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Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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  • Article
    Citation - WoS: 8
    Citation - Scopus: 8
    RAFT-Mediated Synthesis of Poly( N-(2-Hydroxypropyl)Methacrylamide-b-4-vinylpyridine)by Conventional and Microwave Heating
    (Springer, 2013-06-14) Ozdemir, Zeynep; Topuzogullari, Murat; Isoglu, Ismail Alper; Dincer, Sevil
    We report the synthesis of N-(2-hydroxypropyl)methacrylamide (HPMA) macroCTA and HPMA-b-4-Vinylpyridine block copolymers via reversible addition-fragmentation chain transfer (RAFT) reaction. Polymerization was carried out in dimethylformamide (DMF) at 70 A degrees C using 4-Cyano-4(thiobenzoylthio) pentanoic acid as chain transfer agent and AIBN as an initiator. Control over molecular weight and composition was achieved by altering the CTA, monomer and initiator feed ratio. The controlled living character of the polymerization was verified with pseudo-first-order kinetic plots, a linear increase of the molecular weight with conversion, and low polydispersities (PDIs a parts per thousand currency sign 1.2). Effect of microwave heating on the homo- and copolymer formation was investigated and the rates were significantly higher than those observed under conventional heating conditions. These polymerization reactions were in controlled fashion resulting in polymers with low PDIs, too. These polymers have a great potential to be used in developing delivery vehicles and conjugates for further drug or gene delivery applications.
  • Article
    Citation - WoS: 21
    Citation - Scopus: 21
    Polyethylenimine Modified and Non-Modified Polymeric Micelles Used for Nasal Administration of Carvedilol
    (Amer Scientific Publishers, 2015-05-01) Kahraman, Emine; Karagoz, Ayse; Dincer, Sevil; Ozsoy, Yildiz
    This study evaluates the ability of polyethylenimine-modified and non-modified polymeric micelles to enhance permeation through the nasal mucosa for a highly hydrophobic model drug. Carvedilol was loaded into polyethylenimine-modified and non-modified micelles by direct dissolution. Formulations were characterised by critical micelle concentration, micelle particle size and distribution, zeta potential, morphological structure and entrapment efficiency. The drug entrapment efficiency was determined to be as high as 77.14%, while micelle particle sizes and zeta potentials were within the range of 140.0-279.9 nm and (-40.6)-(+25.9) mV, respectively. In vitro studies showed 100% release of carvedilol from micelles in 120 hours. Ex vivo permeation studies showed that the drug in polyethylenimine non-modified micelles passed more efficiently than the drug in polyethylenimine modified micelles. These results demonstrated that polyethylenimine modified micelles did not significantly affect the permeation of the drug when compared to polyethylenimine non-modified micelles. On the contrary, the drug in poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 micelles, the polyethylenimine non-modified micelles, showed the highest permeation rate through bovine nasal mucosa. In conclusion, poly(L-lactide)-block-methoxy poly(ethylene glycol) 5000 polymeric micelles maybe useful as novel drug carriers that increase the permeation through the nasal mucosa.
  • Article
    Citation - WoS: 25
    Citation - Scopus: 25
    Microwave-Assisted Green Approach for Graft Copolymerization of L-Lactic Acid Onto Starch
    (Wiley, 2015-10-15) Salimi, Kouroush; Topuzogullari, Murat; Dincer, Sevil; Aydin, Halil Murat; Piskin, Erhan
    Poly l-lactic acid grafted starch (St-g-PLA) copolymers were directly synthesized under microwave irradiation by using sodium hydroxide (NaOH) and stannous 2-ethyl hexanoate acting as a catalyst, without the use of toxic solvents. The product were characterized by Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (C-13 CP/MAS NMR), X-ray diffraction (XRD), scanning electron microscopy (SEM) and thermogravimetric analysis (TGA-DTG). SEM analysis indicated that microwave heating had a considerable effect on the interfacial adhesion between PLA and starch. Thermogravimetric analysis (TGA-DTG) revealed that copolymers exhibited better thermal stability. Maximum PLA grafting was achieved with the following reaction conditions: 450W microwave power, monomer ratio of 1:5 and 0.4M of NaOH. This study demonstrates that it is possible to obtain St-g-PLA copolymers with better processing characteristics and smaller sizes via microwave-assisted synthesis. The applied procedure is an interesting green synthesis method for the production of biodegradable materials used in a diverse range of applications. (c) 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 42937.