Scopus İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395
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Conference Object Identify Commonly Affected Pathways in Psychiatric Diseases(Institute of Electrical and Electronics Engineers Inc., 2018-09) Bulut, Umit; Bakir-Güngör, BurcuGenome-wide association studies (GWAS) are an extraordinary source of information when it comes to revealing the common variations of human complex diseases. Until now, the large amount of data generated from these studies have not been shown its full potential enough to identify the molecular and functional framework to be able to understand how a molecular system works. Following a more specific perspective, this study focused on the identification of commonly affected pathways of psychiatric diseases. The pathway term as used in molecular biology, depicts a simplified model of a process within the cell or tissue. Lately, several GWAS datasets are publicly available for various disease types such as psychiatric, immune-related, neurodegenerative, cardiovascular and such. A study on each disease and pairwise comparison to understand the behavior of disease and system would be time consuming and exhaustive. Instead of handling the results of these studies one by one, grouping diseases by target points is a more efficient way. This work aims to get one step closer to reveal key points of diseases and target these points to develop personalized medicine approaches. Especially for complex diseases, every drug doesn't show the same effect in every people. This paper contains the definition of molecular pathways, methods to identify disease related pathways, and to find common pathways pairwise in psychiatric diseases. © 2019 Elsevier B.V., All rights reserved.Conference Object Citation - Scopus: 1Integrative Analyses in Omics Data: Machine Learning Perspective(Deutsche Gesellschaft fur Medizinische Informatik, Biometrie und Epidemiologie e.V., 2023) Ünlü Yazici, Miray; Bakir-Güngör, Burcu; Yousef, Malik; Yazici, Miray UnluDevelopments in the high throughput technologies have enabled the production of an immense amount of knowledge at the multi-omics level. Considering complex diseases which are affected by multi-factors, single omics datasets might not be sufficient to unveil the molecular mechanisms of heterogeneous diseases. Providing a comprehensive and systematic overview to explain disease hallmarks in significant depth is critical. Utilizing multi-omics datasets has led to the development of a variety of tools and platforms. Machine learning models are utilized in a wide variety of tools to tackle the complexity of disorders and to identify new biomolecular signatures and potential markers. Underlying aspects of these approaches are based on training the models for making predictions and classification of the given data. In this review, we describe current machine learning-based approaches and available implementations. Challenges in the enlightenment of disease mechanisms of onset and progression and future development of the field of medicine will be discussed. The prominence of biological interpretation of model output with corresponding biological knowledge will be also covered in this review. © 2023 Elsevier B.V., All rights reserved.