Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Article Citation - WoS: 6Citation - Scopus: 7Improved Senescent Cell Segmentation on Bright-Field Microscopy Images Exploiting Representation Level Contrastive Learning(Wiley, 2024-03) Celebi, Fatma; Boyvat, Dudu; Ayaz-Guner, Serife; Tasdemir, Kasim; Icoz, KutayMesenchymal stem cells (MSCs) are stromal cells which have multi-lineage differentiation and self-renewal potentials. Accurate estimation of total number of senescent cells in MSCs is crucial for clinical applications. Traditional manual cell counting using an optical bright-field microscope is time-consuming and needs an expert operator. In this study, the senescence cells were segmented and counted automatically by deep learning algorithms. However, well-performing deep learning algorithms require large numbers of labeled datasets. The manual labeling is time consuming and needs an expert. This makes deep learning-based automated counting process impractically expensive. To address this challenge, self-supervised learning based approach was implemented. The approach incorporates representation level contrastive learning component into the instance segmentation algorithm for efficient senescent cell segmentation with limited labeled data. Test results showed that the proposed model improves mean average precision and mean average recall of downstream segmentation task by 8.3% and 3.4% compared to original segmentation model.Article Citation - WoS: 1Citation - Scopus: 1Enhancing Diagnostic Quality in Panoramic Radiography: A Comparative Evaluation of GAN Models for Image Restoration(Wiley, 2025-09-04) Kolukisa, Burak; Celebi, Fatma; Ersu, Nihal; Yucel, Kemal Selcuk; Canger, Emin Murat; Murat Canger, EminPanoramic imaging is a widely utilized technique to capture a comprehensive view of the maxillary and mandibular dental arches and supporting facial structures. This study evaluates the potential of the Generative Adversarial Network (GAN) models-Pix2Pix, CycleGAN, and RegGAN-in enhancing diagnostic quality by addressing combinations of common image distortions. A panoramic radiograph data set was processed to simulate four types of distortions: (i) blurriness, (ii) noise, (iii) combined blurriness and noise, and (iv) anterior-region-specific blurriness. Three GAN models were trained and analyzed using quantitative metrics such as the peak signal-to-noise ratio (PSNR) and the structural similarity index measure (SSIM). In addition, two oral and maxillofacial radiologists conducted qualitative reviews to assess the diagnostic reliability of the generated images. Pix2Pix consistently outperformed CycleGAN and RegGAN, achieving the highest PSNR and SSIM values across all types of distortions. Expert evaluations also favored Pix2Pix, highlighting its ability to restore image accuracy and enhance clinical utility. CycleGAN showed moderate improvements in noise-affected images but struggled with combined distortions, while RegGAN yielded negligible enhancements. These findings underscore its potential for clinical application in refining radiographic imaging. Future research should focus on combining GAN techniques and utilizing larger datasets to develop universally robust image enhancement models.