TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/396

Browse

Filters

2020 - 20244

Settings

Subject: search.filters.subject.BiyolojiWoS Q: search.filters.wosQuartile.N/A

Search Results

Now showing 1 - 4 of 4
  • Article
    Testing a Metacognitive Regulation Approach for Judgment of Satiation: Might Hunger and Fullness Not Be the Polar Opposites of the Same Dimension
    (2020-12-31) Güzel, Mehmet Akif; Güngör, Duygu
    Despite the existence of several cognitive influences, metacognitive factors on eating and satiation still remain unclear. Therefore, we investigated a relatively recent metacognitive regulation approach and its measurement method in a lab-experiment.Participants (N=216) were shownphotografsof varying portions of common lunch foods (selected after a separate study, N=94) and asked to makepredicted judgmentsof satiation (JOS) for each via considering their actual hunger levels and whilst imagining other bodily states (e.g., extremely hungry and completely full). Differencescalculated between observed-JOS and their reference scores -thosepresumed to yield accurate matches for the cases-produced either deviances or none at all (discordant-or concordant-JOS). Hungry-group yielded significantly lower concordant-JOS percentage than full-group regardless of portion size, indicating a clearercognitive tendency to lose control over consumption when being hungry than satiated. Critically, full-group could notimagine extreme hunger as hungry-group whereas hungry-group imagined complete fullness just as full-group did, suggesting that whilst hunger was not an obstacle to imagine fullness,fullness hindered the ability to imagine hunger. These findingssuggestthathunger and fullness mightnotbe the polar opposites on the very same dimension, which would, for instance,reveal a need to revisit the treatments of eating disorders accordingly.
  • Article
    Investigating the Impact of Birt–hogg–dubé Syndrome Associated Folliculin (Flcn) and Retinitis Pigmentosa 2 (Rp2) Loss on Cilia Function and Morphology
    (2024-06-30) Kaplan, Oktay Ismail
    Folliculin (FLCN), a GTPase-activating protein (GAP), has been linked to Birt–Hogg–Dubé syndrome, the mTORC1 signaling pathway and cilia. Disruptions in cilia structure and function lead to a group of diseases known as ciliopathies. Birt-Hogg-Dubé syndrome is one of 35 different ciliopathy diseases and there are more than 250 genes that cause ciliopathy diseases. FLCN interacts with kinesin-2 along cilia. The specific role of FLCN in regulating Kinesin-IFT trafficking has, however, remained unclear. In the current study, we investigated the effects of flcn-1 loss (the human ortholog of FLCN) on kinesin and IFT trafficking in C. elegans. The loss of flcn-1 alone did not result in any apparent alterations to kinesin or IFT trafficking within the cilia. However, when we combined the deletion of flcn-1 with the deletion of Retinitis Pigmentosa 2 (RP2), another GAP protein, the ciliary entry of a non-ciliary membrane protein TRAM-1 (Translocation Associated Membrane Protein 1) occured. Additionally, although cilia length was unaltered, our analysis of double mutants revealed the extra branch in wing AWB cilia morphology but not the single rod-like PHA/PHB cilia. In summary, our study reveals the previously unknown functions of FLCN in ciliary gating and cilia morphology in C. elegans
  • Article
    In Silico Evaluation of the Potential of Natural Products From Chili Pepper as Antiviral Agents Against DNA-Directed RNA Polymerase of the Monkeypox Virus
    (2024-03-24) Fidan, Ozkan; Mujwar, Somdutt
    This study focused on the discovery of new drug candidates effective against the monkeypox virus. Virtual screening was performed to evaluate the potential of chili pepper natural products against homology-modeled DNA-directed RNA polymerase of the monkeypox virus using molecular docking. Our findings revealed that structurally similar triterpenes such as α-amyrin, β-amyrin, and β-sitosterol had strong binding affinities towards the DNA-directed RNA polymerase and can inhibit this pivotal viral enzyme. The stability of one of the drug candidate molecules, α-amyrin with the strongest binding affinity towards the binding cavity of the enzyme was also confirmed via molecular dynamics simulation. This study showed that α-amyrin is a promising DNA-directed RNA polymerase inhibitor to treat monkeypox disease. It also paves the way for the idea of the potential dietary supplement candidate for monkeypox patients.
  • Article
    Multilevel Thresholding for Brain MR Image Segmentation Using Swarm-Based Optimization Algorithms
    (2024-09-03) Sahin, Omur; Kurban, Rifat; Toprak, Ahmet Nusret
    Bir görüntüyü bölüt adı verilen çeşitli piksel kümelerine ayırma işlemi olan görüntü bölütleme, görüntü işlemede önemli bir tekniktir. Görüntü bölütleme, görüntünün karmaşıklığını azaltmakta ve görüntüyü bölütlere ayırarak analiz edilmesini kolaylaştırmaktadır. Görüntü bölütlemenin en basit ancak etkin yollarından biri, piksellerin değerlerine göre birden çok bölgeye ayrıldığı çok düzeyli eşiklemedir. Bu çalışma, yaygın kullanılan sürü tabanlı optimizasyon algoritmalarının beyin MR görüntülerinde çok düzeyli eşikleme tabanlı görüntü bölütleme performansını araştırmayı ve karşılaştırmayı amaçlamaktadır. Yedi sürü zekâsı temelli optimizasyon algoritması: Parçacık Sürü Optimizasyonu (PSO), Yapay Arı Kolonisi (ABC), Gri Kurt Optimize Edici (GWO), Güve Alevi Optimizasyonu (MFO), Karınca Aslanı Optimizasyonu (ALO), Balina Optimizasyonu (WOA) ve Denizanası Arama Optimizasyon (JS) eşik seviyelerini belirlemek üzere beyin MR görüntülerine uygulanarak karşılaştırılmaktadır. Bahsi geçen algoritmalar ile yapılan deneylerde minimum çapraz entropi ve sınıflar arası varyans amaç fonksiyonları kullanılmıştır. Kapsamlı deneyler, JS, ABC ve PSO algoritmalarının daha iyi performans sergilediğini göstermektedir.