimal residual disease. A microfluidic-based biochip capable of monitoring minimal residual disease is under development by our research group. The role of the biochip is to capture the target cells, which were separated by immunomagnetic beads on micro square tiles. Then biochips are imaged using a bright field optical microscope and it is planned to perform image-processing methods to detect the target cells, immunomagnetic beads and micro tiles. In this work the current progress of image processing methods for differentiating the immunomagnetic beads and micro tiles is presented. © 2020 Elsevier B.V., All rights reserved.Article Citation - WoS: 3Citation - Scopus: 6Simple Staining of Cells on a Chip(MDPI, 2022-11-13) Kosker, Fatma Betul; Aydin, Omer; Icoz, KutaySimple staining of cells is a widely used method in basic medical diagnostics, education, and research laboratories. The stains are low-cost, but the extensive consumption results in excessive toxic waste generation. Thus, to decrease the amount of toxic waste resulting from the cell staining procedure is a need. In this study, we developed a magnetically driven and compartmentalized passive microfluidic chip to perform simple staining of human eukaryotic cells, K562 cells, and lymphocyte cells derived from patients. We demonstrated simple staining on cells with trypan blue, methylene blue, crystal violet, and safranin for high, medium, and low cell densities. The stained cells were imaged using a bright field optical microscope and a cell phone to count cells on the focal plane. The staining improved the color signal of the cell by 25-135-pixel intensity changes for the microscopic images. The validity of the protocol was determined using Jurkat and MDA-MB-231 cell lines as negative controls. In order to demonstrate the practicality of the system, lymphocyte cells derived from human blood samples were stained with trypan blue. The color intensity changes in the first and last compartments were analyzed to evaluate the performance of the chip. The developed method is ultra-low cost, significantly reduces the waste generated, and can be integrated with mobile imaging devices in terms of portability. By combining microfabrication technology with cell staining, this study reported a novel contribution to the field of microfluidic biosensors. In the future, we expect to demonstrate the detection of pathogens using this method.Master Thesis Kağıt Tabanlı Magnetoforetik Sensör Geliştirilmesi(Abdullah Gül Üniversitesi Fen Bilimleri Enstitüsü, 2022) FAROOQI, MUHAMMAD FUAD; Farooqi, Muhammad Fuad; İçöz, KutayOne of the widely used type of biosensors are paper-based lateral flow systems. They are used to detect a wide variety of biomolecules like microorganisms, proteins, chemicals, oligonucleotides among many others. In this research, a setup was created using dual magnet sets in which the flow of cell sample on two kinds of different sample paper was explored. There were two factors which affected the movement of the sample the most, the magnetic field and the wetting. Images were obtained using a cell phone along and/or a bright field optical microscope and then analyzed using image processing. Images were also taken using scanning electron microscope. The effects of the wetting and the magnetic field were tested and studied. It was found that at least 90% of the cells were able to reach the edge of the paper. Although the cells were not able to maintain their shape on the paper due to the unideal conditions of the paper for cells but still this kind of paper-based lateral flow assay setup can be used for cells to see their behavior when they were labelled and exposed to a magnetic field. This research shows support that this technique can be used for separating cells as well as detecting different cells.Doctoral Thesis Optik Saçılma Temelli Rastgele Orman Destekli Parçacık Tespiti ve Sınıflandırılması(Abdullah Gül Üniversitesi / Fen Bilimleri Enstitüsü, 2023) Genç, Sinan; Genç, Sinan; İçöz, Kutay; Erdem, TalhaMicroplastics, tiny plastic particles with sizes smaller than 5 mm., are often found in oceans, rivers, lakes, and atmosphere due to plastic pollution. Microplastics releasing toxic chemicals threaten the environment and harm the aquatic life and humans. Especially, the accumulation of microplastics can have detrimental effects on the food chain as a result of larger organisms consuming smaller organisms. Detecting the microplastics is crucial but also challenging. Over the years, researchers have developed different detection methods. One of the standard methods is using spectroscopy tools such as Fourier transform infrared spectroscopy (FTIR) and Raman spectroscopy. These techniques can identify the chemical composition of microplastics, which can help determine their sources and potential impacts. Another method is the use of microscopy, which allows for the visualization and counting of microplastics in samples. However, these techniques require costly infrastructure, and these instruments being large in size significantly limits the mobility. As a remedy to the cost and mobility problems, in this thesis, we propose and demonstrate a low-cost, portable system to detect size, concentration, and refractive index of microplastics. Our system comprises of low-cost and low-weight components which are utilized for recording the scattering patterns of microplastics in aqueous media. We demonstrate successful predictions of the size and refractive index of microparticles at a given wavelength using a Random Forest Algorithm which relates the measured scattering pattern with the Mie theory. We further employ the refractive index information at various wavelengths for determining the material type of microplastics. We believe that our proposed system enabling an easy, fast, low-cost, and on-site detection of microplastics will be a beneficial tool for the fight against microplastics in the environment.Article Citation - WoS: 5Citation - Scopus: 6Design, Modeling, and Control of a Horizontal Magnetic Micromanipulator(Sage Publications Ltd, 2019-01-31) Ablay, Gunyaz; Boyuk, Mustafa; Icoz, KutayMagnetic micromanipulators with a wide range of force generating capabilities are able to manipulate micron size particles for various applications and measurements. These magnetic particles can be coated with receptors to specifically bind to target biomolecules. In this work, a horizontal magnetic micromanipulator is designed, modeled and controlled for single micron size magnetic particle manipulations. A method is presented for dynamic modeling of magnetic micromanipulators. A feedback control method is designed that allows direct linearization of the system. It is shown that the proposed controller guarantees the stability of the closed-loop system, and yields zero steady-state error in a wide range of operation conditions. We show that the micromanipulator is able to generate a wide range of piconewton (pN) scale forces on a superparamagnetic particle for single molecule separation, and biosensor developments.Article Citation - WoS: 12Citation - Scopus: 13Numerical Analysis and Experimental Verification of Optical Scattering From Microplastics(Royal Soc, 2023-08) Genc, Sinan; Icoz, Kutay; Erdem, TalhaAccurate and fast characterization of the micron-sized plastic particles in aqueous media requires an in-depth understanding of light interaction with these particles. Due to the complexity of Mie scattering theory, the features of the scattered light have rarely been related to the physical properties of these tiny objects. To address this problem, we reveal the relation of the wavelength-dependent optical scattering patterns with the size and refractive index of the particles by numerically studying the angular scattering features. We subsequently present a low-cost setup to measure the optical scattering of the particles. Theoretical investigation shows that the angular distribution of the scattered light by microplastics carries distinct signatures of the particle size and the refractive index. The results can be used to develop a portable, low-cost setup to detect microplastics in water.Conference Object A Horizontal Magnetic Tweezer for Single Molecule Micromanipulations(Institute of Electrical and Electronics Engineers Inc., 2018-10) Ablay, Günyaz; Böyük, Mustafa; Eroǧlu, Yakup; İçöz, KutayMagnetic tweezers are able to manipulate cells or biomolecules for various applications and measurements. In this work, a horizontal magnetic tweezer is designed, modeled and controlled for single molecule manipulations. A method is presented for dynamic modeling of horizontal magnetic tweezers. A linear control method is designed to ensure a wide range of operation conditions with zero steady-state error. The horizontal magnetic tweezer is able to generate a wide range of piconewton scale forces on a superparamagnetic microparticle for single molecule separation, and biosensor developments. © 2019 Elsevier B.V., All rights reserved.Master Thesis Micro Manyetik ve Parçacıklarının Manipülasyonuna Yönelik Sistem Tasarımı(Abdullah Gül Üniversitesi, 2018) BÖYÜK, MUSTAFA; Böyük, Mustafa; İçöz, Kutay; Ablay, GünyazManyetik cımbızlar çeşitli uygulamalar ve ölçümler için hücreleri veya biyomolekülleri manipüle edebilir. Tek moleküllü manipülasyonlar için bir elektromanyetik mikro manipülatör tasarlandı, modellendi ve kontrol edildi. Elektromanyetik cımbız mikron boyutlu süperparamanyetik parçacıkları uygun kontrol mekanizması yardımıyla kontrol edebilir. Bu parçacıklar, hedef biyomoleküllerin yakalanması için reseptörler ile fonksiyonel hale getirilebildiğinden dolayı yüklü partiküller harici bir manyetik alan kullanılarak belirli bir yere taşınabilirler. Manyetik tek kutup ve manyetik devre yaklaşımları, manyetik sistemin dinamik denklemini modellemek için bu çalışmada kullanıldı. Ofset akım tabanlı geri besleme ile doğrusallaştırma yaklaşımı bir kontrolör tasarlanarak, sıfır kararlı-durum hatasıyla geniş çalışma koşulları sağlandı. Tek parçacığın konumunu bulmak için görüntü tabanlı algoritma geliştirilmiştir. Türetilmiş model ve kontrol sistemini doğrulamak için sayısal simülasyonlar yapılır. Tasarlanan manyetik sistem, 1 ila 10 mikrometre çapındaki manyetik bir parçacığı 1 amperden az bir akımla kontrol etmek için 1-100 pN arasında kuvvet uygulayabilmektedir. Manyetik yönlendirici sistemi, tek hücre ayrımı, ve biyosensör gelişmeleri için kullanılabilir.Article Citation - WoS: 12Citation - Scopus: 14Detection of Proteins Using Nano Magnetic Particle Accumulation-Based Signal Amplification(MDPI, 2016-11-29) Icoz, Kutay; Mzava, OmaryWe report a biosensing method based on magnetic particles where coated magnetic particles are used for immunomagnetic separation, and uncoated magnetic particles are used for signal enhancement. To quantify the signal amplification, optical micrographs are analyzed to measure changes in pixel area and pixel intensity. Microcontact-printed surface receptors are arranged in alternating lines on gold chips, enabling differential calculations. In a model experiment, target molecules-streptavidin-are first captured and separated by biotin-coated magnetic particles, and then exposed to a gold surface functionalized with biotin-coupled bovine serum albumin, forming a sandwich assay. Applying a magnetic field and introducing uncoated magnetic particles resulted in accumulation around magnetic particles in the sandwich assay and enhancement of the contrast to noise ratio at least by eight-fold in a range of 0.1-100 mu M.Master Thesis Hedeflenen Lösemik Hücrelerin Sayımı için Görüntü İşleme Tabanlı Ölçüm Sistemi(Abdullah Gül Üniversitesi, 2019) TAŞ, ZEHRA; Taş, Zehra; İçöz, KutayAkut Lenfosit Lösemi (ALL) çocukluk çağında en sık görülen kanser türüdür. Bu kanserin ilerlemesi oldukça hızlıdır, bu yüzden tedavi için zaman çok önemlidir. Hastalar için ilaç tedavisi (kemoterapi), kemik iliği nakli, radyasyon tedavisi ve immünoterapi gibi bazı tedaviler vardır. Bu tedaviler arasında kemoterapi öncelikle tercih edilen bir yöntemdir, ancak sonucu hastadan hastaya farklılık göstermektedir. Hastaların iyileşmesinde ilacın dozajını ayarlamak için kemoterapinin tedaviye etkisini ölçmek çok önemlidir. Kemoterapinin etkisini ölçmek için akım sitometrisi (FC), polimeraz zincir reaksiyonu (PCR) ve mikroskobik inceleme teknikleri kullanılır. Ancak, bu yöntemler zaman alır, pahalıdır ve uzman gerektirir. Bu tezde, sorun görüntü işleme tekniklerine dayanan otomatik bir hücre algılama ve niceleme yöntemi ile ele alınmaktadır. Optik mikroskopi ile elde edilen görüntüler işlenir ve immüno-manyetik boncuklarla yakalanan ALL hücrelerinin ölçümü sağlanır. Geleneksel yöntemlerle karşılaştırıldığında, bu teknik zaman verimli, ucuz ve kullanımı kolaydır. ALL hücrelerinin miktarının yanı sıra, biyosensörlerin sinyal büyütme metodu için projenin ilk bölümünde kullanılan manyetik boncukların belirlenmesi için görüntü işleme algoritmaları da geliştirilmiştir. Görüntüler cep telefonu mikroskopisinden hem mikroskop lamı hem de difraksiyon ızgarası tabanlı biyosensörler için elde edilmiştir. Her iki yöntemde de manyetik boncuk birikimleri gözlenmiş ve geliştirilen algoritmalar cep telefonu mikroskopu görüntülerine uygulanmıştır. Böylece, manyetik boncukların birikimleri bilgisi, görüntü işleme kullanılarak otomatik olarak elde edilmiştir.