Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Book Part
    Sustainable Strategies for Cancer Phytomedicine: Balancing Efficacy and the Environment Responsibility
    (Springer Nature, 2025) Sari, Sibel; Saylan, Demet
    Cancer is a complex disease, with approximately six million new cases reported annually. Despite the numerous treatment strategies employed worldwide, the severity of cancer continues to increase. Conventional cancer treatments, such as surgery, radiotherapy, and chemotherapy, are standard practices, but their clinical success is constrained by toxic side effects leading to damage to healthy tissues, unavoidable off-target effects, and significant cancer recurrence resulting from incomplete surgical removal. Therefore, interest in alternative therapies sourced primarily from natural products is increasing. The popularity of phytomedicine in cancer treatment approaches is increasing because of its efficacy, affordability, accessibility, and minimal adverse effects. Additionally, green chemistry approaches can be used to synthesize a wide array of anticancer drugs with various chemical structures, enhancing their therapeutic efficacy while minimizing or eliminating side effects and toxicity. The enhanced efficacy of cancer medicines made from plants is achieved via molecular innovations that support precise targeting. Various drug delivery systems that aim to reduce environmental pollution while reducing waste can be optimized for better results in therapy through nanotechnology. The delivery of effective cancer therapies while preserving the environment for generations to come is the objective of this approach, which includes green chemistry, sustainable production, and molecular developments. © 2025 Elsevier B.V., All rights reserved.
  • Book Part
    Citation - Scopus: 1
    Measurement of Autophagic Activity in Cancer Cells With Flow Cytometric Analysis Using Cyto-Id Staining
    (Humana Press Inc., 2024) Şansaçar, Merve; Gencer Akçok, Emel Başak
    Autophagy is an evolutionarily conserved process providing the energy that cells need to survive, especially in stress situations, through catabolic processes. Considering the dual role of autophagy in cancer cells depending on the cellular context, it is crucial to comprehend the effect of drug candidates put forward to prevent cancer through the autophagy pathway. The CYTO-ID® Autophagy Detection Kit allows a rapid, specific and quantitative measurement of autophagic activity at the cellular level using a 488 nm-excitable green fluorescent detection reagent via flow cytometer. In this chapter, we present the CYTO-ID® Autophagy Detection method with a stepwise protocol to monitor the autophagy flux after the application of any compound to suspension cancer cell lines with flow cytometric analysis. © 2025 Elsevier B.V., All rights reserved.
  • Article
    Anticancer Effect of Ethanolic Yellow Hawthorn Extract on Chronic Myeloid Leukemia Cells and Acute Myeloid Leukemia Cells
    (Ondokuz Mayis Universitesi, 2025) Arslan, Ayşe Nur; Akçok, Ismail
    Cancer is a disease characterized by abnormal cell growth and invasion and metastasis of these cells to other tissues or organs of the body. Natural products have been used for centuries as drugs or in drug development, especially for the treatment of cancer. Besides, extracting natural products with several bioactive compounds has a promising effect on cancer treatment. In this study, we aimed to investigate the anticancer effect of the ethanolic extract of yellow hawthorn fruits on K562 (Chronic Myeloid Leukemia) and MOLM-13 (Acute Myeloid Leukemia) cell lines. The antiproliferative effect of the ethanolic extract of yellow hawthorn fruits was investigated in time-and dose-dependent manners. The Annexin-V/Propidium Iodide (PI) double staining was used to examine the apoptosis. Furthermore, cell cycle analysis is conducted by PI staining. The cell viability of K562 and MOLM-13 cell lines was significantly reduced by the ethanolic extract of yellow hawthorn fruits with IC50 values of 9144 µg/mL and 3515 µg/mL in 48-hour incubation time, respectively. Moreover, the results showed that the ethanolic extract of yellow hawthorn fruits caused an increased apoptosis by 12.7-and 8.87-fold changes in K562 and MOLM-13 cell lines compared to control groups, respectively. Ethanolic extract of yellow hawthorn fruit has reduced cell proliferation, induced apoptosis and arrested the cell cycle at G0/G1 phase by 71% in MOLM-13 and at G2/M phase by 80.3% and G0/G1 phase by 38.2 % in K562 cells. Further studies should be conducted to elucidate the mechanism of the effect of yellow hawthorn fruit on these cancer cells. © 2025 Elsevier B.V., All rights reserved.