WoS İndeksli Yayınlar Koleksiyonu
Permanent URI for this collectionhttps://hdl.handle.net/20.500.12573/394
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Article A Small Indole Derivative Isolated From Caper (Capparis Ovata) as an Inducer of P53-Mediated Apoptosis in Prostate Cancer: Comprehensive In Vitro and In Silico Studies(Wiley, 2025-12-31) Acar, Ozden Ozgun; Gazioglu, Isil; Oruc, Hatice; Kale, Elif; Senol, Halil; Topcu, Gulacti; Sen, AlaattinNatural products with stunning chemical diversity have been extensively researched for their anticancer potential for more than fifty years. This study aimed to determine the effect of indole derivative 1H-indole-2-hydroxy-3-carboxylic acid (IHCA), isolated as a novel alkaloid from Capparis ovata, on selected tumor suppressor, apoptotic, and cell cycle regulatory genes, which are known to be important in cancer pathophysiology, on Caco-2 and LNCaP cells in comparison with Taxol. The molecular mechanism of IHCA's anticancer activity is essentially undefined. Different concentrations of IHCA increased the expression levels of apoptosis-related genes, including BCL-2 and TNF-alpha. In addition, the tumor suppressor genes PTEN, P53, and RB were increased in LNCaP and Caco-2 cells. KRAS, an oncogenic gene, was significantly downregulated by IHCA in LNCaP cells. Western blot results showed that the protein expression levels of P53 and PTEN in LNCaP cells were increased when treated with IHCA, whereas CDK4 and TNF-alpha were decreased. Finally, IHCA and doxorubicin significantly increased P53-driven luciferase activity compared to the control. The results strongly suggest that the novel natural compound IHCA has an anticancer effect involving the regulation of the P53 gene and its networks in vitro. The molecular docking and MD simulation analyses reveal that IHCA exhibits superior binding potential to the MDM2 protein compared to Nutlin-3a. MD simulations further confirm that IHCA maintains a more stable and consistent interaction with MDM2, as indicated by lower RMSD values and reduced ligand fluctuation. These results highlight IHCA's potential as a more effective MDM2 inhibitor, suggesting its promise as a lead compound for anticancer drug development.Clinical Trial Registration: Not applicable.Conference Object Bioinformatics Analysis of Antifungal Mechanisms in Serratia Fonticola: Protein-Protein Interaction with Botrytis Cinerea BAG1 and Genome-Encoded Enzyme Reportoire(Wiley, 2025) Bozkurt, E. B.; Baysal, O.; Marzec-Grzadziel, A.; Silme, R. S.; Can, A.; Belen, I. N.; Korkut, A.Conference Object The Role of X-Inactive Specific Transcript (XIST) in Neuronal Development, Neuroinflammation, Myelination, and Therapeutic Responses in Cerebral Organoids(Wiley, 2025) Pepe, N. Aktas; Acar, B.; Zararsiz, G. Erturk; Guner, S. Ayaz; Sen, A.Conference Object Identification of Key Biological Pathways and Genes in Multiple Sclerosis via Integrating Domain Knowledge into the Machine Learning Model(Wiley, 2025) Ersoz, N. S.; Yousef, M.; Guner, S. Ayaz; Gungor, B.; Sen, A.Article Citation - WoS: 1Citation - Scopus: 1A Comprehensive Review on the Extraction and Recovery of Lithium from Primary and Secondary Sources: Advances Toward Battery-Grade Materials(Wiley, 2025-10-20) Top, Soner; Kursunoglu, Sait; Altiner, MahmutLithium-ion battery (LIB) technologies have become indispensable to modern energy systems, driving global demand for high-purity lithium compounds. This review focuses on lithium recovery and purification strategies for battery-grade lithium carbonate (Li2CO3) and lithium hydroxide (LiOH), addressing both primary sources (brines and minerals) and secondary sources (waste materials). Industrially established processes, such as evaporation-based brine treatment and conventional metallurgical methods, are discussed alongside emerging techniques, including membrane separation, solvent extraction, and CO2-assisted precipitation. Particular attention is given to lithium precipitation mechanisms, the behaviour of co-existing ions during extraction, and the specific quality requirements for cathode material synthesis. By evaluating process scalability, environmental impact, and product purity, this review provides a comprehensive understanding of current practices and future directions. Additionally, it highlights the growing importance of lithium in the context of accelerating electric vehicle (EV) adoption, underscoring the bright and expanding future of the lithium industry.Conference Object An Innovative Probiotic, Ln-AGA58, Demonstrates Immunosuppressive Effects in Treating Multiple Sclerosis(Wiley, 2025) Ozen, M. B.; Bozkurt, E. B.; Ortakci, F.; Sen, A.; Acar, O. OzgunConference Object Aurora B Inhibition Amplifies Cisplatin-Induced Apoptosis in DLD-1 Cells(Wiley, 2025) Ozsoy, E. R.; Turk, S. SariConference Object Therapeutic Potential of Pyrvinium Pamoate in Multiple Sclerosis Applying Brain Organoids(Wiley, 2025) Demirkol, N. M.; Ayten, M. N.; Acar, B.; Pepe, N. Aktas; Sen, A.Conference Object Co-Culture Spheroid Model for Neurodevelopment and Disease Modeling(Wiley, 2025) Ayten, M. N.; Demirkol, N. M.; Pepe, N. Aktas; Acar, B.; Sen, A.Conference Object In-Depth miRNA Profiling Uncovers Unique Microrna Signatures in the Neuroglia of the Tay-Sachs Disease Mouse Model(Wiley, 2025) Kaya, B.; Orhan, M. E.; Demir, S. A.; Yanbul, S.; Demirci, M. D. Sacar; Seyrantepe, V.