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High Carbohydrate Diet Decreases Microbial Diversity and Increases Il-1β Levels in Mice Colon
(Korean Society Food Science & Technology-kosfost, 2024) Ulutas, Mehmet Sefa; Aydin, Erkin; Cebeci, Aysun
Western diet is known to contribute to intestinal dysbiosis and the progression of inflammation. Although the Turkish diet has different macronutrient contents, the intestinal inflammatory disease incidences in T & uuml;rkiye are comparable to Western countries. Thus, we hypothesized that high carbohydrate diets also contribute to inflammation of the colon. We compared diets with different macronutrient compositions and investigated their effects on colonic microbiota, cytokine, histology, and tight junction protein levels. High carbohydrate diet caused the lowest microbial diversity and is accompanied by the highest expression of interleukin-1 beta and claudin-1. A low carbohydrate diet with zero fiber resulted in the lowest inflammatory markers as well as the lowest occludin and claudin levels. Overall, our results indicate that carbohydrate and fiber contents of the diets are important contributors to colon health.
Citation - WoS: 16
Citation - Scopus: 16
Hexagonal Nanosheets in Amorphous BN: A First Principles Study
(Elsevier Science Bv, 2015) Durandurdu, Murat
Amorphous boron nitrite is modeled by means of first principles molecular dynamics simulations and found to be almost chemically ordered in a stark contrast to the previous predictions. Its average coordination number is 2.97. The main building unit of the amorphous network is hexagonal rings as in the most stable boron nitrite phase but chain-like structures and tetragonal-like rings also exist in amorphous network. The model consists of partially hexagonal nanosheets and hence it is not entirely disordered. Amorphous boron nitrite has a band gap energy of about 2.0 eV. (C) 2015 Elsevier B.V. All rights reserved.
Citation - WoS: 26
Citation - Scopus: 29
A Detailed Investigation of Electronic and Optical Properties of the Exciton, the Biexciton and Charged Excitons in a Multi-Shell Quantum Dot Nanocrystal
(IOP Publishing Ltd, 2014) Akturk, Abdurrahman; Sahin, Mehmet; Koc, Fatih; Erdinc, Ahmet
In the present study, the electronic and optical properties of the exciton (X), the biexciton (XX) and charged excitons (X- and X+) in a multi-shell quantum dot nanocrystal have been systematically explored in detail. The electronic properties have been determined in the framework of the single-band effective mass approximation. For this purpose, the Poisson-Schrodinger equations have been solved self-consistently in the Hartree approximation. In the electronic structure calculations for XX, X- and X+, the quantum mechanical exchange-correlation potentials between particles of the same type have been taken into account in the local density approximation. Some optical parameters, such as the overlap integrals, recombination oscillator strengths, radiative lifetimes, etc, have been determined by using the single-particle energy levels and wavefunctions obtained. A different approximation, reported in Sahin and Koc 2013 Appl. Phys. Lett. 102 183103, has been used in the recombination oscillator strength calculations. The results have been presented comparatively as a function of the shell thicknesses, and the well widths and probable physical reasons underlying them have been discussed in detail.
Citation - WoS: 8
Citation - Scopus: 8
Involvement of Sphingolipid Metabolism Enzymes in Resveratrol-Mediated Cytotoxicity in Philadelphia-Positive Acute Lymphoblastic Leukemia
(Routledge Journals, Taylor & Francis Ltd, 2022) Oguz, Osman; Adan, Aysun
Targeting the key enzymes of sphingolipid metabolism including serine palmitoyltransferase (SPT), sphingosine kinase (SK) and glucosylceramide synthase (GCS) has a therapeutic importance. However, sphingolipid metabolism-mediated anti-leukemic actions of resveratrol in Philadelphia-positive acute lymphoblastic leukemia (Ph + ALL) remain unknown. Therefore, we explored potential mechanisms behind resveratrol-mediated cytotoxicity in SD1 and SUP-B15 Ph + ALL cells in the context of sphingolipid metabolism and apoptosis induction. The anti-proliferative and apoptotic effects of resveratrol alone and in combination with SPT inhibitor (myriocin), SK inhibitor (SKI II), GCS inhibitor (PDMP) were determined by MTT cell proliferation assay and flow cytometry, respectively. The effects of resveratrol on PARP cleavage, SPT, SK and GCS protein levels were investigated by Western blot. Resveratrol inhibited proliferation and triggered apoptosis via PARP activation and externalization of phosphatidylserine (PS). Resveratrol increased the expression of SPT whereas it downregulated SK and GCS. Resveratrol's combinations with SKI II and PDMP intensified its anti-leukemic activity by increasing the relocalization of PS while its combination with myriocin suppressed apoptosis. Therefore, resveratrol inhibited cell proliferation and induced apoptosis through modulating SK, GCS and SPT expression, which may be considered as novel biomarkers of resveratrol-induced cytotoxicity in Ph + ALL.
Effect of Yttrium/Lanthanum-Doped Ultrasonically Assisted Nano-Hydroxyapatite on Remineralization and Bracket Bond Strength in Artificial Enamel Lesions
(BMC, 2025) Ozturk, Taner; Mammadov, Elshan; Bulduk Karakaya, Humeyra; Yagci, Filiz; Dayan, Serkan; Yagci, Ahmet
Background This in vitro study aimed to evaluate the remineralization efficacy of ultrasonically assisted yttrium fluoride-doped (Ult-YF3-nHAP) and lanthanum fluoride-doped (Ult-LaF3-nHAP) nano-hydroxyapatite (nHAP) on artificially induced enamel lesions (aWSLs), and to compare their performance with acidulated phosphate fluoride (APF) gel, fluoride varnish, casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), and resin infiltrant (ICON). Methods This in vitro study followed a four-phase design: enamel lesion creation, application of remineralization agents, a 14-day treatment protocol, and post-treatment analyses using QLF, Micro-CT, SEM-EDX, and SBS testing. This study included 168 extracted human premolars, divided into eight experimental groups (n = 21 per group): (1) Demineralized control (no remineralization treatment), (2) Acidulated phosphate fluoride (APF) gel, (3) Fluoride varnish, (4) Casein phosphopeptide-amorphous calcium phosphate (CPP-ACP), (5) Ultrasonically assisted nHAP (Control nHAP), (6) Ult-YF3-nHAP, (7) Ult-LaF3-nHAP, and (8) Resin infiltrant (ICON). The aWSLs were created under laboratory conditions. Brackets were bonded to the teeth with composite material, and aWSLs were created under laboratory conditions. After lesion formation and at the end of the experimental process, micro-computed tomography (Micro-CT) and laser-assisted quantitative light fluorescence (QLF) analysis were performed to assess lesion progression and remineralization. Additionally, scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX) and shear bond strength (SBS) tests were conducted at the end of the study. Statistical analysis was performed using one-way ANOVA, Kruskal-Wallis, and Mann-Whitney U tests, with a significance level of p < 0.05. Results The bracket bond strength test data showed no significant differences between the groups (p = 0.156). Significant differences were found among groups for QLF fluorescence recovery (Delta F, p < 0.001), with the Ult-YF3-nHAP group showing the greatest increase (median: +0.5, IQR: -1.4 to + 0.7), while the control group showed the greatest decrease (median: -12.1, IQR: -12.4 to -10.2). Micro-CT analysis also revealed significant differences between groups (p = 0.008). The APF Gel group showed values comparable to those of all other experimental groups. The highest remineralization values were recorded in the Ult-YF3-nHAP group (6.87 +/- 3.03 mm(3)), whereas the lowest values were found in the Varnish group. The demineralized control group had significantly higher values than the Varnish group, but lower than the Ult-LaF3-nHAP group. SEM-EDX analysis revealed that fluoride weight was significantly lower in the Tooth Mousse and Varnish groups compared to the other experimental groups (p < 0.001). Ca/P ratio was significantly lower in the demineralized control, Varnish, and Ult-YF3-nHAP groups than in other experimental groups (p = 0.002). Conclusion Ult-YF3-nHAP showed higher efficacy in remineralization of aWSLs compared to fluoride-based treatments, CPP-ACP, and resin infiltrant. The highest remineralization was detected in the Ult-YF3-nHAP group by micro-CT and QLF analysis, while fluoride varnish gave the lowest result.
A Comprehensive Review on the Extraction and Recovery of Lithium from Primary and Secondary Sources: Advances Toward Battery-Grade Materials
(Wiley, 2025) Top, Soner; Kursunoglu, Sait; Altiner, Mahmut
Lithium-ion battery (LIB) technologies have become indispensable to modern energy systems, driving global demand for high-purity lithium compounds. This review focuses on lithium recovery and purification strategies for battery-grade lithium carbonate (Li2CO3) and lithium hydroxide (LiOH), addressing both primary sources (brines and minerals) and secondary sources (waste materials). Industrially established processes, such as evaporation-based brine treatment and conventional metallurgical methods, are discussed alongside emerging techniques, including membrane separation, solvent extraction, and CO2-assisted precipitation. Particular attention is given to lithium precipitation mechanisms, the behaviour of co-existing ions during extraction, and the specific quality requirements for cathode material synthesis. By evaluating process scalability, environmental impact, and product purity, this review provides a comprehensive understanding of current practices and future directions. Additionally, it highlights the growing importance of lithium in the context of accelerating electric vehicle (EV) adoption, underscoring the bright and expanding future of the lithium industry.
Citation - WoS: 28
Citation - Scopus: 37
An Investigation on the Effect of Heat-Moisture Treatment on Baking Quality of Wheat by Using Response Surface Methodology
(Academic Press Ltd- Elsevier Science Ltd, 2017) Cetiner, B.; Acar, O.; Kahraman, K.; Sanal, T.; Koksel, H.
Effect of heat-moisture treatment on quality properties of two bread wheats (cvs. Tosunbey and Bayraktar) were investigated by using response surface methodology (RSM). Temperature and moisture conditions in the experimental design were in the range of 55-95 degrees C and 13-19%. Heat-moisture treated grains were milled into flour and quality properties were determined. The optimum moisture temperature combination for the highest dry gluten, Zeleny sedimentation, Alveograph W and bread volume values were estimated as 14%-63 degrees C for Tosunbey and 19%-55 degrees C for Bayraktar samples. Alveograph W seems to be a good indicator of baking quality for wheats treated at higher temperatures. In order to describe the relationship between the dependent and independent variables (moisture, temperature), the response values were fitted by second order polynomial models. Significance analysis showed that the effect of both moisture and temperature on dry gluten content, sedimentation and falling number values for Tosunbey; falling number and damaged starch values for Bayraktar were significant (p < 0.05). The effect of temperature on Farinograph water absorption, W and PSG, bread volume and firmness values were significant for both cultivars (p < 0.05). It can be concluded that improvement in baking quality can be achieved and flours with different properties can be produced by heat-moisture treatments on wheat. (C) 2017 Published by Elsevier Ltd.
Tuning Properties of Amorphous Boron Via Hydrogenation: An Ab Initio Study
(Elsevier, 2026) Durandurdu, Murat
Ab initio simulations are employed to investigate the structural, mechanical, and electronic properties of hydrogenated amorphous boron (a-B:H) across a range of hydrogen concentrations (approximate to 6-21 at.%). The results indicate that pentagonal-like boron clusters constitute the primary structural motifs. The bonding environment consists of both B-H terminal bonds and B-H-B bridging bonds, with the fraction of bridging bonds ranging from 10 % to 16 %. Increasing the hydrogen content leads to a reduction in density and bulk modulus, accompanied by a systematic widening of the electronic band gap. These results demonstrate that hydrogen incorporation profoundly modifies the atomic structure, softens the network, and enhances the semiconducting character of a-B:H, highlighting the tunability of properties in boron-based amorphous materials.
Citation - WoS: 1
Citation - Scopus: 2
Investigating the Role of Stator Slot Indents in Minimizing Flooded Motor Fluid Damping Loss
(MDPI, 2023) Tekgun, Didem; Tekgun, Burak
This research examines how fluid damping loss affects the operation of a two-pole, 5.5 HP (4 kW) induction machine (IM) within the context of different slot opening configurations developed for downhole water pump applications. Since these motors operate with their cavities filled with fluid, the variations in fluid viscosity and density, compared to air, result in the occurrence of damping losses. Furthermore, this loss can be attributed to the motor's stator and rotor surface geometry, as the liquid within the motor cavity moves unrestrictedly within the motor housing. This study involves the examination of the damping loss in a 24-slot IM under different stator slot indentations. The investigation utilizes computational fluid dynamics (CFD) finite element analysis (FEA) and is subsequently validated through experiments. The aim of this work is to emphasize the significance of fluid damping loss in submerged machines. Results reveal that the damping loss exceeds 8% of the motor output power when the stator surface has indentations, and it diminishes to 3.2% of the output power when a custom wedge structure is employed to eliminate these surface indentations.
Citation - WoS: 27
Citation - Scopus: 32
Cascade Sliding Mode-Based Robust Tracking Control of a Magnetic Levitation System
(Sage Publications Ltd, 2016) Eroglu, Yakup; Ablay, Gunyaz
Magnetic levitation systems are able to provide frictionless, reliable, fast and economical operations in wide-range applications. The effectiveness and applicability of these systems require precise feedback control designs because the magnetic levitation is an unstable process and have highly nonlinear dynamics. In this article, a robust sliding mode-based cascade control approach is proposed for effectively tracking the reference position of a magnetic levitation system. The magnetic levitation plant is described with electrical and mechanical models, and the control problems of these parts are treated with cascade controllers. An integral sliding mode and an output feedback sliding mode controllers are designed for use in the cascade loops. The performance of the sliding mode controllers is compared with a proportional-integral-velocity plus proportional-integral control structure. It is shown that the proposed control structure is able to provide a highly satisfactory tracking performance and can eliminate the effects of the inductance-related uncertainties and operating point originated disturbances. The experimental results are provided to validate the efficacy and feasibility of the approach.
Functional Surfaces of the Future: Integrating Texturing and Coatings for Superior Performance
(Elsevier Sci Ltd, 2025) Yuan, Yanjie; Louhichi, Borhen; Heidarshenas, Behzad; Alrasheedi, Nashmi H.; Bal, Burak; Hussain, Ghulam
Current surface texturing and coating methods exhibit performance improvements but face significant limitations, including inconsistent durability, scalability restrictions, and inadequate integration of their properties. Integrating these approaches can effectively address these challenges. Modern methods, such as laser machining and additive manufacturing, are paving the way for mainstream applications, offering the opportunity to develop new high-performance surfaces in various fields. For instance, combining laser texturing and advanced coating can address durability issues by developing precise patterns and strong adhesion. The combination of surface texturing and coating improves tribological performance and enhances service maintenance by overcoming the limitations of conventional methods. This offers advanced capabilities for various applications, including medical implants and marine environments. In this context, the synergistic application of texturing and coating technologies is expected to be crucial in developing high-performing advanced materials suitable for various applications. This study reviews the progress on synchronizing texturing and coating approaches. Governing mechanisms and controlling factors are identified and discussed. The benefits of applying synergetic approaches to surface performance are recorded. Optimum conditions to realize the best results are determined. Current challenges, emerging trends, and potential solutions to address these issues are proposed.
Citation - WoS: 1
Citation - Scopus: 2
Complementary Medicines Used in Ulcerative Colitis and Unintended Interactions With Cytochrome P450-Dependent Drug-Metabolizing Enzymes
(Tubitak Scientific & Technological Research Council Turkey, 2022) Sen, Alaattin
Ulcerative colitis (UC) is an idiopathic, chronic inflammatory disease with multiple genetic and a variety of environmental risk factors. Although current drugs significantly aid in controlling the disease, many people have led to the application of complementary therapies due to the common belief that they are natural and safe, as well as due to the consideration of the side effect of current drugs. Curcumin, cannabinoids, wheatgrass, Boswellia, wormwood and Aloe vera are among the most commonly used complementary medicines in UC. However, these treatments may have adverse and toxic effects due to unintended interactions with drugs or drug-metabolizing enzymes such as cytochrome P450s; thus, being ignorant of these interactions might cause deleterious effects with severe consequences. In addition, the lack of complete and controlled long-term studies with the use of these complementary medicines regarding drug metabolism pose additional risk and unsafety. Thus, this review aims to give an overview of the potential interactions of drug-metabolizing enzymes with the complementary botanical medicines used in UC, drawing attention to possible adverse effects.
A rational utilization of reinforcement material for flexural design of 3D-printed composite beams
(SAGE PUBLICATIONS LTD, 1 OLIVERS YARD, 55 CITY ROAD, LONDON EC1Y 1SP, ENGLAND, 2019) Ciftci, Cihan; Sas, Hatice S.
Recent developments in composite industry address the adaptation of 3D printing technology to overcome the design and manufacturing challenges of the traditional composite processing techniques. This adaptation can be performed with the development of design methodologies corresponding to the type of structural load-carrying members in a structure. Considering the frequently use of beams in structures, the development of the design methodology of beams is essential for the adaptation of the additive manufacturing. Therefore, in this paper, the flexural loading concept is analytically formulated to derive moment capacity for the flexural behavior of 3D-printed composite beams. Then, the formulation is adapted to develop a design methodology of 3D-printed laminates under flexural loading. Additionally, the analytical solutions developed for the design methodology presented in this paper were verified with a good agreement with experimental studies.
Citation - WoS: 13
Citation - Scopus: 17
Fabrication and Electrochemical Behavior Study of Nano-Fibrous Sodium Titanate Composite
(Elsevier Science Bv, 2017) Ge, Yeqian; Zhu, Jiadeng; Dirican, Mahmut; Jia, Hao; Yanilmaz, Meltem; Lu, Yao; Zhang, Xiangwu
Nanofiber structured Na2Ti3O7 was synthesized via electrospinning process which was further used as an anode material for sodium-ion batteries for the first time. One-dimensional construction of Na2Ti3O7 composite could contribute to better electrochemical activity. It was demonstrated that the capacity of Na2Ti3O7 nanofibers was significantly improved to 257.8 mAh g(-1) at 30 mA g(-1). Furthermore, the rate capability of Na2Ti3O7 nanofibers was significantly enhanced, showing charge capacities were 161.8, 116.5, and 72.4 mAh g(-1) at 100, 200, and 400 mA g(-1), respectively. Therefore, improved specific capacity and rate capability made Na2Ti3O7 nanofibers composite as a promising anode material for sodium-ion batteries.
Citation - WoS: 35
Citation - Scopus: 39
Advances in Micelle-Based Drug Delivery: Cross-Linked Systems
(Bentham Science Publ Ltd, 2017) Isoglu, Ismail Alper; Ozsoy, Yildiz; Isoglu, Sevil Dincer
There are several barriers that drug molecules encounter in body beginning from kidney filtration and reticulo-endothelial system (RES) clearance to cellular trafficking. Multifunctional nanocarriers have a great potential for the delivery of drugs by enhancing therapeutic activity of existing methodologies. A variety of nanocarriers are constructed by different material types, which have unique physicochemical properties for drug delivery applications. Micelles formed by amphiphilic polymers are one of the most important drug/nanocarrier formulation products, in which the core part is suitable for encapsulation of hydrophobic agent whereas the outer shell can be utilized for targeting the drug to the disease area. Micelles as self-assembled nanostructures may encounter difficulties in biodistribution of encapsulated drugs because they have a tendency to be dissociated in dilution or high ionic strength. Therefore, therapeutic efficiency is decreased and it requires high amount of drug to be administered to achieve more efficient result. To overcome this problem, covalently stabilized structures produced by cross-linking in core or shell part, which can prevent the micelle dissociation and regulate drug release, have been proposed. These systems can be designed as responsive systems in which cross-links are degradable or hydrolysable under specific conditions such as low pH or reductive environment. These are enhancing characteristics in drug delivery because their cleavage allows the release of bioactive agent encapsulated in the carrier at a certain site or time. This review describes the chemical methodologies for the preparation of cross-linked micelles, and reports an update of latest studies in literature.
Citation - WoS: 11
Citation - Scopus: 11
Antibacterial Bilayered Skin Patches Made of HPMA and Quaternary Poly(4-Vinyl Pyridine)
(Korean Fiber Soc, 2018) Isoglu, I. Alper; Demirkan, Cemre; Seker, Mine Gul; Tuzlakoglu, Kadriye; Isoglu, Sevil Dincer
This study aimed to produce poly(4-vinyl pyridine) and hydroxypropyl methacrylamide (HPMA)-based bilayer wound dressings materials enhancing healing mechanism for the wounds which have self-healing problem and high infection risk. These materials were designed to protect wound from secondary traumas caused microorganism invasion and do not have toxic substance release problem. Synthesis of quaternary poly(4-vinyl pyridine) (poly(Q4-VP)) which is the antibacterial layer of wound dressing material was carried out in two stages. At first stage, poly(4-vinyl pyridine) polymer was synthesized from 4-vinyl pyridine monomer by free radical polymerization. Then, poly(Q4-VP) was synthesized from poly(4-VP) by alkylation reaction with 6-bromocaproic acid. Resulted polymer was structurally characterized by FT-IR. The macroporous spongy structure, as the lower layer of wound dressing material, was prepared by cryogelation of HPMA. Then, the antibacterial polymer was electrospun onto the cryogel structure and bilayered material was obtained. Cryogel structure, fiber morphology and layer integration was examined by SEM. In order to enhance wound healing process, ascorbic acid (vitamin C) was loaded to cryogel layer and release was followed by spectrophotometrically. The antimicrobial properties of the materials were examined against Escherichia coli, Staphylococcus aureus and Candida albicans, respectively. According to the results, bilayered, antibacterial and antifungal against Staphylococcus aureus and Candida albicans, temporary wound dressings which can stimulate wound healing and have high swelling capacity were obtained successfully.
Citation - Scopus: 1
A Semi-Analytic Method for Solving Singularly Perturbed Twin-Layer Problems With a Turning Point
(Vilnius Gediminas Tech Univ, 2023) Cengizci, Suleyman; Kumar, Devendra; Atay, Mehmet Tarik
This computational study investigates a class of singularly perturbed second-order boundary-value problems having dual (twin) boundary layers and simple turning points. It is well-known that the classical discretization methods fail to resolve sharp gradients arising in solving singularly perturbed differential equations as the perturbation (diffusion) parameter decreases, i.e., epsilon -> 0(+). To this end, this paper proposes a semi-analytic hybrid method consisting of a numerical procedure based on finite differences and an asymptotic method called the Successive Complementary Expansion Method (SCEM) to approximate the solution of such problems. Two numerical experiments are provided to demonstrate the method's implementation and to evaluate its computational performance. Several comparisons with the numerical results existing in the literature are also made. The numerical observations reveal that the hybrid method leads to good solution profiles and achieves this in only a few iterations.
Citation - WoS: 73
Citation - Scopus: 78
Influence of NaNo SiO2 and NaNo CaCo3 Particles on Strength, Workability, and Microstructural Properties of Fly Ash-Based Geopolymer
(Ernst & Sohn, 2020) Durak, Ugur; Karahan, Okan; Uzal, Burak; Ilkentapar, Serhan; Atis, Cengiz Duran
The influence of nano SiO2(NS) and CaCO3(NC) particles on the properties of class F fly ash based geopolymer mortar activated with different sodium ion concentrations have been investigated. Mortar mixture proportions were 1:3:0.3 for binder, sand, and water, respectively. Nano SiO2 and CaCO3 particles were replaced with a binder by weight basis at the ratios of 1, 2, and 3% in the mixtures. Sodium concentrations amount used were 8, 10, and 12% Na+ of binder content. Geopolymer mortar samples were cured at 60, 75, and 90 degrees C in a furnace for 24, 48, and 72 hr. After the heat curing process, flexural, and compressive strength tests were performed. The changes in the microstructure of geopolymer due to influence of nanoparticles were examined by utilizing isothermal calorimetric studies on geopolymer paste, and field-emission scanning electron microscopy (FESEM). Based on laboratory work results, it was concluded that for all sodium ion concentrations, the addition of nano SiO2 and CaCO3 particles improved the flexural and compressive strengths after 24 hr heat curing. However, the favorable effects of nanoparticles on strength properties tend to disappear after 48 and 72 hr heat curing. The results of isothermal calorimetric studies showed that nano SiO2 and CaCO3 particles accelerated the geopolymeric reactions at an early age. FESEM results showed that additions of nanoparticles made the microstructure of geopolymer products more intense and compact.
Citation - WoS: 1
Citation - Scopus: 1
ConVarT: Search Engine for Missense Variants Between Humans and Other Organisms
(Wiley, 2022) Pir, Mustafa S.; Cevik, Sebiha; Kaplan, Oktay I.
ConVarT (https://convart.org/) is a search engine for searching for conjugate variants between humans and other species. The search engine is based on matching conjugate variants called MatchVars between species. Matching equivalent variants requires correct alignment of orthologous proteins with the use of multiple sequence alignments (MSA). Indeed, the ConVarT pipeline has performed over a million MSAs and integrated variants and variant-specific annotations (pathogenicity, phenotypic variants; etc.) into the corresponding positions on MSAs. When a clinically relevant variant is discovered whose functional relevance is unknown, ConVarT offers clinician scientists the possibility to search for a MatchVar in other species and to look for functional data on that variant. Fortunately, ConVarT enables users to paste a protein sequence in FASTA format to search for human orthologous proteins. A pairwise sequence alignment (PSA) is then performed between the provided protein sequence and the human orthologous protein, allowing users to visualize human variants on the PSA. Here, we describe the step-by-step usage of ConVarT.
Citation - WoS: 12
Citation - Scopus: 13
Highly Luminescent ZnCdTeS Nanocrystals With Wide Spectral Tunability for Efficient Color-Conversion White-Light
(IOP Publishing Ltd, 2021) Soheyli, Ehsan; Zargoush, Sirous; Yazici, Ahmet Faruk; Sahraei, Reza; Mutlugun, Evren
CdTe-based semiconductor nanocrystals (NCs) with size and composition-dependent efficient bandgap properties are historically mature nanomaterials for colloidal optoelectronic applications. In this work, we present the highly luminescent quaternary ZnCdTeS NCs with tunable emission across a wide visible spectrum from green to red spectral range. Prepared via a direct aqueous-based approach, a second capping agent of trisodium citrate (TSC) was used to enhance the photoluminescence (PL) emission efficiency, the chemical stability, and to spectrally widen the coverage of the emission spectra of ZnCdTeS NCs. Adding TCS created a remarkable blue shift from 572 nm in the absence of TSC, to 548 nm. On the other hand, upon optimization of experimental parameters, superior ZnCdTeS NCs with a narrow PL profile typically less than 50 nm, the high quantum efficiency of 76%, and tunable emission from 515-to-645 nm were synthesized in an aqueous solvent. The keynotes were the superior and reproducible luminescent properties for the core only NCs, without shell and using relatively low reaction temperatures. It was shown that in the suggested synthesis method, the high efficiency emitted color of ZnCdTeS NCs can be easily controlled from 515-to-650 nm with excellent stability against harsh conditions. The biexponential decay profiles of samples prepared at different reaction temperatures demonstrated that the average recombination lifetime is below 40 ns and increases with the growth of the ZnCdTeS NCs. Results reveal that the excitonic energy levels have the main role in the recombination process. Finally, to demonstrate the functional advantages of the prepared NCs in optoelectronics, the NCs were used to fabricate color-conversion white light-emitting diodes. The color coordinate of the device is recorded as (0.4951, 0.3647) with CRI of 91, CCT of 1954 K, and LER of 251 lm W-1 by employing only two distinct emitters for color conversion.

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