WoS İndeksli Yayınlar Koleksiyonu

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394

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Citation - WoS: 1
GIS-AHP Approach for a Comprehensive Framework to Determine the Suitable Regions for Geothermal Power Plants in Izmir, Turkiye
(Konya Teknik Univ, 2024) Koca, Kemal; Karipoglu, Fatih; Ozturk, Emel Zeray
Geothermal energy is gaining more reputation and importance around the world. Correspondingly, suitable location selection is a critical step and has become necessary for the successful installation and operation of geothermal power plants. This study investigated suitability of & Idot;zmir region, located in the Aegean part of T & uuml;rkiye, in terms of geothermal power plants applications by using the combination of Geographical Information System and Analytic Hierarchy Process. Based on the request of power plants, thirteen important criteria were evaluated under three main categories named as physical (C1), environmental (C2) and technical (C3). Moreover, expert's opinions were taken into consideration to calculate the importance of these criteria. Key results showed that & Idot;zmir was suitable for geothermal power plants. The final suitability map layer pointed out that %8.73 (1.037 km2) of total area were determined as highly suitable regions in terms of installation. In addition, the obtained suitability map layer was compared with actual geothermal power plants. Based on the comparison study, power plants in Seferihisar were moderately suitable for geothermal power plants while the location of Bal & ccedil;ova power plant was highly suitable. Regarding the suitability assessment in the present study, the location of Dikili power plants had the least suitability score.
Apatinib Sensitizes Human Breast Cancer Cells Against Navitoclax and Venetoclax Despite Up-Regulated Bcl-2 and Mcl-1 Gene Expressions
(Kare Publ, 2021) Kavakcioglu Yardimci, Berna; Ozgun Acar, Ozden; Semiz, Asli; Sen, Alaattin
OBJECTIVE Defects in apoptotic cell death which restrict the success of conventional cytotoxic therapies have pivotal roles in a number of pathological conditions including cancer. However, a novel drug class targeting pro-survival Bcl-2 protein family members has been developed with the understanding of the structures and interactions of Bcl-2 proteins. Within this new class, Bcl-2/Bcl-xL inhibitor Navitoclax and Bcl-2 specific inhibitor Venetoclax have been shown to demonstrate strong anticancer activities on several types of cancers. But their low affinity to other anti-apoptotic proteins limits their clinical usage. Here, we investigated the cytotoxic and apoptotic effects of Navitoclax/Venetoclax and their combinations with specific tyrosine kinase inhibitor Apatinib on estrogen receptor (ER)-positive MCF-7 and ER-negative MDA-MB-231 breast cancer cell lines. METHODS MTT assay was used for the evaluation of the inhibition of cancer cell proliferation. ELISA test and Quantitative real-time PCR assay was performed to determine the role of caspase-3, Bak, Bax, Bcl-2, Bcl-xL and Mcl-1 proteins in the inhibition of cell proliferation triggered by the tested agents. RESULTS We found that aggressive MDA-MB-231 cell line was more sensitive to all tested agents. Apatinib significantly enhanced Navitoclax/Venetoclax mediated inhibition of cell viability in both cancer cell lines despite up-regulation in the expression levels of Bcl-2 and Mcl-1 genes. We further demonstrated significant Bak/Bax and caspase-3 expression in less aggressive MCF-7 cells. CONCLUSION Our findings have impacts on Navitoclax/Venetoclax plus Apatinib based therapy for breast adenocarcinoma. On the other hand, further studies should be conducted to elucidate the mechanisms underlying synergistic effects of Navitoclax/Venetoclax plus Apatinib combinations.
A New Approach for Numerical Solution of Linear and Non-Linear Systems
(Korean Soc Computational & Applied Mathematics & Korean Sigcam, 2017) Zeybek, Halil; Dolapci, Ihsan Timucin
In this study, Taylor matrix algorithm is designed for the approximate solution of linear and non-linear differential equation systems. The algorithm is essentially based on the expansion of the functions in differential equation systems to Taylor series and substituting the matrix forms of these expansions into the given equation systems. Using the Mathematica program, the matrix equations are solved and the unknown Taylor coefficients are found approximately. The presented numerical approach is discussed on samples from various linear and non-linear differential equation systems as well as stiff systems. The computational data are then compared with those of some earlier numerical or exact results. As a result, this comparison demonstrates that the proposed method is accurate and reliable.
Citation - WoS: 4
Citation - Scopus: 9
Are We Ready for the New Normal in E-Business Education? Sentiment Analysis of Learners' Opinions on MOOCs
(Russian State Vocational Pedagogical Univ, 2021) Derindag, O. F.; Cizmeci, B.
Introduction. The new digital economy and its constantly evolving paradigm have completely transformed the model of doing business and the learning methods. MOOCs (massive-open-online-courses) and micro-credentials are the educations interfaces, have become an important teaching environment tool. Distance learning has become an indispensable alternative teaching method in updating and transferring classical education materials according to real-world settings, especially for learners in higher education. Aim. The current research is aimed to address the society's readiness and attitude direction to the concept of MOOCs and distance learning, highlighting its emergence and inevitability for educational institutions of all types in order to make a fundamental change in their curricula, especially in e-business courses, which are the most demanded training courses on MOOCs platforms. Methodology and research methods. In the study, the awareness and recognition of the online community on the MOOCs concept is examined. in this direction, Turkish people's perception and attitudes toward MOOCs have been addressed via sentiment analysis on Eksi Sozluk, the largest social communication and discussion platform in Turkey. Results. According to the sentiment analysis results, it has been determined that 52% of respondents have positive judgments on distance education and MOOCs, 29% of responses are neutral and 18% are negative. In general, distance education and MOOCs are perceived as a useful new education model by the Turkish people. Scientific novelty. This paper is the first sentiment analysis of learners' opinions on MOOCs and distance learning in Turkey. Considering the increasing awareness of MOOCs and the need for e-business education, as the most demanded type of MOOCs, this is the first study investigating the priority of these two phenomena within the context of COVID-19. Practical significance. It is thought that this study will contribute to the stakeholders in terms of showing how MOOCs and micro-credentials have a high potential to understanding trends in education especially in the new normal after the COVID-19 pandemic. The holistic education model of institutions has difficulty meeting the competitive nature and result-oriented approach of the e-business ecosystem. This market reality requires the institutions to offer more to-the-point and applied education solutions. In terms of e-business (e-commerce, digital marketing) education, the importance of MOOCs as a solution-focused on "how" rather than "what." has been comprehensively discussed in the paper.
Barriers in Sustainable Lean Supply Chain Management: Implementation in SMEs
(Ege Univ, Fac Economics & Admin Sciences, 2025) Takci, Ebru; Ada, Erhan; Kazancoglu, Yigit
As the world undergoes significant transformations in various domains, including technology, energy supply and communication, the idea of sustainability has become a significant issue. This study investigates the barriers to Sustainable Lean Supply Chain (SLSC) management within Small and Medium-Sized Enterprises (SMEs) and explores the structural interrelationships among these barriers. A comprehensive literature review was carried out to recognize critical elements relevant to the research topic, resulting in the identification of fifteen specific elements that account for 85% of the barriers in SLSC management. The DEMATEL method was used to evaluate the significance and influence levels of these factors. Furthermore, structured in-depth interviews were conducted with ten experts representing sectors that constitute 85% of the SMEs operating in Kayseri Organized Industrial Zone (OIZ), Turkey, including metal products, furniture, plastic packaging, construction materials, textiles and food. The findings reveal that strategies represent the most significant barrier to SLSC management in SMEs. The barriers were analyzed in two dimensions: influencing and influenced factors. The primary influencing factor identified was laws, standards, regulations, and legislation while the most significant influenced factor was found supply and suppliers. The study concludes with findings and actionable recommendations for practitioners and decision-makers.
Citation - WoS: 76
Citation - Scopus: 83
How Renewable Energy Consumption and Natural Resource Abundance Impact Environmental Degradation? New Findings and Policy Implications From Quantile Approach
(Taylor & Francis inc, 2021) Altinoz, Buket; Dogan, Eyup
The EKC literature has ignored the importance of natural resources on environmental degradation. Thus, this paper aims to investigate the impact of renewable energy consumption and the abundance of natural resources on CO2 emissions for a panel of 82 countries by using quantile regressions. Empirical results show that renewable energy consumption reduces CO2 emissions and its effect increases in higher quantiles. The impact on carbon emissions of natural resource abundance is negative at lower quantiles but positive at medium and higher quantiles. Also, the validity of the EKC hypothesis is confirmed for all quantiles, and an increase in trade openness and urbanization increases environmental degradation in lower and middle quantile levels; however, these determinants have negative impacts on carbon emissions at higher quantiles. Policy implications related to this outcome are further discussed in the study.
Rings With Variations of Flat Covers
(Honam Mathematical Soc, 2019) Demirci, Yilmaz Mehmet; Turkmen, Ergul
We introduce flat e-covers of modules and define e-perfect rings as a generalization of perfect rings. We prove that a ring is right perfect if and only if it is semilocal and right e-perfect which generalizes a result due to N. Ding and J. Chen. Moreover, in the light of the fact that a ring R is right perfect if and only if flat covers of any R-module are projective covers, we study on the rings over which flat covers of modules are (generalized) locally projective covers, and obtain some characterizations of (semi) perfect, A-perfect and B-perfect rings.
Real-Effort Tasks in Laboratory Experiments
(Economic and Financial Research Assoc - Efad, 2023) Demirtas, Burak Kagan
Laboratory experiments used in economics are differentiated in terms of many technical features. One of these technical features is whether the experiment involves a real-effort task. A real-effort task can be defined as a task in which the experiment participants work on aAreal job during the experiment, spend time and effort, determine their performance level and as a result earn a certain amount of money. This study aims to examine real-effort tasks that are frequently used in experimental economics studies, and to discuss potential problems that researchers may face when conducting experiments with real- effort tasks. Within the scope of this review, real-effort tasks commonly used in the literature are categorized under four groups: real-effort tasks based on mathematical operations, puzzles, slider task, and word encryption tasks. Choice of the real-effort task is important for an experimental study because it may lead to misinterpretation of the findings. AAsAa result of the study, the learning effect, the boredom of the task and the abilities required by the task are seen as possible sources of measurement error. While the learning effect and boredom may cause problems especially in within-subject designs, it was found that differences in the abilities of participants may cause measurement errors especially in between-subject designs.
Citation - WoS: 1
Citation - Scopus: 1
Investigating the Tradeoff Between the MMF Distortion and End Turn Length of a 2-Pole Line Start SynRM Performance
(Springer int Publ Ag, 2023) Tekgun, Didem; Cosdu, Muhammed M.; Tekgun, Burak; Alan, Irfan
Conventional 2-pole AC machine windings have long end windings and generate harmonics, which increase losses and reduce torque density. This study investigates the performance tradeoff between the level of distortion (THD) in winding magneto-motive force (MMF) and end turn length on a 2-pole line start Synchronous Reluctance Machine (LS-SynRM) machine. A two-stage approach is used, winding and geometry optimization. Various multilayer winding configurations having unevenly distributed number of turns are investigated. First, the percentage of the turns in a coil group is optimized for minimum harmonics and end turn length for all structures. Second, geometric optimization is performed on selected winding configurations. Sixteen different configurations are optimized, and Pareto optimal solutions are obtained. Later, these solutions are graded with a new score-based assessment method to quantify the quality of the results. It is concluded that the designs having lower THD in winding MMF perform better than the designs with shorter end turns in terms of efficiency and torque density.
Citation - WoS: 4
Citation - Scopus: 4
Differential in Vitro Anti-Leukemic Activity of Resveratrol Combined With Serine Palmitoyltransferase Inhibitor Myriocin in FMS-Like Tyrosine Kinase 3-Internal Tandem Duplication (FLT3-LTD) Carrying AML Cells
(Springer, 2022) Ersoz, Nur Sebnem; Adan, Aysun
Treatment of FMS-like tyrosine kinase 3 (FLT3)-internal tandem duplication (ITD) AML is restricted due to toxicity, drug resistance and relapse eventhough targeted therapies are clinically available. Resveratrol with its multi-targeted nature is a promising chemopreventive remaining limitedly studied in FLT3-ITD AML regarding to ceramide metabolism. Here, its cytotoxic, cytostatic and apoptotic effects are investigated in combination with serine palmitoyltransferase (SPT), the first enzyme of de novo pathway of ceramide production, inhibitor myriocin on MOLM-13 and MV4-11 cells. We assessed dose-dependent cell viability, flow cytometric cell death and cell cycle profiles of resveratrol in combination with myriocin by MTT assay, annexin-V/PI staining and PI staining respectively. Resveratrol's dose-dependent effect on SPT protein expression was also checked by western blot. Resveratrol decreased cell viability in a dose- dependent manner whereas myriocin did not affect cell proliferation effectively in both cell lines after 48h treatments. Although resveratrol induced both apoptosis and a significant S phase arrest in MV4-11 cells, it triggered apoptosis and non-significant S phase accumulation in MOLM-13 cells. Co-administrations reduced cell viability. Increased cytotoxic effect of co-treatments was further proved mechanistically through induction of apoptosis via phosphatidylserine relocalization. The cell cycle alteration in co-treatment was significant with an S phase arrest in MV4-11 cells, however, it was not effective on cell cycle progression of MOLM-13 cells. Resveratrol also increased SPT expression. Overall, modulation of SPT together with resveratrol might be the possible explanation for resveratrol's action. It could be an integrative medicine for FLT3-ITD AML after investigating its detailed mechanism of action in relation to de novo pathway of ceramide production.
Citation - Scopus: 1
Correlation of PAPP-A Values With Maternal Characteristics, Biochemical and Ultrasonographic Markers of Pregnancy
(Marmara Univ, Fac Medicine, 2021) Kaymakcalan, Hande; Uzut, Ommu Gulsum; Harkonen, Juho; Bakir Gungor, Burcu
Objective: Our aim is to investigate whether there is a correlation of pregnancy-associated plasma protein A (PAPP-A) values with other variables in pregnancy and maternal characteristics. Materials and Methods: We retrospectively analyzed the relation between the PAPP-A levels, demographics, biochemical and ultrasonographic markers of the first trimester screening of 11,842 pregnant women seen at a tertiary hospital between November 2002 and November 2008. Results: A significant difference between PAPP-A values of the diabetic and non-diabetic pregnant women were observed (p=0.0005, Mann-Whitney U test). In terms of weight, crown-rump length, Beta-hCG values, significant differences were observed between low and medium level PAPP-A subgroups and between low and high level PAPP-A subgroups. PAPP-A levels were found to differ significantly between the pregnant women of Caucasian origin and other racial origins. Conclusions: Pregnant women with different ethnic and medical backgrounds have different PAPP-A values and other markers of the aneuploidy screening. 'lb make patient specific risk predictions, understanding these interactions and differences is important. Future studies are needed to understand the pathopyhsiology behind these differences.
Citation - WoS: 1
Citation - Scopus: 1
Simultaneous Low Noise Radio Frequency Tone and Narrow Linewidth Optical Comb Generation From a Regeneratively Mode-Locked Laser
(SPIE - Society of Photo-Optical Instrumentation Engineers, 2014) Ozdur, Ibrahim; Ozharar, Sarper; Delfyett, Peter J.
A regeneratively mode-locked laser with simultaneous low noise radio frequency (RF) tone and optical comb generation is presented. The laser does not need any external RF signal and emits a pulse train at similar to 10 GHz repetition rate with a 1.5-ps optical pulse width after compression. The generated RF tone has a signal-to-noise ratio of 121 dB/Hz and an RF fluctuation of 10(-9) over 0.1 s. The optical frequency comb spacing is also at similar to 10 GHz and the optical comb tooth has a linewidth of <1 kHz. (C) 2014 Society of Photo-Optical Instrumentation Engineers (SPIE)
Tracing Trajectories of Regime Support in Turkey
(Ege Univ, Fac Economics & Admin Sciences, 2022) Inan, Murat
According to the legitimacy approach of political culture research, public's approval of a particular regime as the best form of government and rejection of its alternatives provides public support for that particular regime. This research attempted to trace temporal trajectories of approval of democratic political system as well as it's three alternative forms of government among the electorates of recent three major political parties in Turkey, the Justice and Development Party (AKP), the Republican People's Party (CHP) and the Nationalist Movement Party (MHP). It also revealed the extent these parties' manifesto documents praise democratic political system across the successive eighteen general elections in the modern Turkish political history. It revealed the changes in both public and party support for four alternative regimes across years in modern Turkish history. This research analyzed the World Values Survey and the Manifesto Project data using quantitative research methods. It has achieved four main findings. First, voters are more stable than their parties across time in terms of pro-democracy. Second, democracy clearly emerges as the strongest alternative among the four alternative regimes for all the three electorates. Third, supporting democracy and rejecting its three alternatives occupy different places in the minds of the three party electorates. Fourth, changes in the three political parties' pro-democracy as identified in their manifesto documents are not always parallel with changes in those of their voters.
Ball Lens Based Mobile Microscope
(Gazi Univ, 2016) Icoz, Kutay
In this paper we report a low cost, simple and mobile microscope based on attachment of a ball lens to a cell phone. The system's noise and parameters affecting the image quality is investigated. The ball lens provides approximately 100X magnification and together with the cell phone's integrated lens and image sensor, 3,4-micron resolution is reached. The field-of-view of the system is 1500x1500 mu m where the price of the ball lens and the holder is less than 10 cents. By using this system as an optical light microscope, we are able to acquire images of micro particles and micro sensors. When combined with image processing methods, this optical system is capable of doing complex analysis as an alternative to commercial optical light microscopes.
Use of Confocal Microscopy to Monitor Structural Transformations in Nanopillars Based on DNA and CdSe/CdZnSe Quantum Dots
(Springer, 2023) Motevich, I. G.; Erdem, T.; Akrema, A.; Maskevich, S. A.; Strekal, N. D.
Chip system prototypes in the form of nanopillars were created from DNA complexes with CdSe/CdZnSe/ZnS quantum dots immobilized on a plasmonic gold fi lm by the use of vacuum deposition technology and inorganic synthesis. The design and presence of terminal DNA labeled with Cy3 cyanine dyes makes it possible to carry out the hybridization reaction of this terminal strand with complementary DNA and to control the process by variation of the giant Raman scattering (GRS) and the fluorescence signal. The effect of molecular recognition of complementary DNA is accompanied by a change in the GRS spectrum, a 20-fold increase in the fluorescence intensity, and a decrease in the duration of fluorescence decay.
What Does the Bibliometrics of an Interdisciplinary Field Tell Us?: The Case of Cognitive Science
(Seoul Natl Univ, inst Cognitive Science, 2023) Arik, Beril T.; Arik, Engin
This study investigated the bibliometric characteristics of an interdisciplinary field, Cognitive Science, which consists of contributions from diverse fields such as psychology, computer science, philosophy, linguistics, and anthropology, among others. The results showed that there were 4,711 publications in Web of Science between 1900 and 2017, with an exponential increase in the number of publications in recent years. About two-thirds of publications were classified as social science, of which 41% were in the field of psychology. Seventy percent of the publications were journal articles, half of the publications were written by researchers in the USA, and 95% of the publications were in English. Corpus analyses of abstracts and keywords showed that frequently used words included cognitive, science, research, theory, model, cognition, information, learning, and psychology. These analyses also showed that research in this field centered on the common themes of cognition, information, psychology, language, learning, representation, artificial intelligence, and mind before 2010 and focused on more restricted themes such as embodied and extended cognition, morality and religion, quantum, and music after 2010.
Handling Incomplete Data Classification Using Imputed Feature Selected Bagging (IFBAG) Method
(Ios Press, 2021) Khan, Ahmad Jaffar; Raza, Basit; Shahid, Ahmad Raza; Kumar, Yogan Jaya; Faheem, Muhammad; Alquhayz, Hani
Almost all real-world datasets contain missing values. Classification of data with missing values can adversely affect the performance of a classifier if not handled correctly. A common approach used for classification with incomplete data is imputation. Imputation transforms incomplete data with missing values to complete data. Single imputation methods are mostly less accurate than multiple imputation methods which are often computationally much more expensive. This study proposes an imputed feature selected bagging (IFBag) method which uses multiple imputation, feature selection and bagging ensemble learning approach to construct a number of base classifiers to classify new incomplete instances without any need for imputation in testing phase. In bagging ensemble learning approach, data is resampled multiple times with substitution, which can lead to diversity in data thus resulting in more accurate classifiers. The experimental results show the proposed IFBag method is considerably fast and gives 97.26% accuracy for classification with incomplete data as compared to common methods used.
Citation - WoS: 3
Citation - Scopus: 3
Optimization of Carbon Dioxide Absorption in a Continuous Bubble Column Reactor Using Response Surface Methodology
(Wiley, 2023) Gul, Ayse; Derakhshandeh, Masoud; Un, Umran Tezcan
Carbon dioxide absorption using amine based solvents is a well-known approach for carbon dioxide removal. Especially with the increasing concerns about greenhouse gas emissions, there is a need for an optimization approach capable of multifactor calibration and prediction of interactions. Since conventional methods based on empirical relations are not efficiently applicable, this study investigates use of Response Surface Methodology as a strong optimization tool. A bubble column reactor was used and the effect of solvent concentration (10.0, 20.0 and 30.0 vol%), flow rate (4.0, 5.0 and 6.0 L min-1), diffuser pore size (0.5, 1.0 and 1.5 mm) and temperature (20.0, 25.0 and 30.0 degrees C) on the absorption capacity and also overall mass transfer coefficient was evaluated. The optimization results for maintaining maximum capacity and overall mass transfer coefficient revealed that different optimization targets led to different tuned operational factors. Overall mass transfer coefficient decreased to 34.7 min-1 when the maximum capacity was the desired target. High reaction rate along with the highest absorption capacity was set as desirable two factor target in this application. As a result, a third scenario was designed to maximize both mass transfer coefficient and absorption capacity simultaneously. The optimized condition was achieved when a gas flow rate of 5.9 L min-1, MEA solution of 29.6 vol%, diffuser pore size of 0.5 mm and temperature of 20.6 degrees C was adjusted. At this condition, mass transfer coefficient reached a maximum of 38.4 min-1, with a forecasted achievable absorption capacity of 120.5 g CO2 per kg MEA.
Değişen Yükseköğretim Sistemini Sosyokültürel ve Mekânsal Bağlamlarda Yeniden Düşünmek
(DEOMED PUBL, ISTANBUL, GUR SOK 7-B, FIKIRTEPE 34720 KADIKOY, ISTANBUL, 00000, TURKEY, 2020) Ayten, Asim Mustafa; Gover, Ibrahim Hakan
Education and research are vital for social development and progress. The changing sociocultural structures and new needs have resulted in some important functional changes in higher education systems with a deep impact on universities serving these needs at the highest level. Besides experiencing these functional changes, the universities today have become spaces of socialization with their social, cultural and sports facilities, replacing their traditional spatial role of offering education only. The local dynamics changing with globalization have now reshaped the global and local roles of universities, highlighting the added value they provide to the society. Sociocultural changes trigger all these functional and structural changes in universities. Therefore, sociocultural factors and their importance should not be ignored in a changing higher education system. In this study, the impact of sociocultural factors with their related spatial structures on world higher education system will be analyzed within their historical contexts, and some suggestions for future universities will be offered considering the current changes. In the first part of the study, the changes in societies and universities will be presented within the historical context. In the second part, the spatial forms and structures of universities will be discussed. In the third part, the catalytic effects of the specific sociocultural factors will be highlighted and elaborated on. Finally, some suggestions will be made for the universities of the future in the light of the current situation and the data available.
Citation - WoS: 4
Citation - Scopus: 4
Determination of 1/V-T (P, Constant) Diagrams of Hydrogen Gases by Graph-Analytical Methods
(Yildiz Technical Univ, 2017) Ibrahimoglu, Beycan; Dindar, Cigdem Kanbes; Erol, Hazal; Karasari, Salih
Graph-analytical methods provide more accurate results in the analysis of V-T (P=constant) and 1/V-T (P=constant) diagrams of gases. In this study, as a continuation of [1, 2]*, the behavior of hydrogen gas was examined by using graph-analytical method under consideration of volume and density parameters at high pressure and temperature. In this paper, graph-analytical method was applied to draw and examine V-T (P=constant) and 1/V-P (T=constant) diagrams which were based on experimental data of hydrogen and other gases (Hydrogen, carbon dioxide, oxygen, argon, helium, neon, xenon and other gases) at high pressure and temperature. The results indicate that the behavior of hydrogen gas is different from the other gases.

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