Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Population Specific Classification of Colorectal Cancer With Meta-Analysis of Metagenomic Data(Institute of Electrical and Electronics Engineers Inc., 2023-10-11) Temiz, Mustafa; Yousef, Malik; Bakir-Güngör, BurcuAdvances in next-generation sequencing and '-omics' technologies makes it possible to characterize the human gut microbiome. While some of these microorganisms are important regulators of our immune system, modulation of the microbiota leads to a variety of diseases. Colorectal cancer (CRC), the third most common cancer worldwide, is caused by genetic mutations, environmental conditions, and abnormalities in the gut microbiota. Using various machine learning methods and meta-analysis techniques, this study aims to build a classification model that can help in CRC diagnosis by analyzing metagenomic datasets of different populations obtained at the species level. Using 8 different countries and 9 different metagenomic datasets, 3 different meta-analyzes are performed: within-population, cross-population, and one population is selected for testing and the rest is used as a training dataset (LODO). For CRC classification, 4 different classification algorithms (Random Forest (RF), Logitboost, Adaboost, and Decision Tree (DT)) are used. The best performance among these methods was obtained with the Random Forest algorithm with an AUC of 0.98 by using JP for the training data set and JPN populations for the test data set in the cross-population performance evaluation. © 2023 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1Blokzincir Tabanlı Kullanıcı Yönetim Sistemi(Institute of Electrical and Electronics Engineers Inc., 2020-10-05) Temiz, Mustafa; Soran, Ahmet; Arslan, Halil; Erel, HilalBlockchain is a reliable and transparent structure formed by distributing the data in blocks connected to each other using various cryptography techniques to other points on the network. The difference from the existing database operations is that the authorities and responsibilities do not exist in a single central authority, and that these powers and responsibilities are distributed to the other nodes in the network and the assignment is shared. To provide this, peer to peer network infrastructure is used. However, at this stage, authentication in terms of security is one of the basic security mechanisms. In this study, a user management system which can be integrated with more reliable and current technologies, which is thought to be the solution to speed problems in blockchain, is proposed. © 2021 Elsevier B.V., All rights reserved.