Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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Department: search.filters.department.Abdullah Gül ÜniversitesiWoS Q: search.filters.wosQuartile.Q4

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  • Article
    Assessment of the Quality of Tuffs in Central Anatolia, Turkey: A Quantitative Classification Approach
    (Acad Sci Czech Republic Inst Rock Structure & Mechanics, 2025-12-03) Koken, Ekin; Ince, Ismail
    The growing global demand for dimension stones necessitates efficient and accurate evaluation methods to ensure their optimal use in various industries. To assess their suitability for various dimension stone applications, this study investigates tuffs from Central Anatolia, Turkey. For this purpose, the fundamental physical and mechanical properties of the tuffs were determined in laboratory studies, and a detailed durability assessment was conducted for each rock type. The analysis results indicate that most of the examined rocks are of low quality and more suitable for non-load-bearing applications. Based on the collected data, fuzzy clustering techniques were applied to develop a new classification system, categorising the tuffs into four classes (Class A-D) according to their potential applications. Additionally, a user-friendly MATLAB-based software tool was also developed to facilitate the implementation of the proposed classification system.
  • Article
    Citation - WoS: 1
    Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
    (Galenos Publishing House, 2025-09-22) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.; Demirci, Muserref Duygu Sacar
    Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.