Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Book Part Citation - Scopus: 1Social Capital, Rurality, and Accessibility: A Comparative Study Between Turkey and Italy(Springer, 2020) Reggiani, Aura; Östh, John; Türk, Umut; Dolciotti, Martina; Nijkamp, PeterArticle Citation - Scopus: 5Integrated Querying and Version Control of Context-Specific Biological Networks(Oxford University Press, 2020-01-01) Coşkun, Mustafa; Grama, Ananth; Koyutürk, Mehmet; Cowman, TylerConference Object Identification of Shared Pathways Among Immune Related Diseases Utilizing Active Subnetworks(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2020-09) Eryilmaz, Mahmut Kaan; Kuzudisli, Cihan; Gungor, Burcu BakirDifferent, but related diseases often contain shared symptoms indicating the presence of possible overlaps in underlying pathogenic mechanisms. The identification of the shared pathways and related factors across these diseases helps to better understand the causes of these diseases, to prevent and treat these diseases. In this study, using immune-related diseases, we proposed a new method on how to compare the development mechanisms of related diseases based on biological pathways. Following the developments in genomic technologies, the genotyping gets cheaper and easier, and hence genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) could he identified. With the help of these studies, in which around a million of SNPs are scanned, the variations and genes that could have a role in specific disease development could be detected. In this study, via using available GWAS datasets and human protein-protein interaction network, and via detecting active subnetworks and affected pathways, seven immune related diseases are analyzed. Via investigating the similarities among the identified pathways for related diseases, we aim to define the underlying pathogenic mechanisms, and hence to contribute to the elucidation of disease development mechanisms and to the drug repositioning studies.Conference Object Ensemble Churn Prediction for Internet Service Provider with Machine Learning Techniques(IEEE, 345 E 47TH ST, NEW YORK, NY 10017 USA, 2020) Goy, Gokhan; Kolukisa, Burak; Bahcevan, Cenk; Gungor, Vehbi CagriWith the developing technology in every fields, a competitive marketing environment has been arised In this competitive environment analyzing customer behavior has become vital In particular, the ability to easily change any service provider has become vet) , critical for the company to continue its existence At the same time, the amount of financial resources spent on retaining instituters much less than to obtain new clients. In this context, the traditional methods of examining vast amount of data obtained today for establishing decision support systems have lost their validities In this study. we used a dataset which is provided by TurkNet serving as an internet service provider in Turkey. Various preprocessing steps has performed on this dataset and then classification algorithms ran. Afterwards results have obtained and compared. The results of these experiments analyzed in terms of the area under the curve value In this context the aunt successful classifier algorithm has been determined as the Random Trees algorithm with a value of 0.936.Research Project Bor Zengini Amorf Malzemeler(TUBİTAK, 2020) Durandurdu, MuratBu TÜBİTAK 1001 projesi kapsamında, bor zengini farklı amorf malzemeler [B1-xSix, B1-xCx, B1-_x000D_ xOx, ve B1-xLix (0, 5 ≥ � ≥ 0,05)] ab initio moleküler dinamik tekniği kullanılarak sıvı hallerin hızlıca_x000D_ soğutulması sonucu modellenmiş ve bu malzemelerin atomik yapıları, elektronik yapıları ve_x000D_ mekanik özellikleri ayrıntı olarak araştırılmıştır. Bunlara ek olarak, bu malzemelerin bazı_x000D_ oranlarının yüksek basınçtaki davranışları incelenmiştir. Bazı malzemelerde, örneğin BC ve BO_x000D_ malzemelerinde, bor oranının artmasıyla iki boyutlu yapıdan üç boyutlu yapıya geçiş_x000D_ gözlemlenmiştir. Ayrıca yüksek bor oranlarında, B12 icosahedralların oluştuğu bulunmuştur. B12_x000D_ molekülüne ek olarak nano boyutunda B7, B10, B14, B16 kafes moleküllerinin oluşumu bazı_x000D_ malzemelerde gözlemlenmiştir. Modellenen malzemelerin her birinin yarıiletken özelliği gösterdiği_x000D_ fakat yasak band aralığında bor oranına bağlı genel bir eğilim olmayıp dalgalanmaların olduğu_x000D_ bulunmuştur. B12 moleküllerinin oluşumunun malzemelerin mekanik özelliğini dikkate değer bir_x000D_ şekilde etkilediği ve bor oranı yüksek olan malzemelerin daha sert bir özellik gösterdiği_x000D_ bulunmuştur. Yüksek basınç uygulamasıyla, malzemelerin daha yoğun bir amorf yapıya faz_x000D_ geçişişi yaptığı ve malzemeye bağlı olarak, faz geçişlerinin tersinir ya da tersinir olmayan faz_x000D_ geçişleri olduğu gözlemlenmiştir.Article Citation - Scopus: 2Zeolite Synthesis by Alkali Fusion Method Using Two Different Fly Ashes Derived From Turkish Thermal Power Plants(Chamber of Mining Engineers of Turkey, 2020-03-01) Top, S.; Vapur, HüseyinIn this study, Faujasite (Na-LSX) (3.5(Ca0.3)3.5(Na0.6)3.5(Mg0.1)Al7Si17O48 32(H2O)) type zeolites and Ca-Filipsite (CaK0.6Na0.4Si5.2Al2.8O16 6(H2O)) type zeolites were produced from Sugözü Thermal Power Plant and Çatalaǧzi Thermal Power Plant fly ashes by alkali fusion method followed by water leaching, respectively. In these methods, fly ashes and sodium hydroxide (NaOH) were mixed in certain proportions and sintered at 600°C in ash furnace. Then, zeolites were obtained from the ground materials after water leaching and solid/liquid separation, respectively. Cation Exchange Capacity (CEC), X-Ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier-Transform Infrared Spectroscopy (FTIR), X-Ray Fluorescence (XRF) and Atomic Absorption Spectrometer (AAS) analyses were used to characterize the synthesized zeolites. The zeolites synthesized with Sugözü fly ashes in a ratio of 1:2 had 136.93 meq/100 g CEC, whereas the CEC of synthesized zeolite from Çatalaǧzi fly ashes was found to be 247.88 meq/100 g. As a result, zeolites, which can be used as wastewater treatment agent, energy storage material, catalyst and separator, were synthesized by using 2 different Class F fly ash. © 2023 Elsevier B.V., All rights reserved.Article Citation - WoS: 8Citation - Scopus: 8Writing Chemical Patterns Using Electrospun Fibers as Nanoscale Inkpots for Directed Assembly of Colloidal Nanocrystals(Royal Soc Chemistry, 2020) Kiremitler, N. Burak; Torun, Ilker; Altintas, Yemliha; Patarroyo, Javier; Demir, Hilmi Volkan; Puntes, Victor F.; Onses, M. SerdarApplications that range from electronics to biotechnology will greatly benefit from low-cost, scalable and multiplex fabrication of spatially defined arrays of colloidal inorganic nanocrystals. In this work, we present a novel additive patterning approach based on the use of electrospun nanofibers (NFs) as inkpots for end-functional polymers. The localized grafting of end-functional polymers from spatially defined nanofibers results in covalently bound chemical patterns. The main factors that determine the width of the nanopatterns are the diameter of the NF and the extent of spreading during the thermal annealing process. Lowering the surface energy of the substrates via silanization and a proper choice of the grafting conditions enable the fabrication of nanoscale patterns over centimeter length scales. The fabricated patterns of end-grafted polymers serve as the templates for spatially defined assembly of colloidal metal and metal oxide nanocrystals of varying sizes (15 to 100 nm), shapes (spherical, cube, rod), and compositions (Au, Ag, Pt, TiO2), as well as semiconductor quantum dots, including the assembly of semiconductor nanoplatelets.Article Citation - WoS: 42Citation - Scopus: 57What Are the Key Success Factors for Strategy Formulation and Implementation? Perspectives of Managers in the Hotel Industry(Elsevier Sci Ltd, 2020-08) Koseoglu, Mehmet Ali; Altin, Mehmet; Chan, Eric; Aladag, Omer FarukThis study investigates how hotel managers describe strategy and identify key success factors for its formulation and implementation. The study analyzes qualitative data collected through semi-structured interviews with property level top managers of hotels in Hong Kong. The findings show that hotel managers prioritize competition analysis and macro-environmental conditions over internal characteristics such as teamwork in strategy formulation. In the implementation phase, however, internal considerations such as employee involvement and strategic consensus are given prominence. This study provides a significant contribution by examining how top level practitioners in the industry interpret success factors in their strategic management efforts, and it highlights a largely neglected area in the hospitality and tourism management literature.Article Citation - WoS: 14Citation - Scopus: 16Triterpenoids and Steroids Isolated from Anatolian Capparis Ovata and Their Activity on the Expression of Inflammatory Cytokines(Taylor & Francis Ltd, 2020-01-01) Gazioglu, Isil; Semen, Sevcan; Acar, Ozden Ozgun; Kolak, Ufuk; Sen, Alaattin; Topcu, GulactiContext CapparisL. (Capparaceae) is grown worldwide. Caper has been used in traditional medicine to treat various diseases including rheumatism, kidney, liver, stomach, as well as headache and toothache. Objective To isolate and elucidate of the secondary metabolites of theC. ovataextracts which are responsible for their anti-inflammatory activities. Materials and methods Buds, fruits, flowers, leaves and stems ofC. ovataDesf. was dried, cut to pieces, then ground separately. From their dichloromethane/hexane (1:1) extracts, eight compounds were isolated and their structures were elucidated by NMR, mass spectroscopic techniques. The effects of compounds on the expression of inflammatory cytokines in SH-SY5Y cell lines were examined by qRT-PCR ranging from 4 to 96 mu M. Cell viability was expressed as a percentage of the control, untreated cells. Results This is a first report on isolation of triterpenoids and steroids fromC. ovatawith anti-inflammatory activity. One new triterpenoid ester olean-12-en-3 beta,28-diol, 3 beta-pentacosanoate (1) and two new natural steroids 5 alpha,6 alpha-epoxycholestan-3 beta-ol (5) and 5 beta,6 beta-epoxycholestan-3 beta-ol (6) were elucidated besides known compounds; oleanolic acid (2), ursolic acid (3), beta-sitosterol (4), stigmast-5,22-dien-3 beta-myristate (7) and bismethyl-octylphthalate (8). mRNA expression levels as EC(10)of all the tested seven genes were decreased, particularly CXCL9 (19.36-fold), CXCL10 (8.14-fold), and TNF (18.69) by the treatment of 26 mu M of compound1on SH-SY5Y cells. Discussion and conclusions Triterpenoids and steroids isolated fromC. ovatawere found to be moderate-strong anti-inflammatory compounds. Particularly, compounds1and3were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases.Article Citation - WoS: 4Citation - Scopus: 4Transparent Films Made of Highly Scattering Particles(Amer Chemical Soc, 2020-01-13) Erdem, Talha; Yang, Lan; Xu, Peicheng; Altintas, Yemliha; O'Neil, Thomas; Caciagli, Alessio; Eiser, ErikaToday, colloids are widely employed in various products from creams and coatings to electronics. The ability to control their chemical, optical, or electronic features by controlling their size and shape explains why these materials are so widely preferred. Nevertheless, altering some of these properties may also lead to some undesired side effects, one of which is an increase in optical scattering upon concentration. Here, we address this strong scattering issue in films made of binary colloidal suspensions. In particular, we focus on raspberry-type polymeric particles made of a spherical polystyrene core decorated by small hemispherical domains of acrylate with an overall positive charge, which display an unusual stability against aggregation in aqueous solutions. Their solid films display a brilliant red color due to Bragg scattering but appear completely white on account of strong scattering otherwise. To suppress the scattering and induce transparency, we prepared films by hybridizing them with oppositely charged PS particles with a size similar to that of the bumps on the raspberries. We report that the smaller PS particles prevent raspberry particle aggregation in solid films and suppress scattering by decreasing the spatial variation of the refractive index inside the film. We believe that the results presented here provide a simple strategy to suppress strong scattering of larger particles to be used in optical coatings.