TR-Dizin İndeksli Yayınlar Koleksiyonu

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  • Article
    Citation - WoS: 1
    Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
    (Galenos Publishing House, 2025-09-22) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.; Demirci, Muserref Duygu Sacar
    Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.
  • Article
    Vergi Uyumu Davranışı ve Laboratuvar Deneyleri: Bir Yazın Taraması
    (Hazine ve Maliye Bakanlığı, 2021) Demirtaş, Burak Kağan
    Bu makalenin amacı, bireylerin vergi kaçırma davranışlarını analiz_x000D_ etmek için yürütülen laboratuvar deneylerine dayalı yayınların bir yazın_x000D_ taramasını yapmaktır. İktisat biliminde deneysel çalışmalar gün geçtikçe_x000D_ önem kazanırken Türkçe İktisat yazınında deneysel çalışmalar yok denecek_x000D_ kadar azdır. Bu makalede yazında bulunan çalışmalar özellikle deneysel_x000D_ tasarım açısından incelenmektedir; zira bu makale, laboratuvar deneyleriyle_x000D_ ilgili farkındalığı artırmayı da hedeflemektedir. Çalışmada mümkün_x000D_ olduğunca farklı deneysel tasarımlara dayanan çalışmalar tercih edilmeye_x000D_ çalışılmıştır. Ayrıca laboratuvar deneylerine getirilen eleştiriler de_x000D_ tartışılmaktadır. Makale, laboratuvar deneylerinden elde edilen sonuçların_x000D_ önemli olduğu ve saha deneyleri ile desteklenmesinin faydalı olacağı_x000D_ sonucuna varmaktadır.
  • Review
    Değişen Yükseköğretim Sistemini Sosyokültürel ve Mekânsal Bağlamlarda Yeniden Düşünmek
    (DEOMED PUBL, ISTANBUL, GUR SOK 7-B, FIKIRTEPE 34720 KADIKOY, ISTANBUL, 00000, TURKEY, 2020) Ayten, Asim Mustafa; Gover, Ibrahim Hakan
    Education and research are vital for social development and progress. The changing sociocultural structures and new needs have resulted in some important functional changes in higher education systems with a deep impact on universities serving these needs at the highest level. Besides experiencing these functional changes, the universities today have become spaces of socialization with their social, cultural and sports facilities, replacing their traditional spatial role of offering education only. The local dynamics changing with globalization have now reshaped the global and local roles of universities, highlighting the added value they provide to the society. Sociocultural changes trigger all these functional and structural changes in universities. Therefore, sociocultural factors and their importance should not be ignored in a changing higher education system. In this study, the impact of sociocultural factors with their related spatial structures on world higher education system will be analyzed within their historical contexts, and some suggestions for future universities will be offered considering the current changes. In the first part of the study, the changes in societies and universities will be presented within the historical context. In the second part, the spatial forms and structures of universities will be discussed. In the third part, the catalytic effects of the specific sociocultural factors will be highlighted and elaborated on. Finally, some suggestions will be made for the universities of the future in the light of the current situation and the data available.
  • Article
    Dayım: Bir İnsanoğlunun Portresi
    (TURKISH LIBRARIANS ASSOC, YENISEHIR, NECATIBEY CAD, ELGIN SOK, PO BOX 175, ANKARA, 06440, TURKEY, 2019) Donmez, Rasim Ozgur
    This is a memoir written by his nephew about our colleague Ali Can, who passed away in last July.
  • Article
    İnşaat Atıklarının Yeraltı Madeni Üretim Boşluklarında Dolgu Malzemesi Olarak Kullanımı
    (2019-12-04) Yılmaz, Ayşe Tekin; Cihangir, Ferdi; Erçıkdı, Bayram
    Bu çalışmada sülfürlü atık yerine ikame olarak %10, %30 ve %50 oranlarında inşaat atığı (İA)kullanılarak hazırlanan çimentolu macun dolgu (ÇMD) numunelerinin 3-28 gün boyunca tek eksenlibasınç dayanımı (TEBD) ve 28 gün sonunda porozite (MIP) testleri yapılarak İA’nın macun dolgumalzemesi olarak kullanımı araştırılmıştır. Kontrol numuneleri %7,5 ve %8,5 bağlayıcı oranındahazırlanırken, İA ikameli ÇMD numuneleri %7,5 çimento oranında hazırlanmıştır. Bulgular, %10 İAikameli ÇMD numunelerinin %7,5 ve %8,5 bağlayıcı oranında hazırlanan kontrol numunelerine kıyasladaha yüksek TEBD ve daha düşük porozite üretirken, daha yüksek oranlarda (%30-50) İA kullanımınındolgunun dayanım ve mikroyapı performansını olumsuz etkilediğini göstermiştir. Ayrıca, 1,0 m3 ÇMDüretiminde bağlayıcı oranı %7,5’e düşürülüp atık malzeme yerine %10 İA ikame edildiğinde %13,22oranında bağlayıcı tasarrufu sağlanmıştır. Sonuç olarak, İA’nın yeraltı üretim boşluklarında ÇMDmalzemesi olarak kullanılabileceği ve yerüstünde oluşabilecek toz, görüntü kirliliği ve depolama alanıyetersizliği vb. problemlerin ortadan kaldırılabileceği/azaltılabileceği öngörülmüştür.
  • Article
    Tracing Trajectories of Regime Support in Turkey
    (Ege Univ, Fac Economics & Admin Sciences, 2022-06-09) Inan, Murat
    According to the legitimacy approach of political culture research, public's approval of a particular regime as the best form of government and rejection of its alternatives provides public support for that particular regime. This research attempted to trace temporal trajectories of approval of democratic political system as well as it's three alternative forms of government among the electorates of recent three major political parties in Turkey, the Justice and Development Party (AKP), the Republican People's Party (CHP) and the Nationalist Movement Party (MHP). It also revealed the extent these parties' manifesto documents praise democratic political system across the successive eighteen general elections in the modern Turkish political history. It revealed the changes in both public and party support for four alternative regimes across years in modern Turkish history. This research analyzed the World Values Survey and the Manifesto Project data using quantitative research methods. It has achieved four main findings. First, voters are more stable than their parties across time in terms of pro-democracy. Second, democracy clearly emerges as the strongest alternative among the four alternative regimes for all the three electorates. Third, supporting democracy and rejecting its three alternatives occupy different places in the minds of the three party electorates. Fourth, changes in the three political parties' pro-democracy as identified in their manifesto documents are not always parallel with changes in those of their voters.
  • Article
    Citation - WoS: 2
    Citation - Scopus: 2
    The Nexus of Leadership, Political Empowerment, and Social Mobilization: The Case of the July 15 Coup Attempt in Turkey
    (Seta Foundation, 2020-06-30) Donmez, Rasim Ozgur; Timur, Kasim; Lloyd, Fatma Armagan Teke
    This study analyzes the mutually empowering relations between Turkish President Recep Tayyip Erdogan and his followers, and how Erdogan's charismatic leadership and image functioned to galvanize his followers on the night of July 15, 2016, when large numbers of them mobilized against the attempted coup. The article has three sections. The first is a theoretical discussion which sheds light on the concept and the underlying mechanisms of political empowerment and its effects on the relationships between leaders and followers. The second section evaluates Erdogan's characteristics and ruling style, which was instrumental in motivating resistance to the abortive coup. Finally, the third section analyzes the various means by which Erdogan was able to inspire the masses to mobilize against the armed junta through interviews and observations.
  • Article
    Citation - WoS: 1
    Citation - Scopus: 1
    The Comparison of Fragility Curves of Moment-Resisting and Braced Frames Used in Steel Structures Under Varying Wind Load
    (Turkish Chamber Civil Engineers, 2025-03-01) Ozalp, Abdulkadir; Gokdemir, Hande; Ciftci, Cihan
    In this study, the performance of two different steel structure types (moment-resisting frame and braced frame) under wind loading was compared by addressing the fragility curves of these structure types. To perform this comparison, the dimensions of the members of these structural systems were first determined. Then, nonlinear static pushover analyses were conducted to assess the performance levels of each frame type. After applying these analyses, time-history analyses were performed with 100 different wind loads for each varying equivalent mean wind speed. Afterwards, the probability of exceeding the predetermined structural performance limits of the structure types was determined using Monte Carlo simulation method. Finally, the results of the simulation method were used to adapt the maximum likelihood estimation method to obtain the fragility curves of the structures. To conclude, it has been revealed that the material cost of the structure doubles when diagonal elements are used, but the wind speed required for a 100% collapse probability to occur in the braced frame is twice as high compared to the moment-resisting frame.
  • Article
    Stratejik Yönelim ve İşletme Performansı: Bir Literatür Taraması
    (2021-06-28) Kalkan, Pelin Karaca; Aladağ, Ömer Faruk
    Stratejik yönelim, işletmelerin faaliyetlerini şekillendiren, etkileyen ve yaşamlarını sürdürmeleri ve performanslarını artırmalarına yönelik davranış geliştirmelerini sağlayan ilkeler olarak tanımlanmaktadır. Stratejik yönelim kavramı uluslararası yazında sıklıkla çalışılan bir konu olmasına rağmen Türkçe yazında yeterince ilgi görmemiştir. İşletmeler için kritik öneme sahip olan bu kavramın ve performansla ilişkisinin irdelenmesi önemli görülmektedir. Literatür taraması kapsamında stratejik yönelimlerden girişimcilik yönelimi, pazar yönelimi, öğrenme yönelimi ve teknolojik yönelim incelenmiştir. Bu araştırmada öncelikle stratejik yönelimlerin net bir şekilde tanımlanması ve işletme performansı ile ilişkilerinin irdelenmesi hedeflenmektedir. Bu doğrultuda stratejik yönelim- işletme performansı ilişkisi üzerine literatür incelenmiş, araştırma dahilindeki stratejik yönelimlerin kavramsal çerçeveleri sunulmuştur. Bununla birlikte, stratejik yönelimler arasındaki farklı ilişkiler ve bu ilişkilerin işletmelerin performans göstergeleri üzerindeki etkileri bütüncül bir şekilde irdelenmiştir. Ayrıca stratejik yönelim ile işletme performansı arasındaki ilişkide aracı mekanizmalar ve bu ilişkilerin hangi koşullar altında farklılaştığı aktarılmıştır. Son olarak, literatür taraması sonucunda geleceğe yönelik potansiyel araştırma konuları tanıtılarak yazına katkı sunulması amaçlanmıştır.
  • Article
    Citation - WoS: 4
    Relationship Between Neutrophil Gelatinase-Associated Lipocalin and Mortality in Acute Kidney Injury
    (Galenos Yayincilik, 2018-12-03) Kayaalti, Selda; Kayaalti, Omer; Aksebzeci, Bekir Hakan
    Objective: Almost half of intensive care patients are affected by acute kidney injury (AKI). The purpose of this study is to determine parameters that can be used for predicting of early (within 28 days) and late (within 90 days) mortality in patients who are followed-up with AKI in intensive care units. Materials and Methods: In this study, a dataset that contains 50 patients with AKI in intensive care units was used. This dataset contains blood urea nitrogen, creatinine, plasma and urinary neutrophil gelatinase-associated hpocalin (NGAL), lactate dehydrogenase, alkaline phosphatase and gammaglutamyl transpeptidase values of patients who were admitted to intensive care for various reasons and who developed AKI on the days 1, 3 and 7. In addition to these values, laboratory results such as serum electrolytes on day 1, blood gas; vital signs such as mean arterial pressure, central venous pressure; and demographic data were also recorded. Data mining techniques were applied to determine correlation between all of these data and mortality. Results: The threshold level of urinary NGAL on day 7 was determined to be 69 ng/mL, and strong correlation was found between this threshold level and early mortality. Similarly, the threshold level of plasma NGAL on day 7 was determined to be 150 ng/mL, and this was highly correlated with early mortality. Besides, strong correlation was also found between the difference in the urinary NGAL levels on day 1 and 7, and early mortality. Conclusion: In this study, plasma and urinary NGAL levels were found to be closely related to early mortality in patients who were followed-up with AKI in intensive care units. On the other hand, any parameter associated with late mortality was not found.