Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Citation - Scopus: 2miRcorrNetPro: Unraveling Algorithmic Insights Through Cross-Validation in Multi-Omics Integration for Comprehensive Data Analysis(Institute of Electrical and Electronics Engineers Inc., 2023-12-05) Ünlü Yazici, Miray; Yousef, Malik; Marron, J. S.; Bakir-Güngör, Burcu; Yazici, Miray UnluHigh throughput -omics technologies facilitate the investigation of regulatory mechanisms of complex diseases. Along this line, scientists develop promising tools and methods to extend our understanding at the molecular and functional levels. To this end, miRcorrNet tool performs integrative analysis of MicroRNA (miRNA) and gene expression profiles via machine learning (ML) approach to identify significant miRNA groups and their associated target genes. In this study, we propose miRcorrNetPro tool, which extends miRcorrNet by tracking group scoring, ranking and other information through the cross-validation iterations. Heatmap visualizations enable deep novel insights into the collective behavior of clusters of groups in cellular signaling and hence facilitate detection of potential biomarkers for the disease under investigation. Although miRcorrNetPro is designed as a generic tool, here we present our findings and potential miRNA biomarkers for Breast Cancer (BRCA). The miRcorrNetPro tool and all other supplementary files are available at https://github.com/Miray-Unlu/miRcorrNetPro. © 2024 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1Words Speak Louder Than Actions: Decoding Emotions Through NLP(Institute of Electrical and Electronics Engineers Inc., 2024-10-26) Paksoy, Melda; Bakal, GokhanEmotion detection in text remains a significant challenge in Natural Language Processing due to human emotions' complexity and subtle nuances. This paper presents multiple experimental models for emotion classification using an up-to-date dataset curated to address 13 emotions implied in Twitter posts. We evaluated various machine learning (ML) models, including Logistic Regression, Random Forest, SVM, and XGBoost, alongside deep learning (DL) architectures such as LSTM and CNN. Our results demonstrate the efficacy of deep learning models, particularly the CNN model by achieving an impressive F1 score of 0.99. This study contributes to emotion detection capabilities, paving the way for more nuanced and accurate sentiment analysis (SA) in various text analysis applications. © 2025 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1Traffic Light Management Systems Using Reinforcement Learning(Institute of Electrical and Electronics Engineers Inc., 2022-09-07) Can, Sultan Kubra; Thahir, Adam Rizvi; Cos¸kun, Mustafa; Güngör, Vehbi Çağrı; Coskun, MustafaWhile reducing traffic congestion and decrease the number of traffic accidents in the intersections, most of the traffic light management approaches cannot adapt well to fast changing traffic dynamics and growing demands of the intersections with modern world developments. To overcome this problem, adaptive traffic controllers are developed, and detectors and sensors are added to systems to enable adoption and dynamism. Recently, reinforcement learning has shown its capability to learn the dynamics of complex environments, such as urban traffic. Although it was studied in single junction systems, one of the problems was the lack of consistency with how the real world system works. Most of the systems assume that the environment is fully observable or actions would be freely executed using simulators. This study aims to merge usefulness of reinforcement learning methods with real-world traffic constraints. Comparative performance evaluations show that the reinforcement learning algorithm (Advantage Actor-Critic (A2C)) converges well while staying stable under changing traffic dynamics. © 2022 Elsevier B.V., All rights reserved.Conference Object The Relationship Between TSH Levels, Maternal Characteristics and Racial Group of the Aneuploidy Screening(Institute of Electrical and Electronics Engineers Inc., 2022-09-07) Soylemez, Ummu Gülsüm; Kaymakçalan, Hande; Härkönen, Juho; Bakir-Güngör, Burcu; Celebiler, Hande KaymakcalanFirst-trimester maternal screening is a widely used test for detecting fetal aneuploidies and neural tube defects for over two decades. Human chorionic gonadotropin hormone (beta-hCG) and pregnancy-associated plasma protein A (PAPP-A) are two serum biomarkers that are analyzed in this screening. The thyroid hormone is a critical hormone for normal pregnancy and fetal development. During the first half of pregnancy, placental and fetal development depends on the thyroid hormone levels in the mother. Therefore, thyroid abnormalities in the mother can result in unfavorable pregnancy outcomes such as intrauterine growth restriction, miscarriage, hypertensive disorders, premature birth, and an increase in the risk of low IQ in the newborn. In this study, we analyzed the first-trimester screening data collected from 410 pregnant women who were seen at Yale University Hospital Prenatal Unit; and checked for possible correlations of TSH levels with maternal characteristics, racial group PAPP-A MoM levels. © 2022 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1The Identification of Discriminative Single Nucleotide Polymorphism Sets for the Classification of Behçet's Disease(Institute of Electrical and Electronics Engineers Inc., 2018-09) Görmez, Yasin; Işik, Yunus Emre; Bakir-Güngör, BurcuBehçet's disease is a long-term multisystem inflammatory disorder, characterized by recurrent attacks affecting several organs. As the genotyping individuals get cheaper and easier following the developments in genomic technologies, genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) are identified. Although several genetic risk factors are identified for Behçet's disease with the help of these studies via scanning around a million of SNPs, these variations could only explain up to 20% of the disease's genetic risk. In this study, for Behçet's disease classification, via comparing all the SNPs genotyped in GWAS, with the SNPs selected via using genetic knowledge, gain ratio and information gain; both reduction in the feature size and improvement in the classification accuracy is aimed. Also, using different classification algorithms such as random forest, k-nearest neighbour and logistic regression, their effects on the classification accuracy are investigated. Our results showed that compared to other feature selection methods, with at least 81% success rate, the selection of the SNPs using the genetic information (of their GWAS p-values, indicating the significance of the SNP against the disease) provides 15% to 42% improvement in all classification algorithms. This improvement is statistically sound. While gain ratio and information gain feature selection techniques yield similar classification accuracies, the models using all SNPs could not exceed 50% accuracies and results in the worst performance. © 2019 Elsevier B.V., All rights reserved.Conference Object The Effects of Intracavity Phase Modulation and Extracavity Optical Filtering on Amplitude Noise of Mode-Locked Pulse Trains(Institute of Electrical and Electronics Engineers Inc., 2018-09) Özharar, Sarper; Ozdur, Ibrahim T.An actively mode-locked, fiber-coupled semiconductor ring laser that employs both a phase modulator and an amplitude modulator was built. The laser was mode-locked by loss modulation at 10 GHz and the intracavity phase modulator was driven at the cavity fundamental frequency of 1.63 MHz. The effects of the intracavity phase modulation on the stability of the optical spectrum, the timing jitter, and the amplitude noise of the pulse train was analyzed. It was found that using this method, the amplitude fluctuation can be reduced by 40%, and the stability of the optical spectrum can be improved while keeping the phase noise of the system unchanged. © 2019 Elsevier B.V., All rights reserved.Conference Object Citation - WoS: 1Citation - Scopus: 1The Effect of Fourth Color Component on Enhancement of Color Gamut(Institute of Electrical and Electronics Engineers Inc., 2017-10) Genc, Sinan; Uguz, Mustafa; Mutlugün, EvrenIn this work, we simulate and analyse the peak emission wavelength and full-width-at-half-maximum (FWHM) parameters of nano emitters using four-color mixing approach to provide a tetragonal area as large as possible in CIE-1931, reaching over 160% NTSC area using emitters having 30nm FWHM. © 2018 Elsevier B.V., All rights reserved.Conference Object The Effect of Different Classifiers on Recursive Cluster Elimination in the Analysis of Transcriptomic Data(Institute of Electrical and Electronics Engineers Inc., 2023-10-11) Bulut, Nurten; Bakir-Güngör, Burcu; Qaqish, Bahjat F.; Yousef, MalikGene expression data with limited sample size and a large number of genes are frequently encountered in genetic studies. In such high-dimensional data, identification of genes that distinguish between disease states is a challenging task. Feature selection (FS) is a useful approach in dealing with high dimensionality. Support Vector Machines Recursive Cluster Elimination (SVM-RCE) is a technique for FS in high-dimensional data. The SVM-RCE approach has been utilized for identification of clusters of genes whose expression levels correlate with pathological state. A key step in SVM-RCE is the use of an SVM classifier to assign an area under the curve (AUC) score to each gene cluster based on its ability to predict class labels. In this study, we investigate the use of alternative classifiers in the cluster-scoring step. Specifically, we compare Support Vector Machines, Random Forest, XgBoost, Naive Bayes, and linear logistic regression. In addition to AUC score performance evaluation, the algorithms are compared in terms of the number of selected genes at different levels of clustering and in terms of the running time. © 2023 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1TextNetTopics_TIS: Enhancing Textnettopics With Random Forest-Based Topic Importance Scoring(Institute of Electrical and Electronics Engineers Inc., 2024-10-16) Voskergian, Daniel; Bakir-Güngör, Burcu; Yousef, MalikTextNetTopics is an innovative Latent Dirichlet Allocation-based topic selection method for training text classification models. One main limitation is its computationally intensive scoring mechanism, especially when applied to many topics. This scoring mechanism involves training a machine learning model (i.e., Random Forest) on each topic using the Monte-Carlo Cross-Validation approach and assigning a score value based on a specific performance metric (e.g., accuracy or F1-score). Moreover, the measured score does not account for the interactions between all features residing in all topics. This paper presents a new topic-scoring mechanism called Topic Importance Scoring. This computationally efficient approach trains a Random Forest model on all topics simultaneously and leverages the extracted feature importance values to give each topic a score reflecting its classification potential. The experiments on three diverse datasets confirm that the proposed method's performance is superior to the Topic Performance Scoring, which was used in the original TextNetTopics method. © 2024 Elsevier B.V., All rights reserved.Conference Object Citation - WoS: 1Citation - Scopus: 5Sliding Mode Control of a Switched Reluctance Motor Drive With Four-Switch Bi-Directional DC-DC Converter for Torque Ripple Minimization(Institute of Electrical and Electronics Engineers Inc., 2020-09) Ates, Ertugrul; Tekgun, Burak; Ablay, GünyazIn this paper, a method to drive switched reluctance motors (SRM) with a modular four-switch bidirectional DC-DC converter and an H-bridge is proposed. The DC-DC converter operates as a buck or a boost converter with constant frequency to control each phase current while the H-bridge inverter switches only twice in a period to adjust the polarity of the phase voltage. Sliding mode control is designed to have fast and robust current control in the DC-DC converter. The sliding surface equation which is derived for all operation modes including buck and boost modes in motoring and regenerating conditions is defined with the estimated inductor current. The proposed drive system eliminates the bulk DC-capacitors and allows one to adjust the bus voltage individually for all phases. Moreover, the proposed system topology works with only one high-frequency switching device in the DC-DC conversion stage rather than two in conventional drives which provides a simpler current control and reduced switching losses. © 2020 Elsevier B.V., All rights reserved.