Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Evaluation of HOTAIR, HOXD8, HOXD9, HOXD11 Gene Expression Levels in Turkish Patients With Acute and Chronic Myeloid Leukemia: A Single Center Experience(Cellular and Molecular Biology Association, 2024-11-27) Saraymen, Esma; Erdem, Yakut; Akalin, Hilal Ünlü; Taşçıoğlu, Nazife; Saraymen, Berkay; Celik, Serhat; Özkul, Yusuf T.Homeobox (HOX) transcript antisense RNA (HOTAIR) and HOX genes are reported to be more expressed in various cancers in humans in recent studies. The role of HOTAIR and HOXD genes in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) is not well known. In this study, expression levels of HOXD8, HOXD9 and HOXD11 from HOXD gene family and HOTAIR were determined from peripheral blood samples of 30 AML and 30 CML patients and 20 healthy volunteers by quantitative Real Time PCR. We determined that the expression levels of HOXD9 and HOXD11 in the AML patients were significantly lower than the control group (p<0.001 and p=0.002, respectively). There was no significant difference in the expression levels of HOTAIR and HOXD8 when compared to the control group. In the CML patients there was a significant increase in the expression level of HOTAIR when compared to the control group (p=0.002). The expression levels of HOXD9 and HOXD11 were found to be significantly lower than the control group (p<0.001). Our study showed that HOTAIR may not be a biomarker in the diagnosis and is not significantly correlated with the clinicopathological prognostic characteristics of AML. Additionally; it can be said that HOTAIR is oncogenic by suppressing the expression of HOXD9 and HOXD11 but not HOXD8 in CML patients. The expression profiles of HOTAIR may be a potential biomarker in the diagnosis of CML patients in predicting and monitoring drug resistance. © 2025 Elsevier B.V., All rights reserved.Article Gazlaştırma Tesisi Odun Atığı ve Sivas Kangal Linyit Kömürünün Boya Adsorpsiyonunda Kullanım Olanaklarının Araştırılması(Chamber of Mining Engineers of Turkey, 2020-12-01) Kırma, Ramazan; Sarikaya, Musa; Top, S.; Uçkun, Şükrü; Timür, İrfanIn this study, the usage possibilities of wood waste obtained from Gebze MDF and Particle Board Gasification Plant preliminary studies and Sivas Kangal lignite coal as absorbents were investigated. In this way, it was aimed both to evaluate the wastes and to prevent environmental pollution with materials that are cheaper and easier to obtain. The structure and surface properties of wood waste and coal samples crushed and ground to -75 µm size and used as adsorbent were investigated by XRD, SEM and BET analyses. In addition, samples have been characterized by elemental, ash, moisture, volatile matter and fixed carbon analyses. In the experiments, methylene blue (MM) with the formulation of C<inf>16</inf>H<inf>18</inf>CIN<inf>3</inf>S.xH<inf>2</inf>O was used. The effects of temperature, mixing time and concentration parameters on MM adsorption were investigated. Langmuir isotherms were created for different temperatures at optimum concentrations. As a result, it has been revealed that lignite coal and wood waste can be used as adsorbent. A 10 ppm MM for lignite coal and 3 ppm MM for wood waste were determined to be ideal concentrations for adsorption. © 2022 Elsevier B.V., All rights reserved.Article Citation - Scopus: 1Düzce Kent Merkezi Zeminlerinin Sıvılaşma Potansiyelinin Değerlendirilmesi(TMMOB - Jeoloji Muhendisleri Odasi jmo@jmo.org.tr, 2019-06-15) Akin, Muge K.Soil liquefaction is one of the ground deformations occurred during an earthquake which may cause serious damages such as settlement and tilting of structures due to loss of bearing capacity of foundations. Düzce and its surrounding settle on a plain which consists of silty and sandy layers with shallow groundwater level. Besides, the North Anatolian Fault Zone is a major seismic source which is capable of producing large magnitude earthquakes. All these data point out that the ground deformations like liquefaction and lateral spreading may occur during a probable large earthquake around Düzce and its close vicinity. In this study, the geotechnical data of 40 boreholes drilled to determine the local ground conditions and the groundwater level in Düzce were considered. Based on the field studies, it was aimed to evaluate the liquefaction potential considering the fact that the groundwater level is shallow as well as the subsurface soil is composed of loose alluvium. Liquefaction Potential Index (LPI) and Liquefaction Severity Index (LSI) methods were taken into account and the liquefaction potential of Düzce province was determined and mapped with respect to various earthquake scenarios in GIS environment. These maps are compared on the basis of different scenarios. Accordingly, it is concluded that the liquefaction potential is high-very high in the south and south-eastern sections of the study area where the construction of new residential buildings progressively continues. © 2019 Elsevier B.V., All rights reserved.Article Citation - Scopus: 4Türkiye’de Yapılan Kuraklık Analiz Çalışmaları Üzerine Bir Derleme(Ankara University, 2022-10-31) Deniz Öztürk, Yasemin; Ünlü, Ramazan; Öztürk, Yasemin DenizDrought has become one of the most studied disaster issues by scientists, especially after the 2000s, with the importance of climate change. Many scientific publications on drought have been produced, due to many different methods on drought and the study of drought by many disciplines of science. In the study, theses, national and international articles, which include drought analysis by using any statistical method over meteorological data in Turkey, were compiled. A total of 270 studies, including 73 master's and Ph.D. theses, 107 national articles, and 90 international articles, written between 1943-2021 were examined. These studies were classified according to the year of publication, the drought analysis methods used, in publication, the scientific field of the first author, and the region examined in the study, and their frequency distributions were revealed. The main conclusions of this study are as follows: Although the first published studies on drought analysis in Turkey were made in 1943, 1956, and 1965, studies on drought started to increase after 2000 and the total number of publications reached 37 in 2019, 43 in 2020, and 64 in 2021. Publications in the period of 2019-2021 correspond to 53% of all publications. This rapid increase in recent years has led to a logarithmic increase in the number of publications. Although 63 different methods are used in drought analysis in the studies, the standardized precipitation index is the dominant method with a usage rate of 56%. Most of the studies were carried out on the basins (113). In 41 studies, the whole of Turkey was examined. Other studies were carried out for geographical regions, provinces, and smaller settlements. According to the scientific fields, it is seen that the Civil Engineering (131 units) and Geography (41 units) departments are the scientific fields that carry out the most drought analysis studies. © 2025 Elsevier B.V., All rights reserved.