Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Citation - Scopus: 1The Identification of Discriminative Single Nucleotide Polymorphism Sets for the Classification of Behçet's Disease(Institute of Electrical and Electronics Engineers Inc., 2018-09) Görmez, Yasin; Işik, Yunus Emre; Bakir-Güngör, BurcuBehçet's disease is a long-term multisystem inflammatory disorder, characterized by recurrent attacks affecting several organs. As the genotyping individuals get cheaper and easier following the developments in genomic technologies, genome-wide association studies (GWAS) emerged. By this means, via studying big-sized case-control groups for a specific disease, potential genetic variations, single nucleotide polymorphisms (SNPs) are identified. Although several genetic risk factors are identified for Behçet's disease with the help of these studies via scanning around a million of SNPs, these variations could only explain up to 20% of the disease's genetic risk. In this study, for Behçet's disease classification, via comparing all the SNPs genotyped in GWAS, with the SNPs selected via using genetic knowledge, gain ratio and information gain; both reduction in the feature size and improvement in the classification accuracy is aimed. Also, using different classification algorithms such as random forest, k-nearest neighbour and logistic regression, their effects on the classification accuracy are investigated. Our results showed that compared to other feature selection methods, with at least 81% success rate, the selection of the SNPs using the genetic information (of their GWAS p-values, indicating the significance of the SNP against the disease) provides 15% to 42% improvement in all classification algorithms. This improvement is statistically sound. While gain ratio and information gain feature selection techniques yield similar classification accuracies, the models using all SNPs could not exceed 50% accuracies and results in the worst performance. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 7Citation - Scopus: 8The Determination of Distinctive Single Nucleotide Polymorphism Sets for the Diagnosis of Behcet's Disease(IEEE Computer Soc, 2022-05-01) Isik, Yunus Emre; Gormez, Yasin; Aydin, Zafer; Bakir-Gungor, BurcuBehcet's Disease (BD) is a multi-system inflammatory disorder in which the etiology remains unclear. The most probable hypothesis is that genetic tendency and environmental factors play roles in the development of BD. In order to find the essential reasons, genetic changes on thousands of genes should be analyzed. Besides, there is a need for extra analysis to find out which genetic factor affects the disease. Machine learning approaches have high potential for extracting the knowledge from genomics and selecting the representative Single Nucleotide Polymorphisms (SNPs) as the most effective features for the clinical diagnosis process. In this study, we have attempted to identify representative SNPs using feature selection methods, incorporating biological information and aimed to develop a machine-learning model for diagnosing Behcet's disease. By combining biological information and machine learning classifiers, up to 99.64 percent accuracy of disease prediction is achieved using only 13,611 out of 311,459 SNPs. In addition, we revealed the SNPs that are most distinctive by performing repeated feature selection in cross-validation experiments.Conference Object Citation - WoS: 16Citation - Scopus: 20Machine Learning Analysis of Inflammatory Bowel Disease-Associated Metagenomics Dataset(Institute of Electrical and Electronics Engineers Inc., 2018-09) Hacilar, Hilal; Nalbantoĝlu, Özkan Ufuk; Bakir-Güngör, BurcuThere is an ongoing interplay between humans and our microbial communities. The microorganisms living in our gut produce energy from our food, strengthen our immune system, break down foreign products, and release metabolites and hormones, which are significant for regulating our physiology. The shifts away from this 'healthy' gut microbiome is considered to be associated with many diseases. Inflammatory bowel diseases (IBD) including Crohn's disease and ulcerative colitis, are gut related disorders affecting the intestinal tract. Although some metagenomics studies are conducted on IBD recently, our current understanding of the precise relationships between the human gut microbiome and IBD remains limited. In this regard, the use of state-of-the art machine learning approaches became popular to address a variety of questions like early diagnosis of certain diseases using human microbiota. In this study, we investigate which subset of gut microbiota are mostly associated with IBD and if disease-associated biomarkers can be detected via applying state-of-the art machine learning algorithms and proper feature selection methods. © 2019 Elsevier B.V., All rights reserved.Article Citation - WoS: 4Citation - Scopus: 7IGPRED-Multitask: A Deep Learning Model to Predict Protein Secondary Structure, Torsion Angles and Solvent Accessibility(IEEE Computer Soc, 2023-03-01) Gormez, Yasin; Aydin, ZaferProtein secondary structure, solvent accessibility and torsion angle predictions are preliminary steps to predict 3D structure of a protein. Deep learning approaches have achieved significant improvements in predicting various features of protein structure. In this study, IGPRED-Multitask, a deep learning model with multi task learning architecture based on deep inception network, graph convolutional network and a bidirectional long short-term memory is proposed. Moreover, hyper-parameters of the model are fine-tuned using Bayesian optimization, which is faster and more effective than grid search. The same benchmark test data sets as in the OPUS-TASS paper including TEST2016, TEST2018, CASP12, CASP13, CASPFM, HARD68, CAMEO93, CAMEO93_HARD, as well as the train and validation sets, are used for fair comparison with the literature. Statistically significant improvements are observed in secondary structure prediction on 4 datasets, in phi angle prediction on 2 datasets and in psi angel prediction on 3 datasets compared to the state-of-the-art methods. For solvent accessibility prediction, TEST2016 and TEST2018 datasets are used only to assess the performance of the proposed model.Conference Object Citation - Scopus: 19A Novel Feature Design and Stacking Approach for Non-Technical Electricity Loss Detection(Institute of Electrical and Electronics Engineers Inc., 2018-05) Aydin, Zafer; Güngör, Vehbi ÇağrıNon-technical electricity losses continue to jeopardize economic and social well-being of many countries. In this work, we develop machine learning classifiers that can identify anomalous electricity consumption in Turkey. Starting from weekly electricity usage data, we develop new features that capture statistical and frequency domain characteristics of the customers and their consumption patterns. We analyze the effect of reducing number of feature descriptors through dimensionality reduction and feature selection techniques. To overcome the class imbalance problem, we implement several ensemble methods and compare their prediction accuracy to those of the standard classifiers. The proposed features and combining strengths of different classifiers bring significant improvements on performance metrics, which is demonstrated through detailed simulations on shopping mall sector. We anticipate that advances in this field will contribute to the economies considerably. © 2018 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 3İki Durumlu Bir Beyin Bilgisayar Arayüzünde Özellik Çıkarımı ve Sınıflandırma(Institute of Electrical and Electronics Engineers Inc., 2016-10) Altindis, Fatih; Yilmaz, BulentBrain Computer Interface (BCI) technology is used to help patients who do not have control over motor neurons such as ALS or paralyzed patients, to communicate with outer world. This work aims to classify motor imageries using real-time EEG dataset, which was published by Graz University, Austria. The dataset consists of two-channel EEG signals of right-hand movement imagery and left-hand movement imagery of 8 subjects. There are a total of 120 motor imagery trials (60 left and 60 right) EEG signals recorded from each subject. EEG signals are filtered and feature vectors were extracted that consist of 24, 32 and 40 relative band power values (RBPV). In this work, feature vectors classified by three different methods, linear discriminant analysis (LDA), K nearest neighbor (KNN) and support vector machines (SVM). Results show that best performance was achieved by 24 RBPV feature vector and LDA classification method. © 2017 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 3Protein İkincil Yapı Tahmini Için Makine Öǧrenmesi Yöntemlerinin Karşılaştırılması(Institute of Electrical and Electronics Engineers Inc., 2018-05) Aydin, Zafer; Kaynar, Oǧuz; Görmez, Yasin; Işik, Yunus EmreThree-dimensional structure prediction is one of the important problems in bioinformatics and theoretical chemistry. One of the most important steps in the three-dimensional structure prediction is the estimation of secondary structure. Due to rapidly growing databases and recent feature extraction methods datasets used for predicting secondary structure can potentially contain a large number of samples and dimensions. For this reason, it is important to use algorithms that are fast and accurate. In this study, various classification algorithms have been optimized for the second phase of a two-stage classifier on EVAset benchmark both in the original input space and in the space reduced using the information gain metric. The most accurate classifier is obtained as the support vector machine while the extreme learning machine is significantly faster in model training. © 2018 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1Koroner Arter Hastalığı Tanısı İçin Alan Bilgisi İçeren Topluluk Öznitelik Seçim Yöntemi(Institute of Electrical and Electronics Engineers Inc., 2020-10-05) Kolukisa, Burak; Güngör, Vehbi Çağrı; Bakir-Güngör, Burcu; Gungor, Burcu BakirCoronary Artery Disease (CAD) is the condition where, the heart is not fed enough as a result of the accumulation of fatty matter called atheroma in the walls of the arteries. In 2016, CAD accounts for 31% (17.9 million) of the world's total deaths and its diagnosis is difficult. It is estimated that approximately 23.6 million people will die from this disease in 2030. With the development of machine learning and data mining techniques, it might be possible to diagnose CAD inexpensively and easily via examining some physical and biochemical values. In this study, for the CAD classification problem, a novel ensemble feature selection methodology that incorporates domain knowledge is proposed. Via applying the proposed methodology on the UCI Cleveland CAD dataset and using different classification algorithms, performance metrics are compared. It is shown that in our experiments, when Multilayer Perceptron classifier is used with 9 selected features, our proposed solution reached 85.47% accuracy, 82.96% accuracy and 0.839 F-Measure. As a future work, we aim to generate a machine learning model that can quickly diagnose CAD on real-time data in hospitals. © 2021 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 13Staging of the Liver Fibrosis From CT Images Using Texture Features(2012) Kayaaltı, Ömer; Aksebzeci, Bekir Hakan; Karahan, Ökkeş Ibrahim; Deniz, Kemal; Öztürk, Menmet; Yilmaz, Bulent; Asyali, Musa Hakan; Karahan, Ibrahim Ö.Even though liver biopsy is critical for evaluating chronic hepatitis and fibrosis, it is an invasive, costly, and difficult to standardize approach. The developments in medical image processing and artificial intelligence methods have advanced the potential of using computer-aided diagnosis techniques in the classification of liver tissues. The aim of this study was to develop a non-invasive, cost-effective, and fast approach to specify fibrosis stage using the texture properties of computed tomography images of liver. Gray level co-occurrence matrix, discrete wavelet transform, and discrete Fourier transform were the image analysis tools in the feature extraction phase. Following dimension reduction of the texture features support vector machines and k-nearest neighbor methods were used in the classification phase of this study. Our results showed that our approach is feasible in fibrosis staging especially in pairwise stage comparisons with success rate of approximately 90%. © 2012 IEEE. © 2012 Elsevier B.V., All rights reserved.Conference Object Evaluation of Hybrid Classification Approaches: Case Studies on Credit Datasets(Springer Verlag service@springer.de, 2018) Cetiner, Erkan; Güngör, Vehbi Çağrı; Kocak, TaskinHybrid classification approaches on credit domain are widely used to obtain valuable information about customer behaviours. Single classification algorithms such as neural networks, support vector machines and regression analysis have been used since years on related area. In this paper, we propose hybrid classification approaches, which try to combine several classifiers and ensemble learners to boost accuracy on classification results. We worked with two credit datasets, German dataset which is a public dataset and a Turkish Corporate Bank dataset. The goal of using such diverse datasets is to search for generalization ability of proposed model. Results show that feature selection plays a vital role on classification accuracy, hybrid approaches which shaped with ensemble learners outperform single classification techniques and hybrid approaches which consists SVM has better accuracy performance than other hybrid approaches. © 2018 Elsevier B.V., All rights reserved.