Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Citation - WoS: 14Citation - Scopus: 15Triterpenoids and Steroids Isolated from Anatolian Capparis Ovata and Their Activity on the Expression of Inflammatory Cytokines(Taylor & Francis Ltd, 2020-01-01) Gazioglu, Isil; Semen, Sevcan; Acar, Ozden Ozgun; Kolak, Ufuk; Sen, Alaattin; Topcu, GulactiContext CapparisL. (Capparaceae) is grown worldwide. Caper has been used in traditional medicine to treat various diseases including rheumatism, kidney, liver, stomach, as well as headache and toothache. Objective To isolate and elucidate of the secondary metabolites of theC. ovataextracts which are responsible for their anti-inflammatory activities. Materials and methods Buds, fruits, flowers, leaves and stems ofC. ovataDesf. was dried, cut to pieces, then ground separately. From their dichloromethane/hexane (1:1) extracts, eight compounds were isolated and their structures were elucidated by NMR, mass spectroscopic techniques. The effects of compounds on the expression of inflammatory cytokines in SH-SY5Y cell lines were examined by qRT-PCR ranging from 4 to 96 mu M. Cell viability was expressed as a percentage of the control, untreated cells. Results This is a first report on isolation of triterpenoids and steroids fromC. ovatawith anti-inflammatory activity. One new triterpenoid ester olean-12-en-3 beta,28-diol, 3 beta-pentacosanoate (1) and two new natural steroids 5 alpha,6 alpha-epoxycholestan-3 beta-ol (5) and 5 beta,6 beta-epoxycholestan-3 beta-ol (6) were elucidated besides known compounds; oleanolic acid (2), ursolic acid (3), beta-sitosterol (4), stigmast-5,22-dien-3 beta-myristate (7) and bismethyl-octylphthalate (8). mRNA expression levels as EC(10)of all the tested seven genes were decreased, particularly CXCL9 (19.36-fold), CXCL10 (8.14-fold), and TNF (18.69) by the treatment of 26 mu M of compound1on SH-SY5Y cells. Discussion and conclusions Triterpenoids and steroids isolated fromC. ovatawere found to be moderate-strong anti-inflammatory compounds. Particularly, compounds1and3were found to be promising therapeutic agents in the treatment of inflammatory and autoimmune diseases.Article Citation - WoS: 1Citation - Scopus: 2The Impact of Knitted Linked Seams on Comfort and Friction Perception(Taylor & Francis Ltd, 2024-08-29) Temel, Mevra; Scott, Eleanor; Cain, Rebecca; Johnson, Andrew A.Friction from knitted clothing can cause discomfort and skin issues, underscoring the importance of tactile comfort for wearers. Seamless knitted garments are assumed to be comfortable to wear, yet there is little understanding of their tactile comfort in comparison to linked seams - the most common form of knitted garment. This novel study examines the influence of a garments knitted structural architecture on clothing comfort and wearability by investigating skin friction and tactile perception across ten body regions in both male and female participants, using two commonly utilised materials and seam designs: cotton and merino wool with plain and linked seams. The impact of seam design and regional factors on skin friction and tactile perception was analysed, revealing varying levels across tested body regions. Removing seams exposed a greater surface area to skin contact, leading to higher perceived friction levels. As such, structural elements in knitted garments enhance wearer comfort. Seamless knitwear manufacturing offers a more environmentally conscious option compared to traditional cut-and-sew processes. This study investigated the impact of knitted garment material and structure on wearer comfort by analysing skin friction and tactile perception across ten upper body regions. Removing seams increased garment-to-skin contact leading to wearer discomfort.Article Citation - WoS: 11Citation - Scopus: 13The Effect of Seed Sludge Type on Aerobic Granulation via Anoxic-Aerobic Operation(Taylor & Francis Ltd, 2014-06-17) Ersan, Yusuf Cagatay; Erguder, Tuba HandeThe effects of two seed sludge types, namely conventional activated sludge (CAS) and membrane bioreactor sludge (MBS), on aerobic granulation were investigated. The treatment performances of the reactors were monitored during and after the granulation. Operational period of 37 days was described in three phases; Phase 1 corresponds to Days 1-10, Phase 2 (overloading conditions) to Days 11-27 and Phase 3 (recovery) to Days 28-37. Aerobic granules of 0.56 +/- 0.23 to 2.48 +/- 1.28mm were successfully developed from both MBS and CAS. First granules appeared on Day 9 in both reactors, indicating that there was no difference between two seed sludge types in terms of the time period for granulation initiation. The results revealed that the granules developed from MBS performed better than CAS in terms of settleability, stability, biomass retention, adaptation, protection of granular structure at high loading rates (0.86 gN/L d and 3.92 gCOD/Ld) and low COD/TAN ratio (5). Granules of MBS were also found to be capable of providing better protection for nitrifiers at toxic free-ammonia concentrations (38-46 mg/L NH3-N), thus showing better treatment recovery than those of CAS.Article Citation - WoS: 8Citation - Scopus: 11The Ascent of Geopolitics: Scientometric Analysis and Ramifications of Geopolitical Risk(Taylor & Francis Ltd, 2022-04-18) Aysan, Ahmet Faruk; Polat, Ali Yavuz; Tekin, Hasan; Tunali, Ahmet SemihIn recent years, geopolitical risk (GPR) has been a crucial factor in investment decisions and stock markets. Therefore, we explore the research on the GPR by employing bibliometric and scientometric analytical techniques. We find 366 scientific contributions in December 2021 from the Scopus database by searching 'Geopolitical risk' in abstracts, keywords, and titles. Our findings show that GPR research has gained momentum in the last three years. Specifically, the journal Defence and Peace Economics has one of the highest numbers of research and citation on GPR. Authors in Asia also dominate the GPR literature. Overall, this study contributes to the literature by presenting the existing research that may give new insights for prospective studies in GPR.Article Citation - WoS: 8Citation - Scopus: 11Stem Cells Combined 3D Electrospun Nanofibrous and Macrochannelled Matrices: A Preliminary Approach in Repair of Rat Cranial Bones(Taylor & Francis Ltd, 2019-04-03) Isoglu, Ismail Alper; Bolgen, Nimet; Korkusuz, Petek; Vargel, Ibrahim; Celik, Hakan Hamdi; Kilic, Emine; Piskin, ErhanRepair of cranial bone defects is an important problem in the clinical area. The use of scaffolds combined with stem cells has become a focus in the reconstruction of critical-sized bone defects. Electrospinning became a very attracting method in the preparation of tissue engineering scaffolds in the last decade, due to the unique nanofibrous structure of the electrospun matrices. However, they have a limitation for three dimensional (3D) applications, due to their two-dimensional structure and pore size which is smaller than a cellular diameter which cannot allow cell migration within the structure. In this study, electrospun poly(epsilon-caprolactone) (PCL) membranes were spirally wounded to prepare 3D matrices composed of nanofibers and macrochannels. Mesenchymal stromal/stem cells were injected inside the scaffolds after the constructs were implanted in the cranial bone defects in rats. New bone formation, vascularisation and intramembranous ossification of the critical size calvarial defect were accelerated by using mesenchymal stem cells combined 3D spiral-wounded electrospun matrices.Article Citation - WoS: 4Citation - Scopus: 6One-Pot Conjugated Linoleic Acid Production From Castor Oil by Rhizopus Oryzae Lipase and Resting Cells of Lactobacillus Plantarum(Taylor & Francis Ltd, 2017-10-03) Khaskheli, Abid Ali; Talpur, Farah Naz; Aydin, Aysun Cebeci; Jawaid, Sana; Surhio, Muhammad Ali; Afridi, Hassan ImranConjugated linoleic acid (CLA) has attracted as novel type of fatty acids having unusual health-promoting properties such as anticarcinogenic and antiobesitic effects. The present work employed castor oil as substrate for one-pot production of CLA using washed cells of Lactobacillus plantarum (L. plantarum) and lipases as catalysts. Among the screened lipases, the lipase Rhizopus oryzae (ROL) greatly assisted resting cells to produce CLA. Mass spectral analysis of the product showed that two major isomers of CLA were produced in the reaction mixture i.e. cis-9, trans-11 56.55% and trans-10, cis-12 43.45%. Optimum factors for CLA synthesis were found as substrate concentration (8mg/mL), pH (6.5), washed cell concentration (12% w/v), and incubation time of 20h. Hence, the combination of ROL with L. plantarum offers one pot production of CLA selectively using castor oil as a cost-effective substrate.Article Citation - WoS: 653Citation - Scopus: 739Flow Cytometry: Basic Principles and Applications(Taylor & Francis Ltd, 2016-01-14) Adan, Aysun; Alizada, Gunel; Kiraz, Yagmur; Baran, Yusuf; Nalbant, AytenFlow cytometry is a sophisticated instrument measuring multiple physical characteristics of a single cell such as size and granularity simultaneously as the cell flows in suspension through a measuring device. Its working depends on the light scattering features of the cells under investigation, which may be derived from dyes or monoclonal antibodies targeting either extracellular molecules located on the surface or intracellular molecules inside the cell. This approach makes flow cytometry a powerful tool for detailed analysis of complex populations in a short period of time. This review covers the general principles and selected applications of flow cytometry such as immunophenotyping of peripheral blood cells, analysis of apoptosis and detection of cytokines. Additionally, this report provides a basic understanding of flow cytometry technology essential for all users as well as the methods used to analyze and interpret the data. Moreover, recent progresses in flow cytometry have been discussed in order to give an opinion about the future importance of this technology.Article Citation - WoS: 2Citation - Scopus: 2An Introduction to Non-Smooth Convex Analysis via Multiplicative Derivative(Taylor & Francis Ltd, 2019-02-12) Tor, Ali HakanIn this study, *-directional derivative and *-subgradient are defined using the multiplicative derivative, making a new contribution to non-Newtonian calculus for use in non-smooth analysis. As for directional derivative and subgradient, which are used in the non-smooth optimization theory, basic definitions and preliminary facts related to optimization theory are stated and proved, and the *-subgradient concept is illustrated by providing some examples, such as absolute value and exponential functions. In addition, necessary and sufficient optimality conditions are obtained for convex problems.Article Citation - WoS: 12Citation - Scopus: 144D-QSAR Investigation and Pharmacophore Identification of Pyrrolo[2,1-C][1,4]Benzodiazepines Using Electron Conformational-Genetic Algorithm Method(Taylor & Francis Ltd, 2016-04-02) Ozalp, A.; Yavuz, S. C.; Sabanci, N.; Copur, F.; Kokbudak, Z.; Saripinar, E.In this paper, we present the results of pharmacophore identification and bioactivity prediction for pyrrolo[2,1-c][1,4]benzodiazepine derivatives using the electron conformational-genetic algorithm (EC-GA) method as 4D-QSAR analysis. Using the data obtained from quantum chemical calculations at PM3/HF level, the electron conformational matrices of congruity (ECMC) were constructed by EMRE software. The ECMC of the lowest energy conformer of the compound with the highest activity was chosen as the template and compared with the ECMCs of the lowest energy conformer of the other compounds within given tolerances to reveal the electron conformational submatrix of activity (ECSA, i.e. pharmacophore) by ECSP software. A descriptor pool was generated taking into account the obtained pharmacophore. To predict the theoretical activity and select the best subset of variables affecting bioactivities, the nonlinear least square regression method and genetic algorithm were performed. For four types of activity including the GI(50), TGI, LC50 and IC50 of the pyrrolo[2,1-c][1,4] benzodiazepine series, the r(train)(2), r(test)(2) and q(2) values were 0.858, 0.810, 0.771; 0.853, 0.848, 0.787; 0.703, 0.787, 0.600; and 0.776, 0.722, 0.687, respectively.Article Citation - WoS: 31Citation - Scopus: 37Gigification, Job Engagement and Satisfaction: The Moderating Role of AI Enabled System Automation in Operations Management(Taylor & Francis Ltd, 2021) Braganza, Ashley; Chen, Weifeng; Canhoto, Ana; Sap, SerapInnovative and highly efficient Artificial Intelligence System Automation (AI-SA) is reshaping jobs and the nature of work throughout supply chain and operations management. It can have one of three effects on existing jobs: no effect, eliminate whole jobs, or eliminate those parts of a job that are automated. This paper focuses on the jobs that remain after the effects of AI-SA, albeit with alterations. We use the term Gigification to describe these jobs, as we posit that the jobs that remain share characteristics of gig work. Our study examines the relationship between Gigification, job engagement and job satisfaction. We develop a theoretical framework to examine the impact of system automation on job satisfaction and job engagement, which we test via 232 survey responses. Our findings show that, while Gigification increases job satisfaction and engagement, AI-SA weakens the positive impact of Gigification on these important worker outcomes. We posit that, over time, the effects of AI-SA on workers is that full-time, permanent jobs will give way to gigified jobs. For future research, we suggest further theory development and testing of the Gigification of operations and supply chain work.