Scopus İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/395

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Citation - Scopus: 1
AlN Piezoelectric Quad-Actuators for 2D Optical Micro Scanning
(Taylor & Francis Ltd, 2022) Hah, Dooyoung
Piezoelectric actuation has been one of the frequent choices for optical micro scanning. In most of the cases, lead zirconate titanate (PZT) has been used as the piezoelectric material. However, PZT has a potential issue in biomedical applications due to the content of lead. For this, AlN can be used as an alternative. The main drawback of AlN is its low piezoelectric coefficients. In order to overcome such a drawback, this paper presents a novel actuator configuration, designed for a quasi-static operation mode. Quad-actuators and meander-shaped hinges are the essence of the proposed actuator configuration. Numerical simulation study is carried out to prove the concept of the device. The study also shows that the proposed scanner can have the optical scan angle of 9 degree at a quasi-static mode. Two different scan modes, a raster-like mode and a Lissajous mode are tested, demonstrating the two-dimensional scanning capability of the device.
Citation - WoS: 2
Citation - Scopus: 2
Analysis of Oscillator Phase Noise Effect on High Order QAM Links
(Springer, 2020) Bicici, Cagri; Ozdur, Ibrahim; Cerezci, Osman
In this work, the effect of oscillator phase noise on the bit error rate (BER) for high order QAM communication systems is analyzed. Two high frequency oscillators are designed, built and tested to get real phase noise data, and a BER simulation of a 1024 QAM signal through a super-heterodyne frequency down-converter is implemented using the measured data from the two oscillators as local oscillator sources for the down-converter. A third frequency source is also added to the simulation to visualize the dramatic effect of phase noise on the system BER analysis.
Apatinib Sensitizes Human Breast Cancer Cells Against Navitoclax and Venetoclax Despite Up-Regulated Bcl-2 and Mcl-1 Gene Expressions
(Kare Publ, 2021) Kavakcioglu Yardimci, Berna; Ozgun Acar, Ozden; Semiz, Asli; Sen, Alaattin
OBJECTIVE Defects in apoptotic cell death which restrict the success of conventional cytotoxic therapies have pivotal roles in a number of pathological conditions including cancer. However, a novel drug class targeting pro-survival Bcl-2 protein family members has been developed with the understanding of the structures and interactions of Bcl-2 proteins. Within this new class, Bcl-2/Bcl-xL inhibitor Navitoclax and Bcl-2 specific inhibitor Venetoclax have been shown to demonstrate strong anticancer activities on several types of cancers. But their low affinity to other anti-apoptotic proteins limits their clinical usage. Here, we investigated the cytotoxic and apoptotic effects of Navitoclax/Venetoclax and their combinations with specific tyrosine kinase inhibitor Apatinib on estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. METHODS MTT assay was used for the evaluation of the inhibition of cancer cell proliferation. ELISA test and Quantitative real-time PCR assay was performed to determine the role of caspase-3, Bak, Bax, Bcl-2, Bcl-xL and Mcl-1 proteins in the inhibition of cell proliferation triggered by the tested agents. RESULTS We found that aggressive MDA-MB-231 cell line was more sensitive to all tested agents. Apatinib significantly enhanced Navitoclax/Venetoclax mediated inhibition of cell viability in both cancer cell lines despite up-regulation in the expression levels of Bcl-2 and Mcl-1 genes. We further demonstrated significant Bak/Bax and caspase-3 expression in less aggressive MCF-7 cells. CONCLUSION Our findings have impacts on Navitoclax/Venetoclax plus Apatinib based therapy for breast adenocarcinoma. On the other hand, further studies should be conducted to elucidate the mechanisms underlying synergistic effects of Navitoclax/Venetoclax plus Apatinib combinations.
Citation - WoS: 4
Citation - Scopus: 9
Are We Ready for the New Normal in E-Business Education? Sentiment Analysis of Learners' Opinions on MOOCs
(Russian State Vocational Pedagogical Univ, 2021) Derindag, O. F.; Cizmeci, B.
Introduction. The new digital economy and its constantly evolving paradigm have completely transformed the model of doing business and the learning methods. MOOCs (massive-open-online-courses) and micro-credentials are the educations interfaces, have become an important teaching environment tool. Distance learning has become an indispensable alternative teaching method in updating and transferring classical education materials according to real-world settings, especially for learners in higher education. Aim. The current research is aimed to address the society's readiness and attitude direction to the concept of MOOCs and distance learning, highlighting its emergence and inevitability for educational institutions of all types in order to make a fundamental change in their curricula, especially in e-business courses, which are the most demanded training courses on MOOCs platforms. Methodology and research methods. In the study, the awareness and recognition of the online community on the MOOCs concept is examined. in this direction, Turkish people's perception and attitudes toward MOOCs have been addressed via sentiment analysis on Eksi Sozluk, the largest social communication and discussion platform in Turkey. Results. According to the sentiment analysis results, it has been determined that 52% of respondents have positive judgments on distance education and MOOCs, 29% of responses are neutral and 18% are negative. In general, distance education and MOOCs are perceived as a useful new education model by the Turkish people. Scientific novelty. This paper is the first sentiment analysis of learners' opinions on MOOCs and distance learning in Turkey. Considering the increasing awareness of MOOCs and the need for e-business education, as the most demanded type of MOOCs, this is the first study investigating the priority of these two phenomena within the context of COVID-19. Practical significance. It is thought that this study will contribute to the stakeholders in terms of showing how MOOCs and micro-credentials have a high potential to understanding trends in education especially in the new normal after the COVID-19 pandemic. The holistic education model of institutions has difficulty meeting the competitive nature and result-oriented approach of the e-business ecosystem. This market reality requires the institutions to offer more to-the-point and applied education solutions. In terms of e-business (e-commerce, digital marketing) education, the importance of MOOCs as a solution-focused on "how" rather than "what." has been comprehensively discussed in the paper.
Citation - WoS: 6
Citation - Scopus: 6
Arsenic Removal From Aqueous Solutions by Ultrafiltration Assisted With Polyacrylamide: An Application of Response Surface Methodology
(Taylor & Francis inc, 2015) Varol, Bekir; Uzal, Nigmet
The present work deals with removal of arsenic from aqueous solutions by ultrafiltration assisted with polyacrylamide as an environmental friendly complexing polymer. The system performance was evaluated in relation to quality of permeate in terms of operating variables as feed concentration of arsenic ions (C-o, gL(-1)), ratio of polymer to arsenic (r, w/w), and pH of feed solution. The effect of the operating variables and maximum arsenic removal efficiency was determined by adopting design of experiments and response surface methodology under different conditions for this polymer. The experimental data were analyzed with a second order polynomial model validated by statistical analysis. Based on the response model developed, the maximum removal efficiency, close to 100%, of arsenic ions has been obtained at optimum operating parameters as C-o: 150 gL(-1), r: 2, and pH 10.
Assessment of the Quality of Tuffs in Central Anatolia, Turkey: A Quantitative Classification Approach
(Acad Sci Czech Republic Inst Rock Structure & Mechanics, 2025) Koken, Ekin; Ince, Ismail
The growing global demand for dimension stones necessitates efficient and accurate evaluation methods to ensure their optimal use in various industries. To assess their suitability for various dimension stone applications, this study investigates tuffs from Central Anatolia, Turkey. For this purpose, the fundamental physical and mechanical properties of the tuffs were determined in laboratory studies, and a detailed durability assessment was conducted for each rock type. The analysis results indicate that most of the examined rocks are of low quality and more suitable for non-load-bearing applications. Based on the collected data, fuzzy clustering techniques were applied to develop a new classification system, categorising the tuffs into four classes (Class A-D) according to their potential applications. Additionally, a user-friendly MATLAB-based software tool was also developed to facilitate the implementation of the proposed classification system.
Citation - WoS: 1
Citation - Scopus: 3
Biosynthesis of Novel Naphthoquinone Derivatives in the Commonly-Used Chassis Cells Saccharomyces Cerevisiae and Escherichia Coli
(Pleiades Publishing inc, 2021) Wu, W.; Wang, S.; Zhang, H.; Guo, W.; Lu, H.; Xu, H.; Sun, L.
Naphthoquinones harboring 1,4-naphthoquinone pharmacophore are considered as privileged structures in medicinal chemistry. In pharmaceutical industry and fundamental research, polyketide naphthoquinones were widely produced by heterologous expression of polyketide synthases in microbial chassis cells, such as Saccharomyces cerevisiae and Escherichia coli. Nevertheless, these cell factories still remain, to a great degree, black boxes that often exceed engineers' expectations. In this work, the biotransformation of juglone or 1,4-naphthoquinone was conducted to generate novel derivatives and it was revealed that these two naphthoquinones can indeed be modified by the chassis cells. Seventeen derivatives, including 6 novel compounds, were isolated and their structural characterizations indicated the attachment of certain metabolites of chassis cells to naphthoquinones. Some of these biosynthesized derivatives were reported as potent antimicrobial agents with reduced cytotoxic activities. Additionally, molecular docking as simple and quick in silico approach was performed to screen the biosynthesized compounds for their potential antiviral activity. It was found that compound 11 and 17 showed the most promising binding affinities against Nsp9 of SARS-CoV-2, demonstrating their potential antiviral activities. Overall, this work provides a new approach to generate novel molecules in the commonly used chassis cells, which would expand the chemical diversity for the drug development pipeline. It also reveals a novel insight into the potential of the catalytic power of the most widely used chassis cells.
Citation - WoS: 4
Citation - Scopus: 4
Camera-Based Wildfire Smoke Detection for Foggy Environments
(SPIE - Society of Photo-Optical Instrumentation Engineers, 2022) Tas, Merve; Tas, Yusuf; Balki, Oguzhan; Aydin, Zafer; Tasdemir, Kasim
Smoke is the first visible sign of forest fires and the most commonly used feature for early forest fire detection using data from cameras. However, one of the natural challenges is the dense fog that appears in forests, which decreases the detection accuracy or triggers false alarms. In this study, we propose a system with a deep neural network-based image preprocessing approach that significantly improves the smoke segmentation and classification performance by dehazing the camera view. Our experimental results provide that the classification models reach 99% F1 score for the correct classification of smoke when the image dehazing method is used before the training process. The smoke localization system achieves 60% average precision when the mask region-based convolutional neural network is used with the ResNet101-FPN backbone. The proposed approach can be utilized for all smoke segmentation frameworks to increase fire detection performance. (c) 2022 SPIE and IS&T
Citation - Scopus: 1
Characteristics of Germinated Corn Flour and Influence of Germination on Cookie Properties
(Akademiai Kiado Zrt, 2022) Oskaybas-Emlek, B.; Ozbey, A.; Kahraman, K.
The aim of this study was to investigate the effect of germination on the physicochemical, structure, pasting, and morphological properties of corn. Germination improved total phenolic content (TPC) and antioxidant capacity (AC). Scanning electron micrographs (SEM) of flour showed that some starch granule was destroyed with germination. In the same way, pasting values decreased due to changes in the starch granule. FT-IR (Fourier Transform Infrared) spectra confirmed that germination leads to changes in the chemical structure. The XRD (X-ray diffractometer) analysis showed that patterns did not change with germination. In addition, raw and germinated corn flour were used in gluten-free cookie preparation. The cookie dough was evaluated for stickiness. The physical, textural, colour, TPC, and AC of cookie samples were determined. Gluten-free cookies prepared with germinated flour exhibited significantly higher AC due to increase in TPC. Germination could be used to enhance functional properties of corn.
Citation - WoS: 3
Citation - Scopus: 4
Clinical Probe Utilizing Surface Enhanced Raman Scattering
(A V S Amer Inst Physics, 2014) Kim, Jeonghwan; Hah, Dooyoung; Daniels-Race, Theda; Feldman, Martin
Conventional Raman scattering is a well-known technique for detecting and identifying complex molecular samples. In surface enhanced Raman scattering, a nanorough metallic surface close to the sample enormously enhances the Raman signal. In previous work, the metallic surface was a thin layer of gold deposited on a rough transparent epoxy substrate. The advantage of the clear substrate was that the Raman signal could be obtained by passing light through the substrate, on to opaque samples simply placed against its surface. In this work, a commercially available Raman spectrometer was coupled to a distant probe. Raman signals were obtained from the surface, and from the interior, of a solid specimen located more than 1 m away from the spectrometer. The practical advantage of this arrangement is that it opens up surface enhanced Raman spectrometry to a clinical environment, with a patient simply sitting or lying near the spectrometer. (C) 2014 American Vacuum Society.
Citation - WoS: 12
Citation - Scopus: 15
CO2 Emissions, Real GDP, Renewable Energy and Tourism: Evidence From Panel of the Most-Visited Countries
(Cesky Statistical office, 2017) Dogan, Eyup
Previous studies on the energy-environment-growth literature overlook the investigation of the most-visited countries. Since these countries do not only belong to the largest economies and the top carbon dioxide (CO2) emitters in the world but are also listed in renewable energy country attractiveness index, this study analyzes the impacts of real GDP, renewable energy and tourism on the level of CO2 emissions for the top 10 most-visited countries. Applying several panel econometric approaches, we find out that renewable energy mitigates the pollution whereas real GDP and tourism contribute to the level of emissions. Thus, regulatory policies are necessary to increase the awareness of sustainable tourism. In addition, the use of renewable energy and the adoption of clean technologies in tourism sector as well as in producing goods and services play a significant role in CO2 mitigation.
Citation - Scopus: 3
Combined Effect of Midostaurin and Sphingosine Kinase-1 İnhibitor on FMS-Like Tyrosine Kinase 3 (FLT3) Wild Type Acute Myeloid Leukemia Cells
(De Gruyter Open Ltd, 2022) Şahin, Hande Nur; Adan, Aysun
Objectives: Therapeutic potential of clinically approved FLT3 inhibitor midostaurin has been neglected in wild-type FLT3 positive acute myeloid leukemia (AML). Sphingosine kinase-1 (SK-1) having anti-proliferative functions is studied in various cancers, but not in FLT3 wild-type AML. We aimed to develop new therapeutic strategies to combat FLT3 wild-type AML by combining midostaurin with SK-1 inhibitor (SKI II) in THP1 cells. Methods: The anti-proliferative effects of midostaurin, SKI II and in combination on THP1 cells were determined by MTT assay. The combination indexes were calculated using calcusyn software. SK-1 expression and PARP cleavage were checked by western blot. Cell cycle distributions (PI staining) and apoptosis (annexin-V/PI dual staining) were assessed by flow cytometry for each agent alone and in combinations. Results: Midostaurin decreased SK-1 protein level. Midostaurin, SKI II and certain combinations decreased cell viability in a dose dependent manner. The combined anti-leukemic effects of the aforementioned drug combination afforded additive effect. Co-administration induced both necrosis and apoptosis via phosphatidylserine externalization, PARP cleavage and cell cycle arrest at G0/G1 and S phases. Conclusions: Targeting sphingosine kinase-1 together with FLT3 inhibition could be a novel mechanism to increase limited clinic response to midostaurin in wild-type FLT3 overexpressing AML after further pre-clinical studies. © 2022 Elsevier B.V., All rights reserved.
Citation - WoS: 1
Citation - Scopus: 1
The Comparison of Fragility Curves of Moment-Resisting and Braced Frames Used in Steel Structures Under Varying Wind Load
(Turkish Chamber Civil Engineers, 2025) Ozalp, Abdulkadir; Gokdemir, Hande; Ciftci, Cihan
In this study, the performance of two different steel structure types (moment-resisting frame and braced frame) under wind loading was compared by addressing the fragility curves of these structure types. To perform this comparison, the dimensions of the members of these structural systems were first determined. Then, nonlinear static pushover analyses were conducted to assess the performance levels of each frame type. After applying these analyses, time-history analyses were performed with 100 different wind loads for each varying equivalent mean wind speed. Afterwards, the probability of exceeding the predetermined structural performance limits of the structure types was determined using Monte Carlo simulation method. Finally, the results of the simulation method were used to adapt the maximum likelihood estimation method to obtain the fragility curves of the structures. To conclude, it has been revealed that the material cost of the structure doubles when diagonal elements are used, but the wind speed required for a 100% collapse probability to occur in the braced frame is twice as high compared to the moment-resisting frame.
Citation - WoS: 11
Citation - Scopus: 15
A Comparison of Proactive and Reactive Environmental Strategies in Green Product Innovation
(Inderscience Publishers, 2019) Genç, Ebru; Di Benedetto, C. Anthony
Companies are exposed to different kinds of pressures to respond to environmental sustainability issues. It is critical to understand how firms integrate environmental issues into their corporate agendas and how these integration strategies affect corporate performance. This paper investigates factors that motivate firms to adopt environmental marketing strategies and their relative impact on green product innovation performance. A comprehensive conceptual framework is developed and tested that portrays the antecedents and consequences of environmental marketing strategy (EMS). The results show that developing environmental strategies that exceed regulations (proactive strategies) leads to better new product performance than those that only adhere to regulations (reactive strategies). In addition, we find that commitment from top management becomes critical only for proactive strategies, not for reactive strategies. Finally, with regard to the consequences, we show that environmental marketing strategies lead to new product advantage and, ultimately, improved sustainable new product performance. © 2021 Elsevier B.V., All rights reserved.
Comprehensive Prediction of FBN1 Targeting Mirnas: A Systems Biology Approach for Marfan Syndrome
(Galenos Publishing House, 2025) Orhan, M.E.; Demirci, Y.M.; Saçar Demirci, M.D.S.
Objective: Marfan syndrome (MFS) is a genetic connective tissue disorder primarily caused by mutations in the FBN1 gene. Emerging evidence highlights the regulatory role of microRNAs (miRNAs) in modulating gene expression in MFS, but a systematic investigation into miRNAs targeting FBN1 is lacking. This study aimed to comprehensively identify miRNAs interacting with the FBN1 transcript to reveal potential molecular regulators and therapeutic targets. Methods: Human miRNA sequences were retrieved from miRBase (Release 22.1), and the canonical FBN1 transcript (RefSeq: NM_000138.5) was used for target prediction. Computational interaction analysis was conducted using the psRNATarget server with stringent parameters to detect potential miRNA binding sites. Expression profiles and disease associations of the top candidate miRNAs were further investigated through database integration and literature review. Results: Out of 2656 human mature miRNAs analyzed, 251 were predicted to bind FBN1, with the hsa-miR-181 family exhibiting the highest number of predicted interactions. Evidence from the literature highlighted dysregulation of hsa-miR-181 expression in MFS patients, suggesting a functional role in disease pathophysiology. Conclusion: This study identifies key members of the hsa-miR-181 family as post-transcriptional regulators of FBN1, offering new insights into miRNA-driven mechanisms in MFS. These findings support the potential of RNA-based diagnostics and therapeutic strategies targeting miRNA-FBN1 interactions. ©Copyright 2025 The Author.
Citation - Scopus: 1
Correlation of PAPP-A Values With Maternal Characteristics, Biochemical and Ultrasonographic Markers of Pregnancy
(Marmara Univ, Fac Medicine, 2021) Kaymakcalan, Hande; Uzut, Ommu Gulsum; Harkonen, Juho; Bakir Gungor, Burcu
Objective: Our aim is to investigate whether there is a correlation of pregnancy-associated plasma protein A (PAPP-A) values with other variables in pregnancy and maternal characteristics. Materials and Methods: We retrospectively analyzed the relation between the PAPP-A levels, demographics, biochemical and ultrasonographic markers of the first trimester screening of 11,842 pregnant women seen at a tertiary hospital between November 2002 and November 2008. Results: A significant difference between PAPP-A values of the diabetic and non-diabetic pregnant women were observed (p=0.0005, Mann-Whitney U test). In terms of weight, crown-rump length, Beta-hCG values, significant differences were observed between low and medium level PAPP-A subgroups and between low and high level PAPP-A subgroups. PAPP-A levels were found to differ significantly between the pregnant women of Caucasian origin and other racial origins. Conclusions: Pregnant women with different ethnic and medical backgrounds have different PAPP-A values and other markers of the aneuploidy screening. 'lb make patient specific risk predictions, understanding these interactions and differences is important. Future studies are needed to understand the pathopyhsiology behind these differences.
Cytotoxic and Cytostatic Effects of Targeting mTOR and Hedgehog Pathways in Acute Myeloid Leukemia
(Istanbul Univ, 2022) Cicek, Enes; Kucuktas, Fulya Mina; Yenigul, Munevver; Akcok, Emel Basak Gencer
Objectives: Acute myeloid leukemia (AML) is a highly aggressive heterogeneous hematopoietic malignancy characterized by a rapid and abnormal proliferation of immature myeloid leukemia cells in the bone marrow and peripheral blood. Aberrant alterations in signal transduction pathways are strongly associated with the progression of AML. This study aimed to investigate cell viability and the cell cycle in AML cells by targeting the Hedgehog and mTOR signaling pathways with rapamycin and GANT61. Materials and Method: The antiproliferative effect of rapamycin and GANT61 was assessed by the MTT cell viability assay in two AML cell lines: CMK and MOLM-13. The effect of the inhibitors on cell-cycle distribution was determined using propidium iodide staining and measured with flow cytometry. Results: Rapamycin, an mTOR inhibitor, and GANT61, a Gli-1 inhibitor, decreased the cell proliferation of CMK and MOLM-13 cells. The IC20 values, which is the drug concentration that inhibits cell growth by 20%, were combined and administered to the cells. The results show the drugs to have a combinatorial inhibitory effect on CMK cells but not on MOLM-13 cells. In addition, the combination of drugs arrested the cells during the G0/G1 phase. Conclusion: This study suggests a novel combination therapy approach for AML via mTOR and Hedgehog signaling pathway inhibition using rapamycin and GANT61, respectively. It also suggest further studies be performed to reveal the mechanism of action.
Citation - WoS: 4
Citation - Scopus: 4
Determination of 1/V-T (P, Constant) Diagrams of Hydrogen Gases by Graph-Analytical Methods
(Yildiz Technical Univ, 2017) Ibrahimoglu, Beycan; Dindar, Cigdem Kanbes; Erol, Hazal; Karasari, Salih
Graph-analytical methods provide more accurate results in the analysis of V-T (P=constant) and 1/V-T (P=constant) diagrams of gases. In this study, as a continuation of [1, 2]*, the behavior of hydrogen gas was examined by using graph-analytical method under consideration of volume and density parameters at high pressure and temperature. In this paper, graph-analytical method was applied to draw and examine V-T (P=constant) and 1/V-P (T=constant) diagrams which were based on experimental data of hydrogen and other gases (Hydrogen, carbon dioxide, oxygen, argon, helium, neon, xenon and other gases) at high pressure and temperature. The results indicate that the behavior of hydrogen gas is different from the other gases.
Citation - Scopus: 2
Developing Empirical Formulae for Scour Depth in Front of Inclined Bridge Piers
(Croatian Association of Civil Engineers, 2023) Fedakar, Halil Ibrahim; Dinçer, A. Ersin; Bozkuş, Zafer
Because of the complex flow mechanism around inclined bridge piers, previous studies have proposed different empirical correlations to predict the scouring depth in front of piers, which include regression analysis developed from laboratory measurements. However, because these correlations were developed for particular datasets, a general equation is still required to accurately predict the scour depth in front of inclined bridge piers. The aim of this study is to develop a general equation to predict the local scour depth in front of inclined bridge pier systems using multilayer perceptron (MLP) and radial-basis neural-network (RBNN) techniques. The experimental datasets used in this study were obtained from previous research. The equation for the scour depth of the front pier was developed using five variables. The results of the artificial neural-network (ANN) analyses revealed that the RBNN and MLP models provided more accurate predictions than the previous empirical correlations for the output variables. Accordingly, analytical equations derived from the RBNN and MLP models were proposed to accurately predict the scouring depth in front of inclined bridge piers. Moreover, from the sensitivity analyses results, we determined that the scour depths in front of the front and back piers were primarily influenced by the inclination angle and flow intensity, respectively. © 2023 Elsevier B.V., All rights reserved.
Development of an Optical Measurement System for Surface Depth Measurements and Study of Focus Effect on Determination of Steel Inclusion Content by EN-10247
(SPIE - Society of Photo-Optical Instrumentation Engineers, 2021) Durkaya, Goksel; Kurtuldu, Huseyin; Cetin, Baris; Bal, Burak
Surface inspections are important in steelmaking processes to characterize the final product's quality. We present a method to measure surface depth profile using laser scattering geometry. This technique is used to analyze the focus effect on microscopic analyses of steel inclusions using the EN-10247 standard. The results presented herein offer promising new perspectives for the metal manufacturing industry through cost-effective solutions that attain quasi in-line process inspection capabilities. (C) 2021 Society of Photo-Optical Instrumentation Engineers (SPIE)

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