Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Electrospun PCL/PEG Nanofibers Incorporating Plantago Lanceolata Extract and Clove Oil for Dual-Function Wound Dressings(IOP Publishing Ltd, 2026) Teke, Selin Nur; Yuruk, Adile; Isoglu, Ismail AlperIn this study, we developed electrospun polycaprolactone/polyethylene glycol (PCL/PEG) nanofibers loaded with Plantago lanceolata (P. lanceolata) extract and clove oil to evaluate their combined potential for wound healing and antibacterial activity. PCL/PEG nanofibers were electrospun and post-loaded with P. lanceolata extract at 5%, 10%, and 15% (w/v), together with 1% (v/v) clove oil. Scanning electron microscope analysis showed a uniform, bead-free nanofibrous structure, with fiber diameters ranging from 768 +/- 140 nm to 892 +/- 206 nm and pore sizes from 3.93 +/- 0.97 & micro;m to 6.20 +/- 1.16 & micro;m. The nanofibers exhibited swelling ratios between 103.23 +/- 16.42% and 133.93 +/- 40.45% within 1 h and showed gradual degradation ranging from 25.92 +/- 2.84% to 57.76 +/- 0.92% over 21 d, with cumulative extract release approaching a plateau by day 28 under the experimental conditions. The incorporation of plant extract and essential oil initially increased the water contact angle from 15.97 +/- 1.07 degrees to 48.61 +/- 7.85 degrees, indicating that the nanofiber surface remained hydrophilic; at higher extract contents, the nanofibers transitioned to a superhydrophilic state. Antibacterial activity was primarily governed by clove oil, yielding up to 85.16 +/- 0.36% efficacy against E. coli (E. coli) and 79.90 +/- 0.29% against S. aureus (S. aureus). While P. lanceolata extract alone showed limited antibacterial activity, its presence within clove oil-loaded nanofibers consistently enhanced antibacterial performance at the composite level. In vitro scratch assays demonstrated pronounced wound closure at later time points (72-96 h), particularly for nanofibers containing higher extract concentrations, confirming the dominant contribution of P. lanceolata to the healing response. Overall, the electrospun PCL/PEG nanofibers represent a dual-function wound dressing, with clove oil contributing antibacterial protection and P. lanceolata extract supporting wound healing.Article Citation - WoS: 11Citation - Scopus: 13On the Detailed Mechanical Response Investigation of PHBV/PCL and PHBV/PLGA Electrospun Mats(IOP Publishing Ltd, 2019-03-29) Bal, Burak; Tugluca, Ibrahim Burkay; Koc, Nuray; Isoglu, Ismail AlperIn this study, electrospun mats of pristine poly(epsilon-caprolactone) (PCL), Poly(D, L-lactide-co-glycolide) (PLGA), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), as well as PHBV/PCL blends and PHBV/PLGA blends in different ratios (80:20, 75:25, 50:50, 25:75, 20:80, 10:90, 5:95%, w/w) and Centella Asiatica (CA) loaded (1, 5, 10%, w/v) PHBV/PCL and PHBV/PLGA polyester blends were prepared. Electrospun mats were characterized by scanning electron microscopy (SEM) in order to show uniform and bead and defect-free fiber structure with average diameter. The blend ratio and strain rate dependencies of mechanical behavior of these electrospun membranes were investigated under tensile loading. The tensile tests were conducted at an initial strain rates of 10(-1) s(-1), 10(-2) s(-1), 10(-3) s(-1) and 10(-4) s(-1) at room temperature and the best and worst combinations of PHBV/PLGA, PHBV/PCL blend ratios for both stress and ductility required applications were specified for each strain rate. The effects of blend ratios on the tensile strength and Young's modulus were also investigated. Moreover, the effects of Centella Asiatica on the electrospun membranes' mechanical behavior were demonstrated at different strain rates. Consequently, this study constitutes an important guideline for the selection and usage of the aforementioned electrospun membranes as a wound dressing material in terms of mechanical response at different loading scenarios.