Scopus İndeksli Yayınlar Koleksiyonu

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  • Book Part
    Citation - Scopus: 1
    Green Magnetic Nanoparticles: Recent Advancements in Synthesis and Characterization
    (Elsevier, 2024) Alrifai, Wardishan Kassem; Dadi, Seyma; Öçsoy, Ismail
    Various types of nanoparticles (NPs) have been used in numerous scientific and industrial fields. Specifically, magnetic nanoparticles (MNPs) have drawn great attention in the last two decades concerning their synthesis, development, functionality, and relevant applications in a variety of areas including data storage, wastewater treatment, catalysis, bio-separation, and medicine. Several strategies have been developed to synthesize MNPs with various shapes, sizes, and compositions. The magnetization performance of MNPs is directly dependent on their high size, size distribution, composition, and crystallinity of the NP. The highly crystalline, monodisperse, and uniform MNPs called “high-quality MNPs” with unique magnetic properties have been synthesized by chemical synthesis method in the presence of hydrophobic surfactant (long hydrocarbon chain) and nonpolar solvents at high temperatures; however, these MNPs are toxic, insoluble in water and lack of use in all bio-related applications. To use these MNPs in biological applications, it is mandatory to apply a ligand exchange process to remove hydrophilic ligands and make MNPs soluble and stable in aqueous solutions. To address these issues, green synthesis methods using biomolecules, plant extracts, and microorganisms have been developed for the synthesis of biocompatible MNPs. This chapter aims to display recent developments in the synthesis of MNPs with green synthesis methods and in their characterization. © 2024 Elsevier B.V., All rights reserved.
  • Article
    Citation - Scopus: 15
    Development of a Nanoparticle-Embedded Chitosan Sponge for Topical and Local Administration of Chemotherapeutic Agents
    (American Society of Mechanical Engineers (ASME) infocentral@asme.org, 2014-11-01) Goldberg, Manijeh; Manzi, Aaron; Aydin, Erkin; Singh, Gurtej; Khoshkenar, Payam; Birdi, Amritpreet; Chen, Julie Y.; Langer, Robert
    The following work describes the development of a novel noninvasive transmucosal drug delivery system, the chitosan sponge matrix (CSM). It is composed of cationic chitosan (CS) nanoparticles (NPs) that encapsulate cisplatin (CDDP) embedded within a polymeric mucoadhesive CS matrix. CSM is designed to swell up when exposed to moisture, facilitating release of the NPs via diffusion across the matrix. CSM is intended to be administered topically and locally to mucosal tissues, with its initial indication being oral cancer (OC). Currently, intravenous (IV) administered CDDP is the gold standard chemotherapeutic agent used in the treatment of OC. However, its clinical use has been limited by its renal and hemotoxicity profile. We aim to locally administer CDDP via encapsulation in CS NPs and deliver them directly to the oral cavity with CSM. It is hypothesized that such a delivery device will greatly reduce any systemic toxicity and increase antitumor efficacy. This paper describes the methods for developing CSM and maintaining the integrity of CDDP NPs embedded in the CSM. © 2016 Elsevier B.V., All rights reserved.