Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Article
    Citation - WoS: 14
    Citation - Scopus: 15
    Image-Analysis Based Readout Method for Biochip: Automated Quantification of Immunomagnetic Beads, Micropads and Patient Leukemia Cell
    (Pergamon-Elsevier Science Ltd, 2020-06) Uslu, Fatma; Icoz, Kutay; Tasdemir, Kasim; Dogan, Refika S.; Yilmaz, Bulent
    For diagnosing and monitoring the progress of cancer, detection and quantification of tumor cells is utmost important. Beside standard bench top instruments, several biochip-based methods have been developed for this purpose. Our biochip design incorporates micron size immunomagnetic beads together with micropad arrays, thus requires automated detection and quantification of not only cells but also the micropads and the immunomagnetic beads. The main purpose of the biochip is to capture target cells having different antigens simultaneously. In this proposed study, a digital image processing-based method to quantify the leukemia cells, immunomagnetic beads and micropads was developed as a readout method for the biochip. Color, size-based object detection and object segmentation methods were implemented to detect structures in the images acquired from the biochip by a bright field optical microscope. It has been shown that manual counting and flow cytometry results are in good agreement with the developed automated counting. Average precision is 85 % and average error rate is 13 % for all images of patient samples, average precision is 99 % and average error rate is 1% for cell culture images. With the optimized micropad size, proposed method can reach up to 95 % precision rate for patient samples with an execution time of 90 s per image.
  • Article
    Development and Radiation Test of a Secondary Emission Ionization Calorimetry Module
    (Pergamon-Elsevier Science Ltd, 2025-06) Paran, Nejdet; Tiras, Emrah; Tekgun, Burak; Abubakar, Saleh
    The demand for precise, robust, and reliable radiation-resistant particle detectors and ionization calorimeters intensifies due to the escalating luminosity and unprecedented radiation conditions at particle colliders and accelerators. Secondary Emission (SE) Ionization Calorimetry is a novel technology designed to measure the energy of electromagnetic and hadronic particles, particularly in extreme radiation conditions. In this study, we have tested and investigated the development and radiation tests of the novel SE modules. The modules were developed by modifying the conventional Hamamatsu single-anode R7761 Photomultiplier Tubes (PMTs). Three different voltage conditions for the same module were created and the new modules were tested using cosmic and gamma radiation sources, Co-60. The results show that all three modes have good sensitivity to electromagnetic showers, and they are suitable for harsh radiation environments. This study also indicates that the SE module is a promising technology shedding light on future radiation-resistant nuclear and high-energy detectors. Here, we discuss the technical design, test characteristics, and cosmic and particle interaction results of the newly developed SE modules.