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Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Conference Object
    Sustainable Approach to Fabricating Flat Micro Ribbon Electric Wires Directly from Turning Process Chips
    (Elsevier B.V., 2026) Kesriklioglu, Sinan; Sivesoglu, Abdurrahman
  • Article
    Probing Adversarial Robustness of Protein Language Models: A Reproducible Case Study of ESM-2 Under Substitution-Based Attacks
    (AIUB Office of Research and Publication, 2026) Aydin, Zafer; Niloy, Md. Robiul Islam; Moazzam, Md. Golam
  • Article
    Modeling Commuter Mobility in Stockholm: A Spatial Panel Approach Using Mobile Phone Data
    (Springer Heidelberg, 2026) Fischer, Manfred M.; Osth, John; Toger, Marina; Turk, Umut
    This paper examines the sociodemographic and socioeconomic determinants of regional commuter mobility in the Greater Stockholm Area using a heteroscedastic spatial Durbin panel data model estimated via Bayesian Markov Chain Monte Carlo methods. Drawing on mobile phone-derived origin-destination flows from the MIND database, the analysis exploits unusually fine spatial and temporal granularity across a balanced panel of 675 regions over the period 2018-2023. A k-nearest neighbor spatial weight matrix (k = 18), selected via Bayesian model comparison, captures the topological structure of interregional connectivity. By modeling spatial lags in both the dependent and independent variables, the framework enables explicit recovery of direct (own-region) and indirect (spillover) effects from scalar summary measures of the matrix of partial derivatives - providing robust posterior inference on how sociodemographic and socioeconomic conditions propagate through space. This approach addresses a key limitation of conventional non-spatial methods, which risk producing biased estimates by ignoring spatial interdependence. Empirical results confirm that spatial spillovers predominate over direct effects, with educational attainment and car ownership emerging as the principal determinants of commuter mobility, while age composition plays a comparatively modest role. These findings underscore that evaluating direct effects in isolation systematically underestimates the broader societal returns to mobility-enhancing regional policies.
  • Article
    Electrospun PCL/PEG Nanofibers Incorporating Plantago Lanceolata Extract and Clove Oil for Dual-Function Wound Dressings
    (IOP Publishing Ltd, 2026) Teke, Selin Nur; Yuruk, Adile; Isoglu, Ismail Alper
    In this study, we developed electrospun polycaprolactone/polyethylene glycol (PCL/PEG) nanofibers loaded with Plantago lanceolata (P. lanceolata) extract and clove oil to evaluate their combined potential for wound healing and antibacterial activity. PCL/PEG nanofibers were electrospun and post-loaded with P. lanceolata extract at 5%, 10%, and 15% (w/v), together with 1% (v/v) clove oil. Scanning electron microscope analysis showed a uniform, bead-free nanofibrous structure, with fiber diameters ranging from 768 +/- 140 nm to 892 +/- 206 nm and pore sizes from 3.93 +/- 0.97 & micro;m to 6.20 +/- 1.16 & micro;m. The nanofibers exhibited swelling ratios between 103.23 +/- 16.42% and 133.93 +/- 40.45% within 1 h and showed gradual degradation ranging from 25.92 +/- 2.84% to 57.76 +/- 0.92% over 21 d, with cumulative extract release approaching a plateau by day 28 under the experimental conditions. The incorporation of plant extract and essential oil initially increased the water contact angle from 15.97 +/- 1.07 degrees to 48.61 +/- 7.85 degrees, indicating that the nanofiber surface remained hydrophilic; at higher extract contents, the nanofibers transitioned to a superhydrophilic state. Antibacterial activity was primarily governed by clove oil, yielding up to 85.16 +/- 0.36% efficacy against E. coli (E. coli) and 79.90 +/- 0.29% against S. aureus (S. aureus). While P. lanceolata extract alone showed limited antibacterial activity, its presence within clove oil-loaded nanofibers consistently enhanced antibacterial performance at the composite level. In vitro scratch assays demonstrated pronounced wound closure at later time points (72-96 h), particularly for nanofibers containing higher extract concentrations, confirming the dominant contribution of P. lanceolata to the healing response. Overall, the electrospun PCL/PEG nanofibers represent a dual-function wound dressing, with clove oil contributing antibacterial protection and P. lanceolata extract supporting wound healing.
  • Article
    Effects of Group Aerobic Exercise on Health and Social Adaptation in Earthquake Survivors: A Qualitative Study
    (Lippincott Williams and Wilkins, 2026) Yardimci, Fatma Betul; Kaya, M. Siyabend; Anaforoglu, Bahar; Altay Ili, Hafize; Apak, Hidir
  • Article
    Comprehensive Evaluation of Microstructure–Property Relationships in Al-Added Sn-Zn Eutectic Solder Alloys from Thermal, Electrical, and Mechanical Perspectives
    (Springer, 2026) Bayram, Ümit; Şahin, Mevlüt
    (Sn-8.8Zn)-XAl (X = 0, 0.5, 1.0, 2.5, 5.0 wt.%) solder alloys were produced using a vacuum muffle furnace. The microstructural images, chemical compositions, and phase structures of the alloys were characterized by field emission scanning electron microscopy (FESEM), field emission scanning electron microscopy-energy dispersive x-ray spectroscopy (FESEM-EDX), and x-ray diffraction (XRD) analyses, respectively. According to FESEM images, a fully eutectic microstructure was observed in the Sn-8.8Zn alloy. With increasing Al content, dendritic structures formed and became denser. The mechanical properties of the alloys (ultimate tensile strength sigma UT, tensile yield strength sigma TY, compressive yield strength sigma CY, and Vickers hardness HV) were measured as a function of composition. The highest strength and hardness values were obtained for the (Sn-8.8Zn)-2.5Al alloy, whereas the (Sn-8.8Zn)-5.0Al alloy exhibited the highest ductility. The melting enthalpies (Delta H) and the specific heat differences between the solid and liquid phases (Delta CP) of the alloys were measured by differential scanning calorimetry (DSC) analysis. It was determined that an increase in the Al content of the eutectic alloy resulted in higher measured thermophysical properties. Finally, electrical resistivity (rho) values at T = 300 K, measured using the standard four-point probe method (FPPM), revealed an increase in resistivity up to 1.0 wt.% Al content, followed by a decrease beyond this value. In contrast, thermal conductivity values calculated using the Wiedemann-Franz law exhibited an opposite trend, decreasing up to 1.0 wt.% Al, and increasing thereafter. Based on microstructure-property relationships, the results were compared with previous studies, highlighting that (Sn-8.8Zn)-XAl alloys represent promising alternatives to lead-free solders.
  • Article
    Three-Dimensional Culture Enhances the Antimicrobial Activity of Mesenchymal Stem Cells against Shiga Toxin-Producing Escherichia Coli O157:H7 in Vitro
    (Oxford Univ Press, 2026) Fidan, Özkan; Türkyılmaz, Süheyla; Bicer, Mesude; Öztürk, Esengül; Sener, Fatma
    Aims This study examines the in vitro antibacterial activity of palatal adipose tissue-derived mesenchymal stem cells (PAT-MSCs) and the expression of antimicrobial peptide LL-37, with a particular focus on the effect of three-dimensional (3D) nanofibrillar cellulose-based hydrogel against Shiga toxin-producing Escherichia coli (STEC) harboring stx1 and/or stx2 genes isolated from mastitis milk in Turkey.Methods and results The antibacterial activity of conventionally cultured PAT-MSCs and 3D-cultured PAT-MSCs (PAT-MSCs-3D) was evaluated against STEC isolates and Escherichia coli ATCC 35150 using quantitative colony-forming unit (CFU) assay. The expression levels of antimicrobial peptide (AMP)-encoding genes were evaluated by quantitative real-time PCR, and AMP production was further validated by immunocytochemical staining. The results indicated that PAT-MSCs-3D exhibited significantly enhanced antibacterial efficacy, resulting in marked bacterial inhibition of all tested STEC strains, with bacterial reductions reaching up to 6-7 log under specific experimental conditions. Molecular and immunocytochemical analyses demonstrated increased expression of the antimicrobial peptide LL-37 in PAT-MSCs-3D compared to 2D cultures.Conclusions Our results show that culturing PAT-MSCs in 3D conditions leads to a significant enhancement in their antimicrobial properties, which could be linked to the upregulation of LL-37.
  • Article
    Spatial Proximity and Accessibility Patterns of X-Minute Cities
    (Elsevier Ltd, 2026) Östh, John; Türk, Umut; Kourtit, Karima; Nijkamp, Peter
    The 15-minute city concept has gained prominence in urban planning as a framework linking proximity, mobility, and quality of life at the intra-urban scale. An open question is whether this concept remains meaningful when applied to spatially connected urban regions or national urban systems. To address this issue, the new X-minute city concept allows proximity thresholds to vary with spatial context, mobility conditions, and service distribution. This paper develops an operational framework with the aim to examine and highlight spatial accessibility patterns from an X-minute city perspective, using the relatively urbanized area of the Netherlands as a national-scale case study. Accessibility is analyzed at the building level using OpenStreetMap data and a combination of object-based k-nearest-neighbor measures, distance-decay functions, inequality metrics, Average Nearest Neighbor analysis, and quantile regression. Concepts from central place theory are employed as an interpretive lens to understand service clustering and accessibility patterns, rather than as a formal model to be tested. The results show pronounced spatial disparities in accessibility between urban and rural areas, as well as substantial variation within cities. Major urban centers such as Amsterdam, Rotterdam, and Utrecht exhibit high accessibility levels due to dense service provision, while peripheral and rural areas face systematically lower accessibility. Next accessibility outcomes also differ sharply across population groups. Elderly residents and groups reliant on walking experience the highest levels of inequality, with accessibility distributions remaining highly uneven at short-distance thresholds. Cycling expands the range of effective activity spaces and reduces inequality, but does not offset structural disadvantages in areas with sparse service provision. The findings point to the limits of uniform proximity targets and reveal the need for context-sensitive accessibility planning that explicitly accounts for service distribution, mobility constraints, and population heterogeneity within national urban systems.
  • Article
    Functional Characterization of Loss of RNF43 Reveals Neuronal Defects in a Caenorhabditis Elegans Model
    (MDPI, 2026) Kazan, Hasan Huseyin; Turkyilmaz, Zafer; Ekim, Burcu; Kaya, Cem; Ergun, Mehmet Ali; Sonmez, Kaan; Güzel, Sinem
    Ring finger protein 43 (RNF43) encodes a transmembrane E3 ubiquitin ligase that negatively regulates canonical Wnt signaling and is classically associated with serrated polyposis syndrome and colorectal cancer. In this study, regarding a homozygous truncating RNF43 variant (NM_001305545.1:c.1906C>T; p.Gln636Ter) in a patient segregating with a severe neurodevelopmental phenotype characterized by developmental delay, neonatal hypotonia, recurrent seizures, progressive microcephaly, and bilateral optic atrophy, the loss of polarity defective 1 (plr-1), an ortholog of RNF43, was modeled in Caenorhabditis elegans and the phenotype was primarily characterized. The results demonstrated that loss of the plr-1 disrupted gamma aminobutyric acid (GABA)ergic axon organization, reduced locomotor speed calculated from 60 s recordings, and altered developmental growth. These findings expand the phenotypic spectrum of RNF43 and support a dosage-dependent developmental role.
  • Article
    Cellulose-Based Hydrogel Matrix Enhances Antimicrobial and Biofilm-Inhibitory Responses of Palatal Mesenchymal Stem Cells
    (Springer Heidelberg, 2026) Fidan, Özkan; Bicer, Mesude; Öztürk, Esengül; Sener, Fatma
    Mesenchymal stem cells (MSCs) have emerged as promising alternatives to fight drug-resistant bacterial infections. This study investigates the antibacterial activity of palatal adipose tissue-derived MSCs (PMSCs), particularly when cultured within a 3D nanofibrillar cellulose hydrogel, against four clinically relevant pathogens: Pseudomonas aeruginosa K6, Staphylococcus aureus ATCC 25,923, Bacillus cereus K9 and Escherichia coli O157:H7. This study showed that both PMSCs alone and PMSCs in 3D cellulose-based hydrogel effectively inhibited the growth of bacterial burden. Notably, PMSCs cultured in the 3D system demonstrated an excellent effect, reducing bacterial burden by up to 14 log in E. coli and 12 log in P. aeruginosa K6 at a 120 & micro;L inoculum after 2 h of incubation. RT-PCR and immunocytochemical analyses found out a remarkable upregulation of the Cathelicidin (LL-37) in PMSCs 3D cultures compared to PMSCs. Furthermore, 3D cellulose-based hydrogel exhibited a significant biofilm-inhibitory effect, reaching a 57.65% reduction. The results demonstrated the importance of 3D cellulose-based hydrogel for treating antibiotic-resistant infections. PMSC therapy based on 3D hydrogel may therefore be offered as more effective antimicrobial agent to overcome drug-resistant bacterial infections.