Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
Browse
14 results
Search Results
Conference Object Citation - Scopus: 1The Identification of Discriminative Single Nucleotide Polymorphism Sets for the Classification of Behçet's Disease(Institute of Electrical and Electronics Engineers Inc., 2018-09) Görmez, Yasin; Işik, Yunus Emre; Bakir-Güngör, BurcuBehçet's disease is a long-term multisystem inflammatory disorder, characterized by recurrent attacks affecting several organs. As the genotyping individuals get cheaper and easier following the developments in genomic technologies, genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) are identified. Although several genetic risk factors are identified for Behçet's disease with the help of these studies via scanning around a million of SNPs, these variations could only explain up to 20% of the disease's genetic risk. In this study, for Behçet's disease classification, via comparing all the SNPs genotyped in GWAS, with the SNPs selected via using genetic knowledge, gain ratio and information gain; both reduction in the feature size and improvement in the classification accuracy is aimed. Also, using different classification algorithms such as random forest, k-nearest neighbour and logistic regression, their effects on the classification accuracy are investigated. Our results showed that compared to other feature selection methods, with at least 81% success rate, the selection of the SNPs using the genetic information (of their GWAS p-values, indicating the significance of the SNP against the disease) provides 15% to 42% improvement in all classification algorithms. This improvement is statistically sound. While gain ratio and information gain feature selection techniques yield similar classification accuracies, the models using all SNPs could not exceed 50% accuracies and results in the worst performance. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 7Citation - Scopus: 8The Determination of Distinctive Single Nucleotide Polymorphism Sets for the Diagnosis of Behcet's Disease(IEEE Computer Soc, 2022-05-01) Isik, Yunus Emre; Gormez, Yasin; Aydin, Zafer; Bakir-Gungor, BurcuBehcet's Disease (BD) is a multi-system inflammatory disorder in which the etiology remains unclear. The most probable hypothesis is that genetic tendency and environmental factors play roles in the development of BD. In order to find the essential reasons, genetic changes on thousands of genes should be analyzed. Besides, there is a need for extra analysis to find out which genetic factor affects the disease. Machine learning approaches have high potential for extracting the knowledge from genomics and selecting the representative Single Nucleotide Polymorphisms (SNPs) as the most effective features for the clinical diagnosis process. In this study, we have attempted to identify representative SNPs using feature selection methods, incorporating biological information and aimed to develop a machine-learning model for diagnosing Behcet's disease. By combining biological information and machine learning classifiers, up to 99.64 percent accuracy of disease prediction is achieved using only 13,611 out of 311,459 SNPs. In addition, we revealed the SNPs that are most distinctive by performing repeated feature selection in cross-validation experiments.Article Citation - Scopus: 6Network Intrusion Detection Based on Machine Learning Strategies: Performance Comparisons on Imbalanced Wired, Wireless, and Software-Defined Networking (SDN) Network Traffics(Turkiye Klinikleri, 2024-07-26) Hacilar, Hilal; Aydin, Zafer; Güngör, Vehbi ÇağrıThe rapid growth of computer networks emphasizes the urgency of addressing security issues. Organizations rely on network intrusion detection systems (NIDSs) to protect sensitive data from unauthorized access and theft. These systems analyze network traffic to detect suspicious activities, such as attempted breaches or cyberattacks. However, existing studies lack a thorough assessment of class imbalances and classification performance for different types of network intrusions: wired, wireless, and software-defined networking (SDN). This research aims to fill this gap by examining these networks’ imbalances, feature selection, and binary classification to enhance intrusion detection system efficiency. Various techniques such as SMOTE, ROS, ADASYN, and SMOTETomek are used to handle imbalanced datasets. Additionally, eXtreme Gradient Boosting (XGBoost) identifies key features, and an autoencoder (AE) assists in feature extraction for the classification task. The study evaluates datasets such as AWID, UNSW, and InSDN, yielding the best results with different numbers of selected features. Bayesian optimization fine-tunes parameters, and diverse machine learning algorithms (SVM, kNN, XGBoost, random forest, ensemble classifiers, and autoencoders) are employed. The optimal results, considering F1-measure, overall accuracy, detection rate, and false alarm rate, have been achieved for the UNSW-NB15, preprocessed AWID, and InSDN datasets, with values of [0.9356, 0.9289, 0.9328, 0.07597], [0.997, 0.9995, 0.9999, 0.0171], and [0.9998, 0.9996, 0.9998, 0.0012], respectively. These findings demonstrate that combining Bayesian optimization with oversampling techniques significantly enhances classification performance across wired, wireless, and SDN networks when compared to previous research conducted on these datasets. © 2024 Elsevier B.V., All rights reserved.Conference Object Citation - WoS: 16Citation - Scopus: 20Machine Learning Analysis of Inflammatory Bowel Disease-Associated Metagenomics Dataset(Institute of Electrical and Electronics Engineers Inc., 2018-09) Hacilar, Hilal; Nalbantoĝlu, Özkan Ufuk; Bakir-Güngör, BurcuThere is an ongoing interplay between humans and our microbial communities. The microorganisms living in our gut produce energy from our food, strengthen our immune system, break down foreign products, and release metabolites and hormones, which are significant for regulating our physiology. The shifts away from this 'healthy' gut microbiome is considered to be associated with many diseases. Inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis, are gut related disorders affecting the intestinal tract. Although some metagenomics studies are conducted on IBD recently, our current understanding of the precise relationships between the human gut microbiome and IBD remains limited. In this regard, the use of state-of-the art machine learning approaches became popular to address a variety of questions like early diagnosis of certain diseases using human microbiota. In this study, we investigate which subset of gut microbiota are mostly associated with IBD and if disease-associated biomarkers can be detected via applying state-of-the art machine learning algorithms and proper feature selection methods. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 4Citation - Scopus: 7IGPRED-Multitask: A Deep Learning Model to Predict Protein Secondary Structure, Torsion Angles and Solvent Accessibility(IEEE Computer Soc, 2023-03-01) Gormez, Yasin; Aydin, ZaferProtein secondary structure, solvent accessibility and torsion angle predictions are preliminary steps to predict 3D structure of a protein. Deep learning approaches have achieved significant improvements in predicting various features of protein structure. In this study, IGPRED-Multitask, a deep learning model with multi task learning architecture based on deep inception network, graph convolutional network and a bidirectional long short-term memory is proposed. Moreover, hyper-parameters of the model are fine-tuned using Bayesian optimization, which is faster and more effective than grid search. The same benchmark test data sets as in the OPUS-TASS paper including TEST2016, TEST2018, CASP12, CASP13, CASPFM, HARD68, CAMEO93, CAMEO93_HARD, as well as the train and validation sets, are used for fair comparison with the literature. Statistically significant improvements are observed in secondary structure prediction on 4 datasets, in phi angle prediction on 2 datasets and in psi angel prediction on 3 datasets compared to the state-of-the-art methods. For solvent accessibility prediction, TEST2016 and TEST2018 datasets are used only to assess the performance of the proposed model.Article Citation - Scopus: 5Hyperplastic and Tubular Polyp Classification Using Machine Learning and Feature Selection(Elsevier B.V., 2024) Doǧan, Refika Sultan; Akay, Ebru; Doǧan, Serkan; Yilmaz, BulentPurpose: The aim of this study is to develop an effective approach for differentiating between hyperplastic and tubular adenoma colon polyps, which is one of the most difficult tasks in colonoscopy procedures. The main research challenge is how to improve the classification of these polyp subtypes applying various focusing levels on the polyp images, data preprocessing approaches, and classification algorithms. Methods: This study employed 202 colonoscopy videos from a total of 201 patients, focusing on 59 videos containing hyperplastic and tubular adenoma polyps. Manually extract key frames and several feature extraction and classification techniques were applied. The influence of different datasets with various focuses as well as data preprocessing steps on the performance of classification was examined, and AUC values were calculated using ten classifiers. Results: The study discovered that the optimal dataset, data preprocessing method, and classification algorithm all had significant effects on classification results. The Random Forest model with the Recursive Feature Elimination (RFE) feature selection approach, for example, consistently outperformed other models and achieved the highest AUC value of 0.9067. In terms of accuracy, F1 score, recall, and AUC, the suggested model outperformed a gastroenterologist, nevertheless precision remained slightly lower. Conclusion: This study emphasizes the importance of dataset selection, data preprocessing, and feature selection in enhancing the classification of difficult colon polyp subtypes. The suggested model offers a promising model for the clinical differentiation of hyperplastic and tubular adenoma polyps, potentially improving diagnostic accuracy in gastroenterology. © 2024 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 19A Novel Feature Design and Stacking Approach for Non-Technical Electricity Loss Detection(Institute of Electrical and Electronics Engineers Inc., 2018-05) Aydin, Zafer; Güngör, Vehbi ÇağrıNon-technical electricity losses continue to jeopardize economic and social well-being of many countries. In this work, we develop machine learning classifiers that can identify anomalous electricity consumption in Turkey. Starting from weekly electricity usage data, we develop new features that capture statistical and frequency domain characteristics of the customers and their consumption patterns. We analyze the effect of reducing number of feature descriptors through dimensionality reduction and feature selection techniques. To overcome the class imbalance problem, we implement several ensemble methods and compare their prediction accuracy to those of the standard classifiers. The proposed features and combining strengths of different classifiers bring significant improvements on performance metrics, which is demonstrated through detailed simulations on shopping mall sector. We anticipate that advances in this field will contribute to the economies considerably. © 2018 Elsevier B.V., All rights reserved.Article Citation - WoS: 2Citation - Scopus: 3A Comprehensive Study on Automatic Non-Informative Frame Detection in Colonoscopy Videos(Wiley, 2024-01) Kacmaz, Rukiye Nur; Dogan, Refika Sultan; Yilmaz, BuelentDespite today's developing healthcare technology, conventional colonoscopy is still a gold-standard method to detect colon abnormalities. Due to the folded structure of the intestine and visual disturbances caused by artifacts, it can be hard for specialists to detect abnormalities during the procedure. Frames that include artifacts such as specular reflection, improper contrast levels from insufficient or excessive illumination gastric juice, bubbles, or residuals should be detected to increase an accurate diagnosis rate. In this work, both conventional machine learning and transfer learning methods have been used to detect non-informative frames in colonoscopy videos. The conventional machine learning part consists of 5 different types of texture features, which are gray level co-occurrence matrix (GLCM), gray level run length matrix (GLRLM), neighborhood gray-tone difference matrix (NGTDM), focus measure operators (FMOs), and first-order statistics. In addition to these methods, we utilized 8 different transfer learning models: AlexNet, SqueezeNet, GoogleNet, ShuffleNet, ResNet50, ResNet18, NasNetMobile, and MobileNet. The results showed that FMOs and decision tree combination gave the best accuracy and f-measure values with almost 89% and 0.79%, respectively, for the conventional machine learning part. When the transfer learning part is taken into account, AlexNet (99.85%) and SqueezeNet (98.80%) have the highest performance metric results. This study shows the potential of both transfer learning and conventional machine learning algorithms to provide fast and accurate non-informative frame detection to be used during a colonoscopy, which may be considered the initial step in identifying and classifying colon-related diseases automatically to help guide physicians.Conference Object Citation - Scopus: 3İki Durumlu Bir Beyin Bilgisayar Arayüzünde Özellik Çıkarımı ve Sınıflandırma(Institute of Electrical and Electronics Engineers Inc., 2016-10) Altindis, Fatih; Yilmaz, BulentBrain Computer Interface (BCI) technology is used to help patients who do not have control over motor neurons such as ALS or paralyzed patients, to communicate with outer world. This work aims to classify motor imageries using real-time EEG dataset, which was published by Graz University, Austria. The dataset consists of two-channel EEG signals of right-hand movement imagery and left-hand movement imagery of 8 subjects. There are a total of 120 motor imagery trials (60 left and 60 right) EEG signals recorded from each subject. EEG signals are filtered and feature vectors were extracted that consist of 24, 32 and 40 relative band power values (RBPV). In this work, feature vectors classified by three different methods, linear discriminant analysis (LDA), K nearest neighbor (KNN) and support vector machines (SVM). Results show that best performance was achieved by 24 RBPV feature vector and LDA classification method. © 2017 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 3Protein İkincil Yapı Tahmini Için Makine Öǧrenmesi Yöntemlerinin Karşılaştırılması(Institute of Electrical and Electronics Engineers Inc., 2018-05) Aydin, Zafer; Kaynar, Oǧuz; Görmez, Yasin; Işik, Yunus EmreThree-dimensional structure prediction is one of the important problems in bioinformatics and theoretical chemistry. One of the most important steps in the three-dimensional structure prediction is the estimation of secondary structure. Due to rapidly growing databases and recent feature extraction methods datasets used for predicting secondary structure can potentially contain a large number of samples and dimensions. For this reason, it is important to use algorithms that are fast and accurate. In this study, various classification algorithms have been optimized for the second phase of a two-stage classifier on EVAset benchmark both in the original input space and in the space reduced using the information gain metric. The most accurate classifier is obtained as the support vector machine while the extreme learning machine is significantly faster in model training. © 2018 Elsevier B.V., All rights reserved.