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TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/396

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  • Article
    Citation - WoS: 1
    Citation - Scopus: 2
    Investigation of the Interaction of Adipose-Derived Mesenchymal Stem Cells With Ε-Polycaprolactone and EGG White Scaffolds
    (Gazi Univ, 2023-12-01) Oztel, Olga N.; Yilmaz, Hilal; Isoglu, I. Alper; Allahverdiyev, Adil
    The development of three-dimensional (3D) cell culture models is becoming increasingly important due to their numerous advantages over conventional monolayer culture. This study aimed to examine the interaction of adipose tissue-derived mesenchymal stem cells (AD-MSCs) with scaffolds composed of e-polycaprolactone (e-PCL) and egg white. In our study, e-PCL and egg white scaffolds were produced from their monomers by tin octoate catalyzed and heat polymerization, respectively. Characterization of e-PCL was carried out by Gel Permeation Chromatography (GPC), Fourier Transform Infrared Spectrophotometry (FTIR), Proton Nuclear Magnetic Resonance (H-NMR), Differential Scanning Calorimetry (DSC) and Scanning Electron Microscopy (SEM). AD-MSCs labeled with red fluorescent CellTracker CM-DiI were cultured on egg white and e-PCL scaffolds for 12 days. Cell viability was determined using 3-(4.5Dimethylthiazol-2yl)-2.5-diphenyltetrazolium bromide (MTT) and nitric oxide (NO) level was evaluated for toxicity. The results showed that the number of AD-MSCs in the egg white scaffold increased periodically for 12 days compared to the other groups. Although the number of ADMSCs in the e-PCL scaffold increased until day 6 of the culture, the number of cells started to decrease after day 6. These results were associated with the toxic effect of lactic acid release on cells resulting from the decomposition of e-PCL scaffolds through catabolic reactions. Therefore, these results indicated that the egg white scaffold enhanced and maintained cell adhesion and cell viability more than the e-Polycaprolactone scaffold and could be used as a scaffold in tissue engineering studies involving stem cells.
  • Article
    Distributed Coverage Control with Mobile Robots: A Potential Game Approach
    (2023-09-17) Guler, Samet
    Endüstriyel uygulamalarda mobil robotların kullanımı, gürbüz ve dağıtık algoritma içeren otonom çoklu-robot sistemlerine bir gereksinim oluşturmuştur. Bir robot takımının sınırlı bir alanda uzaysal-zamansal olaylara cevap vermesi anlamına gelen kapsama kontrolü bu tür sistemlerde kritik bir hedeftir. Bu çalışmada, bir grup mobil robotun doğrusal bir iş istasyonunun iki tarafında belirli lokasyonları kapsamakla görevli olduğu özel bir kapsama problemini ele alıyoruz. Problemi iyi kurgulanmış oyuncu stratejileri ile mobil robotlar arasında oynanan bir oyun olarak formalize ediyor ve ortaya çıkan yapının eşit paylaşılan fayda temelli bir potansiyel oyun olduğunu gösteriyoruz. Sunulan yapı, robotlarda anonim kimlikler ve kısıtlı algılama yeteneklerine izin veren dağıtık ve merkezi olmayan bir yapıdır. Bir grup simülasyon çalışması yaklaşımımızı doğrulamaktadır.