Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Evaluating the Effects of Design and Manufacturing Parameters on Friction at the Surrogate Skin-3D Textile Interface
    (Sage Publications Ltd, 2025-10-30) Temel-Cicek, Mevra; Cicek, Umur I.; Lloyd, Alex B.; Johnson, Andrew A.
    Additive manufacturing (AM) is increasingly employed in the development of 3D-printed wearables, including medical wrist supports, textiles, and protective garments. While the general tribological behavior of 3D-printed components has been widely studied, limited research has focused on the friction behavior of 3D-printed wearables when in contact with human skin, which is a crucial factor for improving wearer comfort by minimizing local skin friction. This study, therefore, investigates the influence of material type, manufacturing technology, and print parameters of 3D-printed textiles on frictional behavior against skin. Specimens were fabricated using three AM technologies: material extrusion (MEX), vat photopolymerization (VATP), and powder bed fusion (PBF). Each technology employed various materials and print parameters, specifically layer thickness (ranging from 0.05 to 0.3 mm) and print orientations (horizontal and vertical). Friction was measured using a custom-built handheld device at the interface between 3D-printed specimens and two surrogate skin models: lorica (representing the dorsal forearm) and silicone (representing the chest). The results revealed that friction was significantly influenced by both layer thickness and print orientation. For MEX specimens, acrylonitrile butadiene styrene, acrylonitrile styrene acrylate, and polycarbonate showed the highest friction, while for VATP, durable resin resulted in the highest friction coefficient. In contrast, PBF specimens exhibited very similar frictional behavior. Regarding layer thickness, higher values consistently resulted in the highest friction coefficients, regardless of manufacturing method or material type. These findings provide valuable insights for designers and engineers seeking to optimize the comfort of 3D-printed wearables, guiding the selection of suitable AM processes and parameters for products intended for direct skin contact.
  • Article
    Failure Analysis of Fused Deposition Modeling 3D Printed Poly Lactic Acid Polymer
    (Sage Publications Ltd, 2025-10-04) Yilmaz, Cagatay; Eltahir, Sara Saeed Abdulrahman
    Additive manufacturing, commonly known as 3D printing (AM), has emerged as one of the most transformative technological advances in the last few decades in global manufacturing, as it allows for the production of intricate components without the use of costly molds. Fused Deposition Modeling (FDM) is widely adopted among various AM techniques due to its accessibility and effectiveness. FDM 3D-printed PLA (Poly Lactic Acid) shows a transversely isotopic symmetry similar to laminated composite structures. Therefore, classical lamination theory can be applied to FDM 3D-printed PLA. This study attempts to expand the knowledge by relying on classical lamination theory and several imposed failure theories like maximum stress, Tsai-Hill, Tsai-Wu, and Hashin to determine how FDM 3D printing of PLA fails. We investigate eight different raster orientations (0 degrees, 10 degrees, 15 degrees, 30 degrees, 45 degrees, 60 degrees, 75 degrees, and 90 degrees) and compare the theoretical prediction of strength with experimental findings. With this comprehensive analysis, we are seeking to better understand the failure analysis of FDM 3D printed PLA. The maximum stress, Tsai-Wu, Tsai-Hill, and Hashin failure theories show good agreement with experimental findings for 0 degrees and 90 degrees raster orientations. As the raster orientation shifts from 0 degrees, the discrepancy between experimental results and theoretical predictions increases, peaks at mid-angles, and then decreases, becoming negligible at 90 degrees.
  • Article
    Citation - WoS: 6
    Citation - Scopus: 4
    Towards Global Sustainable Development: The Role of Financial Innovation and Technological Advancements
    (Sage Publications Ltd, 2024-08-10) Dogan, Eyup; Chishti, Muhammad Zubair; Zaman, Umer; Binsaeed, Rima H.
    The importance of metaverse and blockchain technologies in today's global landscape cannot be overstated. These innovative technologies offer transformative potential for various sectors, including economics, by enhancing connectivity, security and transparency. The present study leverages these technologies to investigate their dynamic impacts, in conjunction with geopolitical risk, on global economic cycles to navigate the challenges of an interconnected world. To ensure the reliability of our findings, this study employs two proxies to gauge economic cycles: global green economic growth and global environmental sustainability. By utilizing daily data, this study reveals several noteworthy findings. First, the quantile-var-based network analysis demonstrates a robust directional connection among the variables in our model. Second, the wavelet quantile correlation technique uncovers the significant role of metaverse technology in influencing economic cycles by promoting global green economic growth and global environmental sustainability across all time horizons (short, medium and long term). Third, economic cycles exhibit a negative association with financial innovation and a positive connection with geopolitical risk across all timeframes. Fourth, the continuous wavelet transform causality test identifies a substantial causal relationship running from metaverse technology, financial innovation and geopolitical risk to economic cycles. Based on our empirical results, this study recommends that the global economy should continue investing in metaverse and blockchain technologies to address economic cycles in the future.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 10
    Three Dimensional Patient-Specific Guides for Guide Pin Positioning in Reverse Shoulder Arthroplasty: An Experimental Study on Different Glenoid Types
    (Sage Publications Ltd, 2022-01) Sadeghi, Majid Mohammad; Kececi, Emin Faruk; Kapicioglu, Mehmet; Aralasmak, Ayse; Tezgel, Okan; Basaran, Murat Alper; Bilsel, Kerem; Mohammad Sadeghi, Majid
    Introduction Incorrect positioning is one of the main factors for glenoid component loosening in reverse shoulder arthroplasty and component placement can be challenging. This study aimed to assess whether Patient-Specific Instrumentation (PSI) provides better guide pin positioning accuracy and is superior to standard guided and freehand instrumentation methods in cases of glenoid bone deformity. Materials and Methods Based on the Walch classification, five different scapula types were acquired by computed tomography (CT). For each type, two different surgeons placed a guide pin into the scapula using three different methods: freehand method, conventional non-patient-specific guide, and PSI guide. Each method was repeated five times by both surgeons. In these experiments, a total of 150 samples of scapula models were used (5 x 2 x 3 x 5 = 150). Post-operative CT scans of the samples with the guide pin were digitally assessed and the accuracy of the pin placement was determined by comparison to the preoperative planning on a three-dimensional (3D) model. Results The PSI method showed accuracies to the preoperative plan of 2.68 (SD 2.10) degrees for version angle (p < .05), 2.59 (SD 2.68) degrees for inclination angle (p < .05), and 1.55 (SD 1.26) mm for entry point offset (p < .05). The mean and standard deviation errors compared to planned values of version angle, inclination angle, and entry point offset were statistically significant for the PSI method for the type C defected glenoid and non-arthritic glenoid. Conclusion Using the PSI guide created by an image processing software tool for guide pin positioning showed advantages in glenoid component positioning over other methods, for defected and intact glenoid types, but correlation with clinical outcomes should be examined.
  • Article
    Citation - WoS: 43
    Citation - Scopus: 49
    The Pleiotropic Effects of Fisetin and Hesperetin on Human Acute Promyelocytic Leukemia Cells Are Mediated Through Apoptosis, Cell Cycle Arrest, and Alterations in Signaling Networks
    (Sage Publications Ltd, 2015-06-17) Adan, Aysun; Baran, Yusuf
    Fisetin and hesperetin, flavonoids from various plants, have several pharmaceutical activities including antioxidative, anti-inflammatory, and anticancer effects. However, studies elucidating the role and the mechanism(s) of action of fisetin and hesperetin in acute promyelocytic leukemia are absent. In this study, we investigated the mechanism of the antiproliferative and apoptotic actions exerted by fisetin and hesperetin on human HL60 acute promyelocytic leukemia cells. The viability of HL60 cells was evaluated using the MTT assay, apoptosis by annexin V/propidium iodide (PI) staining and cell cycle distribution using flow cytometry, and changes in caspase-3 enzyme activity and mitochondrial transmembrane potential. Moreover, we performed whole-genome microarray gene expression analysis to reveal genes affected by fisetin and hesperetin that can be important for developing of future targeted therapy. Based on data obtained from microarray analysis, we also described biological networks modulated after fisetin and hesperetin treatment by KEGG and IPA analysis. Fisetin and hesperetin treatment showed a concentration- and time-dependent inhibition of proliferation and induced G2/M arrest for both agents and G0/G1 arrest for hesperetin at only the highest concentrations. There was a disruption of mitochondrial membrane potential together with increased caspase-3 activity. Furthermore, fisetin- and hesperetin-triggered apoptosis was confirmed by annexin V/PI analysis. The microarray gene profiling analysis revealed some important biological pathways including mitogen-activated protein kinases (MAPK) and inhibitor of DNA binding (ID) signaling pathways altered by fisetin and hesperetin treatment as well as gave a list of genes modulated a parts per thousand yen2-fold involved in cell proliferation, cell division, and apoptosis. Altogether, data suggested that fisetin and hesperetin have anticancer properties and deserve further investigation.
  • Article
    Citation - WoS: 7
    Citation - Scopus: 11
    Robust Estimator-Based Optimal Control Designs for U-Tube Steam Generators
    (Sage Publications Ltd, 2014-05-19) Ablay, Gunyaz; Hamamci, Serdar
    U-tube steam generator level control systems are used to maintain the water level within prescribed narrow limits and to provide constant supply of high-quality steam during power demand variations. Traditional level control systems are often found to be unsatisfactory during low power operations and start-up conditions. Robust non-linear estimator-based optimal control systems are proposed for steam generator level control systems to solve the water level tracking problem during power (or steam) demand variations. It is shown that the proposed control strategies provide optimal and robust water level tracking with a single controller over the complete range of power operation with model and parameter uncertainties and noisy measurements.
  • Article
    Citation - WoS: 29
    Citation - Scopus: 30
    Revealing Genome-Wide mRNA and MicroRNA Expression Patterns in Leukemic Cells Highlighted HSA-MIR as a Tumor Suppressor for Regain of Chemotherapeutic Imatinib Response due to Targeting STAT5A
    (Sage Publications Ltd, 2015-05-08) Kaymaz, Burcin Tezcanli; Gunel, Nur Selvi; Ceyhan, Metin; Cetintas, Vildan Bozok; Ozel, Buket; Yandim, Melis Kartal; Can, Buket Kosova
    BCR-ABL oncoprotein stimulates cell proliferation and inhibits apoptosis in chronic myeloid leukemia (CML). For cure, imatinib is a widely used tyrosine kinase inhibitor, but developing chemotherapeutic resistance has to be overcome. In this study, we aimed to determine differing genome-wide MicroRNA (miRNA) and messenger RNA (mRNA) expression profiles in imatinib resistant (K562/IMA-3 mu M) and parental cells by targeting STAT5A via small interfering RNA (siRNA) applications. After determining possible therapeutic miRNAs, we aimed to check their effects upon cell viability and proliferation, apoptosis, and find a possible miRNA
  • Article
    Citation - WoS: 496
    Citation - Scopus: 550
    Major Apoptotic Mechanisms and Genes Involved in Apoptosis
    (Sage Publications Ltd, 2016-04-09) Kiraz, Yagmur; Adan, Aysun; Yandim, Melis Kartal; Baran, Yusuf; Kartal Yandim, Melis
    As much as the cellular viability is important for the living organisms, the elimination of unnecessary or damaged cells has the opposite necessity for the maintenance of homeostasis in tissues, organs and the whole organism. Apoptosis, a type of cell death mechanism, is controlled by the interactions between several molecules and responsible for the elimination of unwanted cells from the body. Apoptosis can be triggered by intrinsically or extrinsically through death signals from the outside of the cell. Any abnormality in apoptosis process can cause various types of diseases from cancer to auto-immune diseases. Different gene families such as caspases, inhibitor of apoptosis proteins, B cell lymphoma (Bcl)-2 family of genes, tumor necrosis factor (TNF) receptor gene superfamily, or p53 gene are involved and/or collaborate in the process of apoptosis. In this review, we discuss the basic features of apoptosis and have focused on the gene families playing critical roles, activation/inactivation mechanisms, upstream/downstream effectors, and signaling pathways in apoptosis on the basis of cancer studies. In addition, novel apoptotic players such as miRNAs and sphingolipid family members in various kind of cancer are discussed.
  • Article
    Citation - WoS: 5
    Citation - Scopus: 5
    Large Transformations With Moderate Strains of Tensile Membrane Structures
    (Sage Publications Ltd, 2016-04-28) Beatini, Valentina; Carfagni, Gianni Royer; Royer Carfagni, Gianni
    Using a classical non-linear theory, we analytically investigate possible ways for transforming the shape of a curved elastic membrane while keeping it tensioned and moderately strained. This is a critical issue because, as a rule, membranes must be considerably stretched in order to avoid wrinkling and slackening. If the final configuration is fixed, the membrane can be cut and formed according to the final shape, but this cannot be done if more configurations, considerably distant from one another, have to be achieved. Nevertheless, we propose large transformation movements that can be obtained starting from flat membranes while maintaining their strain as limited. We discuss in detail the paradigmatic example of the hyperbolic-paraboloid-shaped membrane. These opportunities are suitable for applications of transformable architecture because they do not require excessive tensioning, compatible with the strength of materials used for this kind of structures.
  • Article
    Citation - WoS: 3
    Citation - Scopus: 3
    Investigations of Strain Rate, Size, and Crack Length Effects on the Mechanical Response of Polycaprolactone Electrospun Membranes
    (Sage Publications Ltd, 2021-06-18) Bayram, Ferdi C.; Kapci, Mehmet F.; Yuruk, Adile; Isoglu, Ismail A.; Bal, Burak
    The effects of strain rate, size (height x width), and pre-existing crack length on the mechanical response of polycaprolactone electrospun membranes were investigated by tension tests conducted at room temperature. In particular, tensile tests were performed with three different strain rates for strain rate effect tests, seven different geometries for elucidating the size effect, and three different initial notch lengths for crack growth experiments. The electrospun membranes were produced by the electrospinning technique using a polycaprolactone solution prepared in 1, 1, 1, 3, 3, 3-hexafluoro-2-propanol as the solvent. Scanning electron microscopy was utilized to show the continuous fiber structure without bead formation. The average fiber diameter was calculated as 1.113 +/- 0.270 mu m by using scanning electron microscopy images of the membranes. The chemical structure of polycaprolactone was analyzed by Fourier transform infrared spectroscopy, and the toxicity and cell viability of the electrospun membranes were shown by CellTiter 96(R) Aqueous One Solution Cell Proliferation Assay (MTS test). It was observed that the ultimate tensile strength and Young's modulus decreased, and the elongation at failure value increased as the strain rate decreased from 10(-1) to 10(-3) s(-1). Besides, positive strain rate sensitivity was observed on the mechanical response of electrospun polycaprolactone membranes. Moreover, the dependency of mechanical response on the size geometry has been well studied, and the optimum height and width combinations were specified. Also, crack growth was studied in terms of both macroscopic and microstructural deformation mechanisms and it is observed that individual fiber deformations and interactions are highly effective on the mechanical behavior and also propagation of the crack. Consequently, in this study, the size and strain rate effects and crack growth on the mechanical response of electrospun polycaprolactone membranes have been investigated extensively, and the results presented herein constitute an essential guideline for the usage of polycaprolactone electrospun membranes at different loading scenarios.