Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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Department: search.filters.department.Abdullah Gül ÜniversitesiPublisher: search.filters.publisher.IEEE

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  • Conference Object
    Enhancing Complex Disease Group Scoring with Mirgedinet: A Multi-Algorithm Machine Learning Framework Based on the GSM Approach
    (IEEE, 2025-06-25) Qumsiyeh, Emma; Bakir-Gungor, Burcu; Yousef, Malik
    Integrating biological prior knowledge for disease gene associations has shown significant promise in discovering new biomarkers with potential translational applications. This work investigates the application of a multi-algorithm machine learning framework based on the Grouping-Scoring-Modeling (G-S-M) approach for improving the prediction of complex diseases. The study identifies the primary gene and miRNA interactions in various complex diseases with the help of miRGediNET, which is a machine-learning based tool that integrates data from three biological databases. Traditional methods have only focused on independence between features; the G-S-M method focuses on aggregating genes based on biological interactions, pinpointing the scoring of gene groups for a disease, and modeling its predictive capability using advanced machine learning algorithms. In this research paper, seven algorithms, including Support Vector Machine, Decision Tree, and CatBoost, were applied to eight datasets extracted from the GEO database. This framework proved very robust in ranking gene clusters, thus predicting critical biomarkers while doing 100-fold randomized cross-validation within the evaluation. The results indicate this approach's high potential for refining disease and supporting research for choosing the best algorithm that can provide biological insights and computational advances.
  • Conference Object
    High Performance and Resource Efficient Low Density Parity Check Decoder Design
    (IEEE, 2025-06-25) Unal, Burak
    Low Density Parity Check (LDPC) codes have gained popularity in communication systems due to their capacity-approaching error correction performance. In this study, a highperformance LDPC decoding algorithm with extremely low resource usage is proposed. Among the hard decision class of LDPC decoders, Gallager B (GaB) provides high-performance hardware due to its computational simplicity. However, GaB suffers from poor error-correction performance. In this study, a new intrinsic computation technique for GaB called Intrinsic Gallager B (IGaB) is introduced to improve error correction performance. Our simulation results show that the IGaB algorithm provides better error correction performance compared with GaB. GaB and IGaB algorithms are implemented on Field Programmable Gate Array (FPGA) to compare hardware performance.
  • Conference Object
    Exploring Microbiome Signatures in Autism Spectrum Disorder via Grouping-Scoring Based Machine Learning
    (IEEE, 2025-06-25) Temiz, Mustafa; Ersoz, Nur Sebnem; Yousef, Malik; Bakir-Gungor, Burcu
    The rapid increase in omic data production increased the importance of machine learning (ML) methods to analze these data. In particular, the use of metagenomic data in the diagnosis, prognosis and treatment of diseases is becoming widespread. Autism Spectrum Disorder (ASD) is a neurodevelopmental disease that occurs in early childhood and continues lifelong. The aim of this study is to increase ML performance, reduce computational costs and achieve successful classification performance using a small number of metagenomic features. In addition, disease prediction is performed; ASD associated biomarkers are determined using the microBiomeGSM on metagenomic data. Classification is performed at three different taxonomic levels (genus, family and order) using the relative abundance values of species. The best performance metric (0.95 AUC) was obtained at the order taxonomic level using an average of 416 features with microBiomeGSM. The identified ASD-related taxonomic species are presented.
  • Conference Object
    Citation - WoS: 2
    Citation - Scopus: 2
    Fine Tuning DeepSeek and Llama Large Language Models with LoRA
    (IEEE, 2025-06-25) Uluirmak, Bugra Alperen; Kurban, Rifat
    In this paper, Low-Rank Adaptation (LoRA) finetuning of two different large language models (DeepSeek R1 Distill 8B and Llama3.1 8B) was performed using the Turkish dataset. Training was performed on Google Colab using A100 40 GB GPU, while the testing phase was carried out on Runpod using L4 24 GB GPU. The 64.6 thousand row dataset was transformed into question-answer pairs from the fields of agriculture, education, law and sustainability. In the testing phase, 40 test questions were asked for each model via Ollama web UI and the results were supported with graphs and detailed tables. It was observed that the performance of the existing language models improved with the fine-tuning method.