TR-Dizin İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/396

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  • Article
    Citation - WoS: 1
    Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
    (Galenos Publishing House, 2025-09-22) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.; Demirci, Muserref Duygu Sacar
    Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    The Comparison of Fragility Curves of Moment-Resisting and Braced Frames Used in Steel Structures Under Varying Wind Load
    (Turkish Chamber Civil Engineers, 2025-03-01) Ozalp, Abdulkadir; Gokdemir, Hande; Ciftci, Cihan
    In this study, the performance of two different steel structure types (moment-resisting frame and braced frame) under wind loading was compared by addressing the fragility curves of these structure types. To perform this comparison, the dimensions of the members of these structural systems were first determined. Then, nonlinear static pushover analyses were conducted to assess the performance levels of each frame type. After applying these analyses, time-history analyses were performed with 100 different wind loads for each varying equivalent mean wind speed. Afterwards, the probability of exceeding the predetermined structural performance limits of the structure types was determined using Monte Carlo simulation method. Finally, the results of the simulation method were used to adapt the maximum likelihood estimation method to obtain the fragility curves of the structures. To conclude, it has been revealed that the material cost of the structure doubles when diagonal elements are used, but the wind speed required for a 100% collapse probability to occur in the braced frame is twice as high compared to the moment-resisting frame.
  • Article
    Tax Compliance Behaviour and Lab Experiments: A Literature Review
    (Maliye Bakanligi, 2021) Demirtas, Burak Kagan
    The purpose of this article is to conduct a literature review of the papers based on laboratory experiments to analyze tax evasion behaviors of individuals. Although experimental studies in economics have become more and more important day by day, there are almost no publications on experimental economics in the Turkish literature. The studies are examined especially in terms of experimental designs because this study also aims to increase awareness about laboratory experiments. This review also discusses the criticism of laboratory experiments and concludes that the results obtained from laboratory experiments are important and it would be beneficial to support them with field experiments.
  • Article
    Citation - WoS: 2
    Reconsidering the Changing Higher Education System from Sociocultural and Spatial Perspectives
    (Deomed Publ, Istanbul, 2020-07-27) Ayten, Asim Mustafa; Gover, Ibrahim Hakan
    Education and research are vital for social development and progress. The changing sociocultural structures and new needs have resulted in some important functional changes in higher education systems with a deep impact on universities serving these needs at the highest level. Besides experiencing these functional changes, the universities today have become spaces of socialization with their social, cultural and sports facilities, replacing their traditional spatial role of offering education only. The local dynamics changing with globalization have now reshaped the global and local roles of universities, highlighting the added value they provide to the society. Sociocultural changes trigger all these functional and structural changes in universities. Therefore, sociocultural factors and their importance should not be ignored in a changing higher education system. In this study, the impact of sociocultural factors with their related spatial structures on world higher education system will be analyzed within their historical contexts, and some suggestions for future universities will be offered considering the current changes. In the first part of the study, the changes in societies and universities will be presented within the historical context. In the second part, the spatial forms and structures of universities will be discussed. In the third part, the catalytic effects of the specific sociocultural factors will be highlighted and elaborated on. Finally, some suggestions will be made for the universities of the future in the light of the current situation and the data available.
  • Other
    Barriers in Sustainable Lean Supply Chain Management: Implementation in SMEs
    (Ege Univ, Fac. Economics & Admin. Sciences, 2025-02-04) Kazancoglu, Yigit; Takcı, Ebru; Ada, Erhan
    As the world undergoes significant transformations in various domains, including technology, energy supply and communication, the idea of sustainability has become a significant issue. This study investigates the barriers to Sustainable Lean Supply Chain (SLSC) management within Small and Medium-Sized Enterprises (SMEs) and explores the structural interrelationships among these barriers. A comprehensive literature review was carried out to recognize critical elements relevant to the research topic, resulting in the identification of fifteen specific elements that account for 85% of the barriers in SLSC management. The DEMATEL method was used to evaluate the significance and influence levels of these factors. Furthermore, structured in-depth interviews were conducted with ten experts representing sectors that constitute 85% of the SMEs operating in Kayseri Organized Industrial Zone (OIZ), Turkey, including metal products, furniture, plastic packaging, construction materials, textiles and food. The findings reveal that strategies represent the most significant barrier to SLSC management in SMEs. The barriers were analyzed in two dimensions: influencing and influenced factors. The primary influencing factor identified was laws, standards, regulations, and legislation while the most significant influenced factor was found supply and suppliers. The study concludes with findings and actionable recommendations for practitioners and decision-makers.