Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Citation - Scopus: 1The Identification of Discriminative Single Nucleotide Polymorphism Sets for the Classification of Behçet's Disease(Institute of Electrical and Electronics Engineers Inc., 2018-09) Görmez, Yasin; Işik, Yunus Emre; Bakir-Güngör, BurcuBehçet's disease is a long-term multisystem inflammatory disorder, characterized by recurrent attacks affecting several organs. As the genotyping individuals get cheaper and easier following the developments in genomic technologies, genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) are identified. Although several genetic risk factors are identified for Behçet's disease with the help of these studies via scanning around a million of SNPs, these variations could only explain up to 20% of the disease's genetic risk. In this study, for Behçet's disease classification, via comparing all the SNPs genotyped in GWAS, with the SNPs selected via using genetic knowledge, gain ratio and information gain; both reduction in the feature size and improvement in the classification accuracy is aimed. Also, using different classification algorithms such as random forest, k-nearest neighbour and logistic regression, their effects on the classification accuracy are investigated. Our results showed that compared to other feature selection methods, with at least 81% success rate, the selection of the SNPs using the genetic information (of their GWAS p-values, indicating the significance of the SNP against the disease) provides 15% to 42% improvement in all classification algorithms. This improvement is statistically sound. While gain ratio and information gain feature selection techniques yield similar classification accuracies, the models using all SNPs could not exceed 50% accuracies and results in the worst performance. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 15Citation - Scopus: 15PriPath: Identifying Dysregulated Pathways From Differential Gene Expression via Grouping, Scoring, and Modeling With an Embedded Feature Selection Approach(BMC, 2023-02-23) Yousef, Malik; Ozdemir, Fatma; Jaber, Amhar; Allmer, Jens; Bakir-Gungor, BurcuBackgroundCell homeostasis relies on the concerted actions of genes, and dysregulated genes can lead to diseases. In living organisms, genes or their products do not act alone but within networks. Subsets of these networks can be viewed as modules that provide specific functionality to an organism. The Kyoto encyclopedia of genes and genomes (KEGG) systematically analyzes gene functions, proteins, and molecules and combines them into pathways. Measurements of gene expression (e.g., RNA-seq data) can be mapped to KEGG pathways to determine which modules are affected or dysregulated in the disease. However, genes acting in multiple pathways and other inherent issues complicate such analyses. Many current approaches may only employ gene expression data and need to pay more attention to some of the existing knowledge stored in KEGG pathways for detecting dysregulated pathways. New methods that consider more precompiled information are required for a more holistic association between gene expression and diseases.ResultsPriPath is a novel approach that transfers the generic process of grouping and scoring, followed by modeling to analyze gene expression with KEGG pathways. In PriPath, KEGG pathways are utilized as the grouping function as part of a machine learning algorithm for selecting the most significant KEGG pathways. A machine learning model is trained to differentiate between diseases and controls using those groups. We have tested PriPath on 13 gene expression datasets of various cancers and other diseases. Our proposed approach successfully assigned biologically and clinically relevant KEGG terms to the samples based on the differentially expressed genes. We have comparatively evaluated the performance of PriPath against other tools, which are similar in their merit. For each dataset, we manually confirmed the top results of PriPath in the literature and found that most predictions can be supported by previous experimental research.ConclusionsPriPath can thus aid in determining dysregulated pathways, which applies to medical diagnostics. In the future, we aim to advance this approach so that it can perform patient stratification based on gene expression and identify druggable targets. Thereby, we cover two aspects of precision medicine.Conference Object Multi-Method Text Summarization: Evaluating Extractive and BART-Based Approaches on CNN/Daily Mail(Institute of Electrical and Electronics Engineers Inc., 2025-06-27) Inal, Yasin; Bakal, Gokhan; Esit, MuhammedWith the exponential growth of digital content, efficient text summarization has become increasingly crucial for managing information overload. This paper presents a comprehensive approach to text summarization using both extractive and abstractive methods, implemented on the CNN/Daily Mail dataset. We leverage pre-trained BART (Bidirectional and AutoRegressive Transformers) models and fine-tuning techniques to generate high-quality summaries. Our approach demonstrates significant improvements, with our best model trained on 287 k samples achieving ROUGE-1 F1 scores of 0.4174, ROUGE-2 F1 scores of 0.1932, and ROUGE-L F1 scores of 0.2910. We provide detailed comparisons between extractive methods and various BART model configurations, analyzing the impact of training dataset size and model architecture on summarization quality. Additionally, we share our implementation through an opensource NLP toolkit to facilitate further research and practical applications in the field. © 2025 Elsevier B.V., All rights reserved.Article Citation - WoS: 3Citation - Scopus: 4Investigating the Carbon Border Adjustment Mechanism Transition Process With Linguistic Summarization Method: A Situational Analysis of Exporting Countries(Elsevier Sci Ltd, 2024-08) Fidan, Fatma Sener; Aydogan, Sena; Akay, Diyar; Şener Fidan, FatmaThe Paris Agreement holds significant importance since it establishes a global framework for addressing the issue of climate change and endeavors to mitigate the release of greenhouse gases. The Carbon Border Adjustment Mechanism was introduced as an integral component of this agreement, aiming to oversee the carbon emissions associated with imported items within the European Union and provide compensation for the emissions from the nations engaged in importation. It is essential to analyze the countries involved in exporting to the European Union within the Carbon Border Adjustment Mechanism context to mitigate carbon leakage and effectively support the objectives outlined in the Paris Agreement. This research investigated 104 nations engaged in exporting activities to 27 European Union member countries. The linguistic summarization method, a descriptive data analytics tool, was employed for the analysis. A total of 42 Combined Nomenclature codes were encompassed within the scope of evaluation throughout the transition phase of the Carbon Border Adjustment Mechanism. This study examines the characteristics of exporting nations based on three variables: The Environmental Performance Index, a sustainability indicator; the Region in which the countries are located as classified by the World Bank; and the quantity of Renewable Energy Consumption. Additionally, the study explores the characteristics of EU countries, focusing on their Environmental Performance Index score and geography. The study employed fuzzy sets and the fuzzy c-means algorithm as parts of the linguistic summarization technique. Polyadic quantifiers were used to extract linguistic summaries, resulting in the acquisition of 124,227 summaries. A total of 1594 summaries have a truth degree exceeding 0.9. The findings were effectively utilized to assess the influence of the linguistic summarization approach and offered a valuable viewpoint for decisionmakers needing more expertise in this domain.Article Citation - WoS: 4Citation - Scopus: 4Integrated Querying and Version Control of Context-Specific Biological Networks(Oxford Univ Press, 2020) Cowman, Tyler; Coskun, Mustafa; Grama, Ananth; Koyuturk, MehmetMotivation: Biomolecular data stored in public databases is increasingly specialized to organisms, context/pathology and tissue type, potentially resulting in significant overhead for analyses. These networks are often specializations of generic interaction sets, presenting opportunities for reducing storage and computational cost. Therefore, it is desirable to develop effective compression and storage techniques, along with efficient algorithms and a flexible query interface capable of operating on compressed data structures. Current graph databases offer varying levels of support for network integration. However, these solutions do not provide efficient methods for the storage and querying of versioned networks. Results: We present VerTIoN, a framework consisting of novel data structures and associated query mechanisms for integrated querying of versioned context-specific biological networks. As a use case for our framework, we study network proximity queries in which the user can select and compose a combination of tissue-specific and generic networks. Using our compressed version tree data structure, in conjunction with state-of-the-art numerical techniques, we demonstrate real-time querying of large network databases. Conclusion: Our results show that it is possible to support flexible queries defined on heterogeneous networks composed at query time while drastically reducing response time for multiple simultaneous queries. The flexibility offered by VerTIoN in composing integrated network versions opens significant new avenues for the utilization of ever increasing volume of context-specific network data in a broad range of biomedical applications. Availability and Implementation: VerTIoN is implemented as a C++ library and is available at http://compbio.case.edu/omics/software/vertion and https://github.com/tjcowman/vertion Contact: tyler.cowman@case.eduConference Object Identify Commonly Affected Pathways in Psychiatric Diseases(Institute of Electrical and Electronics Engineers Inc., 2018-09) Bulut, Umit; Bakir-Güngör, BurcuGenome-wide association studies (GWAS) are an extraordinary source of information when it comes to revealing the common variations of human complex diseases. Until now, the large amount of data generated from these studies have not been shown its full potential enough to identify the molecular and functional framework to be able to understand how a molecular system works. Following a more specific perspective, this study focused on the identification of commonly affected pathways of psychiatric diseases. The pathway term as used in molecular biology, depicts a simplified model of a process within the cell or tissue. Lately, several GWAS datasets are publicly available for various disease types such as psychiatric, immune-related, neurodegenerative, cardiovascular and such. A study on each disease and pairwise comparison to understand the behavior of disease and system would be time consuming and exhaustive. Instead of handling the results of these studies one by one, grouping diseases by target points is a more efficient way. This work aims to get one step closer to reveal key points of diseases and target these points to develop personalized medicine approaches. Especially for complex diseases, every drug doesn't show the same effect in every people. This paper contains the definition of molecular pathways, methods to identify disease related pathways, and to find common pathways pairwise in psychiatric diseases. © 2019 Elsevier B.V., All rights reserved.Conference Object Generating Linguistic Advice for the Carbon Limit Adjustment Mechanism(Springer Science and Business Media Deutschland GmbH, 2023-10-02) Fidan, Fatma Şener; Aydogan, Sena; Akay, DiyarLinguistic summarization, a subfield of data mining, generates summaries in natural language for comprehending big data. This approach simplifies the incorporation of information into decision-making processes since no specialized knowledge is needed to understand the generated language summaries. The present research employs linguistic summarization to examine the circumstances surrounding the Carbon Border Adjustment Mechanism, one of the most significant regulations confronting exporting nations to the European Union, and will be adopted to support sustainable growth. In this paper, associated with several attributes of the countries and product flow from exporting countries to European countries were defined as nodes and relations, respectively. Before the modeling phase, fuzzy c-means automatically identified fuzzy sets and membership degrees of attributes. During the modeling phase, summary forms were generated using polyadic quantifiers. A total of 1944 linguistic summaries were produced between exporting countries and European countries. Thirty-five summaries have a truth degree greater than or equal to the threshold value of 0.9, which is considered reasonable. The provision of natural language descriptions of the Carbon Border Adjustment Mechanism is intended to aid decision-makers and policymakers in their deliberations. © 2023 Elsevier B.V., All rights reserved.Conference Object Citation - WoS: 2Citation - Scopus: 4Data Mining Techniques in Direct Marketing on Imbalanced Data Using Tomek Link Combined With Random Under-Sampling(Assoc Computing Machinery, 2021-05-27) Yilmaz, Umit; Gezer, Cengiz; Aydin, Zafer; Gungor, V. CaGri; Yllmaz, Ümit; Aydln, ZaferDetermining the potential customers is very important in direct marketing. Data mining techniques are one of the most important methods for companies to determine potential customers. However, since the number of potential customers is very low compared to the number of non-potential customers, there is a class imbalance problem that significantly affects the performance of data mining techniques. In this paper, different combinations of basic and advanced resampling techniques such as Synthetic Minority Over-sampling Technique (SMOTE), Tomek Link, RUS, and ROS were evaluated to improve the performance of customer classification. Different feature selection techniques are used in order the decrease the number of non-informative features from the data such as Information Gain, Gain Ratio, Chi-squared, and Relief. Classification performance was compared and utilized using several data mining techniques, such as LightGBM, XGBoost, Gradient Boost, Random Forest, AdaBoost, ANN, Logistic Regression, Decision Trees, SVC, Bagging Classifier based on ROC AUC and sensitivity metrics. A combination of Tomek Link and Random Under-Sampling as a resampling technique and Chi-squared method as feature selection algorithm showed superior performance among the other combinations. Detailed performance evaluations demonstrated that with the proposed approach, LightGBM, which is a gradient boosting algorithm based on decision tree, gave the best results among the other classifiers with 0.947 sensitivity and 0.896 ROC AUC value.Conference Object Citation - Scopus: 21Assessing Employee Attrition Using Classifications Algorithms(Association for Computing Machinery, 2020-05-15) Ozdemir, Fatma; Cos¸kun, Mustafa; Gezer, Cengiz; Güngör, Vehbi Çağrı; Coskun, Mustafa; Cagri Gungor, V.Employees leave an organization when other organizations offer better opportunities than their current organizations. Continuity and sustenance and even completion of jobs are crucial issues for the companies not to suffer financial losses. Especially if the talented employees, who are at critical positions in the companies, leave the job, it becomes difficult for the organizations to maintain their businesses. Today, organizations would like to predict attrition of their employees and plan and prepare for it. However, the HR departments of organizations are not advanced enough to make such predictions in a handcrafted manner. For this reason, organizations are looking for new systems or methods that automatize the prediction of employee attrition utilizing data mining methods. In this study, we use IBM HR data set and apply different classification methods, such as Support Vector Machine (SVM), Random Forest, J48, LogitBoost, Multilayer Perceptron (MLP), K-Nearest Neighbors (KNN), Linear Discriminant Analysis (LDA), Naive Bayes, Bagging, AdaBoost, Logistic Regression, to predict the employee attrition. Different from exiting studies, we systematically evaluate our findings with various classification metrics, such as F-measure, Area Under Curve, accuracy, sensitivity, and specificity. We observe that data mining methods can be useful for predicting the employee attrition. © 2022 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 7A Comparative Analysis on Medical Article Classification Using Text Mining & Machine Learning Algorithms(Institute of Electrical and Electronics Engineers Inc., 2021-09-15) Kolukisa, Burak; Dedeturk, Bilge Kagan; Dedeturk, Beyhan Adanur; Gulsen, Abdulkadir; Bakal, Gokhan; Guisen, AbdulkadirThe document classification task is one of the widely studied research fields on multiple domains. The core motivation of the classification task is that the manual classification efforts are impractical due to the exponentially growing document volumes. Thus, we densely need to exploit automated computational approaches, such as machine learning models along with data & text mining techniques. In this study, we concentrated on the classification of medical articles specifically on common cancer types, due to the significance of the field and the decent number of available documents of interest. We deliberately targeted MEDLINE articles about common cancer types because most cancer types share a similar literature composition. Therefore, this situation makes the classification effort relatively more complicated. To this end, we built multiple machine learning models, including both traditional and deep learning architectures. We achieved the best performance (R¿82% F score) by the LSTM model. Overall, our results demonstrate a strong effect of exploiting both text mining and machine learning methods to distinguish medical articles on common cancer types. © 2022 Elsevier B.V., All rights reserved.