Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Citation - Scopus: 5Identifying Taxonomic Biomarkers of Colorectal Cancer in Human Intestinal Microbiota Using Multiple Feature Selection Methods(Institute of Electrical and Electronics Engineers Inc., 2022-09-07) Jabeer, Amhar; Kocak, Aysegul; Akkaş, Huseyin; Yenisert, Ferhan; Nalbantoĝlu, Özkan Ufuk; Yousef, Malik; Bakir-Güngör, Burcu; Bakir Gungor, BurcuA variety of bacterial species called gut microbiota work together to maintain a steady intestinal environment. The gastrointestinal tract contains tremendous amount of different species including archaea, bacteria, fungi, and viruses. While these organisms are crucial immune system stabilizers, the dysbiosis of the intestinal flora has been related to gastrointestinal disorders including Colorectal cancer (CRC), intestinal cancer, irritable bowel syndrome and inflammatory bowel disease. In the last decade, next-generation sequencing (NGS) methods have accelerated the identification of human gut flora. CRC is a deathly condition that has been on the rise in the last century, affecting half a million people each year. Since early CRC diagnosis is critical for an effective treatment, there is an immediate requirement for a classification system that can expedite CRC diagnosis. In this study, via analyzing the available metagenomics data on CRC, we aim to facilitate the CRC diagnosis via finding biomarkers linked with CRC, and via building a classification model. We have obtained the metagenomic sequencing data of the healthy individuals and CRC patients from a metagenome-wide association analysis and we have classified this data according to the disease stages. Conditional Mutual Information Maximization (CMIM), Fast Correlation Based Filter (FCBF), Extreme Gradient Boosting (XGBoost), min redundancy max relevance (mRMR), Information Gain (IG) and Select K Best (SKB) feature selection algorithms were utilized to cope with the complexity of the features. We observed that the SKB, IG, and XGBoost techniques made significant contributions to decrease the microbiota in use for CRC diagnosis, thereby reducing cost and time. We realized that our Random Forest classifier outperformed Adaboost, Support Vector Machine, Decision Tree, Logitboost and stacking ensemble classifiers in terms of CRC classification performance. Our results reiterated some known and some potential microbiome associated mechanisms in CRC, which could aid the design of new diagnostics based on the microbiome. © 2022 Elsevier B.V., All rights reserved.Conference Object Citation - WoS: 23Citation - Scopus: 52Evaluation of Classification Algorithms, Linear Discriminant Analysis and a New Hybrid Feature Selection Methodology for the Diagnosis of Coronary Artery Disease(Institute of Electrical and Electronics Engineers Inc., 2018-12) Kolukisa, Burak; Hacilar, Hilal; Göy, Gökhan; Kus, Mustafa; Bakir-Güngör, Burcu; Aral, Atilla; Güngör, Vehbi ÇağrıAccording to the World Health Organization (WHO), 31% of the world's total deaths in 2016 (17.9 million) was due to cardiovascular diseases (CVD). With the development of information technologies, it has become possible to predict whether people have heart diseases or not by checking certain physical and biochemical values at a lower cost. In this study, we have evalated a set of different classification algorithms, linear discriminant analysis and proposed a new hybrid feature selection methodology for the diagnosis of coronary heart diseases (CHD). Throughout this research effort, using three publicly available Heart Disease diagnosis datasets (UCI Machine Learning Repository), we have conducted comparative performance evaluations in terms of accuracy, sensitivity, specificity, F-measure, AUC and running time. © 2023 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 3A Hybrid Adaptive Neuro-Fuzzy Inference System (ANFIS) Approach for Professional Bloggers Classification(Institute of Electrical and Electronics Engineers Inc., 2019-11) Asim, Yousra; Raza, Basit; Malik, Ahmad Kamran Kamran; Shahid, Ahmad Raza; Faheem, Muhammed Yasir; Kumar, Y. J.Despite their small numbers, some users of the online social networks demonstrate the ability to influence others. Bloggers are one of such kind of users that through their ideas and opinions on different topics, influence other users. Their identification may be beneficial for several purposes, such as online marketing for products. Much effort has been expanded towards finding the impact of such bloggers within the blogging community. We have expanded on their work by identifying influential bloggers using labeled data. We have improved upon the accuracy of the classification of professional and nonprofessional bloggers. We have made use of Adaptive Neuro-Fuzzy Inference System (ANFIS), and the Fuzzy Inference System (FIS) models. Their performance has been gauged and compared with the existing techniques and approaches, such as an Artificial Neural Network (ANN), Alternating Decision Tree (ADTree) algorithm, and Classification Based on Associations (CBA) algorithm. Adaptive techniques (ANFIS and ANN) are found better than the aforementioned rule-based classifiers. The FIS model outperformed the CBA algorithm, but showed similar performance to the ADTree algorithm. Our proposed ANFIS model showed improved results in terms of performance measures with 93% accuracy for blogger classification. © 2020 Elsevier B.V., All rights reserved.Conference Object Population Specific Classification of Colorectal Cancer With Meta-Analysis of Metagenomic Data(Institute of Electrical and Electronics Engineers Inc., 2023-10-11) Temiz, Mustafa; Yousef, Malik; Bakir-Güngör, BurcuAdvances in next-generation sequencing and '-omics' technologies makes it possible to characterize the human gut microbiome. While some of these microorganisms are important regulators of our immune system, modulation of the microbiota leads to a variety of diseases. Colorectal cancer (CRC), the third most common cancer worldwide, is caused by genetic mutations, environmental conditions, and abnormalities in the gut microbiota. Using various machine learning methods and meta-analysis techniques, this study aims to build a classification model that can help in CRC diagnosis by analyzing metagenomic datasets of different populations obtained at the species level. Using 8 different countries and 9 different metagenomic datasets, 3 different meta-analyzes are performed: within-population, cross-population, and one population is selected for testing and the rest is used as a training dataset (LODO). For CRC classification, 4 different classification algorithms (Random Forest (RF), Logitboost, Adaboost, and Decision Tree (DT)) are used. The best performance among these methods was obtained with the Random Forest algorithm with an AUC of 0.98 by using JP for the training data set and JPN populations for the test data set in the cross-population performance evaluation. © 2023 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 3İki Durumlu Bir Beyin Bilgisayar Arayüzünde Özellik Çıkarımı ve Sınıflandırma(Institute of Electrical and Electronics Engineers Inc., 2016-10) Altindis, Fatih; Yilmaz, BulentBrain Computer Interface (BCI) technology is used to help patients who do not have control over motor neurons such as ALS or paralyzed patients, to communicate with outer world. This work aims to classify motor imageries using real-time EEG dataset, which was published by Graz University, Austria. The dataset consists of two-channel EEG signals of right-hand movement imagery and left-hand movement imagery of 8 subjects. There are a total of 120 motor imagery trials (60 left and 60 right) EEG signals recorded from each subject. EEG signals are filtered and feature vectors were extracted that consist of 24, 32 and 40 relative band power values (RBPV). In this work, feature vectors classified by three different methods, linear discriminant analysis (LDA), K nearest neighbor (KNN) and support vector machines (SVM). Results show that best performance was achieved by 24 RBPV feature vector and LDA classification method. © 2017 Elsevier B.V., All rights reserved.