Scopus İndeksli Yayınlar Koleksiyonu

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  • Article
    Use of Confocal Microscopy to Monitor Structural Transformations in Nanopillars Based on DNA and CdSe/CdZnSe Quantum Dots
    (Springer, 2023-06-24) Motevich, I. G.; Erdem, T.; Akrema, A.; Maskevich, S. A.; Strekal, N. D.
    Chip system prototypes in the form of nanopillars were created from DNA complexes with CdSe/CdZnSe/ZnS quantum dots immobilized on a plasmonic gold fi lm by the use of vacuum deposition technology and inorganic synthesis. The design and presence of terminal DNA labeled with Cy3 cyanine dyes makes it possible to carry out the hybridization reaction of this terminal strand with complementary DNA and to control the process by variation of the giant Raman scattering (GRS) and the fluorescence signal. The effect of molecular recognition of complementary DNA is accompanied by a change in the GRS spectrum, a 20-fold increase in the fluorescence intensity, and a decrease in the duration of fluorescence decay.
  • Book Part
    Citation - Scopus: 3
    Solving Optimization Problem With Particle Swarm Optimization: Solving Hybrid Flow Shop Scheduling Problem With Particle Swarm Optimization Algorithm
    (Springer, 2021) Madenoğlu, Fatma Selen
    The flow shop scheduling problem is widely discussed in the literature since it is frequently applied in real industry. This paper presents a variant of flow shop scheduling problem with parallel machines. The proposed problem includes multistage and identical parallel machines at each stage, and the sequence-dependent setup time and transportation time are considered. The objective function is minimization of makespan. The particle swarm optimization algorithm (PSO) is addressed to solve the problem and compared with genetic algorithm and heuristics. The benchmark instances are generated to demonstrate the performance of the PSO. The numerical results show that the PSO significantly outperforms the comparison set. © 2021 Elsevier B.V., All rights reserved.
  • Conference Object
    Citation - Scopus: 1
    On the Existence of Positive Solutions for the Time-Scale Dynamic Equations on Infinite Intervals
    (Springer, 2020) Doǧan, Abdülkadir Muhittin
    This paper investigates the existence of positive solutions to time-scale boundary value problems on infinite intervals. By applying the Leggett-Williams fixed point theorem in a cone, some new results for the existence of at least three positive solutions of boundary value problems are found. With infinite intervals, the theorem can be used to prove the existence of solutions of boundary value problems for nonlinear dynamic equations dependence on the delta derivative explicitly. Our results are new for the special cases of difference equations and differential equations as well as in the general time scale setting. © 2020 Elsevier B.V., All rights reserved.
  • Article
    Citation - WoS: 4
    Citation - Scopus: 4
    Differential in Vitro Anti-Leukemic Activity of Resveratrol Combined With Serine Palmitoyltransferase Inhibitor Myriocin in FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication (FLT3-LTD) Carrying AML Cells
    (Springer, 2022-02-14) Ersoz, Nur Sebnem; Adan, Aysun
    Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its multi-targeted nature is a promising chemopreventive remaining limitedly studied in FLT3-ITD AML regarding to ceramide metabolism. Here, its cytotoxic, cytostatic and apoptotic effects are investigated in combination with serine palmitoyltransferase (SPT), the first enzyme of de novo pathway of ceramide production, inhibitor myriocin on MOLM-13 and MV4-11 cells. We assessed dose-dependent cell viability, flow cytometric cell death and cell cycle profiles of resveratrol in combination with myriocin by MTT assay, annexin-V/PI staining and PI staining respectively. Resveratrol's dose-dependent effect on SPT protein expression was also checked by western blot. Resveratrol decreased cell viability in a dose- dependent manner whereas myriocin did not affect cell proliferation effectively in both cell lines after 48h treatments. Although resveratrol induced both apoptosis and a significant S phase arrest in MV4-11 cells, it triggered apoptosis and non-significant S phase accumulation in MOLM-13 cells. Co-administrations reduced cell viability. Increased cytotoxic effect of co-treatments was further proved mechanistically through induction of apoptosis via phosphatidylserine relocalization. The cell cycle alteration in co-treatment was significant with an S phase arrest in MV4-11 cells, however, it was not effective on cell cycle progression of MOLM-13 cells. Resveratrol also increased SPT expression. Overall, modulation of SPT together with resveratrol might be the possible explanation for resveratrol's action. It could be an integrative medicine for FLT3-ITD AML after investigating its detailed mechanism of action in relation to de novo pathway of ceramide production.
  • Conference Object
    Citation - WoS: 30
    Citation - Scopus: 30
    Compatibility of Superplasticizers With Limestone-Metakaolin Blended Cementitious System
    (Springer, 2015) Zaribaf, Behnaz H.; Uzal, Burak; Kurtis, Kimberley
    This study investigates the performance of polycarboxylate ether (PCE), polymelamine sulfonate (PMS), sodium lignosulfonate and naphthalene formaldehyde condensate (PNS) superplasticizers (SPs) with ASTM C595 Type IL cement (with up to 15% calcium carbonate) combined with 10 and 30 % metakaolin (MK) substitutions by mass. The required dosage of each SP for 10 % and 30 % MK substitutions were determined based on mini slump test to establish equivalent paste flow. At these dosage rates, the effects of SPs on setting time, hydration kinetics, and strength development were measured. Life cycle assessment (LCA) was carried out on different cement compositions used in this study to evaluate the greenhouse gas emissions and embodied energy of limestone-metakaolin blended cement with SP addition. While MK substitution decreases the workability of samples and shortens the setting time, this study shows that adequate dosages of a compatible type of SP can be used to compensate for these effects. Of the SPs examined, PCE and PMS are found to be more compatible, compared to PNS and sodium lignosulfonate, with limestone-metakaolin blended cements.