Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Citation - Scopus: 1Drug Repositioning via Entity Transformation in Biomedical Knowledge Systems(Springer Science and Business Media Deutschland GmbH, 2025) Erkantarci, B.; Bakal, G.The drug discovery process for known diseases is crucial in bioinformatics, given the extensive clinical trials, regulatory approvals, and high costs. Computational in silico methods are essential to mitigate these challenges, as they help identify promising drug candidates, thereby reducing the time and cost associated with drug discovery. An effective strategy in this domain is drug repositioning, where existing drugs, already approved for one disease, are repurposed for treating another. This approach is advantageous as it leverages the established safety profiles of existing drugs, avoiding toxic effects on human metabolism. In this effort, we employed a translational entity embedding-based neural network model to advance drug repositioning efforts. We utilize the Semantic Medline Database (SemMedDB) as the primary source of biomedical entity relationships for model training. The model is validated using repoDB, a gold standard dataset for drug repositioning. Technically, the model will learn to minimize the vector distance between related entities. This distance will serve as the basis for predicting potential drug-disease pairs in drug repositioning, offering a novel computational method to expedite the drug discovery process. © 2025 Elsevier B.V., All rights reserved.Article Citation - Scopus: 15Design and Multichannel Electromyography System-Based Neural Network Control of a Low-Cost Myoelectric Prosthesis Hand(Copernicus GmbH, 2021-02-04) Siddiq Ahmed, Saygin; Almusawi, Ahmed R.J.; Yilmaz, Bulent; Doǧru, NuranThis study introduces a new control method for electromyography (EMG) in a prosthetic hand application with a practical design of the whole system. The hand is controlled by a motor (which regulates a significant part of the hand movement) and a microcontroller board, which is responsible for receiving and analyzing signals acquired by a Myoware muscle device. The Myoware device accepts muscle signals and sends them to the controller. The controller interprets the received signals based on the designed artificial neural network. In this design, the muscle signals are read and saved in a MATLAB system file. After neural network program processing by MATLAB, they are then applied online to the prosthetic hand. The obtained signal, i.e., electromyogram, is programmed to control the motion of the prosthetic hand with similar behavior to a real human hand. The designed system is tested on seven individuals at Gaziantep University. Due to the sufficient signal of the Mayo armband compared to Myoware sensors, Mayo armband muscle is applied in the proposed system. The discussed results have been shown to be satisfactory in the final proposed system. This system was a feasible, useful, and cost-effective solution for the handless or amputated individuals. They have used the system in their day-to-day activities that allowed them to move freely, easily, and comfortably. © 2021 Elsevier B.V., All rights reserved.