Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
Browse
3 results
Search Results
Article Evaluation of HOTAIR, HOXD8, HOXD9, HOXD11 Gene Expression Levels in Turkish Patients With Acute and Chronic Myeloid Leukemia: A Single Center Experience(Cellular and Molecular Biology Association, 2024-11-27) Saraymen, Esma; Erdem, Yakut; Akalin, Hilal Ünlü; Taşçıoğlu, Nazife; Saraymen, Berkay; Celik, Serhat; Özkul, Yusuf T.Homeobox (HOX) transcript antisense RNA (HOTAIR) and HOX genes are reported to be more expressed in various cancers in humans in recent studies. The role of HOTAIR and HOXD genes in acute myeloid leukemia (AML) and chronic myeloid leukemia (CML) is not well known. In this study, expression levels of HOXD8, HOXD9 and HOXD11 from HOXD gene family and HOTAIR were determined from peripheral blood samples of 30 AML and 30 CML patients and 20 healthy volunteers by quantitative Real Time PCR. We determined that the expression levels of HOXD9 and HOXD11 in the AML patients were significantly lower than the control group (p<0.001 and p=0.002, respectively). There was no significant difference in the expression levels of HOTAIR and HOXD8 when compared to the control group. In the CML patients there was a significant increase in the expression level of HOTAIR when compared to the control group (p=0.002). The expression levels of HOXD9 and HOXD11 were found to be significantly lower than the control group (p<0.001). Our study showed that HOTAIR may not be a biomarker in the diagnosis and is not significantly correlated with the clinicopathological prognostic characteristics of AML. Additionally; it can be said that HOTAIR is oncogenic by suppressing the expression of HOXD9 and HOXD11 but not HOXD8 in CML patients. The expression profiles of HOTAIR may be a potential biomarker in the diagnosis of CML patients in predicting and monitoring drug resistance. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 21Citation - Scopus: 26Convenient Site Selection of a Floating PV Power Plant in Türkiye by Using GIS-Fuzzy Analytical Hierarchy Process(Springer Heidelberg, 2024-02-28) Karipoglu, Fatih; Koca, Kemal; Ilbahar, EsraFloating photovoltaics (FPVs) are appearing as a promising and an alternative renewable energy opinion in which PV panels are mounted on floating platforms in order to produce electricity from renewable energy on water such as seas, dams, rivers, oceans, canals, fish farms, and reservoirs. So far, such studies related to the body knowledge on financial, technical, and environmental aspects of installation of FPV have not been performed in Turkey while expanding steadily in other countries. In this study, suitable site selection for installation of FPV power plants on three lakes in Turkey was studied by performing geographic information system (GIS) and the fuzzy analytic hierarchy process (FAHP) as multi-criteria decision-making (MCDM) method. This detailed study revealed that the criterion of global horizontal irradiance (GHI) was determined as the most crucial criterion for the installation of FPV on Beysehir Lake, Lake of Tuz, and Van Lake. Additionally, it was clearly seen that the Beysehir Lake had the highest value approximately 52% among other lakes for installation, that is why Beysehir Lake is selected as the best option for installation of an FPV system with this multi-criteria approach.Article Citation - Scopus: 5Barriers to Strategy Implementation in Turkey’s Healthcare Industry: Hospital Manager Perspectives(Informa UK Ltd, 2021-08-02) Ocak, Saffet; Aladag, Omer Faruk; Köseoglu, Mehmet Ali; King, Brian E.M.Although strategy implementation has profound implications for delivering efficient service, it has been largely neglected in the healthcare management literature. This study explores the barriers to effective implementation of strategic plans in healthcare organizations. To achieve this end, empirical data were collected from 185 hospital managers in Turkey using a survey-based methodology. A descriptive analysis was undertaken of the survey responses to determine the most important barriers to strategy implementation. The most significant barriers undermining strategy implementation efforts were found to be: low employee motivation, an exclusive focus on financial performance and lack of consensus among decision makers. © 2023 Elsevier B.V., All rights reserved.