Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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Department: search.filters.department.Abdullah Gül ÜniversitesiPublisher: search.filters.publisher.Wiley-VCH Verlag GmbH

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    Ultra-Durable Information-Encoded Anti-Counterfeiting Self-Assembled Nanocrystal Labels
    (Wiley-VCH Verlag GmbH, 2025-11-28) Haddadifam, Taha; Shabani, Farzan; Kalay, Mustafa; Khaligh, Aisan; Mutlugun, Evren; Onses, Mustafa Serdar; Demir, Hilmi Volkan
    Forgery, a serious universal problem, is causing huge economic losses every year. Against forgery, information-encoded labelling systems have attracted significant attention for a diverse range of anti-counterfeiting applications. Here, cost-effective and ultra-durable nanocrystal-based labels are proposed and demonstrated in which information can be encoded as physically unclonable functions (PUFs) of hardware-oriented security systems. The fabrication method of the PUFs is based on the self-assembly of colloidal quantum wells (CQWs) and generation of unclonable features within their pattern at a liquid-liquid interface. These CQW PUFs are analyzed with well-known statistical tests, which show a uniqueness level of 0.5060 +/- 0.0323 and prove their randomness. In addition, a feature-matching algorithm is used to authenticate these information-encoded CQW PUFs. For the safety of the semiconductor chips, a CQW PUF is attached to the surface of the chip to protect against hardware cyber-attacks. Eventually, fabricated labels are examined against high temperatures and moisture environments. The fabricated CQW label is durable for a period of 150 days it is tested, demonstrating ultra-high stability of the label. High stability and durability, cost-effectiveness, and high encoding capacity make these proposed nanocrystal labels extremely attractive for large-scale commercialization.
  • Article
    Toward the Design of New Α-Carboline Derivatives Against Anaplastic Lymphoma Kinase (Alk): A Comprehensive in Silico Approach
    (Wiley-VCH Verlag GmbH, 2025-11) Sari, Ceyhun; Akcok, Ismail
    After the first description of anaplastic lymphoma kinase (ALK) in an anaplastic large cell lymphoma cell line as a nucleophosmin (NPM) fusion partner, ALK and its various fusion partners have been implicated in numerous cancers such as non-small cell lung cancer (NSCLC), anaplastic large cell lymphoma (ALCL), neuroblastoma, and rhabdomyosarcoma. In the last decade, several compounds targeting ALK have been developed and approved by the Food and Drug Administration (FDA). Despite the advances of generations of ALK inhibitors, a recent study highlighted that around half of the ALK-positive NSCLC patients will go through disease progression in response to first-line alectinib, which is a second-generation ALK inhibitor. In this study, we aimed to propose a novel alpha-carboline compound targeting the ALK tyrosine kinase domain to be used against various types of cancer in which ALK fusion proteins may be involved. In this regard, we designed more than 200 alpha-carboline derivatives and investigated their binding properties against ALK tyrosine kinase by using in silico protocols consisting of molecular docking studies, molecular dynamics simulations, MM/PBSA binding free energy calculation, and essential dynamics analysis. Considering the obtained results, we developed two promising candidates, compounds 208 & 209 with -9.05 and -9.80 binding energies, respectively, which demonstrated improved binding profiles over the course of a 300 ns simulation.