Doktora Tezleri

Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/5800

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Akıllı Mikro-Şebekelerde Kontrol Stratejilerinin Geliştirilmesi
(Abdullah Gül Üniversitesi Fen Bilimleri Enstitüsü, 2021) Yoldaş, Yeliz; Yoldaş, Yeliz; Önen, Ahmet
This thesis concerns the transformation of aged power systems to modern power systems that include microgrids with renewable energy sources and energy storage systems. The integration of renewable energy sources brings excellent opportunities to provide better reliability and efficiency. However, the uncertainty and intermittent nature of renewable energy sources may potentially degrade the stability and quality of the electrical grid. Therefore, the aim of this dissertation is to maintain the supply-demand balance in microgrids while minimizing the cost in real time operation. A microgrid energy management system that can optimize the dispatch of the controllable distributed energy resources in grid-connected mode of a pilot microgrid on a university campus in Malta was developed to achieve this goal. Three different methods were used in this study: mixed integer linear programming (MILP), MILP based rolling horizon control and Q-learning, Designing intelligent method for the real-time energy management of the stochastic and dynamic microgrid is the primary goal of this research. Moreover, the detailed mathematical models of the network model and of the technical model are considered for the economic and environmental operation of the microgrid system to solve the optimization problem under more real-world conditions. The objective is to minimize the total daily operation costs, which include the degradation cost of batteries, the cost of energy bought from the main grid, the fuel cost of the diesel generator, and the emission cost. The optimization problem is modeled as a finite Markov decision process (MDP) by combining network and technical constraints, and a Q-learning algorithm is adopted to solve the sequential decision subproblems. The proposed algorithm decomposes a multi-stage mixed-integer nonlinear programming (MINLP) problem into a series of single-stage problems so that each subproblem can be solved using Bellman's equation. To prove the effectiveness of the proposed algorithm, three different case studies are taken into consideration. A predictive control framework is also proposed to provide optimal operation with minimum cost. This method allows the consideration of operational cost values, demand with uncertainty, generation units' profiles with uncertainty, and constraints related to the network model and technical model. The stochastic and deterministic cases are conducted to validate the efficiency of the approach.
Anormallik Tespiti için Veri Madenciliği
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020) Kaçmaz, Rukiye Nur; Yılmaz, Bülent
Gastroentereloji uzmanları için kolon anormalliklerinin tespit edilmesi en zor görevlerden birisidir. Kolonoskopi herhangi bir anormalliği izlemek için kolondan video veya görüntüler kaydetmenin en yaygın yöntemidir. Bununla birlikte işlem sırasında elde edilen görüntü veya videolar, kolonoskopi probunun ya da kapsülün hızlı hareketinden kaynaklanan hareket gürültüsü, kapsülde ve probda ışık kaynağından kaynaklanan yansıma gürültüsü (YG), yetersiz veya aşırı aydınlatmadan kaynaklanan uygun olmayan kontrast gürültüsü, mide öz suyu, baloncuklar veya kalıntılar içermektedir. Bu tarz gürültüler içeren görüntülere bilgi taşımayan çerçeveler adı verilmektedir. Hastalık tespiti işlemi ise bilgi içeren olarak adlandırılan temiz görüntüler ile yürütülmektedir. İlk çalışmada tekstür tabanlı otomatik polip tespitinde YG'nin etkisini ve YG'yi ortadan kaldırmak için kullanılan görüntü enterpolasyonunun kullanımı araştırıldı. Bu amaçla, çeşitli boyutlarda sonradan YG eklenen ve interpolasyon uygulanan görüntülerden ve YG içermeyen görüntülerden çeşitli tekstür özellikleri elde edildi. Polipleri kolon arka planından ayırt etmek için, uygulanan en yakın komşular, bilineer ve bikübik interpolasyon yöntemlerinin, tekstür özellikleri ve sınıflandırma performansı açısından herhangi bir farklılığa neden olup olmadığı test edildi. İkinci çalışmada temel amaç, bilgi taşımayan çerçeveleri tespit etmede geleneksel makine öğrenmesi ve transfer öğrenme yaklaşımlarının performanslarının karşılaştırılmasıydı. Makine öğrenmesi bölümünde, gri seviye eş oluşum matrisi, gri seviye koşu uzunluğu matrisi, komşuluk gri ton farkı matrisi, odak ölçüm operatörleri ve basıklık, standart sapma ve çarpıklık olarak üç adet birinci derece istatistik kullanıldı. Sınıflandırma aşamasında rastgele orman, destek vektör makineleri ve karar ağacı yaklaşımları kullanılmıştır. Transfer öğrenme bölümünde derin sinir ağları olarak AlexNet, SqueezeNet, GoogleNet, ShuffleNet, ResNet-18, ResNet-50, NasNetMobile ve MobileNet tercih edildi. Son çalışma, bilgi taşıyan çerçevelerde Crohn's, ülseratif kolit, kanser ve polip gibi kolon anormalliklerinin saptanmasını içermiştir. Bu çalışmanın amacı, öncelikle sağlıklı çerçeveleri hastalıklılardan ayırmak ve hem geleneksel makine öğrenmesi hem de transfer öğrenme yaklaşımlarını kullanarak hastalık türlerini belirlemekti. İkinci çalışmada kullanılanlarla aynı tekstür özellikleri, sınıflandırma yaklaşımları ve transfer öğrenme yöntemleri kullanılmıştır.
Biyoçipler için Mikro Biyomalzemelerin ve Hücrelerin Görüntü İşleme Yöntemleri ile Otomatik Olarak Sayılması ve Analizi
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023) Çelebi, Fatma; İçöz, Kutay
Quantification of tumor cells is essential for early cancer detection and progression tracking. Multiple techniques have been devised to detect tumor cells. In addition to conventional laboratory instruments, several biochip-based techniques have been devised for this purpose. Our biochip design incorporates micron-sized immunomagnetic beads and micropad arrays, necessitating automated detection and quantification not only of cells but also of the micropads and immunomagnetic beads. The primary function of the biochip is to simultaneously acquire target cells with distinct antigens. As a readout technique for the biochip, this study devised a digital image processing-based method for quantifying leukemia cells, immunomagnetic beads, and micropads. Images were acquired on the chip using bright-field microscopy with image objectives of 20X and 40X. Conventional image processing methods, machine learning methods, and deep learning methods were used to analyze the images. To quantify targets in the images captured by a bright-field microscope, color- and size-based object recognition and machine learning-based methods were first implemented. Secondly, color- and size-based object detection and object segmentation methods were implemented to detect structures in bright-field optical microscope images acquired from the biochip. Third, segmentation of the minimal residual disease (MRD) using deep learning. Implemented biochip images comprised of leukemic cells, immunomagnetic beads, and micropads. Moreover, mesenchymal stem cells (MSCs) are stem cells with the capacity for multilineage differentiation and self-renewal. Estimating the proportion of senescent cells is therefore essential for clinical applications of MSCs. In this study, a self-supervised learning (SSL)-based method for segmenting and quantifying the density of cellular senescence was implemented, which can perform well despite the small size of the labeled dataset.
Blokzincir Tabanlı Eşten-Eşe Enerji Ticareti Uygulamaları
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023) Seven, Serkan; Alkan, Gülay Yalçın
This thesis explores the potential of innovative peer-to-peer (P2P) energy trading schemes for virtual power plants (VPPs) using blockchain technologies, smart contracts, and decentralized finance (DeFi) instruments. Traditional centralized approaches have limitations in terms of transparency and security, which can hinder the successful implementation and operation of VPPs and P2P energy trading systems. The dissertation begins by reviewing the current state of energy sources within the global energy landscape. Understanding the existing landscape provides valuable insights into the potential benefits and challenges of implementing P2P energy trading within VPPs. The focus of the dissertation is to develop and analyze innovative P2P energy trading schemes for VPPs that integrate blockchain technologies and facilities to enhance transparency, security, and automation of energy transactions. Furthermore, DeFi instruments, specifically decentralized exchange (DEX), are used as a novel approach instead of auction methods to determine P2P energy buying and selling prices. Along with blockchain technologies, optimization is used to maximize the economic benefits of peers. The sequential decision problem of the trading schemes is solved with mixed integer linear programming (MILP). In addition, machine/deep learning models are utilized to overcome the drawbacks of conventional mathematical programming like MILP. These models can accelerate the decision-making processes by learning from the optimization results obtained. Overall, frameworks for the successful integration of P2P energy trading within and among VPPs are developed to validate the effectiveness and feasibility of the proposed P2P energy trading schemes through case studies and simulations using realistic data sets and blockchain platforms.
Derin Öğrenme Tabanlı Kompozit Malzemelerin Ultrasonik Tomografi Görüntülerinden Kusurların Tespiti ve Sınıflandırılması
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Gülşen, Abdulkadir; Güngör, Burcu; Kolukısa, Burak
This thesis introduces novel methodologies for enhancing defect classification and characterization in advanced composite materials by leveraging state-of-the-art machine learning (ML), deep learning (DL), and federated learning (FL) techniques within ultrasonic and acoustic emission (AE) inspection environments. First, a new ultrasonic dataset (UNDT), comprising 1,150 images from 60 distinct composite materials, is introduced. Applying transfer learning methods to both the UNDT and a publicly available dataset demonstrates the efficacy of advanced neural architectures—such as DenseNet121 and VGG19—achieving accuracy rates up to 98.8% and 98.6%, respectively. Next, the scope is extended to AE-based health monitoring by introducing an ensemble feature selection methodology to identify features strongly correlated with damage modes. By selecting amplitude and peak frequency for labeling and subsequently applying unsupervised clustering, the analysis confirms that both traditional AE features (e.g., counts and energy) and less commonly employed features (e.g., partial powers) correlate with distinct defect types. Finally, a novel FL framework is introduced to address the scarcity of publicly available, real-world ultrasonic datasets. This decentralized approach preserves data privacy while maintaining performance levels comparable to centralized methods, ensuring scalability and confidentiality in diverse data environments. Overall, these contributions significantly advance the field of NDT, offering robust defect classification and characterization. In doing so, the findings not only improve the accuracy and reliability of material integrity assessments but also lay a durable foundation for more secure, collaborative, and efficient NDT systems.
Derin Öğrenme Yaklaşımlarıyla Küçük Hücreli Dışı Akciğer Kanserinde Tümör Karakterizasyonu
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2021) Bıçakcı, Mustafa; Yılmaz, Bülent
Küçük Hücreli Dışı Akciğer Kanseri (KHDAK) akciğer kanserlerinin büyük çoğunluğunu oluşturur ve adenokarsinom (ADC) ve skuamöz hücreli karsinom (SqCC) olmak üzere iki önemli alt tipi vardır. Genel olarak, bu iki alt tip mikroskobik olarak belirlenen morfolojik kriterler dikkate alınarak birbirinden ayrılır. Ancak, kötü morfoloji bunu oldukça zorlaştırır. Alt tipe özel tedavi yöntemleri için bu tür çalışmalar önemlidir. Bu tezde, pozitron emisyon tomografi (PET) görüntüleri kullanılarak KHDAK'nin alt tiplerinin sınıflandırılması üzerinde derin öğrenme (DÖ) yöntemleri incelenmiştir. İlk çalışmada, DÖ yöntemlerinin temelini oluşturan yapay sinir ağları (YSA) kullanılarak %73 doğru sınıflandırma başarısı elde edilmiştir. İkinci çalışmada, PET görüntülerinden alınan bölütlenmiş tümör kesitleri kullanılarak birkaç DÖ modeli incelenmiştir. Sonuçta, %95 F skoru ile VGG16 ve VGG19 en başarılı modeller olmuştur. Bu çalışmanın sonunda kesit bazlı çalışmalar bırakılarak hasta bazlı çalışmalara geçilmiştir. Üçüncü çalışmada, hasta bazlı dilimlerin birleştirilmesiyle oluşturulan üç boyutlu (3B) verilerin kullanımı yeterli başarıyı sağlamamıştır. Dördüncü çalışmada, PET görüntülerinin doğrudan kullanıldığı, tümör kısımlarının kırpılarak kullanıldığı ve bölütlenmiş tümör parçalarının kullanıldığı üç farklı deney yapılmıştır. Bu çalışma, peritümoral alanların sınıflandırmada olumlu etkisini ortaya koymuş ve VGG19 %74 F skoru değerine ulaşmıştır. Beşinci çalışmada, transfer öğrenme ve hassas ayar çalışmaları başarısızdı. CNN ve ResNet tabanlı sığ ağları içeren son çalışma %71 F skoru ile umut verici olmuştur.
El Protezleri için EEG ve EMG Sinyalleriyle Algı Kestirimi ve Tork Kontrolü
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Karakullukcu, Nedime; Yılmaz, Bülent
Upper extremity prostheses vary based on patients' articulation levels and movement methods. They can be cosmetic, operate mechanically with shoulder movement, or be controlled by myoelectronic and electroencephalography (EEG) signals. However, unnatural prosthesis control burdens users mentally. This thesis seeks to enhance bionic hand prosthesis control using EEG and electromyography (EMG) signals, coupled with users' visual weight perception, aiming to reduce physical and mental discomfort associated with mechanical prostheses. The prototype hand's preconditioning evaluates objects' weight visually, aiming to reduce shoulder force and mental load while holding an object. EEG and EMG signals from subjects were processed for real-time implementation. In the first stage, a study focused on operating the prosthesis using the motor intention waves of prosthesis users, and the machine learning approaches' classification success (detection of the intention to activate the prosthesis) was examined using EEG data from 30 healthy participants. The second stage recorded EEG and EMG signals from 31 participants during reaching, lifting, and placing an object, employing various classifications for object weight. In the real-time classification of multi-channel EEG signals from 20 healthy individuals using Fourier-based synchrosequeezing transform (FSST) and singular value decomposition (SVD) approaches, the system aimed to control the stiffness of the wrist part of the prosthesis. Consequently, the system could detect the weight of the object perceived by the user while using the prosthesis, allowing for the preconditioning of the prosthesis based on this weight when the user wants to hold and move the object.
Endüstriyel Ortamlarda Enerji Hasatlayan Çoğul Ortam Kablosuz Algılayıcı Ağları
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2020) Tekin, Nazlı; Güngör, Vehbi Çağrı
Sert kanal koşullarına sahip olan Endüstriyel Kablosuz Algılayıcı Ağ'larda (EKAA), enerji verimli ve güvenilir kablosuz iletişim sağlamak büyük önem taşımaktadır. Ağ güvenirliğini sağlarken aynı zamanda ağın ömrünü uzatmak da zor bir problemdir. Bu çalışmanın amacı, EKAA'ların ömrünün eniyilenmesidir. Bunu yaparken, endüstriyel ortamlar için uygun olan iç mekan güneş, termal ve titreşime dayalı Enerji Hasatlama (EH) yöntemleri tanımlanmış ve bunların ağ ömrüne katkıları araştırılmıştır. Uygulama güvenilirliğini ve EH yöntemlerini birlikte değerlendirerek, ağ ömrünü eniyilemek için yeni bir Karma Tamsayılı Programlama (KTP) modeli formüle edilmiştir. Ayrıca, Kablosuz Çoğul Ortam Algılayıcı Ağ'larında (KÇOAA) iletişim, büyük veri boyutu nedeniyle fazladan enerji tüketimine sebep olur. Bu nedenle, büyük veri boyutunu iletimden önce azaltmak önemli hale gelir.Bu amaçla, iletişim ve enerji dağıtım hesaplamalarını dikkate alırken, sıkıştırıcı algılama ve görüntü sıkıştırma gibi veri boyutu küçültme yöntemlerinin endüstriyel ağ ömrü üzerindeki etkisi değerlendirilir. Öte yandan, özellikle çok sayıda algılayıcılar bulunduran ağlar için KTP modelini uygun bir zamanda çözmek bir hayli zordur. KTP'nin zaman karmaşıklığı sorununun üstesinden gelmek için sezgisel tabanlı yöntemler geliştirilmiştir.
FDG-PET Görüntülerindeki Tümörlerin Makine ve Derin Öğrenme Tabanlı Analizi
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022) Ayyıldız, Oğuzhan; Yılmaz, Bülent
Analysis of a tumor is essential in treatment planning and evaluation of treatment response. Positron Emission Tomography (PET) is a vital imaging device for clinical oncology in understanding the metabolic structure of the tumor. In this thesis, three separate studies investigating the application of machine, deep learning and statistical approaches on FDG-PET images from patients with non-small cell lung cancer (NSCLC) and pancreatic cancer. The first study aimed at performing a survey on subtype classification of NSCLC by using different texture features, feature selection methods and classifiers. Images from 92 patients and several clinical and metabolic features for each case were used in this study along with histopathological validation for the tumor subtype labeling. Stacking classifier resulted in 76% accuracy. The aim of our second study was to adapt an atrous (dilated) convolution-based tumor segmentation approach (DeepLabV3) on FDG-PET slices with maximum standard uptake value (SUVmax). MobileNet-v2 pretrained on ImageNet served as the backbone to DeepLabV3. The classification layer was interchanged with the Tversky loss layer which helped improve model's performance while the dataset was imbalanced. Images from 141 patients were employed and augmentation was performed in each training phase. Dice similarity index was obtained as 0.76 without preprocessing and 0.85 with preprocessing. The last study focused on determining the features to be used in the prognosis of pancreatic adenocarcinoma on FDG-PET images from 72 patients. Well-known texture, metabolic and physical features were extracted from tumor region that was determined with the help of random walk segmentation algorithm. On these features time-dependent ROC curve analysis was performed for 2-year overall survival (OS) prediction, and, in the univariable analyses, tumor size, energy, entropy, and strength were found to be significant predictors of OS. Keywords: PET/CT, NSCLC, Machine learning, Deep learning, Radiomics, Semantic segmentation
Genetik ve Enfeksiyon Hastalıklarının Tespiti için Makine Öğrenmesi Yöntemleri
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Işık, Yunus Emre; Aydın, Zafer
Completion of the whole human genome in the 2003 has led to various advances in many fields, particularly in biology, genetics, health sciences, treatment, and pharmacology. In the following years, spread of faster and cheaper sequencing technologies has enabled us to extract and analyze genetic profiles of individuals digitally. Consequently, individual-specific forecasting and personalized treatment and precision medicine-, what once seemed like science fiction, have become more and more real. In both approaches, one of the crucial steps is identifying the presence of diseases using individual-specific genetic data. This thesis aims to comprehensively and comparatively evaluate the predictive performance of machine learning methods for Behçet's disease and respiratory infections. Additionally, feature selection methods were employed to identify the genetic factors (such as SNPs and genes) associated with disease presence for both diseases. Furthermore, the usability of selected features depending on biological pathway-driven active subnetworks listed in the literature was analyzed for the prediction of Behçet's disease. For the respiratory infection prediction problem, on the other hand, the prediction performance of features calculated by single-sample gene set enrichment analysis (ssGSEA) was evaluated using different machine learning methods. As the data types used in both experiments were different (genome-wide association studies data, gene expression profiles), the performance of machine learning approaches on different data types was also observed. It is hoped that the findings of both experiments will contribute to future machine learning based disease prediction studies.
Görüntü Tanıma Tabanlı Gökyüzü Kamerası Entegrasyonunu Kullanarak Sezgisel Vektörize Öğrenme Yöntemine Dayalı PV Tahmini
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023) Yavuz, Levent; Önen, Ahmet
In order to ensure the continuity of demand and production balance, the use of renewable energy resources (RES) by countries will increase in the near future. Solar power generation is important for the integration of renewable energy into the power grid, but it can cause problems in power systems due to the uncertain and intermittent nature of solar power. Deep learning methods provide promising results in solar energy prediction, but the performance of these models depends on the initial weights assigned to the network. In this thesis, a novel weight initialization method, the Heuristic Vectorised Learning method, which takes into account certain characteristics of solar generation data has been proposed. This method aims to achieve better accuracy in solar forecasting by combining a statistical approach with a method based on deep learning. The method was compared with other commonly used methods such as Xavier, LeCun, He and Random, and it was seen that the proposed method performed better. Overall, the proposed weight initialization method provides significant benefits for solar forecasting applications in the context of renewable energy integration into the power grid. So, to reach higher accuracy, monitoring the sky is the best option for intra-day forecasts. Therefore, a hybrid model was created for photovoltaic generation prediction by using it together with environmental sensor data. The proposed method and panel shading model achieve higher accuracy values at the Abdullah Gül University campus in Kayseri. The proposed system provides a reliable PV energy forecast for the intraday energy markets.
Hastalık Tahmini ve Biyobelirteçlerin Tespiti için Makine Öğrenim Modellerinin Tasarımı ve Geliştirilmesi
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Temiz, Mustafa; Güngör, Burcu; Yousef, Malik
In medical science, the prediction of diseases and the identification of biomarkers play an important role in the diagnosis and treatment of various health conditions. The recent proliferation of data mining techniques has accelerated the development of disease prediction systems. In particular, machine learning methods are an effective way to analyze medical data and identify patterns to predict the likelihood of the disease development. Machine learning methods also help to identify biomarkers. Recently, the increasing incidence and mortality rates of inflammatory bowel disease, colorectal cancer and type 2 diabetes have drawn researchers' attention to these research areas. The aim of this thesis is to reduce the number of features and improve the prediction performance of machine learning based on complex biological datasets with a large number of disease-related features, as well as to identify potential biomarkers. In this thesis, three different studies are presented. The first study predicts eleven different cancer subgroups using miRNA data and biological domain knowledge and identifies potential biomarkers for these diseases. The second study predicts three different diseases using metagenomic data and biological domain knowledge and identifies potential biomarkers. The third study uses metagenomic data related to colorectal cancer to conduct global and population-based comprehensive experiments with traditional feature selection methods to identify potential biomarkers. This thesis presents a promising avenue for early disease detection, facilitating expedited treatment protocols, improving human survival rates, and potentially alleviating economic burdens within these critical research domains.
Histopatoloji Görüntülerinden Bilgisayar Destekli Kanser Tespiti
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023) Taşdemir, Sena Büşra Yengeç; Yılmaz, Bülent; Aydın, Zafer
Detecting colon adenomatous polyps early is crucial for reducing colon cancer risk. This thesis investigated various deep learning approaches for computer-aided diagnosis of colon polyps on histopathology images using deep learning. The thesis addressed key challenges in polyp classification, including differentiating adenomatous polyps from non-adenomatous tissues and multi-class classification of polyp types. Initially, a histopathology image dataset is collected and refined from Kayseri City Hospital. The first study used stain normalization algorithms and an ensemble framework for binary classification, achieving 95% accuracy on the custom dataset and 91.1% and 90% on UnitoPatho and EBHI datasets, respectively. The second study implemented a tailored version of the supervised contrastive learning model for multi-class classification, outperforming state-of-the-art deep learning models with accuracies of 87.1% on custom dataset and 70.3% on UnitoPatho dataset. The third study proposed a self-supervised contrastive learning approach for utilizing all data in cases of limited labeled images. This approach achieved better performance than transfer learning with ImageNet pre-trained models. In conclusion, this PhD thesis investigated deep learning approaches for computer-aided diagnosis of colon polyps on histopathology images, demonstrating high accuracy in binary and multi-class classification, outperforming state-of-the-art models. These findings contribute to improving colon polyp classification accuracy and efficiency, ultimately facilitating the early detection and prevention of colon cancer.
Koloidal Nanomalzemelerin Akıllı Kendinden Dizilimi ile Nanofotonik Mimarilerin Tasarımı ve Uygulaması
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Şenel, Zeynep; Erdem, Talha
DNA-driven self-assembly techniques offer precise control over the positioning of colloidal nanoparticles through specific Watson–Crick interactions, and its reversibility via controlling the temperature of medium. This thesis explores an alternative strategy to control DNA-functionalized nanoparticles' binding/unbinding process by leveraging laser radiation, inducing localized heating within the nanoparticles to facilitate disassociation. First, we demonstrate the active manipulation of the optical properties of DNA-assembled gold nanoparticle networks via external optical excitation. Specifically, irradiation with a green hand-held laser yields a substantial ∼30% increase in total transmittance, accompanied by a transition from opaque to transparent states observable in optical microscopy images. The reversibility of this process is demonstrated by the restoration of the nanoparticle network post-irradiation cessation, underscoring the efficacy of optical excitation in tailoring both the structure and optical characteristics of DNA-mediated nanoparticle assemblies. Second, we introduce a method to tailor DNA-driven self-assembly of semiconductor nanoparticles on glass by applying an external optical field. A green laser directs the assembly of DNA-functionalized red-emitting quantum dots (QDs) on DNA-functionalized glass, leaving uncoated spots owing to localized heating. This effect becomes prominent after three hours of radiation using a laser with an irradiance of 57.1 W/cm2. Experiments with different lasers and nanoparticle types confirm the role of laser-induced heating in preventing QD-glass bonding via DNA-DNA interaction. Secondary coating of previously uncoated spots with DNA-functionalized green-emitting QDs and dye-functionalized DNAs indicates a successful hierarchical self-assembly. Our findings highlight the potential of light-assisted DNA-driven self-assembly for diverse nanoparticle architectures, promising applications in optoelectronics and nanophotonics. Keywords: Programmable self-assembly, DNA-driven self-assembly, localized heating, colloidal nanoparticles, DNA conjugation.
Makine Öğrenmesi Tabanlı Ağ Anomali Tespiti
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Hacılar, Hilal; Güngör, Burcu; Güngör, Vehbi Çağrı
Intelligent technologies have led to a significant rise in internet users and applications. However, this rise in internet usage has also brought serious security challenges. Organizations rely on Network Intrusion Detection systems (NIDS) to protect sensitive data from unauthorized access and theft. To enhance the capabilities of IDS, Machine Learning (ML) and Deep Learning (DL) techniques have been increasingly integrated into these systems. In this context, anomaly-based network intrusion detection surpasses other detection mechanisms significantly in several instances. These systems analyze network traffic to detect suspicious activities, such as attempted breaches or cyberattacks. However, existing studies lack a thorough assessment of class imbalances, feature selection and extraction methods, hyperparameter optimization, and classification performance for different types of network intrusions: wired, wireless, and Software Defined Networking (SDN). Additionally, existing methods may achieve high accuracy; they may suffer from high training times, low detection rate (DR), and computational complexity. By combining metaheuristics and neural networks, it is possible to solve complex optimization problems that are challenging to solve using conventional methods. To address these challenges, this thesis study first evaluates different network intrusion datasets, such as wired, wireless, and SDN, together, considering class imbalance, feature selection, and hyperparameter optimization tasks. Secondly, it proposes a novel hybrid approach combining Deep Autoencoder (DAE) and Artificial Neural Network (ANN) models trained by a parallel Artificial Bee Colony (ABC) algorithm with Bayesian hyperparameter optimization.
Makine Öğrenmesi Yöntemleriyle Antimikrobiyal Peptit Aktivite Tahmini
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2023) Söylemez, Ümmü Gülsüm; Güngör, Burcu
Antimicrobial peptides (AMPs) are considered as promising alternatives to conventional antibiotics in order to overcome the growing problems of antibiotic resistance. Computational prediction approaches receive an increasing interest to identify and design the best candidate AMPs prior to the in vitro tests. In this thesis, using the multiple properties of the peptides we aimed to develop machine learning approaches that can predict the antimicrobial activities of the peptides. We have created two datasets for the peptides showing antimicrobial activity against Gram-negative and against Gram-positive bacteria separately. In our first study, ten different physico-chemical properties of the peptides were calculated, and used as features of the peptides. Following the data exploration and data preprocessing steps, a variety of classification models were build with 100-fold Monte Carlo Cross-Validation; and the performance of these models were evaluated. In the second study, we proposed a novel method called AMP-GSM. The method was tested for three datasets, and the prediction performance of AMP-GSM was comparatively evaluated with several feature selection methods and several classifiers. In the last study, using motif matching score with the models of activity against Gram-positive and Gram-negative bacteria, we created novel peptides and predicted the target selectivity of these peptides. The studies presented in this thesis advance the field of computational research by making it easier to predict the possible antimicrobial effects of peptides and to design AMPs in wet laboratory environments.
Medikal Termal Görüntülerin Otomatik Olarak İşlenmesi ve Sınıflandırılması
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2022) Özdil, Ahmet; Yılmaz, Bülent
The aim of this dissertation is to develop computer aided methods for processing and evaluating medical infrared thermal images. Throughout this study three problems were evaluated. The first problem was to automatically classify the body part and pose in the thermal images. In this study there were four classes; upper-lower body parts with back-front views. The first step included the segmentation of the background with Otsu's thresholding method applying histogram equalization. Next, DarkNet-19 architecture was used to extract features from images and these features were reduced using PCA and t-SNE methods. Finally reduced feature sets were used for classification. The second problem was to automatically classify liver steatosis from using thermal images. In this study, the classification problem was tested on an anatomical region of interest from abdominal images corresponding to the liver. Deep learning and texture analysis methods were employed for feature extraction, and then the selected feature sets were used for classification. The third problem was to quantify thermograms of multiple sclerosis (MS) patients for better assessment of the disease and monitoring the therapy. Thermal images of two patients and a healthy control from lower limbs were evaluated during experiments, and localized quantification of the effect of MS on the feet of the patients using thermal images method was proposed. The proposed method was fully correlated with the evaluations of physician. It is shown that medical thermal imaging has high potential in many fields of medicine as a non-invasive method for pre-diagnosis and follow-up.
Merkezi Olmayan Elektronik Sağlık Kaydı Yönetim Sistemi ve Makine Öğrenmesi Yöntemleri ile Hastalık Tahmini
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Dedetürk, Beyhan Adanur; Güngör, Burcu
Electronic health records (EHRs) are vital to the advancement of healthcare and can help detect and prevent diseases early. However, EHR sharing faces challenges such as managing large data volumes, ensuring data privacy, security, and interoperability. This thesis aims to develop and analyze a blockchain-based EHR sharing system for disease prediction mechanism integration using SysML. The AguHyper platform, built by merging the InterPlanetary File System (IPFS) with Hyperledger Fabric, ensures the immutability of health records by storing hash values in the blockchain and encrypted records in IPFS. The system architecture and implementation configurations, including CouchDB and the Raft consensus mechanism, are thoroughly examined. The study also presents a novel hybrid approach called CSA-DE-LR, which integrates Differential Evolution (DE) and Clonal Selection Algorithm (CSA) with Logistic Regression (LR) to improve LR weights for precise categorization of cardiovascular diseases. The integration of the AguHyper with the CSA-DE-LR is explained in detail. At the end of our performance evaluations, we concluded that the AguHyper model has the potential to speed up the process of collecting and sharing data, and it offers an efficient platform for the participants.
MRG Taramalarında Alzheimer Hastalığının Zaman Dağılımlı Sınıflandırılması
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Dündar, Mehmet Sait; Yılmaz, Bülent
This thesis presents a comprehensive framework for studying Alzheimer's Disease (AD) progression by focusing on the classification of AD, Mild Cognitive Impairment (MCI), and Cognitively Normal (CN) individuals using advanced machine learning models that analyze changes in brain volumetrics over time through MRI scans. In the first phase of the research, MR images from the Alzheimer's Disease Neuroimaging Initiative database were utilized, which included sequences of 3-4 scans taken annually from 22 CN, 18 AD, and 20 MCI subjects. Key volumetric parameters such as cortical thickness and intracranial volumes were extracted using the CAT12 toolbox in SPM software. A novel classification method based on the rate of volumetric changes over time was employed, effectively capturing the progressive nature of neurological changes. This approach achieved accuracies of 82.5% in distinguishing AD from CN, 71% in differentiating MCI from AD, and 69% in separating MCI from CN, alongside a 55% accuracy in a three-way classification using random forest and support vector machines. Building on these initial insights, the second phase of the study significantly advanced the methodology by integrating a pre-trained 3D ResNet 101 CNN algorithm for initial spatial categorization of MRI scans, followed by the use of Long Short-Term Memory (LSTM) networks. These LSTMs processed the same sequences of 3-4 annual scans for each patient, enhancing the model's ability to analyze and interpret the temporal progression of volumetric changes. This sophisticated approach led to marked improvements in classification accuracy: 96.7% in differentiating AD from CN, 87.5% in distinguishing AD from MCI, and 86.4% in separating MCI from CN. The study effectively demonstrates a significant enhancement in capturing the temporal dynamics of AD progression.
Nesnelerin İnterneti Tabanlı Araç Tipi Sınıflandırma ve Ağ Anomalisi Tespiti için Makine Öğrenmesi Yaklaşımları
(Abdullah Gül Üniversitesi, Fen Bilimleri Enstitüsü, 2024) Kolukısa, Burak; Güngör, Vehbi Çağrı
This thesis presents innovative approaches in the realms of Intelligent Transportation Systems (ITS) and Network Intrusion Detection Systems (NIDS) within the Internet of Things (IoT). Leveraging IoT technologies, a low-cost, battery-operated 3-D magnetic sensor has been developed for ITS to enable the classification of vehicle categories. The research presents machine learning and deep learning models that are improved by using oversampling, feature selection and extraction methods, hyperparameter optimization, and converting signals into 2-D images. New methods have been proposed for vehicle type classification to boost classification performance and achieve an accuracy of up to 92.92%. Additionally, the increasing reliance on IoT devices for such applications introduces significant cybersecurity risks. To mitigate these vulnerabilities, a novel logistic regression model trained with a parallel artificial bee colony (LR-ABC) algorithm has been proposed for network anomaly detection. This model incorporates hyperparameter optimization to enhance detection capabilities, showcasing superior performance on popular benchmark NIDS datasets with accuracies of 88.25% and 90.11%. Overall, this research contributes to the advancement of IoT and IoT cybersecurity by offering robust, scalable, and efficient solutions. These innovations not only enhance vehicle type classification and network security in the IoT era but also pave the way for future IoT infrastructure development in an increasingly connected digital landscape.

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