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Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Conference Object
    Citation - Scopus: 1
    Drug Repositioning via Entity Transformation in Biomedical Knowledge Systems
    (Springer Science and Business Media Deutschland GmbH, 2025) Erkantarci, B.; Bakal, G.
    The drug discovery process for known diseases is crucial in bioinformatics, given the extensive clinical trials, regulatory approvals, and high costs. Computational in silico methods are essential to mitigate these challenges, as they help identify promising drug candidates, thereby reducing the time and cost associated with drug discovery. An effective strategy in this domain is drug repositioning, where existing drugs, already approved for one disease, are repurposed for treating another. This approach is advantageous as it leverages the established safety profiles of existing drugs, avoiding toxic effects on human metabolism. In this effort, we employed a translational entity embedding-based neural network model to advance drug repositioning efforts. We utilize the Semantic Medline Database (SemMedDB) as the primary source of biomedical entity relationships for model training. The model is validated using repoDB, a gold standard dataset for drug repositioning. Technically, the model will learn to minimize the vector distance between related entities. This distance will serve as the basis for predicting potential drug-disease pairs in drug repositioning, offering a novel computational method to expedite the drug discovery process. © 2025 Elsevier B.V., All rights reserved.
  • Conference Object
    Citation - WoS: 7
    Citation - Scopus: 10
    PI-Controlled ANN-Based Energy Consumption Forecasting for Smart Grids
    (SciTePress, 2015) Gezer, Gülsüm; Tuna, Gürkan; Κogias, DImitrios G.; Gülez, Kayhan; Güngör, Vehbi Çağrı; Kogias, Dimitris
    Although Smart Grid (SG) transformation brings many advantages to electric utilities, the longstanding challenge for all them is to supply electricity at the lowest cost. In addition, currently, the electric utilities must comply with new expectations for their operations, and address new challenges such as energy efficiency regulations and guidelines, possibility of economic recessions, volatility of fuel prices, new user profiles and demands of regulators. In order to meet all these emerging economic and regulatory realities, the electric utilities operating SGs must be able to determine and meet load, implement new technologies that can effect energy sales and interact with their customers for their purchases of electricity. In this respect, load forecasting which has traditionally been done mostly at city or country level can address such issues vital to the electric utilities. In this paper, an artificial neural network based energy consumption forecasting system is proposed and the efficiency of the proposed system is shown with the results of a set of simulation studies. The proposed system can provide valuable inputs to smart grid applications. © 2022 Elsevier B.V., All rights reserved.
  • Conference Object
    Modelling of Rock Comminution Using Statistical and Soft Computing Analyses – A Case Study on a Laboratory-Scale Jaw Crusher
    (Baski, 2022) Köken, E.
    The present study encompasses a quantitative investigation on rock comminution using statistical and soft computing analyses. For this purpose, physical and mechanical rock aggregate properties were determined for nine different rock types (R1-R9) in Turkey. Then, crushability tests were performed to determine the size reduction ratio (SRR) using a laboratory-scale jaw crusher. Based on statistical and soft computing analyses, five different predictive models (M1 to M5) were established to estimate the SRR in this study. Consequently, the SRR values are associated with water absorption by weight (w<inf>a</inf>), dry unit weight (γ<inf>d</inf>), and aggregate impact value (AIV) of the investigated rocks. However, the individual use of these independent variables results in undulating SRR estimations. Therefore, among the established predictive models, the empirical formulation based on artificial neural networks (ANN) (M5) was found to be the most reliable model with a correlation of determination value (R2) of 0.88. However, the predictive models stated in this study should be implemented to several portable jaw crushers to observe the similarities or difficulties in quantifying SRR as a function of rock properties in future studies. © 2022 Elsevier B.V., All rights reserved.
  • Book Part
    Hosting Capacity Calculation Methods
    (Elsevier, 2025) Oguzhan, Ceylan; Alper, Savasci
    In this chapter, we focus on hosting capacity (HC) calculations, by giving the methods to determine the maximum amount of distributed energy resources (DER) that can be integrated into power distribution network(s) without compromising reliability or performance. We detail methodologies such as power flow-based approaches, probabilistic techniques, and machine learning algorithms, with sample applications of HC calculations. Initially, we focus on power flow-based methods based on simulating power distribution network(s) to assess system voltage, current flow, and stability impacts from DER installations. Then, we will give the probabilistic approaches that use uncertainties in renewable generation and consumer demand, based on statistical techniques and Monte Carlo simulations aiming to reflect these variability. Machine learning (ML) techniques will also be given based on analyzing large data sets, detecting patterns, and predicting system responses. These kinds of methods include regression analysis and neural networks trained on historical data for optimized HC predictions. It should be stated that HC is impacted by several factors, such as network topology, load profiles, and DER characteristics, and these as well will be discussed. We will provide a practical example of an HC calculation on a 141-node distribution network using a step-by-step algorithm in Matpower, with simulation results based on an iterative deterministic method. Then, we will give the broader implications of HC assessments for grid modernization and energy policy, highlighting how accurate calculations support a more decentralized, sustainable, and resilient energy future. © 2025 Elsevier B.V., All rights reserved.
  • Article
    Citation - WoS: 11
    Citation - Scopus: 12
    Developing New Empirical Formulae for the Resilient Modulus of Fine-Grained Subgrade Soils Using a Large Long-Term Pavement Performance Dataset and Artificial Neural Network Approach
    (Sage Publications inc, 2021-12-17) Fedakar, Halil Ibrahim
    Artificial neural network (ANN) has been successfully used for developing prediction models for resilient modulus (M-r). However, no reliable M-r formula derived from these models has been proposed in previous studies, although engineers/researchers need empirical formulae for hand calculation of M-r. Therefore, this study aimed to propose reliable empirical formulae for the M-r of fine-grained soils using ANN. For this purpose, thousands of ANN models were developed using the long-term pavement performance (LTPP) and external datasets. The input parameters were the percentage of soil particles passing through #200 sieve (P200), silt percentage (SP), clay percentage (CP), liquid limit (LL), plasticity index (PI), maximum dry density ([rho(dry)](max)), optimum moisture content (w(opt)), confining pressure (sigma(c)), and nominal maximum axial stress (sigma(z)). The ANN models were compared with several constitutive models. The results indicate that the constitutive models failed to predict the M-r, and the best M-r predictions were obtained by the ANN-C9 (P200, SP, CP, LL, PI, sigma(c), and sigma(z)), ANN-C10 (P200, SP, CP, [rho(dry)](max), w(opt), sigma(c), and sigma z), and ANN-C11 (P200, SP, CP, LL, PI, [rho(dry)](max), w(opt), sigma(c), and sigma(z)) models. Thus, the structures of these ANN models were formulated and proposed as the new empirical formulae for the M-r of fine-grained soils. Sensitivity analysis was also performed on these ANN models. It was determined that (rho(dry))(max) is the most influential parameter in the ANN-C10 model, and LL is the most influential parameter in the ANN-C9 and ANN-C11 models. On the other hand, sigma(c) and sigma(z) are the least influential parameters.