Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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Now showing 1 - 5 of 5
  • Article
    Citation - WoS: 9
    Citation - Scopus: 13
    The Impact and Future of Artificial Intelligence in Medical Genetics and Molecular Medicine: An Ongoing Revolution
    (Springer Heidelberg, 2024-08) Ozcelik, Firat; Dundar, Mehmet Sait; Yildirim, A. Baki; Henehan, Gary; Vicente, Oscar; Sanchez-Alcazar, Jose A.; Dundar, Munis
    Artificial intelligence (AI) platforms have emerged as pivotal tools in genetics and molecular medicine, as in many other fields. The growth in patient data, identification of new diseases and phenotypes, discovery of new intracellular pathways, availability of greater sets of omics data, and the need to continuously analyse them have led to the development of new AI platforms. AI continues to weave its way into the fabric of genetics with the potential to unlock new discoveries and enhance patient care. This technology is setting the stage for breakthroughs across various domains, including dysmorphology, rare hereditary diseases, cancers, clinical microbiomics, the investigation of zoonotic diseases, omics studies in all medical disciplines. AI's role in facilitating a deeper understanding of these areas heralds a new era of personalised medicine, where treatments and diagnoses are tailored to the individual's molecular features, offering a more precise approach to combating genetic or acquired disorders. The significance of these AI platforms is growing as they assist healthcare professionals in the diagnostic and treatment processes, marking a pivotal shift towards more informed, efficient, and effective medical practice. In this review, we will explore the range of AI tools available and show how they have become vital in various sectors of genomic research supporting clinical decisions.
  • Article
    Citation - WoS: 32
    Citation - Scopus: 33
    Naphthalene Diimide-Based Polymeric Semiconductors. Effect of Chlorine Incorporation and N-Channel Transistors Operating in Water
    (Springer Heidelberg, 2016-03) Ryu, Gi-Seong; Chen, Zhihua; Usta, Hakan; Noh, Yong-Young; Facchetti, Antonio
    We demonstrate here the design, synthesis and characterization of two new chlorinated polymers, P(NDI2HD-T2Cl2) and P(NDI2OD-T2Cl2) based on N,N-difunctionalized naphthalene diimide (NDI) and 3,3-dichloro-2,2-bithiophene (T2Cl2) moieties. Our results indicate that organic thin-film transistors (OTFTs) based on these new chlorinated polymers exhibit electron mobilities approaching 0.1 cm(2)V(-1)s(-1) (I-on:I-off similar to 10(6)-10(7)), with far less ambipolarity due to their lower highest occupied molecular orbital energies, and they are more stable under deleterious high-humidity conditions (RH similar to 60%) and upon submersion in water, compared with those fabricated with the parent non-chlorinated polymers. In addition, OTFTs fabricated with the new chlorinated polymers exhibit excellent operational stabilities with <3% degradations upon bias-stress test.
  • Article
    Citation - WoS: 22
    Citation - Scopus: 28
    Loss in Moment Capacity of Tree Stems Induced by Decay
    (Springer Heidelberg, 2013-12-29) Ciftci, Cihan; Kane, Brian; Brena, Sergio F.; Arwade, Sanjay R.
    We model varying decay in tree cross-sections by considering bending theory to estimate moment capacity loss (MCL) for the sections. We compare MCL with experiments on selected oak trees. Tree failures can damage property and injure people, sometimes with fatal consequences. Arborists assess the likelihood of failure by examining many factors, including strength loss in the stem or branch due to decay. Current methods for assessing strength loss due to decay are limited by not accounting for offset areas of decay and assuming that the neutral axis of the cross-section corresponds to the centroidal axis. This paper considers that strength loss of a tree can be related to moment capacity loss (MCL) of the decayed tree cross-section, because tree failures are assumed to occur when induced moments exceed the moment capacity of the tree cross-section. An estimation of MCL is theoretically derived to account for offset areas of decay and for differences in properties of wood under compressive and tensile stresses. Field measurements are used to validate the theoretical approach, and predictions of loss in moment capacity are plotted for a range of scenarios of decayed stems or branches. Results show that the location and size of decay in the cross-section and relative to the direction of sway are important to determine MCL. The effect of wood properties on MCL was most evident for concentric decay and decreased as the location of decay moved to the periphery of the stem. The effect of the ratio of tensile to compressive moduli of elasticity on calculations of MCL was negligible. Practitioners are cautioned against using certain existing methods because the degree to which they over- or underestimate the likelihood of failure depended on the amount and location of decay in the cross-section.
  • Article
    Citation - WoS: 11
    Citation - Scopus: 10
    Clinical and Molecular Evaluation of MEFV Gene Variants in the Turkish Population: A Study by the National Genetics Consortium
    (Springer Heidelberg, 2022-01-31) Dundar, Munis; Fahrioglu, Umut; Yildiz, Saliha Handan; Bakir-Gungor, Burcu; Temel, Sehime Gulsun; Akin, Haluk; Erdem, Levent
    Familial Mediterranean fever (FMF) is a monogenic autoinflammatory disorder with recurrent fever, abdominal pain, serositis, articular manifestations, erysipelas-like erythema, and renal complications as its main features. Caused by the mutations in the MEditerranean FeVer (MEFV) gene, it mainly affects people of Mediterranean descent with a higher incidence in the Turkish, Jewish, Arabic, and Armenian populations. As our understanding of FMF improves, it becomes clearer that we are facing with a more complex picture of FMF with respect to its pathogenesis, penetrance, variant type (gain-of-function vs. loss-of-function), and inheritance. In this study, MEFV gene analysis results and clinical findings of 27,504 patients from 35 universities and institutions in Turkey and Northern Cyprus are combined in an effort to provide a better insight into the genotype-phenotype correlation and how a specific variant contributes to certain clinical findings in FMF patients. Our results may help better understand this complex disease and how the genotype may sometimes contribute to phenotype. Unlike many studies in the literature, our study investigated a broader symptomatic spectrum and the relationship between the genotype and phenotype data. In this sense, we aimed to guide all clinicians and academicians who work in this field to better establish a comprehensive data set for the patients. One of the biggest messages of our study is that lack of uniformity in some clinical and demographic data of participants may become an obstacle in approaching FMF patients and understanding this complex disease.
  • Article
    Citation - WoS: 6
    Citation - Scopus: 6
    Admissible Invariants of Genus 3 Curves
    (Springer Heidelberg, 2015-06-03) Cinkir, Zubeyir
    Several invariants of polarized metrized graphs and their applications in Arithmetic Geometry are studied recently. In this paper, we explicitly calculated these admissible invariants for all curves of genus 3. We find the sharp lower bound for the invariants phi, lambda and epsilon for all polarized metrized graphs of genus 3. This improves the lower bound given for Effective Bogomolov Conjecture for such curves.