Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Activation and Avoidance Mediate the Relationship Between Depression and Life Satisfaction: Insights from Behavioral Activation Therapy(Springer, 2026) Koşan, Yavuz; Kaya, M. SiyabendBehavioral activation therapy has been increasingly used in depression intervention in recent years. It aims to increase the activation level and decrease the avoidance level. In this way, the individual's life satisfaction is expected to increase while trying to reduce depression. However, the relationship between depression and life satisfaction in behavioral activation therapy-based interventions has not been sufficiently revealed. Furthermore, the effects of activation and avoidance, which are the most basic concepts of behavioral activation therapy, and their underlying mechanisms are not well understood. Therefore, this study focused on this gap and aimed to explore the mediating roles of activation and avoidance variables in the relationship between depression and life satisfaction. Participants (N = 440) from a non-clinical sample group completed various self-report scales on depression, behavioral activation, and life satisfaction. Our results showed that depression and life satisfaction negatively predicted each other, and that activation and avoidance variables mediated this relationship in parallel. Accordingly, increasing activation and decreasing avoidance in young people with depressive symptoms may be an effective way to improve life satisfaction and reduce depression. Effective prevention efforts that reduce depression can increase the life satisfaction levels of young adults. In summary, behavioral activation and avoidance can be used to prevent depression and increase life satisfaction. The current study provides more information about the applicability of activation and avoidance, two important elements of behavioral activation therapy, in depression intervention.Article Effects of Alkanolamines on Calcium Sulfoaluminate Belite Cement Hydration and Fresh Properties(Emerald Group Publishing Ltd, 2026) Uzal, Burak; Wilkinson, Angus P.; Qoku, Elsa; Nguyen, Tu-Nam; Kurtis, Kimberly E.Calcium sulfoaluminate belite cements have found widespread use in specialised applications but have not been applied broadly due to rapid setting times. Conventional set retarders such as citric and tartaric acids modify hydration kinetics, introducing ancillary effects that alkanolamines may avoid. This study examined the effects of three alkanolamines, triisopropanolamine (), triethanolamine () and diisopropanolamine (), on early hydration at 0.02% dosage; was also tested across a broader dosage range. Reaction kinetics and phase evolution were examined in pastes by calorimetry, thermogravimetric analysis () and in situ quantitative X-ray diffraction () for 72 h of hydration, along with setting time and amplitude-sweep rheometry. Calorimetry showed that and delayed and reduced the main cement hydration peak, while all alkanolamines delayed and enhanced the shoulder and secondary hydration peaks. In situ and suggested that alkanolamines decrease ettringite and alumina gel formation by 24 h and may lead to poorly crystallised ettringite that cannot be quantified by . Alkanolamine-containing samples demonstrated increased storage and loss moduli and extended linear viscoelastic ranges. A consistent grouping of similar behaviour emerged: control/TIPA versus TEA/DIPA, suggesting distinct mechanisms. Finally, among the alkanolamines, was the most effective, increasing the setting time by 18 min.Article Optimizing Nanoclay-Enhanced Membranes for Oil Rejection Using Response Surface Methodology(Wiley, 2026) Gul, Ayse; Baris, Mesut; Boyraz, Pınar; Senol-Arslan, Dilek; Alibaz, Name NurThe efficient separation of waste oil from contaminated water is critical due to its challenges in environmental and industrial applications. This study investigated the production and optimization of polysulphone (PSF) membranes using two different types of clay (nanomer clay/CN and commercial nanoclay/NC). Response Surface Methodology (RSM) was applied to optimize the basic production parameters and nanoclay concentrations systematically to maximize oil rejection and permeability flow. The experimental results showed that NC and CN significantly increased the hydrophilicity, permeability, and fouling resistance of the membrane compared to pure PSF membranes. The contact angle significantly decreased from 64.34 degrees (pristine PSF) to 36.23 degrees (2% NC), indicating highly improved hydrophilicity. Consequently, the pure water flux increased from 177.2 L/m2 h to a maximum of 248.6 L/m2 h (1% NC). Furthermore, the modified membranes exhibited outstanding anti-fouling properties; the flux recovery ratio (FRR) improved from 88.09% to 96.20% (1% CN), while the decline ratio (DR) drastically dropped from 60.89% to 32.14%. The optimized condition for maximum removal efficiency using a modified quadratic model revealed that 2572 mg/L oil can be treated with a PSF membrane containing 2.0% CN to remove 98.271% of the oil. The model also suggests superiority of CN over NC with desirability factors of 0.978 and 0.900, respectively, while both demonstrated high efficiency. This theoretically modeled experimental comparative study highlights the importance of PSF membrane technology for efficient and sustainable oil-water separation and demonstrates the promising potential of nanoclay modifications.Article Identification of Potential Dual HDAC6 and HSP90 Inhibitors for the Treatment of Cancer Using Molecular Docking, Molecular Dynamics and MM/PBSA Studies: A Comprehensive In Silico Study(Bentham Science Publ Ltd, 2026) Yucel, Muhsin Samet; Akcok, IsmailBackground Histone deacetylase 6 (HDAC6) and heat shock protein 90 (Hsp90) are crucial therapeutic targets in cancer research with their interconnected roles in regulating protein homeostasis and cellular processes. The interaction of these proteins within the cytosolic complex plays a critical role in regulating cancer cell survival and progression. Notably, current studies highlight that the simultaneous inhibition of HDAC6 and Hsp90 can produce synergistic effects and offer a promising therapeutic potential for combating malignant cancers.Objective The objective of this study was to explore potential compounds that can inhibit both HDAC6 and Hsp90 proteins.Methods In this study, a number of in-silico computational techniques were employed. A total of 791 molecules, sharing at least 30% similarity with previously identified four HDAC inhibitors, were obtained from the ZINC15 database and subjected to docking on HDAC6 and Hsp90 proteins. The top eight ligands demonstrating the best binding scores against both targets, with panobinostat and ganetespib serving as reference compounds for HDAC6 and Hsp90, respectively, were selected for further analysis. Subsequently, ADME prediction and molecular dynamics simulations were conducted on the selected ligands.Results A detailed molecular docking, molecular dynamics simulations and ADME studies have revealed that ZINC27653366 exhibited the highest inhibitory potential against both Hsp90 and HDAC6 target proteins, making it the most promising inhibitor.Conclusion In conclusion, although additional in vitro and in vivo studies are required for the validation, in silico evaluation of ZINC27653366 may position it as a promising candidate for the treatment of different types of cancers.Article Minimization of Thermal Stresses in Instrumented Cutting Tools with Embedded Thin Film Thermocouples(Korean Society of Mechanical Engineers, 2026-04) Kesriklioglu, Sinan; Sivesoglu, AbdurrahmanThis study investigates the optimization of multilayer coatings on cutting tools to minimize thermal stress and temperature differences between the tool-chip interface and embedded thermocouples. The novelty of this study lies in directly linking coating architecture to temperature measurement accuracy, revealing that coatings not only affect heat dissipation and stress development but may also distort the apparent temperature recorded by embedded sensors. The types and thickness ranges of thin film layers in instrumented cutting tools were determined, and multi-physics finite element simulations were then used to evaluate coating configurations under thermal loading, assessing both stress distribution and temperature variance in the multilayer coating system. The Taguchi method, coupled with desirability analysis, identified optimal coating parameters that simultaneously minimize thermal stresses and temperature disparities, which are critical for accurate temperature measurements and extending the lifespan of cutting inserts. This framework enables a controllable trade-off between mechanical reliability and thermal measurement fidelity. The results reveal significant interactions among coating configurations (settings) and between thermal and mechanical properties of the materials used, demonstrating that careful selection of layer materials and thicknesses optimizes stress and temperature responses yielding thermal stress of 1628 MPa (second lowest and only 0.4 % higher than the minimum) and temperature difference of 12.1 degrees C (third lowest and 55 % lower than average). These findings underscore the potential of precise coating design to enhance tool performance and longevity in high temperature machining applications.Article Unveiling the Therapeutic Role of 3D-Cultured Mesenchymal Stem Cells in Diabetic Foot Ulcers through Transcriptomic Integration and Fibroblast Modulation(Springer, 2026-03-31) Ozturk, Esengul; Bicer, MesudeBackground Diabetic foot ulcers (DFUs) are among the most severe complications of diabetes mellitus and remain difficult to manage due to chronic inflammation, defective angiogenesis, delayed tissue repair, which increase the risk of recurrence and limb amputation. Standard treatments, such as debridement, infection management, pressure off-loading and revascularization, are commonly used, however; these interventions often inadequate to fully restore effective wound repair. Mesenchymal stem cells (MSCs) have attracted remarkable interest due to their potential regenerative ability and paracrine activity. Nevertheless, the molecular interaction between MSCs and fibroblasts under hyperglycemic conditions has not been fully elucidated. Objective This study aimed to examine differentially expressed genes (DEGs) associated with DFUs and MSC-related regenerative mechanisms using transcriptomic datasets (such as GSE143735, GSE199939, and GSE217709). Methods and results Differentially expressed genes and protein-protein interaction (PPI) network analysis were performed to determine central regulatory genes. Four key genes including CXCL1, MMP9, THBS1, and POSTN were recognized as hub genes related to inflammatory response, extracellular matrix reorganization, and angiogenesis. For experimental validation, L929 murine fibroblasts were exposed to high-glucose conditions to set-up an in vitro diabetic model and subsequently treated with MSCs with/without a 3D platform. Hyperglycemic conditions significantly reduced fibroblast proliferation and migration downregulated the expression of the identified hub genes and enhanced apoptotic activity. MSC treatment partially increased cellular function, while MSCs embedded into 3D culture enhanced a more pronounced recovery in both gene expression patterns and functional assays. Conclusions These findings suggest that high glucose impair fibroblast functions for wound repair, while 3D-cultured MSCs enhance regenerative responses and may represent a promising strategy for diabetic wound healing.Article TEffectBayes: A Nextflow Pipeline for Exploring the Potential Effect of Transposable Elements in Gene Regulatory Network with Multi-Omic Bayesian Network Model(Springer Heidelberg, 2026-03-10) Karakülah, Gökhan; Güner, Hüseyin; Kutlu, Necati KaanTransposable elements (TEs) are critical contributors to gene regulatory networks, yet their repetitive and abundant nature complicates efforts to elucidate their precise regulatory roles. While existing computational tools facilitate systematic identification of associations between TEs and gene expression, these methods typically cannot account for confounding variables or capture causal and directional interactions. To address these limitations, we developed TEffectBayes, a Nextflow-based pipeline leveraging a multi-omic Bayesian network (BN) framework designed to systematically infer directional, probabilistic regulatory dependencies involving TEs. TEffectBayes integrates diverse omics datasets, including RNA-seq-derived gene and locus-specific TE expression, along with ChIP-seq-based histone modification data processed via custom R and Python scripts. Integrated multi-omic datasets are subsequently employed to build gene-centric Bayesian models, enabling robust inference of context-dependent, probabilistic relationships between TEs, chromatin modifications, and gene expression. TEffectBayes thus provides a reproducible and scalable computational framework for unraveling the complex regulatory landscape shaped by TEs. In summary, TEffectBayes supports systematic prioritization of TE-chromatin-gene regulatory candidates for downstream benchmarking and experimental validation, enabling hypothesis-driven follow-up studies in diverse biological contexts. The pipeline, along with comprehensive user tutorials and example datasets, is publicly accessible at https://github.com/nkaan-kutlu/TEffectBayes.Article Production of Waste-Based Lightweight Geopolymer Concretes Using Calcined Bentonite, Fly Ash, Slag, and Expanded Polystyrene Granules(Taylor & Francis Inc, 2026-03-19) Top, Soner; Nussrat Shukur Shukur, Yasir; Vapur, HüseyinThis study investigates the production of environmentally friendly lightweight geopolymer concretes utilizing fly ash (FA) as the primary precursor with calcined calcium bentonite (CCB), ferrochrome slag (SG), and expanded polystyrene (EPS) as supplementary components. A Box-Behnken design was employed to investigate the combined effects of CCB and SG additions, along with the solid-to-liquid ratio, on the compressive strength. Moderate CCB incorporation, particularly around 10%, improved mechanical performance, achieving strengths above 48 MPa, with a maximum of 51.33 MPa at 90 degrees C for a mix containing 5% CCB and 5% SG. Higher CCB dosages (>20%) reduced strength due to matrix dilution, while SG showed limited contribution at elevated levels. Incorporation of EPS granules reduced density to as low as 1292 kg/m & sup3;, yet compressive strengths between 25 and 30 MPa were maintained in mixes with 10% CCB and 0.3% EPS. SEM-EDX analysis confirmed dense geopolymer matrices in FA-CCB composites, whereas SG particles appeared less integrated. These results confirm the potential for producing high-strength, lightweight geopolymer concretes through the effective valorization of waste. The combined use of FA, CCB, SG, and EPS offers a sustainable pathway for resource-efficient construction that supports circular resource utilization.Article Effects of a Period and a Contact Angle on Absorption Performance of Hemispherical-Shell-Shaped Organic Photovoltaic Cells(SPIE-Soc Photo-Optical Instrumentation Engineers, 2026-02-17) Hah, DooyoungFor wearable electronics applications, organic photovoltaic (OPV) cells are good candidates as sources of renewable energy. Many efforts have been devoted to increasing energy conversion efficiency in OPV cells, and improvement in light retention has been one of the main research directions. Within this context, our group recently proposed an OPV cell structure with a hemispherical-shell-shaped (HSS) active layer and discovered that it has high potential for substantial enhancement in absorption performance. As a continuation of the study, this paper reports an in-depth investigation of the proposed device, examining the effects of several design parameters on its absorption performance. Using finite element analysis, it is found that the absorption performance depends on the periodicity type, and that a hexagonal type results in higher absorption than a square one due to its closer shape resemblance to a circular cross-section. The absorption performance is also affected by a contact angle, i.e., the angle made between a sphere and a flat part of the structure. It is learned that the average integrated absorption generally increases along with the contact angle, which saturates at around 80 deg of contact angle. Lastly, the effects of a cell period are studied, and it turns out that the average integrated absorption decreases as the period increases. It is also observed that at high incidence angles (>similar to 75 deg ), an array with a shorter period results in lower absorption than one with a longer period owing to a partial obstruction issue. All of these results support the understanding that the primary contribution of absorption enhancement in the proposed HSS structure comes from improved light retention rather than from a simple advantage in active layer volume. It is envisaged that these study outcomes will provide important guidelines in the design of HSS OPV cells.Article Borax-Doped Fe2O3 and CeO2 Nanoparticles Regulate Dose-Dependently Inflammation, the Cell Cycle, and Migration in LPS-Activated THP-1 Cells(Wiley-VCH Verlag GmbH, 2026-03) Sulak, Mine; Ceylan Ekiz, Yağmur; Şen, Alaattin; Acar, Büşra; Çelik Turgut, Gurbet; Aktaş Pepe, NihanThis study examined the biological effects of borax-doped Fe2O3 and CeO2 nanoparticles (NPs) on lipopolysaccharide (LPS)-activated THP-1 cells. The morphology and composition of the nanocomposites were confirmed via scanning electron microscopy (SEM) and energy-dispersive x-ray spectroscopy (EDX). Cell viability (resazurin and crystal violet assays), apoptosis/necrosis (annexin V/propidium iodide [PI]), cell cycle (flow cytometry), migration (scratch assay), and inflammatory response (Iba1 immunofluorescence staining, inducible nitric oxide synthase [iNOS] activity, and RT-PCR) were evaluated. The particle sizes ranged from 21.34 to 33.47 nm (Fe2O3-B-NPs) and 31.07 to 36.62 nm (CeO2-B-NPs). The IC10 and IC50 dose ranges were defined for each nanocomposite and applied across different cell lines to evaluate dose-dependent biological effects. Fe2O3-B-NPs altered cell cycle progression, increasing the number of S phase cells. Both nanocomposites promoted migration at low doses but inhibited it at high doses. CeO2-B-NPs reduced Iba1 levels, whereas Fe2O3-B-NPs increased inflammatory marker levels at higher concentrations. CeO2-B-NPs suppressed TNF-alpha and IL-1 beta gene expression at the IC50 dose, while both nanocomposites reduced iNOS activity. These results indicate that the dose-dependent effects of nanocomposites should be carefully evaluated.